Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for TBX4
Z-value: 0.95
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Transcription factors associated with TBX4
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TBX4 | hg19_v2_chr17_+_59529743_59529798 | 0.37 | 2.1e-08 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr3_+_167453493 Show fit | 25.98 |
ENST00000295777.5
ENST00000472747.2 |
serpin peptidase inhibitor, clade I (neuroserpin), member 1 |
|
| chr11_-_5248294 Show fit | 21.09 |
ENST00000335295.4
|
hemoglobin, beta |
|
| chr11_+_73358594 Show fit | 20.20 |
ENST00000227214.6
ENST00000398494.4 ENST00000543085.1 |
pleckstrin homology domain containing, family B (evectins) member 1 |
|
| chr2_-_175869936 Show fit | 17.35 |
ENST00000409900.3
|
chimerin 1 |
|
| chr2_-_175870085 Show fit | 16.35 |
ENST00000409156.3
|
chimerin 1 |
|
| chr14_+_75746781 Show fit | 13.57 |
ENST00000555347.1
|
FBJ murine osteosarcoma viral oncogene homolog |
|
| chr14_+_75745477 Show fit | 13.06 |
ENST00000303562.4
ENST00000554617.1 ENST00000554212.1 ENST00000535987.1 ENST00000555242.1 |
FBJ murine osteosarcoma viral oncogene homolog |
|
| chr20_+_44657845 Show fit | 11.11 |
ENST00000243964.3
|
solute carrier family 12 (potassium/chloride transporter), member 5 |
|
| chr13_-_36429763 Show fit | 10.41 |
ENST00000379893.1
|
doublecortin-like kinase 1 |
|
| chr5_+_74807886 Show fit | 9.76 |
ENST00000514296.1
|
polymerase (DNA directed) kappa |
Network of associatons between targets according to the STRING database.
First level regulatory network of TBX4
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 31.3 | GO:0008045 | motor neuron axon guidance(GO:0008045) |
| 3.6 | 29.0 | GO:0001661 | conditioned taste aversion(GO:0001661) |
| 0.2 | 26.0 | GO:0007422 | peripheral nervous system development(GO:0007422) |
| 5.3 | 21.1 | GO:0030185 | nitric oxide transport(GO:0030185) |
| 0.3 | 20.2 | GO:0007602 | phototransduction(GO:0007602) |
| 4.7 | 14.1 | GO:2000854 | positive regulation of corticosterone secretion(GO:2000854) |
| 4.5 | 13.4 | GO:0032474 | otolith morphogenesis(GO:0032474) |
| 3.1 | 12.6 | GO:0030644 | cellular chloride ion homeostasis(GO:0030644) |
| 1.2 | 11.6 | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus(GO:1990416) |
| 0.5 | 11.2 | GO:0021952 | central nervous system projection neuron axonogenesis(GO:0021952) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 35.7 | GO:0043204 | perikaryon(GO:0043204) |
| 3.3 | 26.6 | GO:0035976 | AP1 complex(GO:0035976) |
| 5.3 | 21.1 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 14.0 | GO:0030424 | axon(GO:0030424) |
| 0.1 | 13.4 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.2 | 11.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.1 | 9.0 | GO:0030018 | Z disc(GO:0030018) |
| 0.9 | 8.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 6.3 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 0.8 | 5.8 | GO:0071203 | WASH complex(GO:0071203) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 39.4 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.7 | 33.7 | GO:0046875 | ephrin receptor binding(GO:0046875) |
| 0.2 | 24.8 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 3.5 | 21.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.4 | 16.3 | GO:0071855 | neuropeptide receptor binding(GO:0071855) |
| 0.0 | 15.7 | GO:0004871 | signal transducer activity(GO:0004871) |
| 3.9 | 11.6 | GO:0004676 | 3-phosphoinositide-dependent protein kinase activity(GO:0004676) |
| 1.0 | 11.1 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) potassium ion symporter activity(GO:0022820) |
| 0.3 | 9.8 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.8 | 8.5 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 33.7 | PID RAC1 REG PATHWAY | Regulation of RAC1 activity |
| 1.2 | 26.6 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.2 | 23.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.1 | 23.0 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.2 | 13.4 | PID ERBB4 PATHWAY | ErbB4 signaling events |
| 0.4 | 11.6 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.2 | 9.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.2 | 5.4 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 0.0 | 5.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 0.1 | 4.6 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 34.6 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.3 | 26.6 | REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS | Genes involved in Activation of the AP-1 family of transcription factors |
| 0.1 | 21.1 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 15.9 | REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES | Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides |
| 0.1 | 14.3 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.4 | 11.6 | REACTOME G BETA GAMMA SIGNALLING THROUGH PI3KGAMMA | Genes involved in G beta:gamma signalling through PI3Kgamma |
| 0.1 | 7.9 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.3 | 7.6 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.1 | 5.5 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 5.3 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |