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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7L1

Z-value: 0.90

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Transcription factors associated with TCF7L1

Gene Symbol Gene ID Gene Info
TCF7L1
ENSG00000152284.4 transcription factor 7 like 1

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L1hg19_v2_chr2_+_85360499_85360598-0.243.1e-04Click!

Activity profile of TCF7L1 motif

Sorted Z-values of TCF7L1 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_175964366 12.40 ENST00000274811.4
RNF44
ring finger protein 44
chr14_+_75746781 12.08 ENST00000555347.1
FOS
FBJ murine osteosarcoma viral oncogene homolog
chr14_-_23451467 10.08 ENST00000555074.1
ENST00000361265.4
RP11-298I3.5
AJUBA
RP11-298I3.5
ajuba LIM protein
chrX_-_135962876 9.61 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX
RNA binding motif protein, X-linked
chr21_-_46330545 9.27 ENST00000320216.6
ENST00000397852.1
ITGB2
integrin, beta 2 (complement component 3 receptor 3 and 4 subunit)
chr14_-_35344093 9.04 ENST00000382422.2
BAZ1A
bromodomain adjacent to zinc finger domain, 1A
chr7_+_80231466 7.75 ENST00000309881.7
ENST00000534394.1
CD36
CD36 molecule (thrombospondin receptor)
chr4_-_109090106 7.39 ENST00000379951.2
LEF1
lymphoid enhancer-binding factor 1
chr7_+_80275953 6.92 ENST00000538969.1
ENST00000544133.1
ENST00000433696.2
CD36
CD36 molecule (thrombospondin receptor)
chr12_-_133464151 6.66 ENST00000315585.7
ENST00000266880.7
ENST00000443047.2
ENST00000432561.2
ENST00000450056.2
CHFR
checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase
chr20_+_55966444 6.61 ENST00000356208.5
ENST00000440234.2
RBM38
RNA binding motif protein 38
chr1_+_32479430 6.57 ENST00000327300.7
ENST00000492989.1
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr17_-_7297833 6.30 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr7_+_80275752 6.25 ENST00000419819.2
CD36
CD36 molecule (thrombospondin receptor)
chr7_+_80275621 6.17 ENST00000426978.1
ENST00000432207.1
CD36
CD36 molecule (thrombospondin receptor)
chr17_-_7297519 5.91 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3
TMEM256-PLSCR3 readthrough (NMD candidate)
chr12_-_54694807 5.91 ENST00000435572.2
NFE2
nuclear factor, erythroid 2
chr15_+_75074410 5.54 ENST00000439220.2
CSK
c-src tyrosine kinase
chr5_+_133450365 5.44 ENST00000342854.5
ENST00000321603.6
ENST00000321584.4
ENST00000378564.1
ENST00000395029.1
TCF7
transcription factor 7 (T-cell specific, HMG-box)
chr1_-_1334685 5.05 ENST00000400809.3
ENST00000408918.4
CCNL2
cyclin L2
chr3_+_152879985 5.05 ENST00000323534.2
RAP2B
RAP2B, member of RAS oncogene family
chr1_-_200992827 4.97 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr16_-_89007491 4.96 ENST00000327483.5
ENST00000564416.1
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr7_-_148581360 4.86 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr7_-_148581251 4.75 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
EZH2
enhancer of zeste homolog 2 (Drosophila)
chr11_+_65339820 4.75 ENST00000316409.2
ENST00000449319.2
ENST00000530349.1
FAM89B
family with sequence similarity 89, member B
chrX_+_100645812 4.67 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
RPL36A
RPL36A-HNRNPH2
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr4_-_109089573 4.59 ENST00000265165.1
LEF1
lymphoid enhancer-binding factor 1
chr7_-_148725733 4.54 ENST00000286091.4
PDIA4
protein disulfide isomerase family A, member 4
chr12_-_58146128 4.51 ENST00000551800.1
ENST00000549606.1
ENST00000257904.6
CDK4
cyclin-dependent kinase 4
chr13_+_30002846 4.50 ENST00000542829.1
MTUS2
microtubule associated tumor suppressor candidate 2
chrX_+_100646190 4.41 ENST00000471855.1
RPL36A
ribosomal protein L36a
chr14_+_20923350 4.37 ENST00000555414.1
ENST00000216714.3
ENST00000553681.1
ENST00000557344.1
ENST00000398030.4
ENST00000557181.1
ENST00000555839.1
ENST00000553368.1
ENST00000556054.1
ENST00000557054.1
ENST00000557592.1
ENST00000557150.1
APEX1
APEX nuclease (multifunctional DNA repair enzyme) 1
chr7_+_115850547 4.21 ENST00000358204.4
ENST00000455989.1
ENST00000537767.1
TES
testis derived transcript (3 LIM domains)
chr7_-_27219849 4.20 ENST00000396344.4
HOXA10
homeobox A10
chr8_+_29953163 4.17 ENST00000518192.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chr3_-_47823298 4.09 ENST00000254480.5
SMARCC1
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1
chr14_-_65409502 4.05 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_182808474 4.04 ENST00000367549.3
DHX9
DEAH (Asp-Glu-Ala-His) box helicase 9
chr19_+_41257084 4.03 ENST00000601393.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr5_-_138725594 4.01 ENST00000302125.8
MZB1
marginal zone B and B1 cell-specific protein
chr8_-_17104356 3.97 ENST00000361272.4
ENST00000523917.1
CNOT7
CCR4-NOT transcription complex, subunit 7
chr5_-_138725560 3.95 ENST00000412103.2
ENST00000457570.2
MZB1
marginal zone B and B1 cell-specific protein
chr1_-_115053781 3.82 ENST00000358465.2
ENST00000369543.2
TRIM33
tripartite motif containing 33
chr19_+_11071652 3.79 ENST00000344626.4
ENST00000429416.3
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr6_+_108881012 3.79 ENST00000343882.6
FOXO3
forkhead box O3
chr21_+_30671690 3.66 ENST00000399921.1
BACH1
BTB and CNC homology 1, basic leucine zipper transcription factor 1
chr19_-_2328572 3.64 ENST00000252622.10
LSM7
LSM7 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr12_+_56324933 3.64 ENST00000549629.1
ENST00000555218.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr10_+_112631547 3.47 ENST00000280154.7
ENST00000393104.2
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chr9_-_35650900 3.47 ENST00000259608.3
SIT1
signaling threshold regulating transmembrane adaptor 1
chr4_-_69215467 3.44 ENST00000579690.1
YTHDC1
YTH domain containing 1
chr5_+_43603229 3.44 ENST00000344920.4
ENST00000512996.2
NNT
nicotinamide nucleotide transhydrogenase
chr4_+_170581213 3.37 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr6_+_119215308 3.34 ENST00000229595.5
ASF1A
anti-silencing function 1A histone chaperone
chr17_+_75447326 3.31 ENST00000591088.1
SEPT9
septin 9
chr19_+_11071546 3.30 ENST00000358026.2
SMARCA4
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4
chr1_+_110091189 3.20 ENST00000369851.4
GNAI3
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr12_+_56324756 3.16 ENST00000331886.5
ENST00000555090.1
DGKA
diacylglycerol kinase, alpha 80kDa
chr14_+_39644387 3.15 ENST00000553331.1
ENST00000216832.4
PNN
pinin, desmosome associated protein
chr16_-_15736881 3.15 ENST00000540441.2
KIAA0430
KIAA0430
chr8_+_29952914 3.09 ENST00000321250.8
ENST00000518001.1
ENST00000520682.1
ENST00000442880.2
ENST00000523116.1
LEPROTL1
leptin receptor overlapping transcript-like 1
chrX_-_153599578 3.07 ENST00000360319.4
ENST00000344736.4
FLNA
filamin A, alpha
chr2_+_169923577 3.03 ENST00000432060.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr7_+_139528952 2.98 ENST00000416849.2
ENST00000436047.2
ENST00000414508.2
ENST00000448866.1
TBXAS1
thromboxane A synthase 1 (platelet)
chr16_+_2820912 2.98 ENST00000570539.1
SRRM2
serine/arginine repetitive matrix 2
chr10_+_11206925 2.84 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr4_+_113152881 2.82 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr4_+_113152978 2.75 ENST00000309703.6
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr6_-_27440837 2.71 ENST00000211936.6
ZNF184
zinc finger protein 184
chr19_+_41256764 2.66 ENST00000243563.3
ENST00000601253.1
ENST00000597353.1
ENST00000599362.1
SNRPA
small nuclear ribonucleoprotein polypeptide A
chr19_-_3061397 2.64 ENST00000586839.1
AES
amino-terminal enhancer of split
chr13_-_72441315 2.55 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr8_-_16859690 2.53 ENST00000180166.5
FGF20
fibroblast growth factor 20
chr17_+_9066252 2.51 ENST00000436734.1
NTN1
netrin 1
chr6_-_27440460 2.45 ENST00000377419.1
ZNF184
zinc finger protein 184
chr10_+_71562180 2.44 ENST00000517713.1
ENST00000522165.1
ENST00000520133.1
COL13A1
collagen, type XIII, alpha 1
chr6_-_33548006 2.42 ENST00000374467.3
BAK1
BCL2-antagonist/killer 1
chr1_+_36348790 2.38 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chrX_-_110655391 2.35 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chrX_+_69488155 2.33 ENST00000374495.3
ARR3
arrestin 3, retinal (X-arrestin)
chr3_+_179280668 2.27 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
ACTL6A
actin-like 6A
chr11_-_65381643 2.27 ENST00000309100.3
ENST00000529839.1
ENST00000526293.1
MAP3K11
mitogen-activated protein kinase kinase kinase 11
chr4_+_78078304 2.25 ENST00000316355.5
ENST00000354403.5
ENST00000502280.1
CCNG2
cyclin G2
chr8_-_145047688 2.25 ENST00000356346.3
PLEC
plectin
chr21_-_34144157 2.23 ENST00000331923.4
PAXBP1
PAX3 and PAX7 binding protein 1
chr6_-_33547975 2.23 ENST00000442998.2
ENST00000360661.5
BAK1
BCL2-antagonist/killer 1
chr2_-_39348137 2.18 ENST00000426016.1
SOS1
son of sevenless homolog 1 (Drosophila)
chr6_+_32146131 2.17 ENST00000375094.3
RNF5
ring finger protein 5, E3 ubiquitin protein ligase
chr2_+_33172221 2.11 ENST00000354476.3
LTBP1
latent transforming growth factor beta binding protein 1
chr17_+_57642886 2.06 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DHX40
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr6_+_143929307 2.06 ENST00000427704.2
ENST00000305766.6
PHACTR2
phosphatase and actin regulator 2
chr5_+_66124590 2.05 ENST00000490016.2
ENST00000403666.1
ENST00000450827.1
MAST4
microtubule associated serine/threonine kinase family member 4
chr17_+_80416050 2.05 ENST00000579198.1
ENST00000390006.4
ENST00000580296.1
NARF
nuclear prelamin A recognition factor
chr9_-_74979420 2.03 ENST00000343431.2
ENST00000376956.3
ZFAND5
zinc finger, AN1-type domain 5
chr17_-_56065484 2.02 ENST00000581208.1
VEZF1
vascular endothelial zinc finger 1
chr7_+_73245193 2.02 ENST00000340958.2
CLDN4
claudin 4
chr13_-_39612176 2.01 ENST00000352251.3
ENST00000350125.3
PROSER1
proline and serine rich 1
chr11_-_117747327 2.00 ENST00000584230.1
ENST00000527429.1
ENST00000584394.1
ENST00000532984.1
FXYD6
FXYD6-FXYD2
FXYD domain containing ion transport regulator 6
FXYD6-FXYD2 readthrough
chr17_-_39526052 2.00 ENST00000251646.3
KRT33B
keratin 33B
chrX_-_110655306 1.98 ENST00000371993.2
DCX
doublecortin
chr6_-_89927151 1.98 ENST00000454853.2
GABRR1
gamma-aminobutyric acid (GABA) A receptor, rho 1
chr10_+_71561649 1.96 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
COL13A1
collagen, type XIII, alpha 1
chr5_+_43602750 1.92 ENST00000505678.2
ENST00000512422.1
ENST00000264663.5
NNT
nicotinamide nucleotide transhydrogenase
chr8_-_42234745 1.91 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chrX_+_69488174 1.90 ENST00000480877.2
ENST00000307959.8
ARR3
arrestin 3, retinal (X-arrestin)
chr5_+_112074029 1.90 ENST00000512211.2
APC
adenomatous polyposis coli
chr4_-_69215699 1.90 ENST00000510746.1
ENST00000344157.4
ENST00000355665.3
YTHDC1
YTH domain containing 1
chr22_-_31688381 1.87 ENST00000487265.2
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chrX_-_39956656 1.87 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr2_+_32288725 1.84 ENST00000315285.3
SPAST
spastin
chr3_+_20081515 1.81 ENST00000263754.4
KAT2B
K(lysine) acetyltransferase 2B
chr22_-_31688431 1.81 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1
phosphoinositide-3-kinase interacting protein 1
chr8_+_11660227 1.79 ENST00000443614.2
ENST00000525900.1
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr17_-_10421853 1.75 ENST00000226207.5
MYH1
myosin, heavy chain 1, skeletal muscle, adult
chr1_-_38061522 1.73 ENST00000373062.3
GNL2
guanine nucleotide binding protein-like 2 (nucleolar)
chr11_-_6677018 1.71 ENST00000299441.3
DCHS1
dachsous cadherin-related 1
chr4_-_103266355 1.69 ENST00000424970.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr10_+_71561704 1.68 ENST00000520267.1
COL13A1
collagen, type XIII, alpha 1
chr5_-_157002775 1.64 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr3_+_183353356 1.63 ENST00000242810.6
ENST00000493074.1
ENST00000437402.1
ENST00000454495.2
ENST00000473045.1
ENST00000468101.1
ENST00000427201.2
ENST00000482138.1
ENST00000454652.2
KLHL24
kelch-like family member 24
chr17_-_38020392 1.60 ENST00000346872.3
ENST00000439167.2
ENST00000377945.3
ENST00000394189.2
ENST00000377944.3
ENST00000377958.2
ENST00000535189.1
ENST00000377952.2
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr12_-_108154925 1.60 ENST00000228437.5
PRDM4
PR domain containing 4
chr8_+_11660120 1.59 ENST00000220584.4
FDFT1
farnesyl-diphosphate farnesyltransferase 1
chr18_+_3449821 1.59 ENST00000407501.2
ENST00000405385.3
ENST00000546979.1
TGIF1
TGFB-induced factor homeobox 1
chr17_-_10372875 1.58 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr8_-_70745575 1.57 ENST00000524945.1
SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr14_+_75230011 1.57 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLPM1
YLP motif containing 1
chr9_+_116225999 1.52 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr2_+_11679963 1.51 ENST00000263834.5
GREB1
growth regulation by estrogen in breast cancer 1
chr10_-_98945515 1.47 ENST00000371070.4
SLIT1
slit homolog 1 (Drosophila)
chr10_+_22605374 1.45 ENST00000448361.1
COMMD3
COMM domain containing 3
chr10_+_22605304 1.40 ENST00000475460.2
ENST00000602390.1
ENST00000489125.2
ENST00000456711.1
ENST00000444869.1
COMMD3-BMI1
COMMD3
COMMD3-BMI1 readthrough
COMM domain containing 3
chr2_+_191273052 1.38 ENST00000417958.1
ENST00000432036.1
ENST00000392328.1
MFSD6
major facilitator superfamily domain containing 6
chr5_-_157002749 1.34 ENST00000517905.1
ENST00000430702.2
ENST00000394020.1
ADAM19
ADAM metallopeptidase domain 19
chr15_+_41136216 1.34 ENST00000562057.1
ENST00000344051.4
SPINT1
serine peptidase inhibitor, Kunitz type 1
chr4_+_79567362 1.30 ENST00000512322.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr10_+_114710211 1.30 ENST00000349937.2
ENST00000369397.4
TCF7L2
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr14_-_23624511 1.27 ENST00000529705.2
SLC7A8
solute carrier family 7 (amino acid transporter light chain, L system), member 8
chr17_+_72428218 1.26 ENST00000392628.2
GPRC5C
G protein-coupled receptor, family C, group 5, member C
chr17_-_39093672 1.25 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
KRT23
keratin 23 (histone deacetylase inducible)
chr11_+_77184416 1.24 ENST00000598970.1
DKFZP434E1119
DKFZP434E1119
chr1_+_68150744 1.24 ENST00000370986.4
ENST00000370985.3
GADD45A
growth arrest and DNA-damage-inducible, alpha
chr7_+_90339169 1.19 ENST00000436577.2
CDK14
cyclin-dependent kinase 14
chr4_-_103266219 1.18 ENST00000394833.2
SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr8_+_21777159 1.17 ENST00000434536.1
ENST00000252512.9
XPO7
exportin 7
chr12_+_15475462 1.13 ENST00000543886.1
ENST00000348962.2
PTPRO
protein tyrosine phosphatase, receptor type, O
chr19_+_8274185 1.10 ENST00000558268.1
ENST00000558331.1
CERS4
ceramide synthase 4
chr10_+_76585303 1.10 ENST00000372725.1
KAT6B
K(lysine) acetyltransferase 6B
chr10_+_71561630 1.10 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
COL13A1
collagen, type XIII, alpha 1
chr13_-_72440901 1.08 ENST00000359684.2
DACH1
dachshund homolog 1 (Drosophila)
chr19_-_11450249 1.08 ENST00000222120.3
RAB3D
RAB3D, member RAS oncogene family
chr12_-_48963829 1.07 ENST00000301046.2
ENST00000549817.1
LALBA
lactalbumin, alpha-
chr14_-_71107921 1.06 ENST00000553982.1
ENST00000500016.1
CTD-2540L5.5
CTD-2540L5.6
CTD-2540L5.5
CTD-2540L5.6
chr13_+_30002741 1.06 ENST00000380808.2
MTUS2
microtubule associated tumor suppressor candidate 2
chr12_+_54402790 1.05 ENST00000040584.4
HOXC8
homeobox C8
chr1_+_200993071 1.05 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
RP11-168O16.1
chr2_-_100721923 1.02 ENST00000356421.2
AFF3
AF4/FMR2 family, member 3
chr4_+_79567314 1.00 ENST00000503539.1
ENST00000504675.1
RP11-792D21.2
long intergenic non-protein coding RNA 1094
chr4_-_70626314 1.00 ENST00000510821.1
SULT1B1
sulfotransferase family, cytosolic, 1B, member 1
chr6_+_134274322 0.98 ENST00000367871.1
ENST00000237264.4
TBPL1
TBP-like 1
chr17_-_38020379 0.96 ENST00000351680.3
ENST00000346243.3
ENST00000350532.3
ENST00000467757.1
ENST00000439016.2
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr9_-_36400920 0.94 ENST00000357058.3
ENST00000350199.4
RNF38
ring finger protein 38
chr1_-_116383322 0.94 ENST00000429731.1
NHLH2
nescient helix loop helix 2
chr8_+_22019168 0.93 ENST00000318561.3
ENST00000521315.1
ENST00000437090.2
ENST00000520605.1
ENST00000522109.1
ENST00000524255.1
ENST00000523296.1
ENST00000518615.1
SFTPC
surfactant protein C
chr17_+_80416482 0.90 ENST00000309794.11
ENST00000345415.7
ENST00000457415.3
ENST00000584411.1
ENST00000412079.2
ENST00000577432.1
NARF
nuclear prelamin A recognition factor
chr2_+_10183651 0.87 ENST00000305883.1
KLF11
Kruppel-like factor 11
chr11_-_87908600 0.83 ENST00000531138.1
ENST00000526372.1
ENST00000243662.6
RAB38
RAB38, member RAS oncogene family
chr17_-_39507064 0.82 ENST00000007735.3
KRT33A
keratin 33A
chr3_-_160283348 0.81 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr6_+_96025341 0.77 ENST00000369293.1
ENST00000358812.4
MANEA
mannosidase, endo-alpha
chr17_-_39222131 0.75 ENST00000394015.2
KRTAP2-4
keratin associated protein 2-4
chrX_-_101726732 0.75 ENST00000457521.2
ENST00000412230.2
ENST00000453326.2
NXF2B
TCP11X2
nuclear RNA export factor 2B
t-complex 11 family, X-linked 2
chr2_+_228678550 0.74 ENST00000409189.3
ENST00000358813.4
CCL20
chemokine (C-C motif) ligand 20
chr12_+_109915179 0.72 ENST00000434735.2
UBE3B
ubiquitin protein ligase E3B
chr19_+_8274204 0.68 ENST00000561053.1
ENST00000251363.5
ENST00000559450.1
ENST00000559336.1
CERS4
ceramide synthase 4
chr2_-_9771075 0.68 ENST00000446619.1
ENST00000238081.3
YWHAQ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chrX_+_101470280 0.66 ENST00000395088.2
ENST00000330252.5
ENST00000333110.5
NXF2
TCP11X1
nuclear RNA export factor 2
t-complex 11 family, X-linked 1
chr17_-_46690839 0.63 ENST00000498634.2
HOXB8
homeobox B8
chr10_-_101380121 0.60 ENST00000370495.4
SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr9_-_74525847 0.54 ENST00000377041.2
ABHD17B
abhydrolase domain containing 17B
chr15_+_65134088 0.53 ENST00000323544.4
ENST00000437723.1
PLEKHO2
AC069368.3
pleckstrin homology domain containing, family O member 2
Uncharacterized protein
chr10_-_99052382 0.53 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr18_+_11751493 0.53 ENST00000269162.5
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr2_+_32288657 0.51 ENST00000345662.1
SPAST
spastin
chr1_-_6479963 0.50 ENST00000377836.4
ENST00000487437.1
ENST00000489730.1
ENST00000377834.4
HES2
hes family bHLH transcription factor 2
chr3_+_189349162 0.48 ENST00000264731.3
ENST00000382063.4
ENST00000418709.2
ENST00000320472.5
ENST00000392460.3
ENST00000440651.2
TP63
tumor protein p63
chr17_-_46035187 0.44 ENST00000300557.2
PRR15L
proline rich 15-like
chr2_+_169923504 0.40 ENST00000357546.2
DHRS9
dehydrogenase/reductase (SDR family) member 9
chr17_-_61819229 0.37 ENST00000447001.3
ENST00000392950.4
STRADA
STE20-related kinase adaptor alpha
chr19_-_40791302 0.36 ENST00000392038.2
ENST00000578123.1
AKT2
v-akt murine thymoma viral oncogene homolog 2
chr12_-_49449107 0.35 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr3_-_167813132 0.34 ENST00000309027.4
GOLIM4
golgi integral membrane protein 4
chr15_-_79103757 0.34 ENST00000388820.4
ADAMTS7
ADAM metallopeptidase with thrombospondin type 1 motif, 7
chr3_+_141106643 0.33 ENST00000514251.1
ZBTB38
zinc finger and BTB domain containing 38
chr1_-_43424500 0.32 ENST00000415851.2
ENST00000426263.3
ENST00000372500.3
SLC2A1
solute carrier family 2 (facilitated glucose transporter), member 1
chr3_-_57199397 0.31 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chr3_+_137483579 0.29 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr7_-_27213893 0.26 ENST00000283921.4
HOXA10
homeobox A10
chr15_-_89764929 0.24 ENST00000268125.5
RLBP1
retinaldehyde binding protein 1

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L1

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.9 27.1 GO:2000334 lipoprotein particle mediated signaling(GO:0055095) low-density lipoprotein particle mediated signaling(GO:0055096) blood microparticle formation(GO:0072564) regulation of blood microparticle formation(GO:2000332) positive regulation of blood microparticle formation(GO:2000334)
3.2 9.6 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
2.4 12.0 GO:0071895 odontoblast differentiation(GO:0071895)
1.9 5.6 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
1.6 6.6 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
1.6 8.0 GO:0002378 immunoglobulin biosynthetic process(GO:0002378) negative regulation of glucose import in response to insulin stimulus(GO:2001274)
1.5 4.6 GO:0048597 B cell negative selection(GO:0002352) post-embryonic camera-type eye morphogenesis(GO:0048597)
1.5 12.1 GO:0001661 conditioned taste aversion(GO:0001661)
1.5 4.4 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
1.4 10.1 GO:0035331 negative regulation of hippo signaling(GO:0035331)
1.4 7.1 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
1.3 3.8 GO:0001544 initiation of primordial ovarian follicle growth(GO:0001544)
1.2 3.7 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
1.2 7.3 GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway(GO:0032511)
1.2 4.7 GO:0060392 negative regulation of SMAD protein import into nucleus(GO:0060392)
1.2 3.5 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
1.1 5.5 GO:0042997 negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
1.1 5.4 GO:0030538 embryonic genitalia morphogenesis(GO:0030538)
1.1 5.4 GO:0006740 NADPH regeneration(GO:0006740)
0.9 4.5 GO:1904637 response to ionomycin(GO:1904636) cellular response to ionomycin(GO:1904637)
0.8 4.0 GO:0035549 positive regulation of interferon-beta secretion(GO:0035549)
0.8 3.1 GO:0021943 formation of radial glial scaffolds(GO:0021943)
0.7 3.4 GO:0008204 ergosterol biosynthetic process(GO:0006696) ergosterol metabolic process(GO:0008204)
0.7 3.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.6 1.9 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.6 5.0 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.6 1.8 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.6 1.7 GO:0072137 condensed mesenchymal cell proliferation(GO:0072137)
0.6 4.0 GO:0060339 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290) negative regulation of type I interferon-mediated signaling pathway(GO:0060339)
0.5 5.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
0.5 2.5 GO:0033564 anterior/posterior axon guidance(GO:0033564)
0.5 1.5 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.5 2.4 GO:0090625 mRNA cleavage involved in gene silencing by miRNA(GO:0035279) mRNA cleavage involved in gene silencing by siRNA(GO:0090625) mRNA cleavage involved in gene silencing(GO:0098795)
0.5 1.4 GO:0005989 lactose metabolic process(GO:0005988) lactose biosynthetic process(GO:0005989)
0.5 10.0 GO:0006337 nucleosome disassembly(GO:0006337)
0.5 3.6 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.4 9.3 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.4 9.6 GO:0048026 positive regulation of mRNA splicing, via spliceosome(GO:0048026)
0.4 2.2 GO:1904693 midbrain morphogenesis(GO:1904693)
0.4 2.4 GO:0051013 microtubule severing(GO:0051013)
0.4 1.1 GO:0036060 filtration diaphragm assembly(GO:0036058) slit diaphragm assembly(GO:0036060)
0.4 6.7 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
0.4 3.3 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.3 2.3 GO:0007256 activation of JNKK activity(GO:0007256)
0.3 3.4 GO:0042905 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905)
0.3 1.8 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.3 2.9 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.3 6.8 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.3 5.1 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.2 0.7 GO:0072679 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) thymocyte migration(GO:0072679)
0.2 1.0 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.2 2.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.2 2.1 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 1.6 GO:0043985 histone H4-R3 methylation(GO:0043985)
0.2 1.1 GO:0018125 peptidyl-cysteine methylation(GO:0018125)
0.2 8.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.2 1.9 GO:1904781 positive regulation of protein localization to centrosome(GO:1904781)
0.2 0.6 GO:0048250 mitochondrial iron ion transport(GO:0048250)
0.2 4.9 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 1.9 GO:2000288 positive regulation of myoblast proliferation(GO:2000288)
0.2 3.0 GO:0019371 cyclooxygenase pathway(GO:0019371)
0.2 3.3 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.1 2.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.1 2.0 GO:0061436 establishment of skin barrier(GO:0061436)
0.1 6.6 GO:0001958 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.1 0.8 GO:1903232 melanosome assembly(GO:1903232)
0.1 3.6 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
0.1 4.5 GO:0000083 regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083)
0.1 2.6 GO:0045577 regulation of B cell differentiation(GO:0045577)
0.1 6.6 GO:0010830 regulation of myotube differentiation(GO:0010830)
0.1 9.1 GO:0002181 cytoplasmic translation(GO:0002181)
0.1 3.5 GO:0043029 T cell homeostasis(GO:0043029)
0.1 2.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.1 2.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 3.2 GO:0046039 GTP metabolic process(GO:0046039)
0.1 1.3 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 1.2 GO:0071850 mitotic cell cycle arrest(GO:0071850)
0.1 1.6 GO:0045109 intermediate filament organization(GO:0045109)
0.1 0.3 GO:0001555 oocyte growth(GO:0001555)
0.1 3.0 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.1 2.5 GO:0014046 dopamine secretion(GO:0014046) regulation of dopamine secretion(GO:0014059)
0.1 0.2 GO:0015743 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.1 2.0 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 9.0 GO:0006261 DNA-dependent DNA replication(GO:0006261)
0.1 4.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 5.5 GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436)
0.0 0.2 GO:0006776 vitamin A metabolic process(GO:0006776)
0.0 0.9 GO:0044705 mating behavior(GO:0007617) multi-organism reproductive behavior(GO:0044705)
0.0 1.8 GO:0007214 gamma-aminobutyric acid signaling pathway(GO:0007214)
0.0 1.6 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 1.0 GO:0006068 ethanol catabolic process(GO:0006068)
0.0 1.3 GO:0015695 organic cation transport(GO:0015695)
0.0 4.8 GO:0031424 keratinization(GO:0031424)
0.0 0.3 GO:0036066 protein O-linked fucosylation(GO:0036066)
0.0 0.1 GO:1903960 regulation of plasma membrane long-chain fatty acid transport(GO:0010746) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960)
0.0 0.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 1.8 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.0 1.0 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 0.8 GO:0019054 modulation by virus of host process(GO:0019054)
0.0 3.8 GO:0017015 regulation of transforming growth factor beta receptor signaling pathway(GO:0017015) regulation of cellular response to transforming growth factor beta stimulus(GO:1903844)
0.0 0.6 GO:0007625 grooming behavior(GO:0007625)
0.0 2.0 GO:0006968 cellular defense response(GO:0006968)
0.0 0.7 GO:0018105 peptidyl-serine phosphorylation(GO:0018105)
0.0 0.2 GO:0032486 Rap protein signal transduction(GO:0032486)
0.0 1.6 GO:0014823 response to activity(GO:0014823)
0.0 1.4 GO:0006611 protein export from nucleus(GO:0006611)
0.0 7.9 GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process(GO:0043161)
0.0 1.1 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 5.5 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 0.9 GO:0007585 respiratory gaseous exchange(GO:0007585)
0.0 0.3 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.1 GO:0070842 aggresome assembly(GO:0070842)
0.0 1.5 GO:0008277 regulation of G-protein coupled receptor protein signaling pathway(GO:0008277)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.9 9.6 GO:0044530 supraspliceosomal complex(GO:0044530)
1.9 9.3 GO:0034688 integrin alphaM-beta2 complex(GO:0034688)
1.8 7.2 GO:0005600 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
1.5 12.1 GO:0035976 AP1 complex(GO:0035976)
1.1 12.0 GO:1990907 beta-catenin-TCF complex(GO:1990907)
1.0 3.1 GO:0031523 Myb complex(GO:0031523)
1.0 4.0 GO:0044094 host cell nucleus(GO:0042025) host cell nuclear part(GO:0044094)
0.9 29.2 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.8 9.0 GO:0031010 ISWI-type complex(GO:0031010)
0.8 4.0 GO:0005726 perichromatin fibrils(GO:0005726)
0.8 4.5 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.7 9.9 GO:0045120 pronucleus(GO:0045120)
0.6 13.5 GO:0071564 npBAF complex(GO:0071564)
0.5 3.6 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.4 4.6 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.3 2.9 GO:0005638 lamin filament(GO:0005638)
0.3 5.9 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.3 2.4 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.2 6.7 GO:0005685 U1 snRNP(GO:0005685)
0.2 4.3 GO:0042588 zymogen granule(GO:0042588)
0.2 1.8 GO:0000125 PCAF complex(GO:0000125)
0.2 2.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.2 1.9 GO:1990909 catenin complex(GO:0016342) Wnt signalosome(GO:1990909)
0.2 2.4 GO:0000815 ESCRT III complex(GO:0000815)
0.2 0.8 GO:0031905 early endosome lumen(GO:0031905)
0.2 5.4 GO:0005719 nuclear euchromatin(GO:0005719)
0.2 4.8 GO:0030057 desmosome(GO:0030057)
0.2 3.3 GO:0031105 septin complex(GO:0031105)
0.1 1.0 GO:0005672 transcription factor TFIIA complex(GO:0005672)
0.1 0.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 3.3 GO:0032982 myosin filament(GO:0032982)
0.1 1.1 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 2.2 GO:0030056 hemidesmosome(GO:0030056)
0.1 2.1 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 8.0 GO:0005667 transcription factor complex(GO:0005667)
0.1 12.6 GO:0016605 PML body(GO:0016605)
0.1 0.9 GO:0097486 multivesicular body lumen(GO:0097486)
0.1 9.1 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 4.2 GO:0001917 photoreceptor inner segment(GO:0001917)
0.1 8.8 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.1 5.2 GO:0055038 recycling endosome membrane(GO:0055038)
0.1 2.0 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.1 5.4 GO:0005746 mitochondrial respiratory chain(GO:0005746)
0.1 1.8 GO:1902711 GABA-A receptor complex(GO:1902711)
0.1 3.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.1 3.0 GO:0015030 Cajal body(GO:0015030)
0.0 2.4 GO:0005871 kinesin complex(GO:0005871)
0.0 16.4 GO:0016607 nuclear speck(GO:0016607)
0.0 3.9 GO:0005882 intermediate filament(GO:0005882)
0.0 0.3 GO:0044666 MLL3/4 complex(GO:0044666)
0.0 4.5 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 8.9 GO:0005770 late endosome(GO:0005770)
0.0 1.6 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 5.2 GO:0031234 extrinsic component of cytoplasmic side of plasma membrane(GO:0031234)
0.0 2.5 GO:0005604 basement membrane(GO:0005604)
0.0 0.8 GO:0031519 PcG protein complex(GO:0031519)
0.0 6.8 GO:0005874 microtubule(GO:0005874)
0.0 2.1 GO:0005681 spliceosomal complex(GO:0005681)
0.0 0.9 GO:0036126 sperm flagellum(GO:0036126)
0.0 0.9 GO:0016328 lateral plasma membrane(GO:0016328)
0.0 3.8 GO:0000790 nuclear chromatin(GO:0000790)
0.0 1.3 GO:0043235 receptor complex(GO:0043235)
0.0 0.5 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.5 27.1 GO:0070892 lipoteichoic acid receptor activity(GO:0070892)
1.6 6.4 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
1.5 4.4 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
1.3 9.3 GO:0030369 ICAM-3 receptor activity(GO:0030369)
1.1 9.6 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
1.0 3.0 GO:0004796 thromboxane-A synthase activity(GO:0004796) 12-hydroxyheptadecatrienoic acid synthase activity(GO:0036134)
1.0 6.7 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.8 4.2 GO:0002046 opsin binding(GO:0002046)
0.8 3.4 GO:0051996 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
0.8 4.0 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.8 10.1 GO:0045294 alpha-catenin binding(GO:0045294)
0.8 3.1 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.7 12.0 GO:0030284 estrogen receptor activity(GO:0030284)
0.6 2.3 GO:0004706 JUN kinase kinase kinase activity(GO:0004706)
0.6 3.4 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.5 7.1 GO:0030957 Tat protein binding(GO:0030957)
0.4 2.1 GO:0050436 microfibril binding(GO:0050436)
0.4 5.3 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.4 2.4 GO:0008568 microtubule-severing ATPase activity(GO:0008568)
0.4 6.8 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.4 1.8 GO:0004468 lysine N-acetyltransferase activity, acting on acetyl phosphate as donor(GO:0004468)
0.3 3.4 GO:0004022 alcohol dehydrogenase (NAD) activity(GO:0004022)
0.3 3.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 15.9 GO:0070412 R-SMAD binding(GO:0070412)
0.3 1.8 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
0.3 4.7 GO:0001222 transcription corepressor binding(GO:0001222)
0.3 6.6 GO:0008266 poly(U) RNA binding(GO:0008266)
0.3 1.1 GO:0004461 lactose synthase activity(GO:0004461)
0.3 3.2 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.3 3.6 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.2 4.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
0.2 0.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.2 4.6 GO:0051400 BH domain binding(GO:0051400)
0.2 5.5 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
0.2 4.5 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.2 3.0 GO:0070742 C2H2 zinc finger domain binding(GO:0070742)
0.2 3.6 GO:0017070 U6 snRNA binding(GO:0017070)
0.2 2.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.2 1.6 GO:1990226 histone methyltransferase binding(GO:1990226)
0.2 6.9 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.2 1.5 GO:0048495 Roundabout binding(GO:0048495)
0.2 6.4 GO:0031492 nucleosomal DNA binding(GO:0031492)
0.2 10.1 GO:0061733 histone acetyltransferase activity(GO:0004402) peptide-lysine-N-acetyltransferase activity(GO:0061733)
0.2 2.9 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.1 4.0 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 2.4 GO:0035198 miRNA binding(GO:0035198)
0.1 3.7 GO:0043548 phosphatidylinositol 3-kinase binding(GO:0043548)
0.1 0.3 GO:0033300 dehydroascorbic acid transporter activity(GO:0033300)
0.1 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.1 1.3 GO:0019534 toxin transporter activity(GO:0019534)
0.1 2.9 GO:0005521 lamin binding(GO:0005521)
0.1 3.8 GO:0001221 transcription cofactor binding(GO:0001221)
0.1 2.5 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.6 GO:0070410 co-SMAD binding(GO:0070410)
0.1 2.8 GO:0036002 pre-mRNA binding(GO:0036002)
0.1 2.2 GO:0030506 ankyrin binding(GO:0030506)
0.1 1.1 GO:0031489 myosin V binding(GO:0031489)
0.1 18.3 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.1 3.5 GO:0042169 SH2 domain binding(GO:0042169)
0.1 5.2 GO:0019003 GDP binding(GO:0019003)
0.1 6.3 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 5.4 GO:0050661 NADP binding(GO:0050661)
0.1 0.2 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.1 14.1 GO:0001047 core promoter binding(GO:0001047)
0.1 1.9 GO:0070840 dynein complex binding(GO:0070840)
0.1 0.2 GO:0005502 11-cis retinal binding(GO:0005502)
0.1 1.8 GO:0004890 GABA-A receptor activity(GO:0004890)
0.0 0.6 GO:0005381 iron ion transmembrane transporter activity(GO:0005381)
0.0 0.8 GO:0004559 alpha-mannosidase activity(GO:0004559)
0.0 2.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.0 1.0 GO:0004062 aryl sulfotransferase activity(GO:0004062)
0.0 1.6 GO:0015347 sodium-independent organic anion transmembrane transporter activity(GO:0015347)
0.0 9.1 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 10.5 GO:0008017 microtubule binding(GO:0008017)
0.0 0.5 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 7.2 GO:0008201 heparin binding(GO:0008201)
0.0 1.0 GO:0017147 Wnt-protein binding(GO:0017147)
0.0 0.9 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.0 3.9 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 3.4 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.1 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.8 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.0 5.2 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.0 0.3 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 3.3 GO:0042393 histone binding(GO:0042393)
0.0 1.6 GO:0003725 double-stranded RNA binding(GO:0003725)
0.0 0.3 GO:0008327 methyl-CpG binding(GO:0008327)
0.0 1.9 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 3.2 GO:0003714 transcription corepressor activity(GO:0003714)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 12.1 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.3 7.1 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 10.1 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 4.5 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.2 9.3 PID INTEGRIN CS PATHWAY Integrin family cell surface interactions
0.2 4.6 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
0.2 3.2 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 4.2 PID CONE PATHWAY Visual signal transduction: Cones
0.2 7.2 NABA COLLAGENS Genes encoding collagen proteins
0.1 7.9 ST B CELL ANTIGEN RECEPTOR B Cell Antigen Receptor
0.1 14.4 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.1 4.7 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.1 5.8 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.1 2.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 4.0 PID ERBB4 PATHWAY ErbB4 signaling events
0.1 2.3 PID IFNG PATHWAY IFN-gamma pathway
0.1 2.3 PID MYC PATHWAY C-MYC pathway
0.1 3.1 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 3.5 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 2.6 PID IL2 1PATHWAY IL2-mediated signaling events
0.1 3.5 PID MTOR 4PATHWAY mTOR signaling pathway
0.1 4.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 1.9 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.5 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 1.1 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 1.1 PID FOXO PATHWAY FoxO family signaling
0.0 1.5 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.0 0.8 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 1.6 PID SMAD2 3NUCLEAR PATHWAY Regulation of nuclear SMAD2/3 signaling
0.0 0.3 PID FGF PATHWAY FGF signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 12.1 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.3 31.6 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 4.4 REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.2 5.4 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
0.2 2.5 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.2 5.5 REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS Genes involved in Phosphorylation of CD3 and TCR zeta chains
0.2 2.9 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.2 2.9 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 2.5 REACTOME SIGNALING BY ACTIVATED POINT MUTANTS OF FGFR1 Genes involved in Signaling by activated point mutants of FGFR1
0.2 1.8 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.2 6.8 REACTOME EFFECTS OF PIP2 HYDROLYSIS Genes involved in Effects of PIP2 hydrolysis
0.2 5.4 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 20.3 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 3.8 REACTOME SIGNALING BY NODAL Genes involved in Signaling by NODAL
0.1 2.2 REACTOME SOS MEDIATED SIGNALLING Genes involved in SOS-mediated signalling
0.1 4.0 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.1 7.2 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 3.4 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 9.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 4.1 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.1 4.3 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.1 9.1 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.1 2.0 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.1 1.8 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 3.0 REACTOME CYTOCHROME P450 ARRANGED BY SUBSTRATE TYPE Genes involved in Cytochrome P450 - arranged by substrate type
0.0 1.8 REACTOME LIGAND GATED ION CHANNEL TRANSPORT Genes involved in Ligand-gated ion channel transport
0.0 0.9 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 5.9 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.0 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.0 2.0 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network
0.0 0.3 REACTOME FACILITATIVE NA INDEPENDENT GLUCOSE TRANSPORTERS Genes involved in Facilitative Na+-independent glucose transporters
0.0 0.8 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.0 0.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 0.2 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1