Project
averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
Navigation
Downloads
Results for TCF12_ASCL2
Z-value: 2.25
Motif logo
Transcription factors associated with TCF12_ASCL2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| TCF12 | hg19_v2_chr15_+_57210961_57211030 | -0.42 | 1.2e-10 | Click! |
| ASCL2 | hg19_v2_chr11_-_2292182_2292212 | 0.26 | 1.3e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of TCF12_ASCL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 278.4 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 2.5 | 252.7 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 3.8 | 247.7 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 1.5 | 94.9 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 29.2 | 87.7 | GO:0035408 | histone H3-T6 phosphorylation(GO:0035408) |
| 26.5 | 79.6 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 2.6 | 46.1 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 5.7 | 45.6 | GO:0051388 | positive regulation of neurotrophin TRK receptor signaling pathway(GO:0051388) |
| 5.6 | 39.2 | GO:2000503 | positive regulation of natural killer cell chemotaxis(GO:2000503) |
| 3.3 | 39.2 | GO:0002315 | marginal zone B cell differentiation(GO:0002315) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.0 | 250.7 | GO:0042571 | immunoglobulin complex(GO:0019814) immunoglobulin complex, circulating(GO:0042571) |
| 0.1 | 139.2 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 75.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.4 | 75.6 | GO:0072562 | blood microparticle(GO:0072562) |
| 2.7 | 57.3 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 9.6 | 48.0 | GO:0034688 | integrin alphaM-beta2 complex(GO:0034688) |
| 1.8 | 41.4 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.3 | 38.1 | GO:0098852 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 3.4 | 37.9 | GO:0042105 | alpha-beta T cell receptor complex(GO:0042105) |
| 1.1 | 37.0 | GO:0042629 | mast cell granule(GO:0042629) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 295.8 | GO:0003823 | antigen binding(GO:0003823) |
| 4.9 | 250.5 | GO:0034987 | immunoglobulin receptor binding(GO:0034987) |
| 0.2 | 118.4 | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977) |
| 0.2 | 100.7 | GO:0003700 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.3 | 95.2 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 29.2 | 87.7 | GO:0035403 | histone kinase activity (H3-T6 specific)(GO:0035403) |
| 26.5 | 79.6 | GO:0008859 | exoribonuclease II activity(GO:0008859) |
| 7.2 | 50.4 | GO:0030369 | ICAM-3 receptor activity(GO:0030369) |
| 0.8 | 45.1 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.5 | 44.8 | GO:0000980 | RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.4 | 119.4 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 1.1 | 71.7 | PID AMB2 NEUTROPHILS PATHWAY | amb2 Integrin signaling |
| 0.8 | 70.9 | PID BCR 5PATHWAY | BCR signaling pathway |
| 1.7 | 67.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.2 | 66.8 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.8 | 50.4 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.2 | 41.2 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.9 | 41.0 | SIG PIP3 SIGNALING IN B LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 1.1 | 40.6 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.6 | 40.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 136.6 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 1.1 | 85.7 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 2.7 | 74.2 | REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS | Genes involved in Trafficking of GluR2-containing AMPA receptors |
| 2.4 | 54.4 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.8 | 48.9 | REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES | Genes involved in Chemokine receptors bind chemokines |
| 0.3 | 46.4 | REACTOME SIGNALING BY RHO GTPASES | Genes involved in Signaling by Rho GTPases |
| 1.8 | 43.6 | REACTOME OTHER SEMAPHORIN INTERACTIONS | Genes involved in Other semaphorin interactions |
| 1.3 | 42.6 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 2.1 | 39.6 | REACTOME PECAM1 INTERACTIONS | Genes involved in PECAM1 interactions |
| 0.3 | 38.5 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |