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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for TP53

Z-value: 1.18

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Transcription factors associated with TP53

Gene Symbol Gene ID Gene Info
ENSG00000141510.11 tumor protein p53

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
TP53hg19_v2_chr17_-_7590745_75908560.502.5e-15Click!

Activity profile of TP53 motif

Sorted Z-values of TP53 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr6_-_30712313 32.55 ENST00000376377.2
ENST00000259874.5
immediate early response 3
chr7_+_116165754 20.19 ENST00000405348.1
caveolin 1, caveolae protein, 22kDa
chr1_+_156052354 19.39 ENST00000368301.2
lamin A/C
chr15_-_64455404 15.82 ENST00000300026.3
peptidylprolyl isomerase B (cyclophilin B)
chr1_+_203830703 15.61 ENST00000414487.2
small nuclear ribonucleoprotein polypeptide E
chr6_-_138428613 15.13 ENST00000421351.3
PERP, TP53 apoptosis effector
chr4_-_10118348 13.66 ENST00000502702.1
WD repeat domain 1
chr20_+_33759854 13.35 ENST00000216968.4
protein C receptor, endothelial
chr20_-_5100591 13.16 ENST00000379143.5
proliferating cell nuclear antigen
chr17_+_76210267 13.14 ENST00000301633.4
ENST00000350051.3
ENST00000374948.2
ENST00000590449.1
baculoviral IAP repeat containing 5
chr3_+_23851928 12.97 ENST00000467766.1
ENST00000424381.1
ubiquitin-conjugating enzyme E2E 1
chr19_-_2456922 12.94 ENST00000582871.1
ENST00000325327.3
lamin B2
chr4_-_10117949 12.70 ENST00000508079.1
WD repeat domain 1
chr15_-_63448973 12.52 ENST00000462430.1
ribosomal protein S27-like
chr1_+_43148625 11.81 ENST00000436427.1
Y box binding protein 1
chr2_-_47168850 11.69 ENST00000409207.1
multiple coagulation factor deficiency 2
chr20_+_35234137 11.57 ENST00000344795.3
ENST00000373852.5
chromosome 20 open reading frame 24
chr20_-_1373682 11.54 ENST00000381724.3
FK506 binding protein 1A, 12kDa
chr1_+_224544552 11.42 ENST00000465271.1
ENST00000366858.3
cornichon family AMPA receptor auxiliary protein 4
chr1_-_209825674 11.16 ENST00000367030.3
ENST00000356082.4
laminin, beta 3
chr20_+_35234223 11.10 ENST00000342422.3
chromosome 20 open reading frame 24
chr7_+_100770328 10.87 ENST00000223095.4
ENST00000445463.2
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
chr4_-_187644930 10.85 ENST00000441802.2
FAT atypical cadherin 1
chr14_+_97263641 10.67 ENST00000216639.3
vaccinia related kinase 1
chr20_-_1373726 10.59 ENST00000400137.4
FK506 binding protein 1A, 12kDa
chr1_-_113249678 10.59 ENST00000369633.2
ENST00000425265.2
ENST00000369632.2
ENST00000436685.2
ras homolog family member C
chr12_-_122712038 10.38 ENST00000413918.1
ENST00000443649.3
diablo, IAP-binding mitochondrial protein
chr5_+_162864575 10.37 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
cyclin G1
chr1_-_113249734 9.94 ENST00000484054.3
ENST00000369636.2
ENST00000369637.1
ENST00000285735.2
ENST00000369638.2
ras homolog family member C
chr18_+_57567180 9.82 ENST00000316660.6
ENST00000269518.9
phorbol-12-myristate-13-acetate-induced protein 1
chr11_-_65626753 9.76 ENST00000526975.1
ENST00000531413.1
cofilin 1 (non-muscle)
chr8_-_22926623 9.36 ENST00000276431.4
tumor necrosis factor receptor superfamily, member 10b
chr16_-_31105870 9.12 ENST00000394971.3
vitamin K epoxide reductase complex, subunit 1
chr6_-_101329191 8.95 ENST00000324723.6
ENST00000369162.2
ENST00000522650.1
activating signal cointegrator 1 complex subunit 3
chr9_+_80912059 8.93 ENST00000347159.2
ENST00000376588.3
phosphoserine aminotransferase 1
chr12_+_12966250 8.74 ENST00000352940.4
ENST00000358007.3
ENST00000544400.1
DEAD (Asp-Glu-Ala-Asp) box polypeptide 47
chrX_-_153285251 8.61 ENST00000444230.1
ENST00000393682.1
ENST00000393687.2
ENST00000429936.2
ENST00000369974.2
interleukin-1 receptor-associated kinase 1
chr16_-_15149828 8.42 ENST00000566419.1
ENST00000568320.1
N-terminal asparagine amidase
chr22_-_18257178 8.38 ENST00000342111.5
BH3 interacting domain death agonist
chr4_-_10118573 8.31 ENST00000382452.2
ENST00000382451.2
WD repeat domain 1
chr15_+_79165372 8.30 ENST00000558502.1
mortality factor 4 like 1
chr11_-_64084959 8.23 ENST00000535750.1
ENST00000535126.1
ENST00000539854.1
ENST00000308774.2
tRNA methyltransferase 11-2 homolog (S. cerevisiae)
chr2_-_47168906 8.15 ENST00000444761.2
ENST00000409147.1
multiple coagulation factor deficiency 2
chr5_+_72794233 7.96 ENST00000335895.8
ENST00000380591.3
ENST00000507081.2
basic transcription factor 3
chr3_-_113465065 7.90 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr20_-_47804894 7.77 ENST00000371828.3
ENST00000371856.2
ENST00000360426.4
ENST00000347458.5
ENST00000340954.7
ENST00000371802.1
ENST00000371792.1
ENST00000437404.2
staufen double-stranded RNA binding protein 1
chr3_+_127771212 7.69 ENST00000243253.3
ENST00000481210.1
Sec61 alpha 1 subunit (S. cerevisiae)
chrX_-_153285395 7.51 ENST00000369980.3
interleukin-1 receptor-associated kinase 1
chr22_-_36924944 7.49 ENST00000405442.1
ENST00000402116.1
eukaryotic translation initiation factor 3, subunit D
chr1_+_54411995 7.46 ENST00000319223.4
ENST00000444987.1
leucine rich repeat containing 42
chr3_+_184079492 7.42 ENST00000456318.1
ENST00000412877.1
ENST00000438240.1
polymerase (RNA) II (DNA directed) polypeptide H
chr12_-_6451186 7.32 ENST00000540022.1
ENST00000536194.1
tumor necrosis factor receptor superfamily, member 1A
chr13_-_50367057 7.26 ENST00000261667.3
karyopherin alpha 3 (importin alpha 4)
chr15_+_79165296 7.21 ENST00000558746.1
ENST00000558830.1
ENST00000559345.1
mortality factor 4 like 1
chr1_-_244615425 7.18 ENST00000366535.3
adenylosuccinate synthase
chr3_+_122785895 7.17 ENST00000316218.7
protein disulfide isomerase family A, member 5
chr12_+_53645870 7.14 ENST00000329548.4
major facilitator superfamily domain containing 5
chrX_-_154688276 7.07 ENST00000369445.2
coagulation factor VIII-associated 3
chr1_-_153588334 7.03 ENST00000476873.1
S100 calcium binding protein A14
chr22_-_36925186 6.96 ENST00000541106.1
ENST00000455547.1
ENST00000432675.1
eukaryotic translation initiation factor 3, subunit D
chr9_+_116037922 6.93 ENST00000374198.4
pre-mRNA processing factor 4
chr3_+_183894566 6.89 ENST00000439647.1
adaptor-related protein complex 2, mu 1 subunit
chr10_+_92631709 6.88 ENST00000413330.1
ENST00000277882.3
ribonuclease P/MRP 30kDa subunit
chr1_+_54411715 6.84 ENST00000371370.3
ENST00000371368.1
leucine rich repeat containing 42
chrX_+_154114635 6.75 ENST00000369446.2
coagulation factor VIII-associated 1
chr4_-_10118469 6.71 ENST00000499869.2
WD repeat domain 1
chr17_+_76210367 6.65 ENST00000592734.1
ENST00000587746.1
baculoviral IAP repeat containing 5
chr15_-_34635314 6.59 ENST00000557912.1
ENST00000328848.4
NOP10 ribonucleoprotein
chr10_-_126847276 6.52 ENST00000531469.1
C-terminal binding protein 2
chr19_+_38865398 6.48 ENST00000585598.1
ENST00000602911.1
ENST00000592561.1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 8
chr9_-_95527079 6.13 ENST00000356884.6
ENST00000375512.3
bicaudal D homolog 2 (Drosophila)
chr3_+_14166440 6.00 ENST00000306077.4
transmembrane protein 43
chr1_-_156710859 5.89 ENST00000361531.2
ENST00000412846.1
mitochondrial ribosomal protein L24
chr22_-_18257249 5.87 ENST00000399765.1
ENST00000399767.1
ENST00000399774.3
BH3 interacting domain death agonist
chr19_+_42364460 5.85 ENST00000593863.1
ribosomal protein S19
chr10_+_48255253 5.81 ENST00000357718.4
ENST00000344416.5
ENST00000456111.2
ENST00000374258.3
annexin A8
Protein LOC100996760
chr3_+_196466710 5.67 ENST00000327134.3
p21 protein (Cdc42/Rac)-activated kinase 2
chr2_+_198365095 5.67 ENST00000409468.1
heat shock 10kDa protein 1
chr16_-_31106048 5.53 ENST00000300851.6
vitamin K epoxide reductase complex, subunit 1
chr12_-_6451235 5.47 ENST00000440083.2
ENST00000162749.2
tumor necrosis factor receptor superfamily, member 1A
chr1_-_155990580 5.45 ENST00000531917.1
ENST00000480567.1
ENST00000526212.1
ENST00000529008.1
ENST00000496742.1
ENST00000295702.4
signal sequence receptor, beta (translocon-associated protein beta)
chr1_-_156710916 5.43 ENST00000368211.4
mitochondrial ribosomal protein L24
chr7_-_56101826 5.41 ENST00000421626.1
phosphoserine phosphatase
chr10_-_71993176 5.32 ENST00000373232.3
pyrophosphatase (inorganic) 1
chr16_-_31106211 5.22 ENST00000532364.1
ENST00000529564.1
ENST00000319788.7
ENST00000354895.4
ENST00000394975.2
Uncharacterized protein
vitamin K epoxide reductase complex, subunit 1
chr10_-_47173994 5.17 ENST00000414655.2
ENST00000545298.1
ENST00000359178.4
ENST00000358140.4
ENST00000503031.1
annexin A8-like 1
long intergenic non-protein coding RNA 842
chr1_-_54411240 5.10 ENST00000371378.2
heat shock protein family B (small), member 11
chr6_-_114292284 5.05 ENST00000520895.1
ENST00000521163.1
ENST00000524334.1
ENST00000368632.2
ENST00000398283.2
histone deacetylase 2
chr4_+_41937131 5.03 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr15_+_79165222 5.02 ENST00000559930.1
mortality factor 4 like 1
chr1_-_6453426 4.96 ENST00000545482.1
acyl-CoA thioesterase 7
chr6_-_114292449 4.93 ENST00000519065.1
histone deacetylase 2
chr7_+_23145884 4.91 ENST00000409689.1
ENST00000410047.1
kelch-like family member 7
chr8_+_95732095 4.90 ENST00000414645.2
dpy-19-like 4 (C. elegans)
chr16_-_58231782 4.86 ENST00000565188.1
ENST00000262506.3
casein kinase 2, alpha prime polypeptide
chr11_-_82997013 4.86 ENST00000529073.1
ENST00000529611.1
coiled-coil domain containing 90B
chr10_+_47746929 4.72 ENST00000340243.6
ENST00000374277.5
ENST00000449464.2
ENST00000538825.1
ENST00000335083.5
annexin A8-like 2
Protein LOC100996760
chr19_+_57874835 4.71 ENST00000543226.1
ENST00000596755.1
ENST00000282282.3
ENST00000597658.1
trafficking protein particle complex 2 pseudogene 1
zinc finger protein 547
Uncharacterized protein
chr7_+_23145347 4.67 ENST00000322231.7
kelch-like family member 7
chr11_+_64002292 4.64 ENST00000426086.2
vascular endothelial growth factor B
chr6_+_24403144 4.56 ENST00000274747.7
ENST00000543597.1
ENST00000535061.1
ENST00000378353.1
ENST00000378386.3
ENST00000443868.2
MRS2 magnesium transporter
chr18_+_9913977 4.56 ENST00000400000.2
ENST00000340541.4
VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa
chr1_-_54411255 4.48 ENST00000371377.3
heat shock protein family B (small), member 11
chr10_+_88854926 4.35 ENST00000298784.1
ENST00000298786.4
family with sequence similarity 35, member A
chr12_+_56546363 4.30 ENST00000551834.1
ENST00000552568.1
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chrX_+_40440146 4.30 ENST00000535539.1
ENST00000378438.4
ENST00000436783.1
ENST00000544975.1
ENST00000535777.1
ENST00000447485.1
ENST00000423649.1
ATPase, H+ transporting, lysosomal accessory protein 2
chr2_+_169312725 4.26 ENST00000392687.4
ceramide synthase 6
chr20_-_33543546 4.24 ENST00000216951.2
glutathione synthetase
chr19_+_42364313 4.11 ENST00000601492.1
ENST00000600467.1
ENST00000221975.2
ribosomal protein S19
chr20_-_43589109 4.06 ENST00000372813.3
translocase of outer mitochondrial membrane 34
chr11_-_108464465 4.03 ENST00000525344.1
exophilin 5
chr11_-_3078838 3.99 ENST00000397111.5
cysteinyl-tRNA synthetase
chr19_-_39926268 3.91 ENST00000599705.1
ribosomal protein S16
chr12_+_53895364 3.90 ENST00000552817.1
ENST00000394357.2
TAR (HIV-1) RNA binding protein 2
chr12_+_53894672 3.89 ENST00000266987.2
ENST00000456234.2
TAR (HIV-1) RNA binding protein 2
chrX_+_152086373 3.87 ENST00000318529.8
zinc finger protein 185 (LIM domain)
chr18_-_34408693 3.83 ENST00000587382.1
ENST00000589049.1
ENST00000587129.1
tubulin polyglutamylase complex subunit 2
chr16_-_15149917 3.82 ENST00000287706.3
N-terminal asparagine amidase
chr20_-_1373606 3.82 ENST00000381715.1
ENST00000439640.2
ENST00000381719.3
FK506 binding protein 1A, 12kDa
chr10_+_70661014 3.77 ENST00000373585.3
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr11_-_3078616 3.75 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
cysteinyl-tRNA synthetase
chr22_-_37415475 3.73 ENST00000403892.3
ENST00000249042.3
ENST00000438203.1
thiosulfate sulfurtransferase (rhodanese)
chr6_+_116692102 3.69 ENST00000359564.2
dermatan sulfate epimerase
chr6_-_30709980 3.63 ENST00000416018.1
ENST00000445853.1
ENST00000413165.1
ENST00000418160.1
flotillin 1
chr5_+_141348640 3.61 ENST00000540015.1
ENST00000506938.1
ENST00000394514.2
ENST00000512565.1
ENST00000394515.3
ring finger protein 14
chr17_+_74372662 3.59 ENST00000591651.1
ENST00000545180.1
sphingosine kinase 1
chr1_+_32645269 3.57 ENST00000373610.3
taxilin alpha
chr4_-_129209944 3.44 ENST00000520121.1
progesterone receptor membrane component 2
chr4_+_103422471 3.40 ENST00000226574.4
ENST00000394820.4
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1
chr19_+_926000 3.33 ENST00000263620.3
AT rich interactive domain 3A (BRIGHT-like)
chr7_+_23145366 3.24 ENST00000339077.5
ENST00000322275.5
ENST00000539124.1
ENST00000542558.1
kelch-like family member 7
chr1_-_202936394 3.15 ENST00000367249.4
cytochrome b5 reductase 1
chr1_-_10532531 3.12 ENST00000377036.2
ENST00000377038.3
DNA fragmentation factor, 45kDa, alpha polypeptide
chr14_+_24702127 3.11 ENST00000557854.1
ENST00000348719.7
ENST00000559104.1
ENST00000456667.3
guanosine monophosphate reductase 2
chr11_+_36397528 3.01 ENST00000311599.5
ENST00000378867.3
proline rich 5 like
chr13_+_76334567 2.87 ENST00000321797.8
LIM domain 7
chr13_+_48877895 2.86 ENST00000267163.4
retinoblastoma 1
chr18_-_34409116 2.81 ENST00000334295.4
tubulin polyglutamylase complex subunit 2
chr15_+_79165151 2.79 ENST00000331268.5
mortality factor 4 like 1
chr4_-_159644507 2.75 ENST00000307720.3
peptidylprolyl isomerase D
chr9_+_119449576 2.74 ENST00000450136.1
ENST00000373983.2
ENST00000411410.1
tripartite motif containing 32
chr2_+_169312350 2.62 ENST00000305747.6
ceramide synthase 6
chr1_-_205744205 2.55 ENST00000446390.2
RAB7, member RAS oncogene family-like 1
chr19_-_6591113 2.49 ENST00000423145.3
ENST00000245903.3
CD70 molecule
chr9_-_138853156 2.48 ENST00000371756.3
UBA domain containing 1
chr11_-_108464321 2.46 ENST00000265843.4
exophilin 5
chr12_+_53895052 2.41 ENST00000552857.1
TAR (HIV-1) RNA binding protein 2
chr15_+_79165112 2.41 ENST00000426013.2
mortality factor 4 like 1
chr8_+_22429205 2.41 ENST00000520207.1
sorbin and SH3 domain containing 3
chr14_-_50999307 2.36 ENST00000013125.4
mitogen-activated protein kinase kinase kinase kinase 5
chr22_-_22901636 2.35 ENST00000406503.1
ENST00000439106.1
ENST00000402697.1
ENST00000543184.1
ENST00000398743.2
preferentially expressed antigen in melanoma
chr19_-_51504411 2.33 ENST00000593490.1
kallikrein-related peptidase 8
chr1_-_6453399 2.31 ENST00000608083.1
acyl-CoA thioesterase 7
chr16_-_29874462 2.30 ENST00000566113.1
ENST00000569956.1
ENST00000570016.1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr16_+_2079637 2.29 ENST00000561844.1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr1_-_205744574 2.27 ENST00000367139.3
ENST00000235932.4
ENST00000437324.2
ENST00000414729.1
RAB7, member RAS oncogene family-like 1
chr6_+_52285131 2.27 ENST00000433625.2
EF-hand domain (C-terminal) containing 1
chr6_+_4776580 2.26 ENST00000397588.3
chromodomain protein, Y-like
chr11_+_64073699 2.25 ENST00000405666.1
ENST00000468670.1
estrogen-related receptor alpha
chr6_+_52285046 2.23 ENST00000371068.5
EF-hand domain (C-terminal) containing 1
chr7_+_140396946 2.21 ENST00000476470.1
ENST00000471136.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr3_-_52804872 2.19 ENST00000535191.1
ENST00000461689.1
ENST00000383721.4
ENST00000233027.5
NIMA-related kinase 4
chr22_-_39715600 2.18 ENST00000427905.1
ENST00000402527.1
ENST00000216146.4
ribosomal protein L3
chr7_-_100239132 2.13 ENST00000223051.3
ENST00000431692.1
transferrin receptor 2
chr6_+_36098262 2.06 ENST00000373761.6
ENST00000373766.5
mitogen-activated protein kinase 13
chr6_+_76458990 2.05 ENST00000369977.3
myosin VI
chr22_+_21133469 2.05 ENST00000406799.1
serpin peptidase inhibitor, clade D (heparin cofactor), member 1
chr14_+_64970662 2.04 ENST00000556965.1
ENST00000554015.1
zinc finger and BTB domain containing 1
chr14_+_102228123 2.01 ENST00000422945.2
ENST00000554442.1
ENST00000556260.2
ENST00000328724.5
ENST00000557268.1
protein phosphatase 2, regulatory subunit B', gamma
chr7_+_140396756 1.99 ENST00000460088.1
ENST00000472695.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr7_-_150924121 1.96 ENST00000441774.1
ENST00000222388.2
ENST00000287844.2
ATP-binding cassette, sub-family F (GCN20), member 2
chrX_-_48827976 1.94 ENST00000218176.3
potassium voltage-gated channel, Shal-related subfamily, member 1
chr7_+_140396465 1.94 ENST00000476279.1
ENST00000247866.4
ENST00000461457.1
ENST00000465506.1
ENST00000204307.5
ENST00000464566.1
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 2, 8kDa
chr1_+_27153173 1.93 ENST00000374142.4
zinc finger, DHHC-type containing 18
chr2_-_242556900 1.91 ENST00000402545.1
ENST00000402136.1
THAP domain containing 4
chr19_+_2785458 1.90 ENST00000307741.6
ENST00000585338.1
thimet oligopeptidase 1
chr15_-_89456630 1.87 ENST00000268150.8
milk fat globule-EGF factor 8 protein
chr5_+_141348721 1.87 ENST00000507163.1
ENST00000394519.1
ring finger protein 14
chr18_-_34408902 1.75 ENST00000593035.1
ENST00000383056.3
ENST00000588909.1
ENST00000590337.1
tubulin polyglutamylase complex subunit 2
chr13_+_38923959 1.71 ENST00000379649.1
ENST00000239878.4
ENST00000437952.1
ENST00000379641.1
ubiquitin-fold modifier 1
chr2_-_18741882 1.71 ENST00000381249.3
retinol dehydrogenase 14 (all-trans/9-cis/11-cis)
chr16_+_2079501 1.66 ENST00000563587.1
solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
chr16_-_68000717 1.62 ENST00000541864.2
solute carrier family 12 (potassium/chloride transporter), member 4
chr17_+_73089382 1.58 ENST00000538213.2
ENST00000584118.1
solute carrier family 16 (monocarboxylate transporter), member 5
chr12_+_56546223 1.58 ENST00000550443.1
ENST00000207437.5
myosin, light chain 6B, alkali, smooth muscle and non-muscle
chr1_-_201438282 1.52 ENST00000367311.3
ENST00000367309.1
pleckstrin homology-like domain, family A, member 3
chr16_-_29874211 1.45 ENST00000563415.1
CDP-diacylglycerol--inositol 3-phosphatidyltransferase
chr2_+_11295624 1.39 ENST00000402361.1
ENST00000428481.1
PQ loop repeat containing 3
chr4_+_671711 1.38 ENST00000400159.2
myosin, light chain 5, regulatory
chrX_+_99899180 1.34 ENST00000373004.3
sushi-repeat containing protein, X-linked 2
chrX_-_70474499 1.32 ENST00000353904.2
zinc finger, MYM-type 3
chr3_-_46037299 1.28 ENST00000296137.2
FYVE and coiled-coil domain containing 1
chr6_-_111804905 1.26 ENST00000358835.3
ENST00000435970.1
REV3-like, polymerase (DNA directed), zeta, catalytic subunit
chr19_+_49458107 1.23 ENST00000539787.1
ENST00000345358.7
ENST00000391871.3
ENST00000415969.2
ENST00000354470.3
ENST00000506183.1
ENST00000293288.8
BCL2-associated X protein
chr10_+_90750493 1.18 ENST00000357339.2
ENST00000355279.2
Fas cell surface death receptor
chr14_-_75079026 1.18 ENST00000261978.4
latent transforming growth factor beta binding protein 2
chr5_+_141348598 1.16 ENST00000394520.2
ENST00000347642.3
ring finger protein 14
chr15_-_89456593 1.16 ENST00000558029.1
ENST00000539437.1
ENST00000542878.1
ENST00000268151.7
ENST00000566497.1
milk fat globule-EGF factor 8 protein
chr2_-_89417335 1.15 ENST00000490686.1
immunoglobulin kappa variable 1-17
chr8_-_22926526 1.08 ENST00000347739.3
ENST00000542226.1
tumor necrosis factor receptor superfamily, member 10b

Network of associatons between targets according to the STRING database.

First level regulatory network of TP53

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
10.3 41.4 GO:0016334 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
6.7 20.2 GO:1903609 negative regulation of peptidyl-tyrosine autophosphorylation(GO:1900085) negative regulation of inward rectifier potassium channel activity(GO:1903609)
5.3 15.8 GO:1901873 regulation of post-translational protein modification(GO:1901873)
4.8 14.4 GO:0001732 formation of cytoplasmic translation initiation complex(GO:0001732)
3.9 19.4 GO:0035105 sterol regulatory element binding protein import into nucleus(GO:0035105)
3.6 10.9 GO:2000097 chronological cell aging(GO:0001300) regulation of smooth muscle cell-matrix adhesion(GO:2000097)
3.4 20.5 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
3.3 13.2 GO:0006272 leading strand elongation(GO:0006272)
2.6 7.8 GO:0046726 positive regulation by virus of viral protein levels in host cell(GO:0046726)
2.6 7.7 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
2.5 10.0 GO:0060265 positive regulation of respiratory burst involved in inflammatory response(GO:0060265)
2.4 7.2 GO:0044208 'de novo' AMP biosynthetic process(GO:0044208)
2.2 25.9 GO:0022417 protein maturation by protein folding(GO:0022417)
2.1 8.2 GO:0018364 peptidyl-glutamine methylation(GO:0018364)
2.0 10.0 GO:0061198 fungiform papilla formation(GO:0061198)
2.0 19.9 GO:0042373 vitamin K metabolic process(GO:0042373)
1.9 5.8 GO:1900138 negative regulation of phospholipase A2 activity(GO:1900138)
1.8 7.3 GO:1900533 medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535)
1.8 8.9 GO:0042816 vitamin B6 metabolic process(GO:0042816)
1.8 5.3 GO:0071344 diphosphate metabolic process(GO:0071344)
1.7 10.2 GO:0035087 targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087)
1.7 11.8 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
1.7 8.4 GO:0051510 regulation of unidimensional cell growth(GO:0051510) negative regulation of unidimensional cell growth(GO:0051511) establishment of cell polarity regulating cell shape(GO:0071964) regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000769) positive regulation of establishment or maintenance of cell polarity regulating cell shape(GO:2000771) regulation of establishment of cell polarity regulating cell shape(GO:2000782) positive regulation of establishment of cell polarity regulating cell shape(GO:2000784) regulation of barbed-end actin filament capping(GO:2000812) positive regulation of barbed-end actin filament capping(GO:2000814)
1.7 5.0 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.6 4.9 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
1.6 13.0 GO:0032020 ISG15-protein conjugation(GO:0032020)
1.5 7.7 GO:0006620 posttranslational protein targeting to membrane(GO:0006620)
1.5 4.6 GO:0044828 negative regulation by host of viral genome replication(GO:0044828)
1.4 14.3 GO:0010918 positive regulation of mitochondrial membrane potential(GO:0010918)
1.4 9.9 GO:0043987 histone H3-S10 phosphorylation(GO:0043987)
1.4 5.7 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
1.4 15.1 GO:0002934 desmosome organization(GO:0002934)
1.3 6.6 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
1.3 7.9 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
1.3 8.9 GO:0006307 DNA dealkylation involved in DNA repair(GO:0006307)
1.2 3.7 GO:0035928 rRNA import into mitochondrion(GO:0035928)
1.2 6.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
1.2 3.6 GO:0046521 sphingoid catabolic process(GO:0046521)
1.2 12.8 GO:0090154 positive regulation of sphingolipid biosynthetic process(GO:0090154) positive regulation of ceramide biosynthetic process(GO:2000304)
1.1 19.8 GO:1990001 inhibition of cysteine-type endopeptidase activity involved in apoptotic process(GO:1990001)
1.0 3.1 GO:1903625 negative regulation of DNA catabolic process(GO:1903625)
1.0 9.8 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
0.9 25.7 GO:0043968 histone H2A acetylation(GO:0043968)
0.8 16.1 GO:0034134 toll-like receptor 2 signaling pathway(GO:0034134)
0.8 2.4 GO:0048385 retinoic acid receptor signaling pathway(GO:0048384) regulation of retinoic acid receptor signaling pathway(GO:0048385) negative regulation of retinoic acid receptor signaling pathway(GO:0048387)
0.7 9.6 GO:0070986 left/right axis specification(GO:0070986)
0.7 2.8 GO:0071492 cellular response to UV-A(GO:0071492)
0.7 3.4 GO:2000630 negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) positive regulation of miRNA metabolic process(GO:2000630)
0.6 10.0 GO:0008635 activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635)
0.6 3.6 GO:0034141 positive regulation of toll-like receptor 3 signaling pathway(GO:0034141) positive regulation of cell adhesion molecule production(GO:0060355)
0.6 6.0 GO:0071763 nuclear membrane organization(GO:0071763)
0.6 2.9 GO:0007070 negative regulation of transcription during mitosis(GO:0007068) negative regulation of transcription from RNA polymerase II promoter during mitosis(GO:0007070)
0.6 12.5 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.5 2.7 GO:0030047 actin modification(GO:0030047)
0.5 4.6 GO:0060754 positive regulation of mast cell chemotaxis(GO:0060754)
0.5 1.5 GO:0051898 negative regulation of protein kinase B signaling(GO:0051898)
0.5 15.6 GO:0008334 histone mRNA metabolic process(GO:0008334)
0.5 5.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.4 1.8 GO:0002572 pro-T cell differentiation(GO:0002572)
0.4 6.9 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.4 4.3 GO:0021903 rostrocaudal neural tube patterning(GO:0021903)
0.4 6.5 GO:0043248 proteasome assembly(GO:0043248)
0.4 7.0 GO:0090026 positive regulation of monocyte chemotaxis(GO:0090026)
0.4 11.2 GO:0031581 hemidesmosome assembly(GO:0031581)
0.4 4.6 GO:1903830 magnesium ion transmembrane transport(GO:1903830)
0.4 6.9 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
0.4 6.5 GO:0071985 multivesicular body sorting pathway(GO:0071985)
0.4 2.1 GO:0098707 ferrous iron import into cell(GO:0097460) ferrous iron import across plasma membrane(GO:0098707)
0.3 19.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
0.3 5.7 GO:0051085 chaperone mediated protein folding requiring cofactor(GO:0051085)
0.3 6.5 GO:0050872 white fat cell differentiation(GO:0050872)
0.3 2.0 GO:0008218 bioluminescence(GO:0008218)
0.3 2.3 GO:0031642 negative regulation of myelination(GO:0031642)
0.3 0.9 GO:1990523 endothelial cell-cell adhesion(GO:0071603) bone regeneration(GO:1990523)
0.3 3.0 GO:0038203 TORC2 signaling(GO:0038203)
0.3 7.3 GO:0019054 modulation by virus of host process(GO:0019054)
0.3 1.3 GO:1901096 regulation of autophagosome maturation(GO:1901096) positive regulation of autophagosome maturation(GO:1901098)
0.3 3.0 GO:2000427 positive regulation of apoptotic cell clearance(GO:2000427)
0.2 3.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.2 1.7 GO:1990564 protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 1.0 GO:0043335 protein unfolding(GO:0043335)
0.2 12.5 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.2 0.9 GO:0086097 phospholipase C-activating angiotensin-activated signaling pathway(GO:0086097)
0.2 3.8 GO:0046341 CDP-diacylglycerol metabolic process(GO:0046341)
0.2 1.2 GO:0071455 cellular response to hyperoxia(GO:0071455)
0.2 4.2 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.2 1.3 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050)
0.2 6.6 GO:0060765 regulation of androgen receptor signaling pathway(GO:0060765)
0.2 13.4 GO:0050819 negative regulation of coagulation(GO:0050819)
0.2 0.6 GO:0090283 regulation of protein glycosylation in Golgi(GO:0090283)
0.2 7.4 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
0.2 5.8 GO:0097421 liver regeneration(GO:0097421)
0.2 11.3 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 34.2 GO:0014066 regulation of phosphatidylinositol 3-kinase signaling(GO:0014066)
0.2 2.2 GO:0001302 replicative cell aging(GO:0001302)
0.2 10.4 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.1 0.8 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.1 3.9 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
0.1 0.6 GO:0045347 negative regulation of MHC class II biosynthetic process(GO:0045347)
0.1 10.4 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
0.1 3.1 GO:0043101 purine-containing compound salvage(GO:0043101)
0.1 4.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
0.1 0.5 GO:0021759 globus pallidus development(GO:0021759)
0.1 0.3 GO:1903347 negative regulation of bicellular tight junction assembly(GO:1903347)
0.1 12.2 GO:0007613 memory(GO:0007613)
0.1 0.6 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.1 4.5 GO:0021795 cerebral cortex cell migration(GO:0021795)
0.1 6.5 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 1.4 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.1 12.5 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1 5.9 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 2.2 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.1 0.7 GO:0015937 coenzyme A biosynthetic process(GO:0015937)
0.1 1.3 GO:0042276 error-prone translesion synthesis(GO:0042276)
0.1 1.0 GO:0036010 protein localization to endosome(GO:0036010)
0.1 1.7 GO:0042572 retinol metabolic process(GO:0042572)
0.0 11.3 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.0 5.5 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.0 2.9 GO:0032755 positive regulation of interleukin-6 production(GO:0032755)
0.0 2.4 GO:0051496 positive regulation of stress fiber assembly(GO:0051496)
0.0 1.4 GO:0006937 regulation of muscle contraction(GO:0006937)
0.0 0.3 GO:0045116 protein neddylation(GO:0045116)
0.0 1.6 GO:0016126 sterol biosynthetic process(GO:0016126)
0.0 2.0 GO:0007605 sensory perception of sound(GO:0007605)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
8.3 41.4 GO:0042643 actomyosin, actin portion(GO:0042643)
5.2 25.9 GO:1990425 ryanodine receptor complex(GO:1990425)
4.4 13.2 GO:0070557 PCNA-p21 complex(GO:0070557)
3.6 32.3 GO:0005638 lamin filament(GO:0005638)
3.2 16.1 GO:0045323 interleukin-1 receptor complex(GO:0045323)
2.5 19.8 GO:0032133 chromosome passenger complex(GO:0032133)
2.0 11.8 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
2.0 15.6 GO:0034715 U7 snRNP(GO:0005683) pICln-Sm protein complex(GO:0034715)
1.7 6.9 GO:0071001 U4/U6 snRNP(GO:0071001)
1.6 14.4 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
1.5 35.7 GO:0016580 Sin3 complex(GO:0016580)
1.4 20.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
1.4 11.2 GO:0005610 laminin-5 complex(GO:0005610)
1.1 10.2 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
1.1 7.9 GO:0031415 NatA complex(GO:0031415)
1.1 6.6 GO:0090661 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
1.0 6.9 GO:0000172 ribonuclease MRP complex(GO:0000172)
1.0 2.9 GO:0035189 Rb-E2F complex(GO:0035189)
0.8 15.8 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
0.7 10.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.7 7.9 GO:0016461 unconventional myosin complex(GO:0016461)
0.7 2.7 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.6 6.5 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
0.6 20.5 GO:0032420 stereocilium(GO:0032420)
0.5 3.1 GO:1902560 GMP reductase complex(GO:1902560)
0.5 6.1 GO:0005642 annulate lamellae(GO:0005642)
0.5 16.8 GO:0030057 desmosome(GO:0030057)
0.5 6.5 GO:0097470 ribbon synapse(GO:0097470)
0.5 9.6 GO:0030992 intraciliary transport particle B(GO:0030992)
0.4 7.4 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.4 6.9 GO:0036020 endolysosome membrane(GO:0036020)
0.4 26.4 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.3 3.4 GO:0033256 I-kappaB/NF-kappaB complex(GO:0033256)
0.3 11.3 GO:0000315 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.3 3.6 GO:0016600 flotillin complex(GO:0016600)
0.2 19.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 4.0 GO:0044453 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
0.2 4.6 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
0.2 12.5 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.2 6.8 GO:0031258 lamellipodium membrane(GO:0031258)
0.2 3.0 GO:0031932 TORC2 complex(GO:0031932)
0.2 15.5 GO:0005791 rough endoplasmic reticulum(GO:0005791)
0.2 2.1 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.2 2.0 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
0.2 8.8 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.1 0.6 GO:0005797 Golgi medial cisterna(GO:0005797)
0.1 8.3 GO:0032592 integral component of mitochondrial membrane(GO:0032592)
0.1 3.1 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 12.3 GO:0005643 nuclear pore(GO:0005643)
0.1 1.2 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.1 11.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 1.3 GO:0042575 DNA polymerase complex(GO:0042575)
0.1 4.1 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.3 GO:0005832 chaperonin-containing T-complex(GO:0005832)
0.1 40.3 GO:0005925 focal adhesion(GO:0005925)
0.1 1.2 GO:0031265 CD95 death-inducing signaling complex(GO:0031265)
0.1 4.5 GO:0072686 mitotic spindle(GO:0072686)
0.1 3.8 GO:0101003 ficolin-1-rich granule membrane(GO:0101003)
0.1 6.8 GO:0031902 late endosome membrane(GO:0031902)
0.0 2.3 GO:0045171 intercellular bridge(GO:0045171)
0.0 1.0 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 6.9 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.0 3.1 GO:0005811 lipid particle(GO:0005811)
0.0 1.4 GO:0005859 muscle myosin complex(GO:0005859)
0.0 8.0 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 9.0 GO:0005819 spindle(GO:0005819)
0.0 26.1 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 0.5 GO:0043194 axon initial segment(GO:0043194)
0.0 1.9 GO:0001669 acrosomal vesicle(GO:0001669)
0.0 1.9 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 1.9 GO:0034705 voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705)
0.0 10.9 GO:0009986 cell surface(GO:0009986)
0.0 1.2 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 1.1 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
6.7 20.2 GO:0070320 inward rectifier potassium channel inhibitor activity(GO:0070320)
5.0 19.9 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
3.3 13.2 GO:0030337 DNA polymerase processivity factor activity(GO:0030337)
2.8 14.0 GO:0043120 tumor necrosis factor binding(GO:0043120)
2.7 10.7 GO:0031493 nucleosomal histone binding(GO:0031493)
2.6 7.7 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
2.3 16.1 GO:0004704 NF-kappaB-inducing kinase activity(GO:0004704)
2.2 13.0 GO:0042296 ISG15 transferase activity(GO:0042296)
1.9 25.9 GO:0034713 type I transforming growth factor beta receptor binding(GO:0034713)
1.6 15.6 GO:1990446 U1 snRNP binding(GO:1990446)
1.5 4.6 GO:0033149 FFAT motif binding(GO:0033149)
1.3 5.3 GO:0004427 inorganic diphosphatase activity(GO:0004427)
1.3 3.8 GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881)
1.2 3.7 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
1.1 6.9 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
1.1 11.4 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
1.1 10.2 GO:0070883 pre-miRNA binding(GO:0070883)
1.1 8.9 GO:0043140 ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
1.1 6.6 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
1.1 5.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
1.0 6.9 GO:0030621 U4 snRNA binding(GO:0030621)
0.9 6.5 GO:0030267 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.8 4.6 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.7 12.5 GO:0008494 translation activator activity(GO:0008494)
0.7 7.3 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
0.7 2.9 GO:0061676 importin-alpha family protein binding(GO:0061676)
0.7 10.0 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.7 14.4 GO:0000339 RNA cap binding(GO:0000339)
0.6 3.7 GO:0004792 thiosulfate sulfurtransferase activity(GO:0004792)
0.6 7.9 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.6 3.6 GO:0008481 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.6 7.2 GO:0042301 phosphate ion binding(GO:0042301)
0.5 2.1 GO:0004998 transferrin receptor activity(GO:0004998)
0.5 3.1 GO:0016657 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.5 6.1 GO:0034452 dynactin binding(GO:0034452)
0.4 14.3 GO:0005123 death receptor binding(GO:0005123)
0.4 6.9 GO:0004526 ribonuclease P activity(GO:0004526)
0.4 19.8 GO:0008536 Ran GTPase binding(GO:0008536)
0.4 7.4 GO:0001054 RNA polymerase I activity(GO:0001054)
0.4 2.4 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.3 7.2 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.3 4.6 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.3 6.9 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 4.2 GO:0016594 glycine binding(GO:0016594)
0.3 7.3 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.3 10.0 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.3 0.9 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.3 7.8 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.3 2.2 GO:0008097 5S rRNA binding(GO:0008097)
0.3 5.0 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.3 3.1 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.3 4.9 GO:0000030 mannosyltransferase activity(GO:0000030)
0.3 15.8 GO:0070063 RNA polymerase binding(GO:0070063)
0.3 61.5 GO:0051015 actin filament binding(GO:0051015)
0.2 1.7 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.2 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 3.0 GO:0008429 phosphatidylethanolamine binding(GO:0008429)
0.2 5.7 GO:0030296 protein tyrosine kinase activator activity(GO:0030296)
0.2 6.9 GO:0031624 ubiquitin conjugating enzyme binding(GO:0031624)
0.2 2.8 GO:0016018 cyclosporin A binding(GO:0016018)
0.2 2.7 GO:0030957 Tat protein binding(GO:0030957)
0.2 12.5 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.2 7.7 GO:0043022 ribosome binding(GO:0043022)
0.2 0.7 GO:0004594 pantothenate kinase activity(GO:0004594)
0.2 26.5 GO:0047485 protein N-terminus binding(GO:0047485)
0.2 0.6 GO:0016639 oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor(GO:0016639)
0.2 1.5 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.1 7.3 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 2.4 GO:0017166 vinculin binding(GO:0017166)
0.1 4.4 GO:0044183 protein binding involved in protein folding(GO:0044183)
0.1 12.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.1 3.6 GO:0035255 ionotropic glutamate receptor binding(GO:0035255)
0.1 1.2 GO:0051434 BH3 domain binding(GO:0051434)
0.1 10.5 GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811)
0.1 1.0 GO:0030911 TPR domain binding(GO:0030911)
0.1 2.2 GO:0008483 transaminase activity(GO:0008483)
0.1 1.8 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.1 11.8 GO:0003697 single-stranded DNA binding(GO:0003697)
0.1 3.4 GO:0042805 actinin binding(GO:0042805)
0.1 4.6 GO:0043621 protein self-association(GO:0043621)
0.1 15.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.8 GO:0042379 chemokine receptor binding(GO:0042379)
0.1 0.6 GO:0051525 NFAT protein binding(GO:0051525)
0.1 2.5 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.1 5.7 GO:0051082 unfolded protein binding(GO:0051082)
0.1 3.6 GO:0019905 syntaxin binding(GO:0019905)
0.0 0.5 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.0 1.0 GO:0070300 phosphatidic acid binding(GO:0070300)
0.0 1.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.9 GO:0005112 Notch binding(GO:0005112)
0.0 3.9 GO:0032947 protein complex scaffold(GO:0032947)
0.0 3.4 GO:0008276 protein methyltransferase activity(GO:0008276)
0.0 24.4 GO:0005509 calcium ion binding(GO:0005509)
0.0 12.9 GO:0005198 structural molecule activity(GO:0005198)
0.0 9.2 GO:0003924 GTPase activity(GO:0003924)
0.0 1.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 3.4 GO:0020037 heme binding(GO:0020037)
0.0 2.0 GO:0019888 protein phosphatase regulator activity(GO:0019888)
0.0 1.9 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 2.2 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 25.9 PID ALK2 PATHWAY ALK2 signaling events
0.7 72.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.7 20.2 PID ALK1 PATHWAY ALK1 signaling events
0.6 20.5 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
0.5 16.1 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.5 11.2 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.4 9.6 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
0.3 19.8 PID AURORA B PATHWAY Aurora B signaling
0.3 65.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.3 8.3 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
0.3 6.9 PID ARF 3PATHWAY Arf1 pathway
0.2 4.3 PID VEGF VEGFR PATHWAY VEGF and VEGFR signaling network
0.2 12.8 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.2 2.9 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 3.6 PID S1P S1P1 PATHWAY S1P1 pathway
0.1 4.3 PID WNT SIGNALING PATHWAY Wnt signaling network
0.1 11.8 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.1 5.8 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.0 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.1 3.6 SIG PIP3 SIGNALING IN B LYMPHOCYTES Genes related to PIP3 signaling in B lymphocytes
0.1 2.7 PID LYSOPHOSPHOLIPID PATHWAY LPA receptor mediated events
0.0 2.0 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 0.9 PID ARF6 PATHWAY Arf6 signaling events
0.0 3.4 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 16.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
1.3 19.9 REACTOME GAMMA CARBOXYLATION TRANSPORT AND AMINO TERMINAL CLEAVAGE OF PROTEINS Genes involved in Gamma-carboxylation, transport, and amino-terminal cleavage of proteins
1.1 13.2 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
1.1 25.9 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
1.0 15.6 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
0.9 23.3 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.8 24.4 REACTOME EXTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Extrinsic Pathway for Apoptosis
0.7 21.2 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
0.6 17.6 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
0.6 8.9 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
0.5 15.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
0.5 14.9 REACTOME SEMA3A PAK DEPENDENT AXON REPULSION Genes involved in Sema3A PAK dependent Axon repulsion
0.5 20.8 REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE Genes involved in Sema4D induced cell migration and growth-cone collapse
0.5 13.0 REACTOME CONVERSION FROM APC C CDC20 TO APC C CDH1 IN LATE ANAPHASE Genes involved in Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
0.4 7.2 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.4 28.3 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.4 10.0 REACTOME INTRINSIC PATHWAY FOR APOPTOSIS Genes involved in Intrinsic Pathway for Apoptosis
0.4 13.1 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.4 2.9 REACTOME INHIBITION OF REPLICATION INITIATION OF DAMAGED DNA BY RB1 E2F1 Genes involved in Inhibition of replication initiation of damaged DNA by RB1/E2F1
0.3 48.9 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.3 18.2 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.2 19.4 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.2 15.8 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.2 21.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 3.1 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.2 14.2 REACTOME ER PHAGOSOME PATHWAY Genes involved in ER-Phagosome pathway
0.1 4.9 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.1 3.1 REACTOME PURINE SALVAGE Genes involved in Purine salvage
0.1 4.2 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.1 3.7 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.1 10.0 REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING Genes involved in p75 NTR receptor-mediated signalling
0.1 4.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 11.2 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 7.3 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.1 4.1 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.1 8.4 REACTOME CELL JUNCTION ORGANIZATION Genes involved in Cell junction organization
0.1 7.6 REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE Genes involved in SRP-dependent cotranslational protein targeting to membrane
0.1 3.7 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.1 0.7 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
0.0 1.9 REACTOME VOLTAGE GATED POTASSIUM CHANNELS Genes involved in Voltage gated Potassium channels
0.0 2.2 REACTOME PPARA ACTIVATES GENE EXPRESSION Genes involved in PPARA Activates Gene Expression
0.0 0.5 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.0 0.8 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import