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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7

Z-value: 1.02

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Transcription factors associated with TCF7

Gene Symbol Gene ID Gene Info
TCF7
ENSG00000081059.15 transcription factor 7

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7hg19_v2_chr5_+_133477868_133477885-0.171.5e-02Click!

Activity profile of TCF7 motif

Sorted Z-values of TCF7 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_151344172 28.07 ENST00000375734.2
ENST00000263895.4
ENST00000454202.1
RND3
Rho family GTPase 3
chr5_+_34757309 20.05 ENST00000397449.1
RAI14
retinoic acid induced 14
chr10_+_54074033 15.66 ENST00000373970.3
DKK1
dickkopf WNT signaling pathway inhibitor 1
chr1_+_68150744 14.49 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr22_-_42336209 12.48 ENST00000472374.2
CENPM
centromere protein M
chr7_-_107643674 11.87 ENST00000222399.6
LAMB1
laminin, beta 1
chr12_+_69080734 11.40 ENST00000378905.2
NUP107
nucleoporin 107kDa
chr12_+_6309963 10.74 ENST00000382515.2
CD9
CD9 molecule
chr11_-_64013288 10.42 ENST00000542235.1
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr11_-_64013663 9.52 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr18_+_3449821 9.36 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr5_+_135364584 9.16 ENST00000442011.2
ENST00000305126.8
TGFBI
transforming growth factor, beta-induced, 68kDa
chr15_+_74218787 8.85 ENST00000261921.7
LOXL1
lysyl oxidase-like 1
chr5_+_32531893 8.64 ENST00000512913.1
SUB1
SUB1 homolog (S. cerevisiae)
chr12_-_54653313 8.40 ENST00000550411.1
ENST00000439541.2
CBX5
chromobox homolog 5
chr2_+_234621551 8.02 ENST00000608381.1
ENST00000373414.3
UGT1A1
UGT1A5
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chrX_-_153599578 8.01 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr12_+_21654714 7.74 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
GOLT1B
golgi transport 1B
chr1_-_75198681 7.72 ENST00000370872.3
ENST00000370871.3
ENST00000340866.5
ENST00000370870.1
CRYZ
crystallin, zeta (quinone reductase)
chr1_-_75198940 7.56 ENST00000417775.1
CRYZ
crystallin, zeta (quinone reductase)
chr7_+_94023873 7.28 ENST00000297268.6
COL1A2
collagen, type I, alpha 2
chr6_+_83073334 7.17 ENST00000369750.3
TPBG
trophoblast glycoprotein
chr12_+_69979446 7.06 ENST00000543146.2
CCT2
chaperonin containing TCP1, subunit 2 (beta)
chr7_+_134576317 6.88 ENST00000424922.1
ENST00000495522.1
CALD1
caldesmon 1
chr1_-_209824643 6.88 ENST00000391911.1
ENST00000415782.1
LAMB3
laminin, beta 3
chr4_-_139163491 6.83 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr7_+_130131907 6.77 ENST00000223215.4
ENST00000437945.1
MEST
mesoderm specific transcript
chr7_+_73868439 6.51 ENST00000424337.2
GTF2IRD1
GTF2I repeat domain containing 1
chr9_-_35691017 6.50 ENST00000378292.3
TPM2
tropomyosin 2 (beta)
chr7_+_134576151 6.44 ENST00000393118.2
CALD1
caldesmon 1
chr1_-_33502528 6.39 ENST00000354858.6
AK2
adenylate kinase 2
chr14_-_71107921 6.08 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr7_-_80548667 5.49 ENST00000265361.3
SEMA3C
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
chr12_+_121131970 5.48 ENST00000535656.1
MLEC
malectin
chr17_-_18266660 5.43 ENST00000582653.1
ENST00000352886.6
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr8_+_30244580 5.42 ENST00000523115.1
ENST00000519647.1
RBPMS
RNA binding protein with multiple splicing
chr3_+_52719936 5.34 ENST00000418458.1
ENST00000394799.2
GNL3
guanine nucleotide binding protein-like 3 (nucleolar)
chr1_+_10459111 5.23 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr10_+_17271266 5.11 ENST00000224237.5
VIM
vimentin
chr6_+_64281906 5.10 ENST00000370651.3
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr6_+_83073952 5.09 ENST00000543496.1
TPBG
trophoblast glycoprotein
chr4_-_71705027 5.07 ENST00000545193.1
GRSF1
G-rich RNA sequence binding factor 1
chr5_-_16936340 5.07 ENST00000507288.1
ENST00000513610.1
MYO10
myosin X
chr4_-_7069760 4.96 ENST00000264954.4
GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr3_+_159570722 4.96 ENST00000482804.1
SCHIP1
schwannomin interacting protein 1
chr3_+_133502877 4.96 ENST00000466490.2
SRPRB
signal recognition particle receptor, B subunit
chr17_-_79818354 4.94 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
P4HB
prolyl 4-hydroxylase, beta polypeptide
chr7_-_27213893 4.93 ENST00000283921.4
HOXA10
homeobox A10
chr7_-_16840820 4.90 ENST00000450569.1
AGR2
anterior gradient 2
chr7_+_56119323 4.88 ENST00000275603.4
ENST00000335503.3
ENST00000540286.1
CCT6A
chaperonin containing TCP1, subunit 6A (zeta 1)
chr19_+_1026566 4.87 ENST00000348419.3
ENST00000565096.2
ENST00000562958.2
ENST00000562075.2
ENST00000607102.1
CNN2
calponin 2
chr17_+_34848049 4.82 ENST00000588902.1
ENST00000591067.1
ZNHIT3
zinc finger, HIT-type containing 3
chr6_+_160183492 4.81 ENST00000541436.1
ACAT2
acetyl-CoA acetyltransferase 2
chr12_+_104359576 4.80 ENST00000392872.3
ENST00000436021.2
TDG
thymine-DNA glycosylase
chr16_-_73082274 4.76 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr13_+_29233218 4.69 ENST00000380842.4
POMP
proteasome maturation protein
chr5_-_157002775 4.66 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr19_+_58898627 4.56 ENST00000598098.1
ENST00000598495.1
ENST00000196551.3
ENST00000596046.1
RPS5
ribosomal protein S5
chr14_+_61201445 4.52 ENST00000261245.4
ENST00000539616.2
MNAT1
MNAT CDK-activating kinase assembly factor 1
chr8_+_73921085 4.51 ENST00000276603.5
ENST00000276602.6
ENST00000518874.1
TERF1
telomeric repeat binding factor (NIMA-interacting) 1
chr4_-_71705060 4.49 ENST00000514161.1
GRSF1
G-rich RNA sequence binding factor 1
chr8_-_101962777 4.43 ENST00000395951.3
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr1_-_149900122 4.43 ENST00000271628.8
SF3B4
splicing factor 3b, subunit 4, 49kDa
chr14_+_24458093 4.33 ENST00000558753.1
ENST00000537912.1
DHRS4L2
dehydrogenase/reductase (SDR family) member 4 like 2
chr17_-_18266765 4.30 ENST00000354098.3
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr11_-_10829851 4.28 ENST00000532082.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr17_-_18266797 4.26 ENST00000316694.3
ENST00000539052.1
SHMT1
serine hydroxymethyltransferase 1 (soluble)
chr19_+_1026298 4.24 ENST00000263097.4
CNN2
calponin 2
chr17_-_56065484 4.18 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr1_-_33502441 4.17 ENST00000548033.1
ENST00000487289.1
ENST00000373449.2
ENST00000480134.1
ENST00000467905.1
AK2
adenylate kinase 2
chr4_-_52904425 4.10 ENST00000535450.1
SGCB
sarcoglycan, beta (43kDa dystrophin-associated glycoprotein)
chr2_+_189157536 3.92 ENST00000409580.1
ENST00000409637.3
GULP1
GULP, engulfment adaptor PTB domain containing 1
chr13_+_102104980 3.86 ENST00000545560.2
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr19_+_41257084 3.86 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr6_+_64282447 3.84 ENST00000370650.2
ENST00000578299.1
PTP4A1
protein tyrosine phosphatase type IVA, member 1
chr7_-_148725733 3.64 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr22_+_39052632 3.54 ENST00000411557.1
ENST00000396811.2
ENST00000216029.3
ENST00000416285.1
CBY1
chibby homolog 1 (Drosophila)
chrX_+_102883620 3.50 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr2_+_172378757 3.41 ENST00000409484.1
ENST00000321348.4
ENST00000375252.3
CYBRD1
cytochrome b reductase 1
chr6_+_32146131 3.39 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr1_+_955448 3.37 ENST00000379370.2
AGRN
agrin
chr17_-_17485731 3.33 ENST00000395783.1
PEMT
phosphatidylethanolamine N-methyltransferase
chr2_-_217560248 3.29 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr2_+_46926326 3.24 ENST00000394861.2
SOCS5
suppressor of cytokine signaling 5
chr1_-_110933663 3.24 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
SLC16A4
solute carrier family 16, member 4
chrX_+_100645812 3.20 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr8_-_119964434 3.19 ENST00000297350.4
TNFRSF11B
tumor necrosis factor receptor superfamily, member 11b
chrX_+_54835493 3.17 ENST00000396224.1
MAGED2
melanoma antigen family D, 2
chr12_+_104359614 3.13 ENST00000266775.9
ENST00000544861.1
TDG
thymine-DNA glycosylase
chr11_-_33774944 3.13 ENST00000532057.1
ENST00000531080.1
FBXO3
F-box protein 3
chrX_+_100646190 3.09 ENST00000471855.1
RPL36A
ribosomal protein L36a
chrX_+_12993336 3.07 ENST00000380635.1
TMSB4X
thymosin beta 4, X-linked
chr1_-_110933611 3.04 ENST00000472422.2
ENST00000437429.2
SLC16A4
solute carrier family 16, member 4
chr1_-_147142557 2.98 ENST00000369238.6
ACP6
acid phosphatase 6, lysophosphatidic
chr17_+_79953310 2.97 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr4_-_129209944 2.93 ENST00000520121.1
PGRMC2
progesterone receptor membrane component 2
chr22_+_39077947 2.85 ENST00000216034.4
TOMM22
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr17_-_20946338 2.84 ENST00000261497.4
USP22
ubiquitin specific peptidase 22
chr1_-_211752073 2.84 ENST00000367001.4
SLC30A1
solute carrier family 30 (zinc transporter), member 1
chr4_-_106629796 2.81 ENST00000416543.1
ENST00000515819.1
ENST00000420368.2
ENST00000503746.1
ENST00000340139.5
ENST00000433009.1
INTS12
integrator complex subunit 12
chr11_-_10830463 2.77 ENST00000527419.1
ENST00000530211.1
ENST00000530702.1
ENST00000524932.1
ENST00000532570.1
EIF4G2
eukaryotic translation initiation factor 4 gamma, 2
chr13_+_30002846 2.73 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chr13_+_102142296 2.72 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr17_-_7297519 2.71 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr19_-_2328572 2.67 ENST00000252622.10
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr2_+_177134201 2.63 ENST00000452865.1
MTX2
metaxin 2
chr2_+_69240302 2.59 ENST00000303714.4
ANTXR1
anthrax toxin receptor 1
chr1_-_53793584 2.56 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr11_-_122930121 2.51 ENST00000524552.1
HSPA8
heat shock 70kDa protein 8
chr17_+_68100989 2.47 ENST00000585558.1
ENST00000392670.1
KCNJ16
potassium inwardly-rectifying channel, subfamily J, member 16
chr2_-_27592867 2.45 ENST00000451130.2
EIF2B4
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
chr1_+_169079823 2.44 ENST00000367813.3
ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr6_+_125540951 2.42 ENST00000524679.1
TPD52L1
tumor protein D52-like 1
chr2_-_238499303 2.41 ENST00000409576.1
RAB17
RAB17, member RAS oncogene family
chr5_-_148930960 2.38 ENST00000261798.5
ENST00000377843.2
CSNK1A1
casein kinase 1, alpha 1
chr17_-_37009882 2.36 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
RPL23
ribosomal protein L23
chr19_-_20844368 2.33 ENST00000595094.1
ENST00000601440.1
ENST00000291750.6
CTC-513N18.7
ZNF626
CTC-513N18.7
zinc finger protein 626
chr9_-_21187598 2.28 ENST00000421715.1
IFNA4
interferon, alpha 4
chr8_-_145047688 2.17 ENST00000356346.3
PLEC
plectin
chr2_-_88427568 2.16 ENST00000393750.3
ENST00000295834.3
FABP1
fatty acid binding protein 1, liver
chr12_+_104359641 2.15 ENST00000537100.1
TDG
thymine-DNA glycosylase
chr5_-_82969405 2.15 ENST00000510978.1
HAPLN1
hyaluronan and proteoglycan link protein 1
chr17_-_46623441 2.14 ENST00000330070.4
HOXB2
homeobox B2
chr2_+_46926048 2.14 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr2_-_238499337 2.12 ENST00000411462.1
ENST00000409822.1
RAB17
RAB17, member RAS oncogene family
chr5_+_140579162 2.11 ENST00000536699.1
ENST00000354757.3
PCDHB11
protocadherin beta 11
chr12_-_49582593 2.11 ENST00000295766.5
TUBA1A
tubulin, alpha 1a
chr14_-_35344093 2.10 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr1_+_182808474 2.07 ENST00000367549.3
DHX9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr4_-_146019693 2.03 ENST00000514390.1
ANAPC10
anaphase promoting complex subunit 10
chr17_+_41150290 2.02 ENST00000589037.1
ENST00000253788.5
RPL27
ribosomal protein L27
chr2_-_29093132 1.96 ENST00000306108.5
TRMT61B
tRNA methyltransferase 61 homolog B (S. cerevisiae)
chr1_-_19426149 1.95 ENST00000429347.2
UBR4
ubiquitin protein ligase E3 component n-recognin 4
chr1_+_15479054 1.95 ENST00000376014.3
ENST00000451326.2
TMEM51
transmembrane protein 51
chr1_+_15479021 1.94 ENST00000428417.1
TMEM51
transmembrane protein 51
chr1_-_28527152 1.91 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr17_-_26989136 1.90 ENST00000247020.4
SDF2
stromal cell-derived factor 2
chr13_+_45694583 1.86 ENST00000340473.6
GTF2F2
general transcription factor IIF, polypeptide 2, 30kDa
chr1_+_11072696 1.85 ENST00000240185.3
ENST00000476201.1
TARDBP
TAR DNA binding protein
chr5_-_130500922 1.84 ENST00000513012.1
ENST00000508488.1
ENST00000506908.1
ENST00000304043.5
HINT1
histidine triad nucleotide binding protein 1
chr13_+_102104952 1.81 ENST00000376180.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_-_112575912 1.81 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
LAMA4
laminin, alpha 4
chr12_-_49351148 1.78 ENST00000398092.4
ENST00000539611.1
RP11-302B13.5
ARF3
ADP-ribosylation factor 3
ADP-ribosylation factor 3
chr7_+_23286182 1.77 ENST00000258733.4
ENST00000381990.2
ENST00000409458.3
ENST00000539136.1
ENST00000453162.2
GPNMB
glycoprotein (transmembrane) nmb
chr1_-_151345159 1.75 ENST00000458566.1
ENST00000447402.3
ENST00000426705.2
ENST00000435071.1
ENST00000368868.5
SELENBP1
selenium binding protein 1
chr12_+_49717019 1.74 ENST00000549275.1
ENST00000551245.1
ENST00000380327.5
ENST00000548311.1
ENST00000550346.1
ENST00000550709.1
ENST00000549534.1
ENST00000257909.3
TROAP
trophinin associated protein
chr17_+_74372662 1.74 ENST00000591651.1
ENST00000545180.1
SPHK1
sphingosine kinase 1
chr11_-_87908600 1.70 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chr17_+_75283973 1.66 ENST00000431235.2
ENST00000449803.2
SEPT9
septin 9
chr16_+_68678739 1.66 ENST00000264012.4
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr4_-_7873981 1.66 ENST00000360265.4
AFAP1
actin filament associated protein 1
chr3_+_118892362 1.65 ENST00000497685.1
ENST00000264234.3
UPK1B
uroplakin 1B
chrX_-_102757802 1.63 ENST00000372633.1
RAB40A
RAB40A, member RAS oncogene family
chr2_+_1417228 1.62 ENST00000382269.3
ENST00000337415.3
ENST00000345913.4
ENST00000346956.3
ENST00000349624.3
ENST00000539820.1
ENST00000329066.4
ENST00000382201.3
TPO
thyroid peroxidase
chr16_-_46865047 1.62 ENST00000394806.2
C16orf87
chromosome 16 open reading frame 87
chr15_-_44116873 1.61 ENST00000267812.3
MFAP1
microfibrillar-associated protein 1
chr19_+_13134772 1.59 ENST00000587760.1
ENST00000585575.1
NFIX
nuclear factor I/X (CCAAT-binding transcription factor)
chrX_+_146993449 1.59 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
FMR1
fragile X mental retardation 1
chr17_+_75447326 1.57 ENST00000591088.1
SEPT9
septin 9
chr19_+_41256764 1.54 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr6_+_52285046 1.53 ENST00000371068.5
EFHC1
EF-hand domain (C-terminal) containing 1
chr19_+_45281118 1.51 ENST00000270279.3
ENST00000341505.4
CBLC
Cbl proto-oncogene C, E3 ubiquitin protein ligase
chr15_+_74466012 1.50 ENST00000249842.3
ISLR
immunoglobulin superfamily containing leucine-rich repeat
chr9_-_86593238 1.50 ENST00000351839.3
HNRNPK
heterogeneous nuclear ribonucleoprotein K
chr3_+_197677379 1.47 ENST00000442341.1
RPL35A
ribosomal protein L35a
chr2_-_231989808 1.46 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr17_+_26989109 1.46 ENST00000314616.6
ENST00000347486.4
SUPT6H
suppressor of Ty 6 homolog (S. cerevisiae)
chr17_+_48503519 1.45 ENST00000300441.4
ENST00000541920.1
ENST00000506582.1
ENST00000504392.1
ENST00000427954.2
ACSF2
acyl-CoA synthetase family member 2
chr9_+_91003271 1.44 ENST00000375859.3
ENST00000541629.1
SPIN1
spindlin 1
chr2_-_36825281 1.42 ENST00000405912.3
ENST00000379245.4
FEZ2
fasciculation and elongation protein zeta 2 (zygin II)
chr3_+_36421826 1.40 ENST00000273183.3
STAC
SH3 and cysteine rich domain
chr2_-_172750733 1.36 ENST00000392592.4
ENST00000422440.2
SLC25A12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr1_-_79472365 1.34 ENST00000370742.3
ELTD1
EGF, latrophilin and seven transmembrane domain containing 1
chr2_-_27593180 1.33 ENST00000493344.2
ENST00000445933.2
EIF2B4
eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa
chr3_+_197677047 1.28 ENST00000448864.1
RPL35A
ribosomal protein L35a
chr4_+_87515454 1.27 ENST00000427191.2
ENST00000436978.1
ENST00000502971.1
PTPN13
protein tyrosine phosphatase, non-receptor type 13 (APO-1/CD95 (Fas)-associated phosphatase)
chrX_+_100663243 1.26 ENST00000316594.5
HNRNPH2
heterogeneous nuclear ribonucleoprotein H2 (H')
chr8_+_77593448 1.20 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr8_-_90996459 1.18 ENST00000517337.1
ENST00000409330.1
NBN
nibrin
chr17_+_79679299 1.17 ENST00000331531.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr17_+_79679369 1.15 ENST00000350690.5
SLC25A10
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr2_+_234580525 1.12 ENST00000609637.1
UGT1A1
UDP glucuronosyltransferase 1 family, polypeptide A8
chr17_+_41150479 1.12 ENST00000589913.1
RPL27
ribosomal protein L27
chr12_+_100594557 1.12 ENST00000546902.1
ENST00000552376.1
ENST00000551617.1
ACTR6
ARP6 actin-related protein 6 homolog (yeast)
chrX_+_135618258 1.11 ENST00000440515.1
ENST00000456412.1
VGLL1
vestigial like 1 (Drosophila)
chr7_+_111846643 1.07 ENST00000361822.3
ZNF277
zinc finger protein 277
chr1_-_53793725 1.03 ENST00000371454.2
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr11_-_108422926 1.00 ENST00000428840.1
ENST00000526312.1
EXPH5
exophilin 5
chr1_-_16345245 0.97 ENST00000311890.9
HSPB7
heat shock 27kDa protein family, member 7 (cardiovascular)
chr5_-_157286104 0.95 ENST00000530742.1
ENST00000523908.1
ENST00000523094.1
ENST00000296951.5
ENST00000411809.2
CLINT1
clathrin interactor 1
chr17_-_39580775 0.90 ENST00000225550.3
KRT37
keratin 37
chr12_-_71003568 0.89 ENST00000547715.1
ENST00000451516.2
ENST00000538708.1
ENST00000550857.1
ENST00000261266.5
PTPRB
protein tyrosine phosphatase, receptor type, B
chrX_+_12993202 0.89 ENST00000451311.2
ENST00000380636.1
TMSB4X
thymosin beta 4, X-linked
chr14_+_24458021 0.88 ENST00000397071.1
ENST00000559411.1
ENST00000335125.6
DHRS4L2
dehydrogenase/reductase (SDR family) member 4 like 2
chr2_+_234580499 0.82 ENST00000354728.4
UGT1A9
UDP glucuronosyltransferase 1 family, polypeptide A9
chr5_+_150040403 0.81 ENST00000517768.1
ENST00000297130.4
MYOZ3
myozenin 3
chr11_+_46740730 0.79 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2
coagulation factor II (thrombin)
chr12_-_133405288 0.76 ENST00000204726.3
GOLGA3
golgin A3
chr10_-_61122220 0.75 ENST00000422313.2
ENST00000435852.2
ENST00000442566.3
ENST00000373868.2
ENST00000277705.6
ENST00000373867.3
ENST00000419214.2
FAM13C
family with sequence similarity 13, member C
chr5_+_43603229 0.74 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.2 15.7 GO:0009996 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
4.7 14.0 GO:1904481 response to tetrahydrofolate(GO:1904481) cellular response to tetrahydrofolate(GO:1904482)
3.5 10.6 GO:0006172 ADP biosynthetic process(GO:0006172)
3.0 11.9 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
2.5 10.1 GO:1902544 oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544)
2.4 7.1 GO:0051086 chaperone mediated protein folding independent of cofactor(GO:0051086)
2.3 11.4 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
2.0 8.0 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
1.8 9.1 GO:0070980 biphenyl catabolic process(GO:0070980)
1.7 5.2 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.5 4.5 GO:0031627 telomeric loop formation(GO:0031627) negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
1.3 6.5 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.2 4.8 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.1 3.3 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
1.0 15.3 GO:0042178 xenobiotic catabolic process(GO:0042178)
0.9 5.5 GO:0003350 pulmonary myocardium development(GO:0003350)
0.9 4.5 GO:0002415 immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor(GO:0002415)
0.9 5.4 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.9 2.6 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
0.8 3.4 GO:1904398 positive regulation of neuromuscular junction development(GO:1904398)
0.8 4.9 GO:1903899 positive regulation of PERK-mediated unfolded protein response(GO:1903899)
0.8 3.2 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.8 2.3 GO:1902356 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.8 10.7 GO:0030913 paranodal junction assembly(GO:0030913)
0.8 14.5 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.7 3.6 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.7 2.1 GO:0021569 rhombomere 3 development(GO:0021569)
0.7 10.2 GO:1904816 positive regulation of protein localization to chromosome, telomeric region(GO:1904816)
0.7 4.0 GO:2000483 negative regulation of interleukin-8 secretion(GO:2000483)
0.7 2.0 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
0.6 4.9 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
0.6 2.4 GO:1903288 protein transport into plasma membrane raft(GO:0044861) positive regulation of potassium ion import(GO:1903288)
0.6 1.7 GO:0046521 sphingoid catabolic process(GO:0046521)
0.6 2.8 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.6 3.3 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.6 1.7 GO:0051796 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
0.5 7.8 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
0.5 2.5 GO:1904764 negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
0.5 7.3 GO:0043589 skin morphogenesis(GO:0043589)
0.5 3.8 GO:0032057 negative regulation of translational initiation in response to stress(GO:0032057)
0.5 2.4 GO:0072717 cellular response to actinomycin D(GO:0072717)
0.5 5.1 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.5 1.4 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.5 3.2 GO:0070294 renal sodium ion absorption(GO:0070294)
0.4 2.1 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.4 12.5 GO:0061641 CENP-A containing nucleosome assembly(GO:0034080) CENP-A containing chromatin organization(GO:0061641)
0.4 6.8 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.4 1.2 GO:0031860 telomeric 3' overhang formation(GO:0031860)
0.4 1.5 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.4 1.5 GO:0061086 negative regulation of histone H3-K27 methylation(GO:0061086)
0.3 2.4 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.3 4.5 GO:0007512 adult heart development(GO:0007512)
0.3 1.6 GO:2000301 regulation of intracellular transport of viral material(GO:1901252) negative regulation of synaptic vesicle exocytosis(GO:2000301)
0.3 4.1 GO:0097084 vascular smooth muscle cell development(GO:0097084)
0.3 9.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.3 4.4 GO:0090168 Golgi reassembly(GO:0090168)
0.3 4.4 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.3 4.7 GO:0043248 proteasome assembly(GO:0043248)
0.3 1.5 GO:0010513 positive regulation of phosphatidylinositol biosynthetic process(GO:0010513)
0.3 10.5 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261)
0.3 5.4 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.2 5.4 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.2 3.9 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.2 1.7 GO:1903232 melanosome assembly(GO:1903232)
0.2 2.2 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 1.4 GO:1902902 negative regulation of autophagosome assembly(GO:1902902)
0.2 0.9 GO:0006740 NADPH regeneration(GO:0006740)
0.2 4.6 GO:0006450 regulation of translational fidelity(GO:0006450)
0.2 1.9 GO:0071763 nuclear membrane organization(GO:0071763)
0.2 4.9 GO:0060065 uterus development(GO:0060065)
0.2 7.4 GO:0006378 mRNA polyadenylation(GO:0006378)
0.2 1.5 GO:0007175 negative regulation of epidermal growth factor-activated receptor activity(GO:0007175)
0.2 0.5 GO:0051684 maintenance of Golgi location(GO:0051684)
0.2 0.8 GO:0051552 flavone metabolic process(GO:0051552)
0.2 3.2 GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein(GO:0033141)
0.2 0.8 GO:0051801 cytolysis in other organism involved in symbiotic interaction(GO:0051801) positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 2.8 GO:0016180 snRNA processing(GO:0016180)
0.1 11.2 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.1 0.6 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
0.1 0.6 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.1 6.8 GO:0035904 aorta development(GO:0035904)
0.1 0.4 GO:0009804 coumarin metabolic process(GO:0009804)
0.1 2.5 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 4.8 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 2.8 GO:0016578 histone deubiquitination(GO:0016578)
0.1 5.1 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.1 8.3 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
0.1 0.6 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.1 1.6 GO:0006904 vesicle docking involved in exocytosis(GO:0006904)
0.1 0.4 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582) synaptic growth at neuromuscular junction(GO:0051124)
0.1 7.1 GO:0006446 regulation of translational initiation(GO:0006446)
0.1 2.7 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 9.0 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 9.0 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.1 0.3 GO:0038180 nerve growth factor signaling pathway(GO:0038180)
0.1 0.6 GO:0007288 sperm axoneme assembly(GO:0007288)
0.1 1.6 GO:0006590 thyroid hormone generation(GO:0006590)
0.1 0.7 GO:0070072 proton-transporting V-type ATPase complex assembly(GO:0070070) vacuolar proton-transporting V-type ATPase complex assembly(GO:0070072)
0.1 0.7 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.1 8.0 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 6.5 GO:0043462 regulation of ATPase activity(GO:0043462)
0.1 0.4 GO:0070307 lens fiber cell development(GO:0070307)
0.1 0.5 GO:0061302 smooth muscle cell-matrix adhesion(GO:0061302)
0.1 1.0 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.4 GO:1903286 regulation of potassium ion import(GO:1903286)
0.1 1.5 GO:0031954 positive regulation of protein autophosphorylation(GO:0031954)
0.1 0.4 GO:0033629 negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.1 4.0 GO:0001885 endothelial cell development(GO:0001885)
0.1 2.0 GO:0010107 potassium ion import(GO:0010107)
0.1 4.8 GO:0006695 cholesterol biosynthetic process(GO:0006695)
0.1 2.2 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
0.0 5.0 GO:0036498 IRE1-mediated unfolded protein response(GO:0036498)
0.0 3.6 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.3 GO:0070574 cadmium ion transport(GO:0015691) cadmium ion transmembrane transport(GO:0070574)
0.0 3.4 GO:0006879 cellular iron ion homeostasis(GO:0006879)
0.0 2.1 GO:0007416 synapse assembly(GO:0007416)
0.0 1.8 GO:0009154 purine ribonucleotide catabolic process(GO:0009154)
0.0 1.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.0 3.0 GO:0046324 regulation of glucose import(GO:0046324)
0.0 0.7 GO:0006098 pentose-phosphate shunt(GO:0006098)
0.0 4.4 GO:0007498 mesoderm development(GO:0007498)
0.0 1.0 GO:0048268 clathrin coat assembly(GO:0048268)
0.0 1.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 2.9 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 4.0 GO:0015718 monocarboxylic acid transport(GO:0015718)
0.0 2.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.7 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.0 5.7 GO:0006936 muscle contraction(GO:0006936)
0.0 2.1 GO:0055007 cardiac muscle cell differentiation(GO:0055007)
0.0 0.2 GO:0015760 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
0.0 0.7 GO:0042220 response to cocaine(GO:0042220)
0.0 0.2 GO:0086073 cardiac muscle cell-cardiac muscle cell adhesion(GO:0086042) bundle of His cell-Purkinje myocyte adhesion involved in cell communication(GO:0086073)
0.0 3.2 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.5 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.0 4.8 GO:0006457 protein folding(GO:0006457)
0.0 0.3 GO:0055072 iron ion homeostasis(GO:0055072)
0.0 0.3 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.8 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.0 0.2 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.0 1.8 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
0.0 0.1 GO:0030220 platelet formation(GO:0030220)
0.0 3.8 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 1.0 GO:0006986 response to unfolded protein(GO:0006986)
0.0 1.5 GO:0006626 protein targeting to mitochondrion(GO:0006626)
0.0 4.1 GO:0000086 G2/M transition of mitotic cell cycle(GO:0000086)
0.0 0.4 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.6 GO:0007274 neuromuscular synaptic transmission(GO:0007274)
0.0 0.6 GO:0001961 positive regulation of cytokine-mediated signaling pathway(GO:0001961)
0.0 1.7 GO:0051493 regulation of cytoskeleton organization(GO:0051493)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 0.0 GO:0034165 regulation of toll-like receptor 9 signaling pathway(GO:0034163) positive regulation of toll-like receptor 9 signaling pathway(GO:0034165)
0.0 0.1 GO:0000717 nucleotide-excision repair, DNA duplex unwinding(GO:0000717) UV-damage excision repair(GO:0070914)
0.0 1.6 GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:0042787)
0.0 0.3 GO:0052646 alditol phosphate metabolic process(GO:0052646)
0.0 6.1 GO:0030036 actin cytoskeleton organization(GO:0030036)
0.0 6.9 GO:0045087 innate immune response(GO:0045087)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.0 11.9 GO:0005607 laminin-2 complex(GO:0005607)
2.7 8.0 GO:0031523 Myb complex(GO:0031523)
1.6 4.9 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
1.2 5.0 GO:0001405 presequence translocase-associated import motor(GO:0001405)
0.9 6.9 GO:0005610 laminin-5 complex(GO:0005610)
0.8 3.9 GO:0005726 perichromatin fibrils(GO:0005726)
0.7 11.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.7 5.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.7 10.4 GO:0030478 actin cap(GO:0030478)
0.7 2.0 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
0.6 11.9 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.6 1.9 GO:0005674 transcription factor TFIIF complex(GO:0005674)
0.6 7.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.6 8.4 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 9.1 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.5 1.6 GO:0019034 viral replication complex(GO:0019034)
0.5 4.1 GO:0016012 sarcoglycan complex(GO:0016012)
0.5 3.4 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.5 3.8 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.5 4.5 GO:0070187 telosome(GO:0070187)
0.4 2.8 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.4 2.7 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 3.3 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.4 2.5 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
0.3 6.5 GO:0005862 muscle thin filament tropomyosin(GO:0005862)
0.3 1.7 GO:0031905 early endosome lumen(GO:0031905)
0.3 10.8 GO:0005685 U1 snRNP(GO:0005685)
0.3 7.1 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.3 2.8 GO:0032039 integrator complex(GO:0032039)
0.3 4.5 GO:0005675 holo TFIIH complex(GO:0005675)
0.3 5.1 GO:0032433 filopodium tip(GO:0032433)
0.3 4.4 GO:0005689 U12-type spliceosomal complex(GO:0005689)
0.3 2.2 GO:0045179 apical cortex(GO:0045179)
0.3 0.8 GO:0090498 extrinsic component of Golgi membrane(GO:0090498)
0.3 7.8 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.2 GO:0030870 Mre11 complex(GO:0030870)
0.2 25.7 GO:0005604 basement membrane(GO:0005604)
0.2 2.1 GO:0031010 ISWI-type complex(GO:0031010)
0.2 2.8 GO:0000124 SAGA complex(GO:0000124)
0.2 9.3 GO:0042645 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.2 2.4 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.1 3.2 GO:0031105 septin complex(GO:0031105)
0.1 2.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 11.1 GO:0036126 sperm flagellum(GO:0036126)
0.1 12.5 GO:0000777 condensed chromosome kinetochore(GO:0000777)
0.1 14.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 2.4 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.1 6.9 GO:0031526 brush border membrane(GO:0031526)
0.1 9.0 GO:1904724 tertiary granule lumen(GO:1904724)
0.1 2.6 GO:0031527 filopodium membrane(GO:0031527)
0.1 15.1 GO:0001650 fibrillar center(GO:0001650)
0.1 14.4 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 13.8 GO:0031901 early endosome membrane(GO:0031901)
0.1 6.6 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 1.6 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 4.3 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.1 2.0 GO:0005680 anaphase-promoting complex(GO:0005680)
0.1 8.1 GO:0035579 specific granule membrane(GO:0035579)
0.1 4.6 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 5.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 27.9 GO:0005925 focal adhesion(GO:0005925)
0.1 1.5 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 2.9 GO:0030315 T-tubule(GO:0030315)
0.0 6.0 GO:0016605 PML body(GO:0016605)
0.0 19.7 GO:0016607 nuclear speck(GO:0016607)
0.0 0.5 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 3.0 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.0 0.2 GO:0005916 fascia adherens(GO:0005916)
0.0 10.2 GO:0016604 nuclear body(GO:0016604)
0.0 0.5 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.0 2.2 GO:0005901 caveola(GO:0005901)
0.0 1.8 GO:0000118 histone deacetylase complex(GO:0000118)
0.0 1.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 5.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.1 GO:0000110 nucleotide-excision repair factor 1 complex(GO:0000110)
0.0 0.6 GO:0005865 striated muscle thin filament(GO:0005865)
0.0 0.7 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.4 GO:0031594 neuromuscular junction(GO:0031594)
0.0 0.5 GO:0030667 secretory granule membrane(GO:0030667)
0.0 3.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 7.8 GO:0009986 cell surface(GO:0009986)
0.0 0.9 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.0 3.7 GO:0005667 transcription factor complex(GO:0005667)
0.0 1.0 GO:0030136 clathrin-coated vesicle(GO:0030136)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 10.1 GO:0043739 G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739)
3.1 15.3 GO:0070404 NADH binding(GO:0070404)
2.8 14.0 GO:0070905 serine binding(GO:0070905)
2.0 8.0 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
1.7 5.2 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
1.7 5.0 GO:0005047 signal recognition particle binding(GO:0005047)
1.5 10.8 GO:0035614 snRNA stem-loop binding(GO:0035614)
1.5 16.0 GO:0039706 co-receptor binding(GO:0039706)
1.4 6.8 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
1.2 4.9 GO:0071987 WD40-repeat domain binding(GO:0071987)
1.2 4.8 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
1.1 3.3 GO:0000773 phosphatidyl-N-methylethanolamine N-methyltransferase activity(GO:0000773) phosphatidylethanolamine N-methyltransferase activity(GO:0004608) phosphatidyl-N-dimethylethanolamine N-methyltransferase activity(GO:0080101)
1.0 4.9 GO:0004656 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
0.9 3.6 GO:0038025 reelin receptor activity(GO:0038025)
0.9 5.1 GO:1990254 keratin filament binding(GO:1990254)
0.8 9.6 GO:0004017 adenylate kinase activity(GO:0004017)
0.8 2.3 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.7 2.0 GO:0016429 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
0.6 4.5 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
0.6 4.5 GO:0071532 ankyrin repeat binding(GO:0071532)
0.6 2.4 GO:0070180 large ribosomal subunit rRNA binding(GO:0070180)
0.6 3.4 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.6 5.1 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.6 3.4 GO:0035374 chondroitin sulfate binding(GO:0035374)
0.6 8.9 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.5 7.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.5 13.9 GO:0005523 tropomyosin binding(GO:0005523)
0.4 1.7 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.4 19.9 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.4 11.4 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.4 5.0 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.4 2.1 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.4 5.5 GO:0030215 semaphorin receptor binding(GO:0030215)
0.4 3.3 GO:0000990 transcription factor activity, core RNA polymerase binding(GO:0000990)
0.3 9.4 GO:0070410 co-SMAD binding(GO:0070410)
0.3 1.6 GO:0034046 poly(G) binding(GO:0034046)
0.3 1.9 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.3 2.2 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 3.3 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.3 1.7 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.3 3.4 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.3 1.4 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
0.3 1.6 GO:0004447 iodide peroxidase activity(GO:0004447)
0.3 10.0 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.3 2.8 GO:0015266 protein channel activity(GO:0015266)
0.2 0.7 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.2 3.2 GO:0005132 type I interferon receptor binding(GO:0005132)
0.2 2.5 GO:0055131 C3HC4-type RING finger domain binding(GO:0055131)
0.2 10.5 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.2 0.7 GO:0017057 glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057)
0.2 3.0 GO:0003993 acid phosphatase activity(GO:0003993)
0.2 4.9 GO:0002162 dystroglycan binding(GO:0002162)
0.2 7.1 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.2 1.8 GO:0045545 syndecan binding(GO:0045545)
0.2 8.9 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.2 3.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 2.8 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.2 0.7 GO:0022850 serotonin-gated cation channel activity(GO:0022850)
0.2 5.3 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.2 0.8 GO:0051373 FATZ binding(GO:0051373)
0.2 1.7 GO:0008430 selenium binding(GO:0008430)
0.2 9.6 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 2.4 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.1 2.8 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
0.1 14.5 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 10.9 GO:0003743 translation initiation factor activity(GO:0003743)
0.1 1.3 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
0.1 2.7 GO:0017070 U6 snRNA binding(GO:0017070)
0.1 9.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 0.6 GO:0004666 prostaglandin-endoperoxide synthase activity(GO:0004666)
0.1 1.5 GO:0043176 amine binding(GO:0043176) serotonin binding(GO:0051378)
0.1 1.4 GO:0003996 acyl-CoA ligase activity(GO:0003996)
0.1 6.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.1 11.7 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 4.8 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 15.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.1 2.0 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 6.3 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 3.5 GO:0050699 WW domain binding(GO:0050699)
0.1 31.6 GO:0003924 GTPase activity(GO:0003924)
0.1 4.0 GO:0003785 actin monomer binding(GO:0003785)
0.1 4.6 GO:0019843 rRNA binding(GO:0019843)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 11.8 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 0.7 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.3 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.1 2.1 GO:0004402 histone acetyltransferase activity(GO:0004402)
0.1 1.8 GO:0005080 protein kinase C binding(GO:0005080)
0.0 4.9 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 9.5 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.6 GO:0001222 transcription corepressor binding(GO:0001222)
0.0 5.1 GO:0005178 integrin binding(GO:0005178)
0.0 0.2 GO:0086083 cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication(GO:0086083)
0.0 0.4 GO:0097016 L27 domain binding(GO:0097016)
0.0 2.4 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 1.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 0.2 GO:0015562 efflux transmembrane transporter activity(GO:0015562)
0.0 5.9 GO:0005516 calmodulin binding(GO:0005516)
0.0 2.9 GO:0005496 steroid binding(GO:0005496)
0.0 2.2 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.8 GO:0001530 lipopolysaccharide binding(GO:0001530)
0.0 0.4 GO:0070330 aromatase activity(GO:0070330)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 1.3 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.5 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.9 GO:0050661 NADP binding(GO:0050661)
0.0 1.5 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 1.3 GO:0044325 ion channel binding(GO:0044325)
0.0 3.8 GO:0005198 structural molecule activity(GO:0005198)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 18.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.5 15.7 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 13.9 PID P38 MKK3 6PATHWAY p38 MAPK signaling pathway
0.3 21.5 PID INTEGRIN3 PATHWAY Beta3 integrin cell surface interactions
0.3 10.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.3 8.9 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.2 19.9 PID ILK PATHWAY Integrin-linked kinase signaling
0.2 13.3 PID A6B1 A6B4 INTEGRIN PATHWAY a6b1 and a6b4 Integrin signaling
0.2 4.0 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.2 9.7 PID AURORA B PATHWAY Aurora B signaling
0.1 2.6 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.1 5.1 PID NETRIN PATHWAY Netrin-mediated signaling events
0.1 4.5 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.1 14.3 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.1 3.4 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.1 11.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.1 2.6 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.1 3.9 PID ARF6 PATHWAY Arf6 signaling events
0.1 0.8 PID THROMBIN PAR4 PATHWAY PAR4-mediated thrombin signaling events
0.1 4.5 PID TELOMERASE PATHWAY Regulation of Telomerase
0.1 5.3 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 2.4 PID P53 REGULATION PATHWAY p53 pathway
0.0 0.9 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
0.0 9.6 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.0 2.4 PID CMYB PATHWAY C-MYB transcription factor network
0.0 2.1 PID P73PATHWAY p73 transcription factor network
0.0 4.9 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 1.7 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.7 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.0 3.4 NABA ECM AFFILIATED Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins
0.0 1.3 ST FAS SIGNALING PATHWAY Fas Signaling Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.1 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.5 14.0 REACTOME FORMATION OF TUBULIN FOLDING INTERMEDIATES BY CCT TRIC Genes involved in Formation of tubulin folding intermediates by CCT/TriC
0.4 4.5 REACTOME PACKAGING OF TELOMERE ENDS Genes involved in Packaging Of Telomere Ends
0.4 10.0 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 19.8 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.3 11.4 REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery
0.3 9.6 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 5.5 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.2 2.4 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 3.5 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.2 4.9 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
0.2 9.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.2 14.0 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.2 3.2 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 9.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.2 11.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.2 4.5 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
0.2 4.4 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.2 4.1 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.2 3.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.2 30.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
0.2 12.5 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.1 3.4 REACTOME HS GAG DEGRADATION Genes involved in HS-GAG degradation
0.1 5.0 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 3.2 REACTOME REGULATION OF IFNA SIGNALING Genes involved in Regulation of IFNA signaling
0.1 4.4 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 4.4 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway
0.1 3.3 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 2.0 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.1 1.5 REACTOME SEROTONIN RECEPTORS Genes involved in Serotonin receptors
0.1 7.1 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 9.2 REACTOME AMYLOIDS Genes involved in Amyloids
0.1 10.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 5.1 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.1 11.4 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.1 1.7 REACTOME ASSOCIATION OF TRIC CCT WITH TARGET PROTEINS DURING BIOSYNTHESIS Genes involved in Association of TriC/CCT with target proteins during biosynthesis
0.1 1.8 REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE Genes involved in Synthesis of PIPs at the Golgi membrane
0.1 3.3 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
0.1 2.7 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.1 3.8 REACTOME TRANSLATION Genes involved in Translation
0.1 1.6 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 3.2 REACTOME IRON UPTAKE AND TRANSPORT Genes involved in Iron uptake and transport
0.1 6.8 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 8.4 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.1 7.4 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 2.3 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 2.0 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 1.2 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
0.0 0.9 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.0 0.4 REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS Genes involved in Ionotropic activity of Kainate Receptors
0.0 1.8 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 3.4 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates