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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TBX21_TBR1

Z-value: 1.14

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Transcription factors associated with TBX21_TBR1

Gene Symbol Gene ID Gene Info
ENSG00000073861.2 T-box transcription factor 21
ENSG00000136535.10 T-box brain transcription factor 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TBX21hg19_v2_chr17_+_45810594_458106100.564.9e-19Click!
TBR1hg19_v2_chr2_+_162272605_1622727530.474.1e-13Click!

Activity profile of TBX21_TBR1 motif

Sorted Z-values of TBX21_TBR1 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_54320078 21.64 ENST00000231009.2
granzyme K (granzyme 3; tryptase II)
chr11_+_73358594 21.43 ENST00000227214.6
ENST00000398494.4
ENST00000543085.1
pleckstrin homology domain containing, family B (evectins) member 1
chr5_-_131132614 18.10 ENST00000307968.7
ENST00000307954.8
folliculin interacting protein 1
chr14_+_95078714 17.58 ENST00000393078.3
ENST00000393080.4
ENST00000467132.1
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
chr15_-_83316087 15.69 ENST00000568757.1
cytoplasmic polyadenylation element binding protein 1
chr14_+_75745477 15.51 ENST00000303562.4
ENST00000554617.1
ENST00000554212.1
ENST00000535987.1
ENST00000555242.1
FBJ murine osteosarcoma viral oncogene homolog
chr15_-_83316254 14.20 ENST00000567678.1
ENST00000450751.2
cytoplasmic polyadenylation element binding protein 1
chr22_-_38699003 14.15 ENST00000451964.1
casein kinase 1, epsilon
chr2_-_175869936 13.17 ENST00000409900.3
chimerin 1
chr8_-_27457494 12.44 ENST00000521770.1
clusterin
chr1_+_38022513 12.41 ENST00000296218.7
dynein, axonemal, light intermediate chain 1
chr5_+_74807886 12.09 ENST00000514296.1
polymerase (DNA directed) kappa
chr2_-_175870085 11.96 ENST00000409156.3
chimerin 1
chr11_+_112832202 11.84 ENST00000534015.1
neural cell adhesion molecule 1
chr13_+_42031679 11.48 ENST00000379359.3
regulator of cell cycle
chr9_+_17134980 11.16 ENST00000380647.3
centlein, centrosomal protein
chr11_+_112832090 10.99 ENST00000533760.1
neural cell adhesion molecule 1
chr22_+_23243156 10.52 ENST00000390323.2
immunoglobulin lambda constant 2 (Kern-Oz- marker)
chr1_-_11907829 10.44 ENST00000376480.3
natriuretic peptide A
chr7_-_100026280 10.00 ENST00000360951.4
ENST00000398027.2
ENST00000324725.6
ENST00000472716.1
zinc finger, CW type with PWWP domain 1
chrX_+_56259316 9.88 ENST00000468660.1
Kruppel-like factor 8
chr14_+_75746781 9.85 ENST00000555347.1
FBJ murine osteosarcoma viral oncogene homolog
chr11_-_133826852 9.75 ENST00000533871.2
ENST00000321016.8
immunoglobulin superfamily, member 9B
chr3_-_66551397 9.60 ENST00000383703.3
leucine-rich repeats and immunoglobulin-like domains 1
chr1_-_163172625 9.51 ENST00000527988.1
ENST00000531476.1
ENST00000530507.1
regulator of G-protein signaling 5
chr9_+_17135016 9.46 ENST00000425824.1
ENST00000262360.5
ENST00000380641.4
centlein, centrosomal protein
chr11_-_236326 9.23 ENST00000525237.1
ENST00000532956.1
ENST00000525319.1
ENST00000524564.1
ENST00000382743.4
sirtuin 3
chr7_-_36764004 9.14 ENST00000431169.1
acyloxyacyl hydrolase (neutrophil)
chr17_-_8066843 8.96 ENST00000404970.3
vesicle-associated membrane protein 2 (synaptobrevin 2)
chr5_-_131132658 8.96 ENST00000514667.1
ENST00000511848.1
ENST00000510461.1
Folliculin-interacting protein 1
folliculin interacting protein 1
chr12_+_69742121 8.73 ENST00000261267.2
ENST00000549690.1
ENST00000548839.1
lysozyme
chr7_-_36764142 8.61 ENST00000258749.5
ENST00000535891.1
acyloxyacyl hydrolase (neutrophil)
chr1_+_89829610 8.61 ENST00000370456.4
ENST00000535065.1
guanylate binding protein family, member 6
chr17_+_34431212 8.38 ENST00000394495.1
chemokine (C-C motif) ligand 4
chr2_-_157189180 8.26 ENST00000539077.1
ENST00000424077.1
ENST00000426264.1
ENST00000339562.4
ENST00000421709.1
nuclear receptor subfamily 4, group A, member 2
chr3_-_179169330 7.97 ENST00000232564.3
guanine nucleotide binding protein (G protein), beta polypeptide 4
chrY_+_2709527 7.96 ENST00000250784.8
ribosomal protein S4, Y-linked 1
chr3_-_66551351 7.91 ENST00000273261.3
leucine-rich repeats and immunoglobulin-like domains 1
chr11_+_17756279 7.89 ENST00000265969.6
potassium voltage-gated channel, Shaw-related subfamily, member 1
chr1_-_25256368 7.82 ENST00000308873.6
runt-related transcription factor 3
chr12_+_14572070 7.64 ENST00000545769.1
ENST00000428217.2
ENST00000396279.2
ENST00000542514.1
ENST00000536279.1
activating transcription factor 7 interacting protein
chr10_+_118305435 7.56 ENST00000369221.2
pancreatic lipase
chr8_+_1993173 7.54 ENST00000523438.1
myomesin 2
chrY_+_2709906 7.45 ENST00000430575.1
ribosomal protein S4, Y-linked 1
chr6_+_131894284 7.43 ENST00000368087.3
ENST00000356962.2
arginase 1
chr16_-_30546141 7.40 ENST00000535210.1
ENST00000395094.3
zinc finger protein 747
chr11_-_76155700 7.25 ENST00000572035.1
RP11-111M22.3
chr19_-_39390350 7.01 ENST00000447739.1
ENST00000358931.5
ENST00000407552.1
sirtuin 2
chr9_+_134378289 6.85 ENST00000423007.1
ENST00000404875.2
ENST00000441334.1
ENST00000341012.7
ENST00000372228.3
ENST00000402686.3
ENST00000419118.2
ENST00000541219.1
ENST00000354713.4
ENST00000418774.1
ENST00000415075.1
ENST00000448212.1
ENST00000430619.1
protein-O-mannosyltransferase 1
chr6_-_84937314 6.71 ENST00000257766.4
ENST00000403245.3
KIAA1009
chr22_-_31688431 6.68 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
phosphoinositide-3-kinase interacting protein 1
chr11_-_76155618 6.67 ENST00000530759.1
RP11-111M22.3
chr14_-_81687575 6.65 ENST00000434192.2
general transcription factor IIA, 1, 19/37kDa
chr2_+_219247021 6.59 ENST00000539932.1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr7_+_150264365 6.48 ENST00000255945.2
ENST00000461940.1
GTPase, IMAP family member 4
chr17_+_25799008 6.36 ENST00000583370.1
ENST00000398988.3
ENST00000268763.6
kinase suppressor of ras 1
chr4_+_166300084 6.32 ENST00000402744.4
carboxypeptidase E
chr6_-_52705641 6.10 ENST00000370989.2
glutathione S-transferase alpha 5
chr3_-_196065248 6.06 ENST00000446879.1
ENST00000273695.3
transmembrane 4 L six family member 19
chr1_+_184356188 6.03 ENST00000235307.6
chromosome 1 open reading frame 21
chr5_-_39270725 6.00 ENST00000512138.1
ENST00000512982.1
ENST00000540520.1
FYN binding protein
chr6_+_142468361 5.91 ENST00000367630.4
vesicle (multivesicular body) trafficking 1
chr1_+_38022572 5.84 ENST00000541606.1
dynein, axonemal, light intermediate chain 1
chr12_-_45269430 5.83 ENST00000395487.2
NEL-like 2 (chicken)
chr8_-_22089845 5.72 ENST00000454243.2
phytanoyl-CoA 2-hydroxylase interacting protein
chr20_+_44509857 5.64 ENST00000372523.1
ENST00000372520.1
zinc finger, SWIM-type containing 1
chr8_-_22089533 5.58 ENST00000321613.3
phytanoyl-CoA 2-hydroxylase interacting protein
chr8_+_103563792 5.54 ENST00000285402.3
outer dense fiber of sperm tails 1
chr11_-_6440624 5.46 ENST00000311051.3
amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65)
chr2_+_143886877 5.46 ENST00000295095.6
Rho GTPase activating protein 15
chr1_-_156786634 5.42 ENST00000392306.2
ENST00000368199.3
SH2 domain containing 2A
chr6_+_32132360 5.37 ENST00000333845.6
ENST00000395512.1
ENST00000432129.1
EGF-like-domain, multiple 8
chr6_-_13487784 5.35 ENST00000379287.3
glucose-fructose oxidoreductase domain containing 1
chr10_+_135050908 5.34 ENST00000325980.9
VENT homeobox
chr6_-_46459675 5.34 ENST00000306764.7
regulator of calcineurin 2
chr1_-_153029980 5.34 ENST00000392653.2
small proline-rich protein 2A
chr3_-_61237050 5.31 ENST00000476844.1
ENST00000488467.1
ENST00000492590.1
ENST00000468189.1
fragile histidine triad
chr16_+_75681650 5.31 ENST00000300086.4
telomeric repeat binding factor 2, interacting protein
chr7_+_143013198 5.29 ENST00000343257.2
chloride channel, voltage-sensitive 1
chr5_+_66124590 5.15 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
microtubule associated serine/threonine kinase family member 4
chr9_-_96717654 5.11 ENST00000253968.6
BARX homeobox 1
chr11_+_6281036 5.07 ENST00000532715.1
ENST00000525014.1
ENST00000531712.1
ENST00000525462.1
cholecystokinin B receptor
chr1_+_182758900 5.03 ENST00000367555.1
ENST00000367554.3
N-acetylneuraminate pyruvate lyase (dihydrodipicolinate synthase)
chrX_+_129473859 4.96 ENST00000424447.1
solute carrier family 25 (mitochondrial carrier, brain), member 14
chr1_+_50513686 4.85 ENST00000448907.2
ELAV like neuron-specific RNA binding protein 4
chr19_-_50529193 4.80 ENST00000596445.1
ENST00000599538.1
vaccinia related kinase 3
chr2_-_73053126 4.79 ENST00000272427.6
ENST00000410104.1
exocyst complex component 6B
chr1_-_19229014 4.74 ENST00000538839.1
ENST00000290597.5
aldehyde dehydrogenase 4 family, member A1
chr1_-_156786530 4.73 ENST00000368198.3
SH2 domain containing 2A
chr6_+_170190417 4.71 ENST00000420557.2
long intergenic non-protein coding RNA 574
chr1_+_150898812 4.70 ENST00000271640.5
ENST00000448029.1
ENST00000368962.2
ENST00000534805.1
ENST00000368969.4
ENST00000368963.1
ENST00000498193.1
SET domain, bifurcated 1
chr6_+_45390222 4.68 ENST00000359524.5
runt-related transcription factor 2
chr17_-_7493390 4.66 ENST00000538513.2
ENST00000570788.1
ENST00000250055.2
SRY (sex determining region Y)-box 15
chr15_+_25200074 4.66 ENST00000390687.4
ENST00000584968.1
ENST00000346403.6
ENST00000554227.2
small nuclear ribonucleoprotein polypeptide N
chr6_-_112194484 4.65 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
FYN oncogene related to SRC, FGR, YES
chr4_-_121843985 4.62 ENST00000264808.3
ENST00000428209.2
ENST00000515109.1
ENST00000394435.2
PR domain containing 5
chr22_-_31688381 4.59 ENST00000487265.2
phosphoinositide-3-kinase interacting protein 1
chr1_+_2036149 4.57 ENST00000482686.1
ENST00000400920.1
ENST00000486681.1
protein kinase C, zeta
chr1_-_183387723 4.57 ENST00000287713.6
nicotinamide nucleotide adenylyltransferase 2
chr19_-_15529790 4.56 ENST00000596195.1
ENST00000595067.1
ENST00000595465.2
ENST00000397410.5
ENST00000600247.1
A kinase (PRKA) anchor protein 8-like
chr17_-_76356148 4.53 ENST00000587578.1
ENST00000330871.2
suppressor of cytokine signaling 3
chr5_+_176853702 4.52 ENST00000507633.1
ENST00000393576.3
ENST00000355958.5
ENST00000528793.1
ENST00000512684.1
G protein-coupled receptor kinase 6
chr12_-_7848364 4.52 ENST00000329913.3
growth differentiation factor 3
chr12_+_4918342 4.52 ENST00000280684.3
ENST00000433855.1
potassium voltage-gated channel, shaker-related subfamily, member 6
chr17_+_54911444 4.51 ENST00000284061.3
ENST00000572810.1
diacylglycerol kinase, epsilon 64kDa
chr1_-_19229248 4.46 ENST00000375341.3
aldehyde dehydrogenase 4 family, member A1
chr17_-_9929581 4.46 ENST00000437099.2
ENST00000396115.2
growth arrest-specific 7
chr17_-_37309480 4.36 ENST00000539608.1
plexin domain containing 1
chr16_+_28834531 4.31 ENST00000570200.1
ataxin 2-like
chr3_+_167453493 4.30 ENST00000295777.5
ENST00000472747.2
serpin peptidase inhibitor, clade I (neuroserpin), member 1
chr14_+_24583836 4.30 ENST00000559115.1
ENST00000558215.1
ENST00000557810.1
ENST00000561375.1
ENST00000446197.3
ENST00000559796.1
ENST00000560713.1
ENST00000560901.1
ENST00000559382.1
DDB1 and CUL4 associated factor 11
chr19_+_10381769 4.29 ENST00000423829.2
ENST00000588645.1
intercellular adhesion molecule 1
chr17_+_76356516 4.22 ENST00000592569.1
RP11-806H10.4
chr3_-_49466686 4.20 ENST00000273598.3
ENST00000436744.2
nicolin 1
chr1_+_32716857 4.19 ENST00000482949.1
ENST00000495610.2
lymphocyte-specific protein tyrosine kinase
chr17_-_40333099 4.18 ENST00000607371.1
potassium voltage-gated channel, subfamily H (eag-related), member 4
chr13_+_53602894 4.15 ENST00000219022.2
olfactomedin 4
chrX_+_16804544 4.15 ENST00000380122.5
ENST00000398155.4
taxilin gamma
chr4_-_90757364 4.12 ENST00000508895.1
synuclein, alpha (non A4 component of amyloid precursor)
chr6_+_45389893 4.07 ENST00000371432.3
runt-related transcription factor 2
chr9_+_33750515 4.07 ENST00000361005.5
protease, serine, 3
chr19_-_13213662 4.07 ENST00000264824.4
lymphoblastic leukemia derived sequence 1
chr17_-_37308824 4.05 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
plexin domain containing 1
chr6_+_39760129 4.00 ENST00000274867.4
dishevelled associated activator of morphogenesis 2
chrX_+_18443703 3.98 ENST00000379996.3
cyclin-dependent kinase-like 5
chr1_+_32716840 3.97 ENST00000336890.5
lymphocyte-specific protein tyrosine kinase
chr1_+_172628154 3.91 ENST00000340030.3
ENST00000367721.2
Fas ligand (TNF superfamily, member 6)
chr9_+_33750667 3.91 ENST00000457896.1
ENST00000342836.4
ENST00000429677.3
protease, serine, 3
chr22_+_40342819 3.90 ENST00000407075.3
GRB2-related adaptor protein 2
chr11_-_59950622 3.87 ENST00000323961.3
ENST00000412309.2
membrane-spanning 4-domains, subfamily A, member 6A
chr17_-_76713100 3.81 ENST00000585509.1
cytohesin 1
chr17_+_76311791 3.80 ENST00000586321.1
AC061992.2
chr16_-_79634595 3.79 ENST00000326043.4
ENST00000393350.1
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog
chr11_+_28129795 3.73 ENST00000406787.3
ENST00000342303.5
ENST00000403099.1
ENST00000407364.3
methyltransferase like 15
chr14_-_75518129 3.71 ENST00000556257.1
ENST00000557648.1
ENST00000553263.1
ENST00000355774.2
ENST00000380968.2
ENST00000238662.7
mutL homolog 3
chr2_-_219031709 3.71 ENST00000295683.2
chemokine (C-X-C motif) receptor 1
chrX_+_69642881 3.70 ENST00000453994.2
ENST00000536730.1
ENST00000538649.1
ENST00000374382.3
glycerophosphodiester phosphodiesterase domain containing 2
chr12_-_91576561 3.70 ENST00000547568.2
ENST00000552962.1
decorin
chr17_-_56406117 3.69 ENST00000268893.6
ENST00000355701.3
benzodiazepine receptor (peripheral) associated protein 1
chr11_-_33913708 3.68 ENST00000257818.2
LIM domain only 2 (rhombotin-like 1)
chr5_+_161274940 3.65 ENST00000393943.4
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_+_66582919 3.63 ENST00000545837.1
ENST00000457197.2
interleukin-1 receptor-associated kinase 3
chr12_-_8025499 3.59 ENST00000431042.2
solute carrier family 2 (facilitated glucose transporter), member 14
chr1_+_16062820 3.57 ENST00000294454.5
solute carrier family 25, member 34
chr3_-_146213722 3.53 ENST00000336685.2
ENST00000489015.1
phospholipid scramblase 2
chr4_-_90756769 3.50 ENST00000345009.4
ENST00000505199.1
ENST00000502987.1
synuclein, alpha (non A4 component of amyloid precursor)
chr17_-_56609302 3.49 ENST00000581607.1
ENST00000317256.6
ENST00000426861.1
ENST00000580809.1
ENST00000577729.1
ENST00000583291.1
septin 4
chr5_-_34043310 3.49 ENST00000231338.7
C1q and tumor necrosis factor related protein 3
chr9_+_124048864 3.46 ENST00000545652.1
gelsolin
chr20_+_43595115 3.44 ENST00000372806.3
ENST00000396731.4
ENST00000372801.1
ENST00000499879.2
serine/threonine kinase 4
chr3_-_57678772 3.43 ENST00000311128.5
DENN/MADD domain containing 6A
chr1_+_92417716 3.41 ENST00000402388.1
bromodomain, testis-specific
chr12_-_8025442 3.41 ENST00000340749.5
ENST00000535295.1
ENST00000539234.1
solute carrier family 2 (facilitated glucose transporter), member 14
chr5_+_161274685 3.41 ENST00000428797.2
gamma-aminobutyric acid (GABA) A receptor, alpha 1
chr12_-_8025398 3.38 ENST00000535344.1
ENST00000543909.1
solute carrier family 2 (facilitated glucose transporter), member 14
chr17_-_38721711 3.36 ENST00000578085.1
ENST00000246657.2
chemokine (C-C motif) receptor 7
chr14_-_93651186 3.35 ENST00000556883.1
ENST00000298894.4
modulator of apoptosis 1
chr4_+_48833234 3.34 ENST00000510824.1
ENST00000425583.2
OCIA domain containing 1
chr7_+_5919458 3.34 ENST00000416608.1
oncomodulin
chr12_-_91576429 3.32 ENST00000552145.1
ENST00000546745.1
decorin
chr12_+_32112340 3.30 ENST00000540924.1
ENST00000312561.4
KIAA1551
chr10_-_75226166 3.30 ENST00000544628.1
protein phosphatase 3, catalytic subunit, beta isozyme
chr1_-_111148241 3.28 ENST00000440270.1
potassium voltage-gated channel, shaker-related subfamily, member 2
chr4_-_186732048 3.28 ENST00000448662.2
ENST00000439049.1
ENST00000420158.1
ENST00000431808.1
ENST00000319471.9
sorbin and SH3 domain containing 2
chr5_+_35856951 3.25 ENST00000303115.3
ENST00000343305.4
ENST00000506850.1
ENST00000511982.1
interleukin 7 receptor
chr12_+_57853918 3.25 ENST00000532291.1
ENST00000543426.1
ENST00000228682.2
ENST00000546141.1
GLI family zinc finger 1
chr14_-_106963409 3.24 ENST00000390621.2
immunoglobulin heavy variable 1-45
chr2_-_241737128 3.21 ENST00000404283.3
kinesin family member 1A
chr11_-_59950519 3.20 ENST00000528851.1
membrane-spanning 4-domains, subfamily A, member 6A
chr6_+_391739 3.15 ENST00000380956.4
interferon regulatory factor 4
chr4_+_48833119 3.13 ENST00000444354.2
ENST00000509963.1
ENST00000509246.1
OCIA domain containing 1
chr6_+_108487245 3.13 ENST00000368986.4
nuclear receptor subfamily 2, group E, member 1
chr7_+_27282319 3.12 ENST00000222761.3
even-skipped homeobox 1
chr16_+_6069072 3.05 ENST00000547605.1
ENST00000550418.1
ENST00000553186.1
RNA binding protein, fox-1 homolog (C. elegans) 1
chr1_+_213123976 3.05 ENST00000366965.2
ENST00000366967.2
vasohibin 2
chr15_+_65903680 3.04 ENST00000537259.1
solute carrier family 24 (sodium/potassium/calcium exchanger), member 1
chr7_+_110731062 3.00 ENST00000308478.5
ENST00000451085.1
ENST00000422987.3
ENST00000421101.1
leucine rich repeat neuronal 3
chr2_+_79252834 2.98 ENST00000409471.1
regenerating islet-derived 3 gamma
chr16_-_67965756 2.96 ENST00000571044.1
ENST00000571605.1
chymotrypsin-like
chr10_-_23003460 2.92 ENST00000376573.4
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
chr16_-_20681177 2.90 ENST00000524149.1
acyl-CoA synthetase medium-chain family member 1
chr22_-_41215328 2.89 ENST00000434185.1
ENST00000435456.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
chr8_-_82395461 2.88 ENST00000256104.4
fatty acid binding protein 4, adipocyte
chr10_-_76868931 2.87 ENST00000372700.3
ENST00000473072.2
ENST00000491677.2
ENST00000607131.1
ENST00000372702.3
dual specificity phosphatase 13
chr2_+_219246746 2.85 ENST00000233202.6
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr2_+_61108771 2.85 ENST00000394479.3
v-rel avian reticuloendotheliosis viral oncogene homolog
chr11_+_5009424 2.84 ENST00000300762.1
matrix metallopeptidase 26
chr11_-_59950486 2.83 ENST00000426738.2
ENST00000533023.1
ENST00000420732.2
membrane-spanning 4-domains, subfamily A, member 6A
chr2_+_176972000 2.82 ENST00000249504.5
homeobox D11
chr1_+_151584544 2.82 ENST00000458013.2
ENST00000368843.3
sorting nexin family member 27
chr6_+_127587755 2.81 ENST00000368314.1
ENST00000476956.1
ENST00000609447.1
ENST00000356799.2
ENST00000477776.1
ENST00000609944.1
ring finger protein 146
chr17_+_45331184 2.79 ENST00000559488.1
ENST00000571680.1
ENST00000435993.2
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
chr2_+_79252822 2.77 ENST00000272324.5
regenerating islet-derived 3 gamma
chr17_+_7531281 2.77 ENST00000575729.1
ENST00000340624.5
sex hormone-binding globulin
chr10_-_79789291 2.75 ENST00000372371.3
polymerase (RNA) III (DNA directed) polypeptide A, 155kDa
chr14_-_76447494 2.75 ENST00000238682.3
transforming growth factor, beta 3
chr11_-_47736896 2.75 ENST00000525123.1
ENST00000528244.1
ENST00000532595.1
ENST00000529154.1
ENST00000530969.1
ATP/GTP binding protein-like 2
chr1_+_202995611 2.73 ENST00000367240.2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4
chr1_+_199996702 2.73 ENST00000367362.3
nuclear receptor subfamily 5, group A, member 2
chr14_-_24584138 2.72 ENST00000558280.1
ENST00000561028.1
neural retina leucine zipper

Network of associatons between targets according to the STRING database.

First level regulatory network of TBX21_TBR1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
5.8 17.5 GO:0032474 otolith morphogenesis(GO:0032474)
3.8 11.5 GO:2000048 negative regulation of cell-cell adhesion mediated by cadherin(GO:2000048)
3.8 11.3 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
3.7 29.9 GO:2000766 negative regulation of cytoplasmic translation(GO:2000766)
3.4 27.5 GO:0001661 conditioned taste aversion(GO:0001661)
3.4 16.9 GO:0043091 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
2.8 8.3 GO:0021538 epithalamus development(GO:0021538) habenula development(GO:0021986)
2.7 8.2 GO:0044278 cell wall disruption in other organism(GO:0044278)
2.6 18.3 GO:1903818 positive regulation of voltage-gated potassium channel activity(GO:1903818)
2.3 7.0 GO:2000777 positive regulation of oocyte maturation(GO:1900195) negative regulation of NLRP3 inflammasome complex assembly(GO:1900226) positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia(GO:2000777)
2.3 9.2 GO:0019470 4-hydroxyproline catabolic process(GO:0019470)
2.1 12.4 GO:1902847 macrophage proliferation(GO:0061517) microglial cell proliferation(GO:0061518) regulation of neuronal signal transduction(GO:1902847) positive regulation of neurofibrillary tangle assembly(GO:1902998)
1.8 5.5 GO:0050760 negative regulation of thymidylate synthase biosynthetic process(GO:0050760)
1.7 8.7 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
1.7 5.1 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
1.6 4.7 GO:0048627 myoblast development(GO:0048627) positive regulation of G0 to G1 transition(GO:0070318)
1.5 7.6 GO:0051622 negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of glutathione peroxidase activity(GO:1903282) positive regulation of glutathione peroxidase activity(GO:1903284) positive regulation of hydrogen peroxide catabolic process(GO:1903285) regulation of peroxidase activity(GO:2000468) positive regulation of peroxidase activity(GO:2000470)
1.4 6.9 GO:1904100 regulation of protein O-linked glycosylation(GO:1904098) positive regulation of protein O-linked glycosylation(GO:1904100)
1.3 9.0 GO:1903593 regulation of histamine secretion by mast cell(GO:1903593)
1.3 6.4 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
1.3 6.3 GO:0030070 insulin processing(GO:0030070)
1.3 10.0 GO:0002074 extraocular skeletal muscle development(GO:0002074)
1.2 3.7 GO:0098758 response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759)
1.2 8.4 GO:2000503 positive regulation of natural killer cell chemotaxis(GO:2000503)
1.2 7.0 GO:2001181 positive regulation of interleukin-10 secretion(GO:2001181)
1.2 9.2 GO:0034983 peptidyl-lysine deacetylation(GO:0034983)
1.1 20.6 GO:0010457 centriole-centriole cohesion(GO:0010457)
1.1 3.4 GO:0051037 histone displacement(GO:0001207) regulation of transcription involved in meiotic cell cycle(GO:0051037) positive regulation of transcription involved in meiotic cell cycle(GO:0051039)
1.1 4.5 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
1.1 4.5 GO:0048859 formation of anatomical boundary(GO:0048859)
1.1 3.4 GO:2000523 dendritic cell dendrite assembly(GO:0097026) regulation of T cell costimulation(GO:2000523) positive regulation of T cell costimulation(GO:2000525) regulation of dendritic cell dendrite assembly(GO:2000547)
1.1 8.8 GO:0002051 osteoblast fate commitment(GO:0002051)
1.1 3.2 GO:0007418 ventral midline development(GO:0007418) smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation(GO:0021938)
1.1 1.1 GO:0048022 negative regulation of melanin biosynthetic process(GO:0048022) negative regulation of secondary metabolite biosynthetic process(GO:1900377)
1.1 4.3 GO:0097368 establishment of Sertoli cell barrier(GO:0097368)
1.1 3.2 GO:0045082 interleukin-4 biosynthetic process(GO:0042097) positive regulation of interleukin-10 biosynthetic process(GO:0045082) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404)
1.0 3.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
1.0 3.1 GO:0021913 regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification(GO:0021913)
1.0 4.9 GO:0048388 endosomal lumen acidification(GO:0048388)
1.0 2.9 GO:0018874 benzoate metabolic process(GO:0018874) butyrate metabolic process(GO:0019605)
0.9 2.7 GO:0035610 protein side chain deglutamylation(GO:0035610)
0.9 4.6 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.9 4.5 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.9 17.6 GO:0030277 maintenance of gastrointestinal epithelium(GO:0030277)
0.9 6.1 GO:0006749 glutathione metabolic process(GO:0006749)
0.8 5.0 GO:0019262 N-acetylneuraminate catabolic process(GO:0019262)
0.8 2.5 GO:0071284 cellular response to lead ion(GO:0071284)
0.8 3.3 GO:0021633 optic nerve structural organization(GO:0021633)
0.8 16.5 GO:2000052 positive regulation of non-canonical Wnt signaling pathway(GO:2000052)
0.8 2.3 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.7 2.2 GO:0032661 central nervous system myelin formation(GO:0032289) regulation of interleukin-18 production(GO:0032661) detection of bacterial lipoprotein(GO:0042494) detection of triacyl bacterial lipopeptide(GO:0042495) detection of bacterial lipopeptide(GO:0070340)
0.7 25.1 GO:0008045 motor neuron axon guidance(GO:0008045)
0.7 3.5 GO:0030382 sperm mitochondrion organization(GO:0030382)
0.7 2.8 GO:0045715 negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715)
0.7 4.2 GO:0016554 cytidine to uridine editing(GO:0016554)
0.7 2.8 GO:0061113 pancreas morphogenesis(GO:0061113)
0.7 4.9 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.7 3.5 GO:0044856 plasma membrane raft distribution(GO:0044855) plasma membrane raft localization(GO:0044856) plasma membrane raft polarization(GO:0044858) regulation of plasma membrane raft polarization(GO:1903906)
0.7 2.7 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.7 2.0 GO:0033214 iron assimilation(GO:0033212) iron assimilation by chelation and transport(GO:0033214) positive regulation of bone mineralization involved in bone maturation(GO:1900159) negative regulation of tumor necrosis factor (ligand) superfamily member 11 production(GO:2000308)
0.6 2.5 GO:0000255 allantoin metabolic process(GO:0000255)
0.6 4.3 GO:0000160 phosphorelay signal transduction system(GO:0000160)
0.6 0.6 GO:0045976 negative regulation of mitotic cell cycle, embryonic(GO:0045976)
0.6 4.2 GO:2000389 regulation of neutrophil extravasation(GO:2000389)
0.6 7.0 GO:1900747 negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747)
0.6 1.2 GO:0048867 stem cell fate determination(GO:0048867)
0.6 4.6 GO:0006531 aspartate metabolic process(GO:0006531)
0.6 2.8 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.6 1.7 GO:1990502 dense core granule maturation(GO:1990502)
0.5 6.5 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.5 8.2 GO:0050862 positive regulation of T cell receptor signaling pathway(GO:0050862)
0.5 2.1 GO:1904327 maintenance of unfolded protein(GO:0036506) protein localization to cytosolic proteasome complex(GO:1904327) maintenance of unfolded protein involved in ERAD pathway(GO:1904378) protein localization to cytosolic proteasome complex involved in ERAD pathway(GO:1904379)
0.5 9.0 GO:0097151 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.5 3.5 GO:0035356 cellular triglyceride homeostasis(GO:0035356)
0.5 1.5 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
0.5 5.3 GO:0031848 protection from non-homologous end joining at telomere(GO:0031848)
0.5 5.3 GO:0098870 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.5 7.6 GO:0061365 positive regulation of triglyceride lipase activity(GO:0061365)
0.5 3.7 GO:0070475 rRNA base methylation(GO:0070475)
0.5 4.7 GO:1902951 negative regulation of dendritic spine maintenance(GO:1902951)
0.5 5.9 GO:1904903 ESCRT complex disassembly(GO:1904896) ESCRT III complex disassembly(GO:1904903)
0.5 1.8 GO:2000317 T-helper 1 cell lineage commitment(GO:0002296) cellular response to mercury ion(GO:0071288) negative regulation of complement-dependent cytotoxicity(GO:1903660) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320) positive regulation of eosinophil migration(GO:2000418)
0.4 5.8 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.4 12.1 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.4 3.0 GO:0009642 response to light intensity(GO:0009642)
0.4 5.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.4 3.7 GO:0007144 female meiosis I(GO:0007144)
0.4 1.2 GO:0051710 regulation of cytolysis in other organism(GO:0051710)
0.4 4.1 GO:0001955 blood vessel maturation(GO:0001955)
0.4 0.4 GO:0021855 hypothalamus cell migration(GO:0021855)
0.4 2.0 GO:0072023 thick ascending limb development(GO:0072023) metanephric thick ascending limb development(GO:0072233)
0.4 0.4 GO:2000171 negative regulation of dendrite development(GO:2000171)
0.4 1.5 GO:0014028 notochord formation(GO:0014028)
0.4 3.4 GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin(GO:2000049)
0.4 1.1 GO:0061394 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394)
0.4 10.4 GO:0035428 hexose transmembrane transport(GO:0035428) glucose transmembrane transport(GO:1904659)
0.4 1.8 GO:0060718 negative regulation of cytokinesis(GO:0032466) chorionic trophoblast cell differentiation(GO:0060718)
0.4 9.2 GO:0009235 cobalamin metabolic process(GO:0009235)
0.4 7.1 GO:0071420 cellular response to histamine(GO:0071420)
0.3 5.2 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.3 4.8 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)
0.3 1.7 GO:0018243 protein O-linked glycosylation via threonine(GO:0018243)
0.3 4.3 GO:0010603 regulation of cytoplasmic mRNA processing body assembly(GO:0010603)
0.3 2.7 GO:0002710 negative regulation of T cell mediated immunity(GO:0002710)
0.3 0.3 GO:0002408 myeloid dendritic cell chemotaxis(GO:0002408)
0.3 1.9 GO:1903760 regulation of voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization(GO:1903760)
0.3 7.8 GO:0048935 peripheral nervous system neuron differentiation(GO:0048934) peripheral nervous system neuron development(GO:0048935)
0.3 2.2 GO:0045653 negative regulation of megakaryocyte differentiation(GO:0045653)
0.3 21.4 GO:0007602 phototransduction(GO:0007602)
0.3 2.6 GO:0034378 acylglycerol transport(GO:0034196) triglyceride transport(GO:0034197) chylomicron assembly(GO:0034378)
0.3 2.0 GO:0097354 protein prenylation(GO:0018342) protein geranylgeranylation(GO:0018344) prenylation(GO:0097354)
0.3 3.7 GO:0090527 actin filament reorganization(GO:0090527)
0.3 5.7 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.3 0.8 GO:0097254 renal tubular secretion(GO:0097254)
0.3 0.3 GO:0071926 endocannabinoid signaling pathway(GO:0071926)
0.3 1.4 GO:0090309 positive regulation of methylation-dependent chromatin silencing(GO:0090309)
0.3 1.3 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.3 0.8 GO:0034124 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) negative regulation of macrophage apoptotic process(GO:2000110)
0.3 1.1 GO:0035962 response to interleukin-13(GO:0035962)
0.2 2.0 GO:0010533 regulation of activation of Janus kinase activity(GO:0010533)
0.2 2.9 GO:2000786 positive regulation of autophagosome assembly(GO:2000786)
0.2 2.7 GO:0015871 choline transport(GO:0015871)
0.2 2.9 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.2 1.9 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 7.2 GO:0045898 regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898)
0.2 1.1 GO:0014835 myoblast differentiation involved in skeletal muscle regeneration(GO:0014835)
0.2 2.0 GO:0045617 negative regulation of keratinocyte differentiation(GO:0045617)
0.2 1.8 GO:0035934 corticosterone secretion(GO:0035934) regulation of corticosterone secretion(GO:2000852)
0.2 3.4 GO:1990573 potassium ion import across plasma membrane(GO:1990573)
0.2 4.2 GO:2001275 positive regulation of glucose import in response to insulin stimulus(GO:2001275)
0.2 2.3 GO:0045046 protein import into peroxisome membrane(GO:0045046)
0.2 1.0 GO:0032455 nerve growth factor processing(GO:0032455)
0.2 1.4 GO:0043654 recognition of apoptotic cell(GO:0043654)
0.2 1.0 GO:0070092 regulation of glucagon secretion(GO:0070092)
0.2 1.6 GO:0006116 NADH oxidation(GO:0006116)
0.2 3.7 GO:0042789 mRNA transcription from RNA polymerase II promoter(GO:0042789)
0.2 2.4 GO:0015812 gamma-aminobutyric acid transport(GO:0015812)
0.2 0.9 GO:0032571 response to vitamin K(GO:0032571)
0.2 2.3 GO:1902593 single-organism nuclear import(GO:1902593)
0.2 1.5 GO:2001205 negative regulation of osteoclast development(GO:2001205)
0.2 0.6 GO:0002331 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
0.2 1.9 GO:0007130 synaptonemal complex assembly(GO:0007130)
0.2 4.3 GO:0007422 peripheral nervous system development(GO:0007422)
0.2 5.9 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.2 1.5 GO:0043152 induction of bacterial agglutination(GO:0043152)
0.2 0.5 GO:0035522 monoubiquitinated histone deubiquitination(GO:0035521) monoubiquitinated histone H2A deubiquitination(GO:0035522)
0.2 1.4 GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development(GO:0060770)
0.1 3.2 GO:1903861 positive regulation of dendrite extension(GO:1903861)
0.1 1.6 GO:0008612 peptidyl-lysine modification to peptidyl-hypusine(GO:0008612)
0.1 3.6 GO:0006957 complement activation, alternative pathway(GO:0006957)
0.1 4.8 GO:0006607 NLS-bearing protein import into nucleus(GO:0006607)
0.1 19.7 GO:0046718 viral entry into host cell(GO:0046718)
0.1 7.2 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 2.3 GO:0006878 cellular copper ion homeostasis(GO:0006878)
0.1 2.2 GO:0035635 entry of bacterium into host cell(GO:0035635)
0.1 1.9 GO:0016264 gap junction assembly(GO:0016264)
0.1 5.1 GO:0048536 spleen development(GO:0048536)
0.1 2.9 GO:0050872 white fat cell differentiation(GO:0050872)
0.1 1.4 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.1 5.2 GO:0018149 peptide cross-linking(GO:0018149)
0.1 3.3 GO:0003301 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.1 1.1 GO:0000722 telomere maintenance via recombination(GO:0000722)
0.1 2.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.1 1.2 GO:0042118 endothelial cell activation(GO:0042118)
0.1 0.8 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.1 1.6 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.1 3.4 GO:0001569 patterning of blood vessels(GO:0001569)
0.1 2.1 GO:0048485 sympathetic nervous system development(GO:0048485)
0.1 1.6 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 3.3 GO:0051567 histone H3-K9 methylation(GO:0051567)
0.1 13.1 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)
0.1 2.4 GO:0035338 long-chain fatty-acyl-CoA biosynthetic process(GO:0035338)
0.1 4.3 GO:0071377 cellular response to glucagon stimulus(GO:0071377)
0.1 8.4 GO:0021510 spinal cord development(GO:0021510)
0.1 3.8 GO:0070306 lens fiber cell differentiation(GO:0070306)
0.1 1.1 GO:0060484 lung-associated mesenchyme development(GO:0060484)
0.1 0.3 GO:0060474 positive regulation of sperm motility involved in capacitation(GO:0060474)
0.1 3.0 GO:0045026 plasma membrane fusion(GO:0045026)
0.1 6.4 GO:0019933 cAMP-mediated signaling(GO:0019933)
0.1 0.3 GO:0086023 adrenergic receptor signaling pathway involved in heart process(GO:0086023) regulation of the force of heart contraction by cardiac conduction(GO:0086092) G-protein coupled receptor signaling pathway involved in heart process(GO:0086103) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) negative regulation of calcium-transporting ATPase activity(GO:1901895) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.1 1.3 GO:0060134 prepulse inhibition(GO:0060134)
0.1 0.7 GO:0060137 maternal process involved in parturition(GO:0060137)
0.1 5.4 GO:0051865 protein autoubiquitination(GO:0051865)
0.1 3.4 GO:0014047 glutamate secretion(GO:0014047)
0.1 4.0 GO:0050775 positive regulation of dendrite morphogenesis(GO:0050775)
0.1 1.1 GO:0006611 protein export from nucleus(GO:0006611)
0.1 2.8 GO:0006383 transcription from RNA polymerase III promoter(GO:0006383)
0.1 1.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.1 2.2 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.1 0.5 GO:0010944 negative regulation of transcription by competitive promoter binding(GO:0010944)
0.1 6.7 GO:0042795 snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795)
0.1 1.2 GO:0045954 positive regulation of natural killer cell mediated cytotoxicity(GO:0045954)
0.1 1.4 GO:0007030 Golgi organization(GO:0007030)
0.1 4.6 GO:0007368 determination of left/right symmetry(GO:0007368)
0.1 1.6 GO:0045494 photoreceptor cell maintenance(GO:0045494)
0.1 1.1 GO:0001764 neuron migration(GO:0001764)
0.1 2.0 GO:0034080 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.1 0.7 GO:0046606 negative regulation of centrosome cycle(GO:0046606)
0.1 3.2 GO:0006306 DNA alkylation(GO:0006305) DNA methylation(GO:0006306)
0.1 0.8 GO:0030220 platelet formation(GO:0030220)
0.1 0.7 GO:0015884 folic acid transport(GO:0015884)
0.1 4.3 GO:0031295 T cell costimulation(GO:0031295)
0.1 3.2 GO:0006910 phagocytosis, recognition(GO:0006910)
0.1 3.6 GO:0032435 negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435)
0.1 0.5 GO:2000507 positive regulation of energy homeostasis(GO:2000507)
0.1 0.7 GO:0014059 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 1.2 GO:0090200 positive regulation of release of cytochrome c from mitochondria(GO:0090200)
0.1 0.6 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.6 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.1 2.6 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 1.6 GO:0048247 lymphocyte chemotaxis(GO:0048247)
0.0 0.9 GO:0008053 mitochondrial fusion(GO:0008053)
0.0 0.7 GO:0034599 cellular response to oxidative stress(GO:0034599)
0.0 0.3 GO:0018879 biphenyl metabolic process(GO:0018879)
0.0 4.5 GO:0048010 vascular endothelial growth factor receptor signaling pathway(GO:0048010)
0.0 1.0 GO:0006590 thyroid hormone generation(GO:0006590)
0.0 0.2 GO:0039536 negative regulation of RIG-I signaling pathway(GO:0039536)
0.0 2.0 GO:0070527 platelet aggregation(GO:0070527)
0.0 2.3 GO:0006730 one-carbon metabolic process(GO:0006730)
0.0 1.2 GO:0050832 defense response to fungus(GO:0050832)
0.0 0.8 GO:0021591 ventricular system development(GO:0021591)
0.0 1.0 GO:0045746 negative regulation of Notch signaling pathway(GO:0045746)
0.0 2.5 GO:0007218 neuropeptide signaling pathway(GO:0007218)
0.0 0.3 GO:0071447 cellular response to hydroperoxide(GO:0071447)
0.0 0.2 GO:0048739 cardiac muscle fiber development(GO:0048739)
0.0 1.4 GO:0016050 vesicle organization(GO:0016050)
0.0 1.2 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.3 GO:0008285 negative regulation of cell proliferation(GO:0008285)
0.0 3.8 GO:0002262 myeloid cell homeostasis(GO:0002262)
0.0 10.4 GO:0002250 adaptive immune response(GO:0002250)
0.0 1.9 GO:0050728 negative regulation of inflammatory response(GO:0050728)
0.0 1.1 GO:0051693 actin filament capping(GO:0051693)
0.0 2.8 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.0 1.1 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
0.0 0.8 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.0 1.1 GO:0051568 histone H3-K4 methylation(GO:0051568)
0.0 4.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.4 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 3.8 GO:0042742 defense response to bacterium(GO:0042742)
0.0 0.4 GO:0006874 cellular calcium ion homeostasis(GO:0006874) calcium ion homeostasis(GO:0055074)
0.0 0.8 GO:0016236 macroautophagy(GO:0016236)
0.0 4.1 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.1 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408) oxidative stress-induced premature senescence(GO:0090403)
0.0 0.9 GO:0009953 dorsal/ventral pattern formation(GO:0009953)
0.0 1.2 GO:0030500 regulation of bone mineralization(GO:0030500)
0.0 0.1 GO:1900220 semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis(GO:1900220)
0.0 0.2 GO:0035095 behavioral response to nicotine(GO:0035095)
0.0 1.5 GO:0006687 glycosphingolipid metabolic process(GO:0006687)
0.0 0.3 GO:0032060 bleb assembly(GO:0032060)
0.0 0.7 GO:0006654 phosphatidic acid biosynthetic process(GO:0006654) phosphatidic acid metabolic process(GO:0046473)
0.0 0.5 GO:0033344 cholesterol efflux(GO:0033344)
0.0 1.7 GO:0071222 cellular response to lipopolysaccharide(GO:0071222)
0.0 1.1 GO:0030168 platelet activation(GO:0030168)
0.0 0.4 GO:0030101 natural killer cell activation(GO:0030101)
0.0 1.4 GO:0070268 cornification(GO:0070268)
0.0 0.3 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.1 GO:0018022 peptidyl-lysine methylation(GO:0018022)
0.0 0.2 GO:0022037 cerebellum development(GO:0021549) metencephalon development(GO:0022037)
0.0 1.2 GO:0030879 mammary gland development(GO:0030879)
0.0 1.2 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.9 GO:0051291 protein heterooligomerization(GO:0051291)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
3.2 25.4 GO:0035976 AP1 complex(GO:0035976)
2.2 9.0 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032) synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
1.4 4.2 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
1.2 22.8 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.9 3.7 GO:0005712 chiasma(GO:0005712)
0.9 10.3 GO:0033010 paranodal junction(GO:0033010)
0.8 6.7 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.8 9.8 GO:0060077 inhibitory synapse(GO:0060077)
0.8 5.5 GO:0001520 outer dense fiber(GO:0001520)
0.8 5.5 GO:1990812 growth cone filopodium(GO:1990812)
0.8 5.3 GO:0030870 Mre11 complex(GO:0030870)
0.7 12.4 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.7 5.8 GO:0044294 dendritic growth cone(GO:0044294)
0.7 2.2 GO:0035354 Toll-like receptor 1-Toll-like receptor 2 protein complex(GO:0035354)
0.7 2.8 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.6 4.8 GO:0045179 apical cortex(GO:0045179)
0.6 1.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.5 2.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.5 2.0 GO:0005968 Rab-protein geranylgeranyltransferase complex(GO:0005968)
0.5 7.0 GO:0098647 collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647)
0.5 2.4 GO:0031501 mannosyltransferase complex(GO:0031501)
0.5 3.2 GO:0097013 phagocytic vesicle lumen(GO:0097013)
0.4 2.8 GO:0071203 WASH complex(GO:0071203)
0.4 10.2 GO:0032982 myosin filament(GO:0032982)
0.4 3.3 GO:0005955 calcineurin complex(GO:0005955)
0.4 8.2 GO:0000242 pericentriolar material(GO:0000242)
0.3 18.2 GO:0030286 dynein complex(GO:0030286)
0.3 9.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.3 10.4 GO:0042629 mast cell granule(GO:0042629)
0.3 30.9 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 4.8 GO:0000145 exocyst(GO:0000145)
0.3 4.7 GO:0005687 U4 snRNP(GO:0005687)
0.3 3.5 GO:0097227 sperm annulus(GO:0097227)
0.3 1.6 GO:0034464 BBSome(GO:0034464)
0.3 3.5 GO:0030478 actin cap(GO:0030478)
0.3 1.8 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.3 7.9 GO:0030673 axolemma(GO:0030673)
0.2 2.8 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.2 2.1 GO:0098839 postsynaptic density membrane(GO:0098839)
0.2 3.2 GO:0000788 nuclear nucleosome(GO:0000788)
0.2 16.5 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.2 7.1 GO:1902711 GABA-A receptor complex(GO:1902711)
0.2 4.2 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.2 1.9 GO:0043219 lateral loop(GO:0043219)
0.2 9.9 GO:0016235 aggresome(GO:0016235)
0.2 3.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 3.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 25.5 GO:0031225 anchored component of membrane(GO:0031225)
0.2 1.9 GO:0008385 IkappaB kinase complex(GO:0008385)
0.1 2.5 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 12.7 GO:0005814 centriole(GO:0005814)
0.1 5.1 GO:0034707 chloride channel complex(GO:0034707)
0.1 3.8 GO:0097542 ciliary tip(GO:0097542)
0.1 1.5 GO:0005577 fibrinogen complex(GO:0005577)
0.1 16.6 GO:0005923 bicellular tight junction(GO:0005923)
0.1 1.1 GO:0097197 tetraspanin-enriched microdomain(GO:0097197)
0.1 1.6 GO:0034451 centriolar satellite(GO:0034451)
0.1 8.6 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 2.8 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
0.1 4.3 GO:0001772 immunological synapse(GO:0001772)
0.1 1.9 GO:0005922 connexon complex(GO:0005922)
0.1 1.6 GO:0000124 SAGA complex(GO:0000124)
0.1 1.1 GO:0044666 MLL3/4 complex(GO:0044666)
0.1 1.6 GO:0005859 muscle myosin complex(GO:0005859)
0.1 2.6 GO:0043235 receptor complex(GO:0043235)
0.1 2.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 4.2 GO:0001533 cornified envelope(GO:0001533)
0.1 17.7 GO:0072562 blood microparticle(GO:0072562)
0.1 8.8 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.1 7.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 3.2 GO:0048786 presynaptic active zone(GO:0048786)
0.1 2.9 GO:0005776 autophagosome(GO:0005776)
0.1 1.8 GO:0009897 external side of plasma membrane(GO:0009897)
0.1 1.2 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 2.2 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.1 1.1 GO:0005682 U5 snRNP(GO:0005682)
0.1 1.9 GO:0000795 synaptonemal complex(GO:0000795)
0.1 4.5 GO:0015030 Cajal body(GO:0015030)
0.1 5.8 GO:0043202 lysosomal lumen(GO:0043202)
0.1 8.8 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.1 7.2 GO:0032587 ruffle membrane(GO:0032587)
0.1 3.2 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.1 0.3 GO:0090533 cation-transporting ATPase complex(GO:0090533)
0.1 1.5 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.1 1.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.0 1.6 GO:0031672 A band(GO:0031672)
0.0 3.5 GO:0005581 collagen trimer(GO:0005581)
0.0 4.1 GO:0098852 lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852)
0.0 0.2 GO:0097208 alveolar lamellar body(GO:0097208)
0.0 0.3 GO:0043196 varicosity(GO:0043196)
0.0 1.4 GO:0045095 keratin filament(GO:0045095)
0.0 4.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 4.3 GO:0043204 perikaryon(GO:0043204)
0.0 2.2 GO:0005796 Golgi lumen(GO:0005796)
0.0 0.7 GO:0031231 integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231)
0.0 1.4 GO:0008023 transcription elongation factor complex(GO:0008023)
0.0 4.6 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.6 GO:0035580 specific granule lumen(GO:0035580)
0.0 0.8 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.0 1.4 GO:0005764 lytic vacuole(GO:0000323) lysosome(GO:0005764)
0.0 0.3 GO:0097225 sperm midpiece(GO:0097225)
0.0 3.4 GO:0055037 recycling endosome(GO:0055037)
0.0 2.8 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 3.9 GO:0030027 lamellipodium(GO:0030027)
0.0 16.5 GO:0005615 extracellular space(GO:0005615)
0.0 0.5 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 0.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.5 GO:0016605 PML body(GO:0016605)
0.0 0.2 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.3 GO:0002102 podosome(GO:0002102)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.8 27.3 GO:0042030 ATPase inhibitor activity(GO:0042030)
5.9 17.8 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
3.1 9.4 GO:0051139 metal ion:proton antiporter activity(GO:0051139)
2.3 7.0 GO:0034739 histone deacetylase activity (H4-K16 specific)(GO:0034739)
2.1 12.8 GO:0042610 CD8 receptor binding(GO:0042610)
1.9 29.9 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
1.7 5.1 GO:0004951 cholecystokinin receptor activity(GO:0004951)
1.7 5.0 GO:0016833 oxo-acid-lyase activity(GO:0016833)
1.5 7.6 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
1.5 4.6 GO:0004515 nicotinate-nucleotide adenylyltransferase activity(GO:0004515)
1.5 4.5 GO:0047696 beta-adrenergic receptor kinase activity(GO:0047696)
1.5 8.7 GO:0003796 lysozyme activity(GO:0003796)
1.2 3.7 GO:0016434 rRNA (cytosine) methyltransferase activity(GO:0016434)
1.2 3.7 GO:0019959 interleukin-8 binding(GO:0019959)
1.2 8.4 GO:0031726 CCR1 chemokine receptor binding(GO:0031726)
1.1 9.2 GO:1904315 neurotransmitter receptor activity involved in regulation of postsynaptic membrane potential(GO:0099529) transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1904315)
1.1 6.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
1.1 3.2 GO:0004917 interleukin-7 receptor activity(GO:0004917)
1.0 2.9 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
1.0 10.6 GO:0070492 oligosaccharide binding(GO:0070492)
0.9 3.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
0.9 2.8 GO:0034714 type III transforming growth factor beta receptor binding(GO:0034714)
0.9 18.2 GO:0045504 dynein heavy chain binding(GO:0045504)
0.9 5.3 GO:0008597 calcium-dependent protein serine/threonine phosphatase regulator activity(GO:0008597)
0.8 2.5 GO:0050698 proteoglycan sulfotransferase activity(GO:0050698)
0.8 2.5 GO:0032767 copper-dependent protein binding(GO:0032767)
0.8 14.5 GO:0051787 misfolded protein binding(GO:0051787)
0.7 10.4 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.7 36.8 GO:0070412 R-SMAD binding(GO:0070412)
0.7 4.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155)
0.7 15.7 GO:0005251 delayed rectifier potassium channel activity(GO:0005251)
0.7 8.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.6 9.2 GO:0017136 NAD-dependent histone deacetylase activity(GO:0017136)
0.6 3.0 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.6 2.4 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.6 2.4 GO:0060422 peptidyl-dipeptidase inhibitor activity(GO:0060422)
0.6 2.3 GO:0015220 choline transmembrane transporter activity(GO:0015220)
0.6 26.7 GO:0046875 ephrin receptor binding(GO:0046875)
0.6 10.7 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.5 1.6 GO:0010698 acetyltransferase activator activity(GO:0010698)
0.5 7.4 GO:0016813 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813)
0.5 5.3 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
0.5 5.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.5 4.6 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.5 4.6 GO:0017151 DEAD/H-box RNA helicase binding(GO:0017151)
0.5 5.5 GO:0048156 tau protein binding(GO:0048156)
0.5 1.5 GO:0015403 thiamine transmembrane transporter activity(GO:0015234) thiamine uptake transmembrane transporter activity(GO:0015403)
0.5 2.0 GO:0070051 fibrinogen binding(GO:0070051)
0.5 11.3 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.5 4.2 GO:0046935 1-phosphatidylinositol-3-kinase regulator activity(GO:0046935)
0.5 10.5 GO:0051428 peptide hormone receptor binding(GO:0051428)
0.5 6.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.4 1.8 GO:0070996 type 1 melanocortin receptor binding(GO:0070996)
0.4 10.0 GO:0097493 muscle alpha-actinin binding(GO:0051371) structural molecule activity conferring elasticity(GO:0097493)
0.4 2.1 GO:0008046 axon guidance receptor activity(GO:0008046)
0.4 12.1 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.4 1.7 GO:0019828 aspartic-type endopeptidase inhibitor activity(GO:0019828)
0.4 3.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.4 1.2 GO:0016019 peptidoglycan receptor activity(GO:0016019)
0.4 2.4 GO:0015185 gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185)
0.4 6.0 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
0.4 3.7 GO:0019237 satellite DNA binding(GO:0003696) centromeric DNA binding(GO:0019237)
0.4 5.1 GO:0071723 lipopeptide binding(GO:0071723)
0.4 9.2 GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646)
0.3 2.8 GO:0019960 C-X3-C chemokine binding(GO:0019960)
0.3 7.6 GO:0004806 triglyceride lipase activity(GO:0004806)
0.3 5.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 2.9 GO:0004321 fatty-acyl-CoA synthase activity(GO:0004321)
0.3 3.7 GO:0019957 C-C chemokine binding(GO:0019957)
0.3 9.3 GO:0017075 syntaxin-1 binding(GO:0017075)
0.3 3.5 GO:0045159 myosin II binding(GO:0045159)
0.3 6.3 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.3 1.6 GO:0005119 smoothened binding(GO:0005119)
0.3 1.1 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.3 12.9 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.2 1.2 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.2 24.0 GO:0001618 virus receptor activity(GO:0001618)
0.2 4.8 GO:0017091 AU-rich element binding(GO:0017091)
0.2 3.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 5.7 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.2 1.1 GO:0031697 beta-1 adrenergic receptor binding(GO:0031697)
0.2 21.4 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.2 1.6 GO:0005497 androgen binding(GO:0005497)
0.2 1.8 GO:0004791 thioredoxin-disulfide reductase activity(GO:0004791)
0.2 1.1 GO:0030109 HLA-B specific inhibitory MHC class I receptor activity(GO:0030109)
0.2 0.5 GO:0034041 sterol-transporting ATPase activity(GO:0034041)
0.2 1.9 GO:0097016 L27 domain binding(GO:0097016)
0.2 6.8 GO:0017025 TBP-class protein binding(GO:0017025)
0.2 1.0 GO:0004447 iodide peroxidase activity(GO:0004447)
0.2 6.7 GO:0001784 phosphotyrosine binding(GO:0001784)
0.2 0.7 GO:0017040 ceramidase activity(GO:0017040)
0.2 14.9 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.2 2.7 GO:0043522 leucine zipper domain binding(GO:0043522)
0.2 0.6 GO:0004307 diacylglycerol cholinephosphotransferase activity(GO:0004142) ethanolaminephosphotransferase activity(GO:0004307)
0.1 9.1 GO:0016278 lysine N-methyltransferase activity(GO:0016278) protein-lysine N-methyltransferase activity(GO:0016279)
0.1 10.7 GO:0019843 rRNA binding(GO:0019843)
0.1 1.6 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.1 39.7 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.1 1.1 GO:0034061 telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) DNA polymerase activity(GO:0034061)
0.1 1.8 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 2.3 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.1 2.4 GO:0102391 decanoate--CoA ligase activity(GO:0102391)
0.1 2.0 GO:0005159 insulin-like growth factor receptor binding(GO:0005159)
0.1 1.9 GO:0005243 gap junction channel activity(GO:0005243)
0.1 2.5 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.1 1.0 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 6.1 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 2.8 GO:0001056 RNA polymerase III activity(GO:0001056)
0.1 2.3 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 1.2 GO:0031419 cobalamin binding(GO:0031419)
0.1 7.0 GO:0050840 extracellular matrix binding(GO:0050840)
0.1 0.7 GO:0004035 alkaline phosphatase activity(GO:0004035)
0.1 1.7 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 2.8 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.1 15.2 GO:0030674 protein binding, bridging(GO:0030674)
0.1 2.0 GO:0019864 IgG binding(GO:0019864)
0.1 16.0 GO:0003823 antigen binding(GO:0003823)
0.1 1.1 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.1 15.7 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.1 9.6 GO:0017048 Rho GTPase binding(GO:0017048)
0.1 0.8 GO:0009982 pseudouridine synthase activity(GO:0009982)
0.1 3.4 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 0.8 GO:1901702 urate transmembrane transporter activity(GO:0015143) salt transmembrane transporter activity(GO:1901702)
0.1 3.9 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 5.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 4.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 0.6 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
0.1 0.8 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 0.2 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 3.4 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 2.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.1 2.6 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.8 GO:0004065 arylsulfatase activity(GO:0004065)
0.1 0.8 GO:0030215 semaphorin receptor binding(GO:0030215)
0.1 2.9 GO:0005504 fatty acid binding(GO:0005504)
0.1 0.3 GO:0039552 RIG-I binding(GO:0039552)
0.1 1.1 GO:0043539 protein serine/threonine kinase activator activity(GO:0043539)
0.1 1.3 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.1 1.6 GO:0048020 CCR chemokine receptor binding(GO:0048020)
0.1 1.7 GO:0030507 spectrin binding(GO:0030507)
0.1 3.2 GO:0005507 copper ion binding(GO:0005507)
0.1 1.2 GO:0005248 voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030)
0.0 14.3 GO:0005096 GTPase activator activity(GO:0005096)
0.0 0.9 GO:0051400 BH domain binding(GO:0051400)
0.0 0.6 GO:0004859 phospholipase inhibitor activity(GO:0004859)
0.0 1.3 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 2.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.7 GO:0005542 folic acid binding(GO:0005542)
0.0 5.0 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.0 0.5 GO:0008190 eukaryotic initiation factor 4E binding(GO:0008190)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 4.2 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.6 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.0 0.3 GO:0015643 toxic substance binding(GO:0015643)
0.0 0.2 GO:0017018 myosin phosphatase activity(GO:0017018)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 2.3 GO:0051117 ATPase binding(GO:0051117)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 1.1 GO:0005518 collagen binding(GO:0005518)
0.0 0.3 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.0 2.0 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.0 0.6 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 3.5 GO:0030246 carbohydrate binding(GO:0030246)
0.0 2.3 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 0.4 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 1.7 GO:0019900 kinase binding(GO:0019900)
0.0 0.3 GO:0043495 protein anchor(GO:0043495)
0.0 3.5 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.3 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.3 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 25.4 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.6 14.1 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.6 4.5 PID CXCR4 PATHWAY CXCR4-mediated signaling events
0.6 32.5 PID AURORA A PATHWAY Aurora A signaling
0.5 16.2 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.4 28.9 PID ERBB4 PATHWAY ErbB4 signaling events
0.4 25.1 PID RAC1 REG PATHWAY Regulation of RAC1 activity
0.4 27.6 PID FGF PATHWAY FGF signaling pathway
0.3 10.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 6.0 ST G ALPHA S PATHWAY G alpha s Pathway
0.3 13.2 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.2 19.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.2 1.5 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.2 11.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.2 3.9 PID TCR JNK PATHWAY JNK signaling in the CD4+ TCR pathway
0.2 2.8 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.2 9.3 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 3.7 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.2 3.5 PID AVB3 OPN PATHWAY Osteopontin-mediated events
0.2 9.9 PID FAK PATHWAY Signaling events mediated by focal adhesion kinase
0.2 5.4 PID ALPHA SYNUCLEIN PATHWAY Alpha-synuclein signaling
0.2 3.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.2 3.2 ST GA12 PATHWAY G alpha 12 Pathway
0.2 28.6 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.2 11.6 PID AP1 PATHWAY AP-1 transcription factor network
0.2 5.7 PID PI3KCI PATHWAY Class I PI3K signaling events
0.1 2.7 ST GRANULE CELL SURVIVAL PATHWAY Granule Cell Survival Pathway is a specific case of more general PAC1 Receptor Pathway.
0.1 4.3 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 2.2 PID NECTIN PATHWAY Nectin adhesion pathway
0.1 13.2 PID ERBB1 DOWNSTREAM PATHWAY ErbB1 downstream signaling
0.1 6.3 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.1 3.6 PID IL1 PATHWAY IL1-mediated signaling events
0.1 6.1 PID IL12 2PATHWAY IL12-mediated signaling events
0.1 2.2 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 2.8 PID GLYPICAN 1PATHWAY Glypican 1 network
0.1 1.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.1 28.5 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 6.0 PID TCR PATHWAY TCR signaling in naïve CD4+ T cells
0.1 2.6 PID BCR 5PATHWAY BCR signaling pathway
0.1 1.9 ST JNK MAPK PATHWAY JNK MAPK Pathway
0.1 2.8 PID RAC1 PATHWAY RAC1 signaling pathway
0.1 3.2 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 7.4 PID MYC REPRESS PATHWAY Validated targets of C-MYC transcriptional repression
0.1 5.6 PID CMYB PATHWAY C-MYB transcription factor network
0.1 2.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.1 2.2 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 1.6 PID MYC PATHWAY C-MYC pathway
0.0 0.9 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 4.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.8 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.0 0.9 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 10.4 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.3 PID IFNG PATHWAY IFN-gamma pathway
0.0 0.3 PID NCADHERIN PATHWAY N-cadherin signaling events
0.0 0.3 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 26.5 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.8 15.6 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.6 15.3 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.5 19.2 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.5 5.3 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.5 44.2 REACTOME INTERFERON GAMMA SIGNALING Genes involved in Interferon gamma signaling
0.5 9.9 REACTOME IL 7 SIGNALING Genes involved in Interleukin-7 signaling
0.4 20.0 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.4 2.8 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.4 8.1 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.3 4.5 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.3 7.0 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.2 2.5 REACTOME BETA DEFENSINS Genes involved in Beta defensins
0.2 9.9 REACTOME GENERATION OF SECOND MESSENGER MOLECULES Genes involved in Generation of second messenger molecules
0.2 5.9 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.2 2.8 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
0.2 4.6 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.2 7.1 REACTOME GABA A RECEPTOR ACTIVATION Genes involved in GABA A receptor activation
0.2 14.6 REACTOME CIRCADIAN CLOCK Genes involved in Circadian Clock
0.2 9.3 REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D Genes involved in Metabolism of steroid hormones and vitamins A and D
0.2 13.5 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.2 16.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 18.5 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 3.5 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.2 6.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 3.6 REACTOME INITIAL TRIGGERING OF COMPLEMENT Genes involved in Initial triggering of complement
0.2 4.1 REACTOME GLUCAGON SIGNALING IN METABOLIC REGULATION Genes involved in Glucagon signaling in metabolic regulation
0.2 1.2 REACTOME DEFENSINS Genes involved in Defensins
0.2 2.3 REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE Genes involved in Reversible Hydration of Carbon Dioxide
0.2 4.8 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 6.2 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.1 2.1 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF CAMKII Genes involved in CREB phosphorylation through the activation of CaMKII
0.1 3.2 REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
0.1 8.2 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.1 2.6 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.1 10.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.1 3.9 REACTOME AMINE COMPOUND SLC TRANSPORTERS Genes involved in Amine compound SLC transporters
0.1 18.1 REACTOME SIGNALING BY EGFR IN CANCER Genes involved in Signaling by EGFR in Cancer
0.1 0.4 REACTOME PD1 SIGNALING Genes involved in PD-1 signaling
0.1 2.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 5.9 REACTOME ION TRANSPORT BY P TYPE ATPASES Genes involved in Ion transport by P-type ATPases
0.1 1.9 REACTOME GAP JUNCTION ASSEMBLY Genes involved in Gap junction assembly
0.1 3.7 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
0.1 2.9 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 2.0 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
0.1 2.4 REACTOME PTM GAMMA CARBOXYLATION HYPUSINE FORMATION AND ARYLSULFATASE ACTIVATION Genes involved in PTM: gamma carboxylation, hypusine formation and arylsulfatase activation
0.1 1.5 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.1 0.9 REACTOME COMMON PATHWAY Genes involved in Common Pathway
0.1 2.6 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.7 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
0.1 2.2 REACTOME CELL CELL JUNCTION ORGANIZATION Genes involved in Cell-cell junction organization
0.1 11.0 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.1 2.5 REACTOME LATENT INFECTION OF HOMO SAPIENS WITH MYCOBACTERIUM TUBERCULOSIS Genes involved in Latent infection of Homo sapiens with Mycobacterium tuberculosis
0.0 1.0 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.8 REACTOME ORGANIC CATION ANION ZWITTERION TRANSPORT Genes involved in Organic cation/anion/zwitterion transport
0.0 0.7 REACTOME HIGHLY CALCIUM PERMEABLE POSTSYNAPTIC NICOTINIC ACETYLCHOLINE RECEPTORS Genes involved in Highly calcium permeable postsynaptic nicotinic acetylcholine receptors
0.0 5.1 REACTOME PEPTIDE LIGAND BINDING RECEPTORS Genes involved in Peptide ligand-binding receptors
0.0 1.7 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.0 1.1 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.6 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.0 2.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.6 REACTOME SYNTHESIS OF PE Genes involved in Synthesis of PE
0.0 1.4 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 0.9 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
0.0 0.5 REACTOME ABCA TRANSPORTERS IN LIPID HOMEOSTASIS Genes involved in ABCA transporters in lipid homeostasis
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.6 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.8 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell