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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TCF7L2

Z-value: 0.99

Motif logo

Transcription factors associated with TCF7L2

Gene Symbol Gene ID Gene Info
ENSG00000148737.11 transcription factor 7 like 2

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TCF7L2hg19_v2_chr10_+_114709999_1147100310.466.4e-13Click!

Activity profile of TCF7L2 motif

Sorted Z-values of TCF7L2 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr11_+_69455855 21.60 ENST00000227507.2
ENST00000536559.1
cyclin D1
chr5_-_16936340 17.13 ENST00000507288.1
ENST00000513610.1
myosin X
chr11_+_114128522 16.30 ENST00000535401.1
nicotinamide N-methyltransferase
chr17_-_40169659 12.31 ENST00000457167.4
DnaJ (Hsp40) homolog, subfamily C, member 7
chrX_-_10588459 11.46 ENST00000380782.2
midline 1 (Opitz/BBB syndrome)
chrX_-_10588595 10.63 ENST00000423614.1
ENST00000317552.4
midline 1 (Opitz/BBB syndrome)
chr13_+_76334795 10.48 ENST00000526202.1
ENST00000465261.2
LIM domain 7
chr10_+_54074033 10.44 ENST00000373970.3
dickkopf WNT signaling pathway inhibitor 1
chr3_-_134093275 10.38 ENST00000513145.1
ENST00000422605.2
angiomotin like 2
chr13_+_76334567 9.85 ENST00000321797.8
LIM domain 7
chr3_-_134093395 9.53 ENST00000249883.5
angiomotin like 2
chr4_-_157892498 9.16 ENST00000502773.1
platelet derived growth factor C
chr1_-_94079648 9.16 ENST00000370247.3
breast cancer anti-estrogen resistance 3
chr10_+_114709999 8.78 ENST00000355995.4
ENST00000545257.1
ENST00000543371.1
ENST00000536810.1
ENST00000355717.4
ENST00000538897.1
ENST00000534894.1
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr3_-_149375783 8.71 ENST00000467467.1
ENST00000460517.1
ENST00000360632.3
WW domain containing transcription regulator 1
chr2_+_234621551 8.58 ENST00000608381.1
ENST00000373414.3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A5
chr5_+_102201509 8.10 ENST00000348126.2
ENST00000379787.4
peptidylglycine alpha-amidating monooxygenase
chr10_+_114710211 7.99 ENST00000349937.2
ENST00000369397.4
transcription factor 7-like 2 (T-cell specific, HMG-box)
chr5_-_175815565 7.43 ENST00000509257.1
ENST00000507413.1
ENST00000510123.1
NOP16 nucleolar protein
chr7_+_73868439 6.86 ENST00000424337.2
GTF2I repeat domain containing 1
chr7_-_27213893 6.47 ENST00000283921.4
homeobox A10
chr1_-_54303934 6.10 ENST00000537333.1
NDC1 transmembrane nucleoporin
chr4_-_139163491 5.95 ENST00000280612.5
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_-_54304212 5.90 ENST00000540001.1
NDC1 transmembrane nucleoporin
chr5_+_102201430 5.60 ENST00000438793.3
ENST00000346918.2
peptidylglycine alpha-amidating monooxygenase
chr1_-_54303949 5.15 ENST00000234725.8
NDC1 transmembrane nucleoporin
chr6_+_32146131 5.15 ENST00000375094.3
ring finger protein 5, E3 ubiquitin protein ligase
chr1_-_110933663 5.13 ENST00000369781.4
ENST00000541986.1
ENST00000369779.4
solute carrier family 16, member 4
chr10_+_105005644 4.90 ENST00000441178.2
ribulose-5-phosphate-3-epimerase-like 1
chr1_-_110933611 4.82 ENST00000472422.2
ENST00000437429.2
solute carrier family 16, member 4
chr5_-_16742330 4.75 ENST00000505695.1
ENST00000427430.2
myosin X
chr10_+_71561630 4.70 ENST00000398974.3
ENST00000398971.3
ENST00000398968.3
ENST00000398966.3
ENST00000398964.3
ENST00000398969.3
ENST00000356340.3
ENST00000398972.3
ENST00000398973.3
collagen, type XIII, alpha 1
chr2_-_9770706 4.68 ENST00000381844.4
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr17_-_56065484 4.62 ENST00000581208.1
vascular endothelial zinc finger 1
chr5_-_148930960 4.57 ENST00000261798.5
ENST00000377843.2
casein kinase 1, alpha 1
chrX_+_54835493 4.55 ENST00000396224.1
melanoma antigen family D, 2
chr14_-_65409502 4.52 ENST00000389614.5
glutathione peroxidase 2 (gastrointestinal)
chr2_-_9771075 4.44 ENST00000446619.1
ENST00000238081.3
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
chr17_+_34848049 4.34 ENST00000588902.1
ENST00000591067.1
zinc finger, HIT-type containing 3
chr1_+_147013182 4.33 ENST00000234739.3
B-cell CLL/lymphoma 9
chr10_+_71561649 4.31 ENST00000398978.3
ENST00000354547.3
ENST00000357811.3
collagen, type XIII, alpha 1
chr5_+_131593364 4.29 ENST00000253754.3
ENST00000379018.3
PDZ and LIM domain 4
chr16_-_73082274 4.15 ENST00000268489.5
zinc finger homeobox 3
chr17_+_75447326 4.13 ENST00000591088.1
septin 9
chr10_+_71561704 4.07 ENST00000520267.1
collagen, type XIII, alpha 1
chr6_-_11779403 3.90 ENST00000414691.3
androgen-dependent TFPI-regulating protein
chr2_+_69240302 3.88 ENST00000303714.4
anthrax toxin receptor 1
chrX_-_47004878 3.88 ENST00000377811.3
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr15_+_43985725 3.87 ENST00000413453.2
creatine kinase, mitochondrial 1A
chrX_-_47004437 3.87 ENST00000276062.8
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 11, 17.3kDa
chr2_+_69240415 3.77 ENST00000409829.3
anthrax toxin receptor 1
chr12_-_49582593 3.62 ENST00000295766.5
tubulin, alpha 1a
chr17_+_37618257 3.60 ENST00000447079.4
cyclin-dependent kinase 12
chr19_-_3061397 3.59 ENST00000586839.1
amino-terminal enhancer of split
chr10_+_101542462 3.57 ENST00000370449.4
ENST00000370434.1
ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_69240511 3.55 ENST00000409349.3
anthrax toxin receptor 1
chr7_-_27219849 3.54 ENST00000396344.4
homeobox A10
chr5_+_140797296 3.47 ENST00000398594.2
protocadherin gamma subfamily B, 7
chr22_+_41347363 3.39 ENST00000216225.8
ring-box 1, E3 ubiquitin protein ligase
chr6_+_64281906 3.33 ENST00000370651.3
protein tyrosine phosphatase type IVA, member 1
chr1_+_110091189 3.32 ENST00000369851.4
guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
chr7_-_148581251 3.20 ENST00000478654.1
ENST00000460911.1
ENST00000350995.2
enhancer of zeste homolog 2 (Drosophila)
chr13_+_102142296 3.10 ENST00000376162.3
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_-_11779174 2.98 ENST00000379413.2
androgen-dependent TFPI-regulating protein
chr11_-_108422926 2.83 ENST00000428840.1
ENST00000526312.1
exophilin 5
chr3_-_113465065 2.83 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr7_-_148581360 2.75 ENST00000320356.2
ENST00000541220.1
ENST00000483967.1
ENST00000536783.1
enhancer of zeste homolog 2 (Drosophila)
chr15_+_57511609 2.75 ENST00000543579.1
ENST00000537840.1
ENST00000343827.3
transcription factor 12
chr21_-_35284635 2.74 ENST00000429238.1
AP000304.12
chr2_+_201936707 2.62 ENST00000433898.1
ENST00000454214.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chr12_+_122326662 2.59 ENST00000261817.2
ENST00000538613.1
ENST00000542602.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr12_+_122326630 2.57 ENST00000541212.1
ENST00000340175.5
proteasome (prosome, macropain) 26S subunit, non-ATPase, 9
chr16_+_29819372 2.55 ENST00000568544.1
ENST00000569978.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr15_+_43885252 2.54 ENST00000453782.1
ENST00000300283.6
ENST00000437924.1
ENST00000450086.2
creatine kinase, mitochondrial 1B
chrX_-_153599578 2.51 ENST00000360319.4
ENST00000344736.4
filamin A, alpha
chr1_-_109935819 2.50 ENST00000538502.1
sortilin 1
chr15_+_43985084 2.46 ENST00000434505.1
ENST00000411750.1
creatine kinase, mitochondrial 1A
chr6_-_32145861 2.41 ENST00000336984.6
1-acylglycerol-3-phosphate O-acyltransferase 1
chr17_-_39093672 2.38 ENST00000209718.3
ENST00000436344.3
ENST00000485751.1
keratin 23 (histone deacetylase inducible)
chr2_-_88427568 2.30 ENST00000393750.3
ENST00000295834.3
fatty acid binding protein 1, liver
chr7_-_148725733 2.30 ENST00000286091.4
protein disulfide isomerase family A, member 4
chrX_-_43832711 2.25 ENST00000378062.5
Norrie disease (pseudoglioma)
chr6_-_11779840 2.22 ENST00000506810.1
androgen-dependent TFPI-regulating protein
chr9_-_27005686 2.15 ENST00000380055.5
leucine rich repeat containing 19
chr6_-_112575912 2.14 ENST00000522006.1
ENST00000230538.7
ENST00000519932.1
laminin, alpha 4
chr8_-_16859690 2.09 ENST00000180166.5
fibroblast growth factor 20
chr19_-_39924349 2.02 ENST00000602153.1
ribosomal protein S16
chr12_+_1738363 1.99 ENST00000397196.2
wingless-type MMTV integration site family, member 5B
chr5_+_170846640 1.95 ENST00000274625.5
fibroblast growth factor 18
chr1_-_153522562 1.87 ENST00000368714.1
S100 calcium binding protein A4
chr17_-_46035187 1.81 ENST00000300557.2
proline rich 15-like
chr5_+_140734570 1.80 ENST00000571252.1
protocadherin gamma subfamily A, 4
chr2_+_228678550 1.72 ENST00000409189.3
ENST00000358813.4
chemokine (C-C motif) ligand 20
chr8_+_32579341 1.68 ENST00000519240.1
ENST00000539990.1
neuregulin 1
chr10_-_104192405 1.64 ENST00000369937.4
CUE domain containing 2
chr12_-_49582978 1.60 ENST00000301071.7
tubulin, alpha 1a
chrX_-_39956656 1.57 ENST00000397354.3
ENST00000378444.4
BCL6 corepressor
chr10_+_115312766 1.56 ENST00000351270.3
hyaluronan binding protein 2
chr17_+_68100989 1.55 ENST00000585558.1
ENST00000392670.1
potassium inwardly-rectifying channel, subfamily J, member 16
chr5_-_135290705 1.54 ENST00000274507.1
leukocyte cell-derived chemotaxin 2
chr4_+_30721968 1.51 ENST00000361762.2
protocadherin 7
chr16_+_29819446 1.50 ENST00000568282.1
MYC-associated zinc finger protein (purine-binding transcription factor)
chr2_+_71357434 1.49 ENST00000244230.2
M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein)
chr15_-_31393910 1.39 ENST00000397795.2
ENST00000256552.6
ENST00000559179.1
transient receptor potential cation channel, subfamily M, member 1
chr5_-_157002775 1.32 ENST00000257527.4
ADAM metallopeptidase domain 19
chr2_+_201936458 1.29 ENST00000237889.4
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa
chrX_+_100646190 1.24 ENST00000471855.1
ribosomal protein L36a
chr5_+_175815732 1.20 ENST00000274787.2
HIG1 hypoxia inducible domain family, member 2A
chr17_-_73389737 1.19 ENST00000392563.1
growth factor receptor-bound protein 2
chr3_+_141106643 1.13 ENST00000514251.1
zinc finger and BTB domain containing 38
chr6_-_112575687 1.13 ENST00000521398.1
ENST00000424408.2
ENST00000243219.3
laminin, alpha 4
chr16_+_72088376 1.12 ENST00000570083.1
ENST00000355906.5
ENST00000398131.2
ENST00000569639.1
ENST00000564499.1
ENST00000357763.4
ENST00000562526.1
ENST00000565574.1
ENST00000568417.2
ENST00000356967.5
haptoglobin
haptoglobin-related protein
chr12_+_85673868 1.09 ENST00000316824.3
ALX homeobox 1
chr17_+_42923686 1.05 ENST00000591513.1
HIG1 hypoxia inducible domain family, member 1B
chr17_-_7297519 1.02 ENST00000576362.1
ENST00000571078.1
TMEM256-PLSCR3 readthrough (NMD candidate)
chr14_+_23235886 1.01 ENST00000604262.1
ENST00000431881.2
ENST00000412791.1
ENST00000358043.5
oxidase (cytochrome c) assembly 1-like
chr8_-_119964434 0.96 ENST00000297350.4
tumor necrosis factor receptor superfamily, member 11b
chr14_+_75230011 0.96 ENST00000552421.1
ENST00000325680.7
ENST00000238571.3
YLP motif containing 1
chrX_+_100645812 0.95 ENST00000427805.2
ENST00000553110.3
ENST00000392994.3
ENST00000409338.1
ENST00000409170.3
ribosomal protein L36a
RPL36A-HNRNPH2 readthrough
chr1_+_16693578 0.83 ENST00000401088.4
ENST00000471507.1
ENST00000401089.3
ENST00000375590.3
ENST00000492354.1
SUZ RNA binding domain containing 1
chr6_-_112575838 0.83 ENST00000455073.1
laminin, alpha 4
chr1_+_154244987 0.82 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HCLS1 associated protein X-1
chrX_+_15525426 0.77 ENST00000342014.6
BMX non-receptor tyrosine kinase
chr1_+_62417957 0.76 ENST00000307297.7
ENST00000543708.1
InaD-like (Drosophila)
chr3_+_29323043 0.73 ENST00000452462.1
ENST00000456853.1
RNA binding motif, single stranded interacting protein 3
chr5_+_112074029 0.73 ENST00000512211.2
adenomatous polyposis coli
chr14_+_21236586 0.70 ENST00000326783.3
epididymal protein 3B
chr7_-_80141328 0.66 ENST00000398291.3
guanine nucleotide binding protein, alpha transducing 3
chr17_+_79679299 0.65 ENST00000331531.5
solute carrier family 25 (mitochondrial carrier; dicarboxylate transporter), member 10
chr10_-_105677427 0.56 ENST00000369764.1
oligonucleotide/oligosaccharide-binding fold containing 1
chrX_+_47004639 0.52 ENST00000345781.6
RNA binding motif protein 10
chr7_-_75452673 0.51 ENST00000416943.1
chemokine (C-C motif) ligand 24
chr8_+_29953163 0.49 ENST00000518192.1
leptin receptor overlapping transcript-like 1
chr12_-_52779433 0.47 ENST00000257951.3
keratin 84
chr19_-_40791302 0.45 ENST00000392038.2
ENST00000578123.1
v-akt murine thymoma viral oncogene homolog 2
chr6_+_152130240 0.45 ENST00000427531.2
estrogen receptor 1
chrX_+_47004599 0.43 ENST00000329236.7
RNA binding motif protein 10
chr20_-_17511962 0.43 ENST00000377873.3
beaded filament structural protein 1, filensin
chr6_-_112575758 0.40 ENST00000431543.2
ENST00000453937.2
ENST00000368638.4
ENST00000389463.4
laminin, alpha 4
chr14_+_32798547 0.28 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
A kinase (PRKA) anchor protein 6
chr22_+_19950060 0.28 ENST00000449653.1
catechol-O-methyltransferase
chrX_+_69488155 0.28 ENST00000374495.3
arrestin 3, retinal (X-arrestin)
chrX_+_152760397 0.27 ENST00000331595.4
ENST00000431891.1
biglycan
chrX_-_63005405 0.25 ENST00000374878.1
ENST00000437457.2
Cdc42 guanine nucleotide exchange factor (GEF) 9
chr8_-_133123406 0.24 ENST00000434736.2
HERV-H LTR-associating 1
chr6_+_29427548 0.23 ENST00000377132.1
olfactory receptor, family 2, subfamily H, member 1
chr17_-_38256973 0.18 ENST00000246672.3
nuclear receptor subfamily 1, group D, member 1
chr17_-_7297833 0.18 ENST00000571802.1
ENST00000576201.1
ENST00000573213.1
ENST00000324822.11
TMEM256-PLSCR3 readthrough (NMD candidate)
chr5_-_58335281 0.17 ENST00000358923.6
phosphodiesterase 4D, cAMP-specific
chr12_+_52056548 0.16 ENST00000545061.1
ENST00000355133.3
sodium channel, voltage gated, type VIII, alpha subunit
chr7_-_16505440 0.14 ENST00000307068.4
sclerostin domain containing 1
chr5_+_175288631 0.12 ENST00000509837.1
complexin 2
chr1_-_32801825 0.10 ENST00000329421.7
MARCKS-like 1
chr1_+_151138526 0.07 ENST00000368902.1
sodium channel modifier 1
chr14_-_75179774 0.06 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
apoptosis resistant E3 ubiquitin protein ligase 1
Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr8_-_95220775 0.03 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
cadherin 17, LI cadherin (liver-intestine)
chr17_-_39646116 0.01 ENST00000328119.6
keratin 36
chr2_-_55647057 0.00 ENST00000436346.1
coiled-coil domain containing 88A

Network of associatons between targets according to the STRING database.

First level regulatory network of TCF7L2

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0030474 spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790)
3.7 11.2 GO:1901202 negative regulation of extracellular matrix assembly(GO:1901202)
3.5 10.4 GO:0009996 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) negative regulation of cell fate specification(GO:0009996) Wnt signaling pathway involved in somitogenesis(GO:0090244)
3.4 13.7 GO:0031179 peptide amidation(GO:0001519) protein amidation(GO:0018032) peptide modification(GO:0031179)
2.5 15.3 GO:0010909 regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010908) positive regulation of heparan sulfate proteoglycan biosynthetic process(GO:0010909) canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition(GO:0044334) positive regulation of proteoglycan biosynthetic process(GO:1902730)
2.2 21.6 GO:0070141 response to UV-A(GO:0070141)
2.0 6.0 GO:1904772 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
1.7 8.6 GO:0070980 biphenyl catabolic process(GO:0070980)
1.7 22.1 GO:0035372 protein localization to microtubule(GO:0035372)
1.4 6.9 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.4 16.3 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
1.2 3.6 GO:0050787 antibiotic metabolic process(GO:0016999) detoxification of mercury ion(GO:0050787) response to antineoplastic agent(GO:0097327)
1.0 4.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
1.0 5.2 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.9 12.3 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.8 8.7 GO:0035414 negative regulation of catenin import into nucleus(GO:0035414)
0.8 5.3 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
0.7 2.1 GO:1904338 regulation of dopaminergic neuron differentiation(GO:1904338)
0.7 4.6 GO:0003096 renal sodium ion transport(GO:0003096) renal sodium ion absorption(GO:0070294)
0.6 2.5 GO:0042483 negative regulation of odontogenesis(GO:0042483)
0.6 6.3 GO:0006600 creatine metabolic process(GO:0006600)
0.6 1.7 GO:0045360 regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362)
0.6 2.3 GO:0035426 extracellular matrix-cell signaling(GO:0035426)
0.5 2.8 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.4 10.8 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.4 2.5 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.4 2.0 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.4 18.0 GO:0035329 hippo signaling(GO:0035329)
0.4 1.1 GO:2000296 negative regulation of hydrogen peroxide catabolic process(GO:2000296)
0.4 9.2 GO:0002089 lens morphogenesis in camera-type eye(GO:0002089)
0.4 10.0 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.3 3.4 GO:0010265 SCF complex assembly(GO:0010265)
0.3 1.0 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.3 1.6 GO:0010936 negative regulation of macrophage cytokine production(GO:0010936)
0.3 3.6 GO:2000210 positive regulation of anoikis(GO:2000210)
0.3 5.2 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
0.3 21.9 GO:0051489 regulation of filopodium assembly(GO:0051489)
0.3 6.0 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.3 13.1 GO:0036075 endochondral ossification(GO:0001958) replacement ossification(GO:0036075)
0.2 2.5 GO:0051005 negative regulation of lipoprotein lipase activity(GO:0051005)
0.2 2.4 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.2 0.7 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.2 2.4 GO:0070307 lens fiber cell development(GO:0070307)
0.2 0.6 GO:0071423 thiosulfate transport(GO:0015709) oxaloacetate transport(GO:0015729) malate transport(GO:0015743) malate transmembrane transport(GO:0071423) oxaloacetate(2-) transmembrane transport(GO:1902356)
0.2 9.1 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
0.2 4.1 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
0.2 11.7 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
0.2 3.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.2 2.4 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
0.2 2.8 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.1 0.1 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
0.1 2.5 GO:0098869 cellular oxidant detoxification(GO:0098869)
0.1 0.8 GO:0001865 NK T cell differentiation(GO:0001865)
0.1 7.4 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.1 0.5 GO:2000418 positive regulation of eosinophil migration(GO:2000418)
0.1 4.3 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.1 1.4 GO:0046548 retinal rod cell development(GO:0046548)
0.1 3.3 GO:0046039 GTP metabolic process(GO:0046039)
0.1 4.8 GO:0001885 endothelial cell development(GO:0001885)
0.1 0.2 GO:0060086 circadian temperature homeostasis(GO:0060086)
0.1 0.3 GO:0045963 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) negative regulation of catecholamine metabolic process(GO:0045914) negative regulation of dopamine metabolic process(GO:0045963) positive regulation of homocysteine metabolic process(GO:0050668)
0.1 0.8 GO:0060670 branching involved in labyrinthine layer morphogenesis(GO:0060670)
0.1 2.0 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.8 GO:2000251 positive regulation of actin cytoskeleton reorganization(GO:2000251)
0.1 0.5 GO:0060523 prostate epithelial cord elongation(GO:0060523)
0.0 2.8 GO:1902036 regulation of hematopoietic stem cell differentiation(GO:1902036)
0.0 19.6 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.2 GO:0060316 positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316)
0.0 0.5 GO:0035878 nail development(GO:0035878)
0.0 2.3 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 1.4 GO:0010107 potassium ion import(GO:0010107)
0.0 5.1 GO:0030705 cytoskeleton-dependent intracellular transport(GO:0030705)
0.0 1.4 GO:1904893 negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.0 3.3 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 1.5 GO:0002576 platelet degranulation(GO:0002576)
0.0 2.1 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 2.2 GO:0002181 cytoplasmic translation(GO:0002181)
0.0 2.4 GO:0045995 regulation of embryonic development(GO:0045995)
0.0 1.9 GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043123)
0.0 0.9 GO:0000381 regulation of alternative mRNA splicing, via spliceosome(GO:0000381)
0.0 0.7 GO:0006509 membrane protein ectodomain proteolysis(GO:0006509)
0.0 1.1 GO:0001843 neural tube closure(GO:0001843) tube closure(GO:0060606)
0.0 1.8 GO:0070268 cornification(GO:0070268)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 17.2 GO:0070762 nuclear pore transmembrane ring(GO:0070762)
3.3 13.1 GO:0030936 collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936)
2.5 15.3 GO:0070369 beta-catenin-TCF7L2 complex(GO:0070369)
1.1 3.4 GO:0043224 nuclear SCF ubiquitin ligase complex(GO:0043224)
1.1 21.9 GO:0032433 filopodium tip(GO:0032433)
0.8 2.5 GO:0031523 Myb complex(GO:0031523)
0.5 3.6 GO:0046581 intercellular canaliculus(GO:0046581)
0.5 5.2 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
0.5 8.6 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.4 6.0 GO:0045120 pronucleus(GO:0045120)
0.4 5.3 GO:0030877 beta-catenin destruction complex(GO:0030877)
0.4 2.8 GO:0031415 NatA complex(GO:0031415)
0.4 25.2 GO:0000307 cyclin-dependent protein kinase holoenzyme complex(GO:0000307)
0.4 27.1 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.3 1.4 GO:0035838 growing cell tip(GO:0035838)
0.3 11.2 GO:0031258 lamellipodium membrane(GO:0031258)
0.3 2.3 GO:0045179 apical cortex(GO:0045179)
0.3 1.1 GO:0031838 haptoglobin-hemoglobin complex(GO:0031838)
0.3 5.2 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.2 4.1 GO:0031105 septin complex(GO:0031105)
0.2 11.7 GO:0045271 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
0.2 3.3 GO:0042588 zymogen granule(GO:0042588)
0.1 0.8 GO:0070436 Grb2-EGFR complex(GO:0070436)
0.1 18.1 GO:0005923 bicellular tight junction(GO:0005923)
0.1 4.5 GO:0005605 basal lamina(GO:0005605)
0.1 1.8 GO:0005882 intermediate filament(GO:0005882)
0.1 2.5 GO:0030140 trans-Golgi network transport vesicle(GO:0030140)
0.1 6.0 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.1 4.3 GO:0005801 cis-Golgi network(GO:0005801)
0.1 10.6 GO:0043204 perikaryon(GO:0043204)
0.1 17.7 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.1 1.7 GO:0030673 axolemma(GO:0030673)
0.1 2.2 GO:0070469 respiratory chain(GO:0070469)
0.0 7.2 GO:0031901 early endosome membrane(GO:0031901)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.0 4.6 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 1.6 GO:0031519 PcG protein complex(GO:0031519)
0.0 10.7 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 2.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 10.2 GO:0005667 transcription factor complex(GO:0005667)
0.0 2.2 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 4.8 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)
0.0 9.1 GO:0005925 focal adhesion(GO:0005925)
0.0 0.1 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.0 0.2 GO:0043194 axon initial segment(GO:0043194)
0.0 0.5 GO:0045095 keratin filament(GO:0045095)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 16.3 GO:0030760 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
3.4 13.7 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
2.4 21.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
1.2 6.0 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.9 10.4 GO:0039706 co-receptor binding(GO:0039706)
0.8 6.3 GO:0004111 creatine kinase activity(GO:0004111)
0.7 21.6 GO:0070064 proline-rich region binding(GO:0070064)
0.7 13.4 GO:0045295 gamma-catenin binding(GO:0045295)
0.7 6.0 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.6 2.5 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.6 17.2 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.6 1.7 GO:0031731 CCR6 chemokine receptor binding(GO:0031731)
0.5 2.5 GO:0010465 nerve growth factor receptor activity(GO:0010465)
0.5 2.0 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105)
0.4 5.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.4 3.4 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.4 9.2 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.4 12.3 GO:0001671 ATPase activator activity(GO:0001671)
0.3 2.3 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.3 9.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.3 3.6 GO:0043225 anion transmembrane-transporting ATPase activity(GO:0043225)
0.3 3.3 GO:0031821 G-protein coupled serotonin receptor binding(GO:0031821)
0.2 8.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.2 2.8 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.2 0.6 GO:0015117 thiosulfate transmembrane transporter activity(GO:0015117) oxaloacetate transmembrane transporter activity(GO:0015131)
0.2 1.1 GO:0030492 hemoglobin binding(GO:0030492)
0.2 21.7 GO:0051219 phosphoprotein binding(GO:0051219)
0.2 10.0 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.2 1.7 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.2 3.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.1 2.8 GO:0035497 cAMP response element binding(GO:0035497)
0.1 0.5 GO:0031728 CCR3 chemokine receptor binding(GO:0031728)
0.1 11.2 GO:0005518 collagen binding(GO:0005518)
0.1 2.3 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 4.2 GO:0005109 frizzled binding(GO:0005109)
0.1 4.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
0.1 1.9 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 9.2 GO:0005070 SH3/SH2 adaptor activity(GO:0005070)
0.1 11.6 GO:0042826 histone deacetylase binding(GO:0042826)
0.1 1.9 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
0.1 2.1 GO:0043395 heparan sulfate proteoglycan binding(GO:0043395)
0.1 1.5 GO:0015467 G-protein activated inward rectifier potassium channel activity(GO:0015467)
0.1 2.5 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.1 8.9 GO:0003705 transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705)
0.1 3.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
0.1 3.9 GO:0008137 NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136)
0.1 13.1 GO:0008201 heparin binding(GO:0008201)
0.1 0.8 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.5 GO:0038052 RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding(GO:0038052)
0.1 1.1 GO:0008327 methyl-CpG binding(GO:0008327)
0.1 4.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 12.7 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 4.1 GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979)
0.0 0.3 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.0 1.2 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.5 GO:0030280 structural constituent of epidermis(GO:0030280)
0.0 1.0 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031) death receptor activity(GO:0005035)
0.0 1.6 GO:0005539 glycosaminoglycan binding(GO:0005539)
0.0 10.0 GO:0003924 GTPase activity(GO:0003924)
0.0 0.1 GO:0098821 BMP receptor activity(GO:0098821)
0.0 1.0 GO:0043022 ribosome binding(GO:0043022)
0.0 4.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.2 GO:0031698 beta-2 adrenergic receptor binding(GO:0031698)
0.0 0.2 GO:0008179 adenylate cyclase binding(GO:0008179)
0.0 0.8 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.4 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 5.5 GO:0004842 ubiquitin-protein transferase activity(GO:0004842)
0.0 1.1 GO:0004860 protein kinase inhibitor activity(GO:0004860)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 21.6 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.5 11.2 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.4 21.9 PID NETRIN PATHWAY Netrin-mediated signaling events
0.3 10.4 PID WNT SIGNALING PATHWAY Wnt signaling network
0.3 10.0 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.3 13.1 NABA COLLAGENS Genes encoding collagen proteins
0.3 3.3 PID S1P S1P4 PATHWAY S1P4 pathway
0.2 7.1 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.2 9.2 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 10.1 PID CDC42 REG PATHWAY Regulation of CDC42 activity
0.1 3.3 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.1 4.5 NABA BASEMENT MEMBRANES Genes encoding structural components of basement membranes
0.1 5.2 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.1 15.1 PID AP1 PATHWAY AP-1 transcription factor network
0.1 3.4 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
0.1 3.6 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.1 6.2 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.1 0.8 SA TRKA RECEPTOR The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth.
0.1 19.3 NABA SECRETED FACTORS Genes encoding secreted soluble factors
0.0 1.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 2.5 PID P75 NTR PATHWAY p75(NTR)-mediated signaling
0.0 0.8 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.0 0.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 28.6 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
0.9 21.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.5 9.2 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.3 21.9 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.3 8.6 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.3 4.0 REACTOME SIGNALING BY FGFR3 MUTANTS Genes involved in Signaling by FGFR3 mutants
0.2 5.3 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.2 13.1 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 3.3 REACTOME ADENYLATE CYCLASE INHIBITORY PATHWAY Genes involved in Adenylate cyclase inhibitory pathway
0.2 5.2 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
0.2 16.6 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.1 6.0 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.1 3.4 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 3.1 REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT Genes involved in ABC-family proteins mediated transport
0.1 5.2 REACTOME SIGNALING BY WNT Genes involved in Signaling by Wnt
0.1 2.5 REACTOME SHC1 EVENTS IN ERBB4 SIGNALING Genes involved in SHC1 events in ERBB4 signaling
0.0 3.9 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 1.5 REACTOME GABA B RECEPTOR ACTIVATION Genes involved in GABA B receptor activation
0.0 9.5 REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES Genes involved in Metabolism of amino acids and derivatives
0.0 2.3 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 2.5 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME SYNTHESIS OF PA Genes involved in Synthesis of PA
0.0 1.7 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.0 2.0 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.0 2.2 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 0.8 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.8 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation