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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for THRB

Z-value: 0.73

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Transcription factors associated with THRB

Gene Symbol Gene ID Gene Info
THRB
ENSG00000151090.13 thyroid hormone receptor beta

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
THRBhg19_v2_chr3_-_24536253_24536328-0.144.3e-02Click!

Activity profile of THRB motif

Sorted Z-values of THRB motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_21810726 15.79 ENST00000396076.1
LDHB
lactate dehydrogenase B
chr12_-_21810765 15.46 ENST00000450584.1
ENST00000350669.1
LDHB
lactate dehydrogenase B
chr13_-_24007815 12.44 ENST00000382298.3
SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr10_+_62538089 11.88 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
CDK1
cyclin-dependent kinase 1
chr10_+_62538248 11.33 ENST00000448257.2
CDK1
cyclin-dependent kinase 1
chr11_-_64014379 10.54 ENST00000309318.3
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chrX_-_1511617 9.96 ENST00000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr10_+_60145155 8.69 ENST00000373895.3
TFAM
transcription factor A, mitochondrial
chr11_+_73498898 8.43 ENST00000535529.1
ENST00000497094.2
ENST00000411840.2
ENST00000535277.1
ENST00000398483.3
ENST00000542303.1
MRPL48
mitochondrial ribosomal protein L48
chrY_-_1461617 8.35 ENSTR0000381401.5
SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr8_-_124037890 8.09 ENST00000519018.1
ENST00000523036.1
DERL1
derlin 1
chr16_-_69368774 7.01 ENST00000562949.1
RP11-343C2.12
Conserved oligomeric Golgi complex subunit 8
chr11_+_46366918 6.89 ENST00000528615.1
ENST00000395574.3
DGKZ
diacylglycerol kinase, zeta
chr2_-_9563469 6.20 ENST00000484735.1
ENST00000456913.2
ITGB1BP1
integrin beta 1 binding protein 1
chr6_-_99842041 5.90 ENST00000254759.3
ENST00000369242.1
COQ3
coenzyme Q3 methyltransferase
chr8_-_100905925 5.35 ENST00000518171.1
COX6C
cytochrome c oxidase subunit VIc
chr20_+_388679 4.61 ENST00000356286.5
ENST00000475269.1
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr11_-_47399942 4.01 ENST00000227163.4
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr7_+_102937869 4.01 ENST00000249269.4
ENST00000428154.1
ENST00000420236.2
PMPCB
peptidase (mitochondrial processing) beta
chr8_-_100905850 3.93 ENST00000520271.1
ENST00000522940.1
ENST00000523016.1
ENST00000517682.2
ENST00000297564.2
COX6C
cytochrome c oxidase subunit VIc
chr22_+_19938419 3.47 ENST00000412786.1
COMT
catechol-O-methyltransferase
chr12_+_54378923 3.14 ENST00000303460.4
HOXC10
homeobox C10
chr11_-_47400062 3.13 ENST00000533030.1
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr11_-_47400078 2.89 ENST00000378538.3
SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr19_+_55085248 2.87 ENST00000391738.3
ENST00000251376.3
ENST00000391737.1
ENST00000396321.2
ENST00000418536.2
ENST00000448689.1
LILRA2
LILRB1
leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2
leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1
chr8_-_100905363 2.72 ENST00000524245.1
COX6C
cytochrome c oxidase subunit VIc
chrX_+_101854096 1.98 ENST00000246174.2
ENST00000537008.1
ENST00000541409.1
ARMCX5
armadillo repeat containing, X-linked 5
chr2_-_9563319 1.49 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1
integrin beta 1 binding protein 1
chr2_-_74692473 1.37 ENST00000535045.1
ENST00000409065.1
ENST00000414701.1
ENST00000448666.1
ENST00000233616.4
ENST00000452063.2
MOGS
mannosyl-oligosaccharide glucosidase
chr6_+_42883727 1.08 ENST00000304672.1
ENST00000441198.1
ENST00000446507.1
PTCRA
pre T-cell antigen receptor alpha
chr8_+_28174496 0.68 ENST00000518479.1
PNOC
prepronociceptin
chr8_+_28174649 0.68 ENST00000301908.3
PNOC
prepronociceptin
chr7_-_38394118 0.46 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr20_+_37434329 0.44 ENST00000299824.1
ENST00000373331.2
PPP1R16B
protein phosphatase 1, regulatory subunit 16B
chr11_+_5617952 0.38 ENST00000354852.5
TRIM6-TRIM34
TRIM6-TRIM34 readthrough
chr16_+_8736232 0.33 ENST00000562973.1
METTL22
methyltransferase like 22
chr4_+_114214125 0.33 ENST00000509550.1
ANK2
ankyrin 2, neuronal
chr20_+_388791 0.23 ENST00000441733.1
ENST00000353660.3
RBCK1
RanBP-type and C3HC4-type zinc finger containing 1
chr9_-_139268068 0.15 ENST00000371734.3
ENST00000371732.5
ENST00000315908.7
CARD9
caspase recruitment domain family, member 9
chr1_-_113498943 0.06 ENST00000369626.3
SLC16A1
solute carrier family 16 (monocarboxylate transporter), member 1

Network of associatons between targets according to the STRING database.

First level regulatory network of THRB

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
6.1 18.3 GO:0052553 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
3.9 23.2 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
2.5 10.0 GO:0044027 hypermethylation of CpG island(GO:0044027)
2.2 8.7 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
2.1 31.2 GO:0006089 lactate metabolic process(GO:0006089)
1.3 8.1 GO:0019060 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
1.0 7.7 GO:0006933 negative regulation of cell adhesion involved in substrate-bound cell migration(GO:0006933)
0.8 12.4 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.7 2.9 GO:2001193 gamma-delta T cell activation involved in immune response(GO:0002290) negative regulation of interferon-beta secretion(GO:0035548) regulation of gamma-delta T cell activation involved in immune response(GO:2001191) positive regulation of gamma-delta T cell activation involved in immune response(GO:2001193)
0.7 3.5 GO:0050668 cellular response to phosphate starvation(GO:0016036) positive regulation of sulfur amino acid metabolic process(GO:0031337) positive regulation of homocysteine metabolic process(GO:0050668)
0.6 4.8 GO:0097039 protein linear polyubiquitination(GO:0097039)
0.6 12.0 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.4 5.9 GO:0010566 regulation of ketone biosynthetic process(GO:0010566)
0.3 3.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.3 4.0 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
0.3 6.9 GO:0046339 diacylglycerol metabolic process(GO:0046339)
0.1 0.4 GO:1902309 negative regulation of peptidyl-serine dephosphorylation(GO:1902309)
0.1 8.4 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.1 0.3 GO:0036309 protein localization to M-band(GO:0036309) protein localization to T-tubule(GO:0036371)
0.0 0.1 GO:0032494 response to peptidoglycan(GO:0032494)
0.0 1.4 GO:0009311 oligosaccharide metabolic process(GO:0009311)
0.0 1.4 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 23.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
2.0 8.1 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
1.8 12.4 GO:0070852 cell body fiber(GO:0070852)
1.5 18.3 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
1.0 4.8 GO:0071797 LUBAC complex(GO:0071797)
0.4 4.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
0.3 3.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.2 8.4 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.2 8.7 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.1 31.2 GO:0043209 myelin sheath(GO:0043209)
0.1 14.6 GO:0030027 lamellipodium(GO:0030027)
0.0 17.9 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 3.5 GO:0043197 dendritic spine(GO:0043197)
0.0 1.4 GO:0043679 axon terminus(GO:0043679)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.6 18.3 GO:0015207 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
4.5 31.2 GO:0004459 lactate dehydrogenase activity(GO:0004457) L-lactate dehydrogenase activity(GO:0004459)
1.7 8.7 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
1.0 23.2 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.9 10.0 GO:0051525 NFAT protein binding(GO:0051525)
0.7 2.9 GO:0030107 HLA-A specific inhibitory MHC class I receptor activity(GO:0030107)
0.6 12.4 GO:0070628 proteasome binding(GO:0070628)
0.6 8.1 GO:1990381 ubiquitin-specific protease binding(GO:1990381)
0.5 3.5 GO:0016206 catechol O-methyltransferase activity(GO:0016206)
0.4 12.0 GO:0016676 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.4 5.9 GO:0008171 O-methyltransferase activity(GO:0008171)
0.4 6.9 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.3 7.7 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.2 10.5 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 1.4 GO:0001515 opioid peptide activity(GO:0001515)
0.1 1.4 GO:0015926 glucosidase activity(GO:0015926)
0.0 4.8 GO:0043130 ubiquitin binding(GO:0043130)
0.0 4.0 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.1 GO:0050700 CARD domain binding(GO:0050700)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 23.2 SA G2 AND M PHASES Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition.
0.1 10.5 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 10.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 1.1 PID NOTCH PATHWAY Notch signaling pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 23.2 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
1.1 29.8 REACTOME PYRUVATE METABOLISM Genes involved in Pyruvate metabolism
0.4 18.3 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.1 12.0 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.1 4.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.1 1.4 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
0.0 3.5 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.0 2.9 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.0 4.8 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation