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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UAAGACU

Z-value: 0.32

Motif logo

logo of

miRNA associated with seed UAAGACU

NamemiRBASE accession
hsa-miR-499a-5p
MIMAT0002870

Activity profile of UAAGACU motif

Sorted Z-values of UAAGACU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr7_-_139876812 2.68 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr3_-_18466787 2.51 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr3_+_43328004 1.98 ENST00000454177.1
ENST00000429705.2
ENST00000296088.7
ENST00000437827.1
SNRK
SNF related kinase
chr8_+_56014949 1.75 ENST00000327381.6
XKR4
XK, Kell blood group complex subunit-related family, member 4
chr6_-_99797522 1.62 ENST00000389677.5
FAXC
failed axon connections homolog (Drosophila)
chr10_+_112631547 1.57 ENST00000280154.7
ENST00000393104.2
PDCD4
programmed cell death 4 (neoplastic transformation inhibitor)
chrX_+_16737718 1.55 ENST00000380155.3
SYAP1
synapse associated protein 1
chrY_+_15016725 1.51 ENST00000336079.3
DDX3Y
DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked
chr14_-_99737565 1.41 ENST00000357195.3
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr8_+_38614807 1.41 ENST00000330691.6
ENST00000348567.4
TACC1
transforming, acidic coiled-coil containing protein 1
chr6_+_72596604 1.32 ENST00000348717.5
ENST00000517960.1
ENST00000518273.1
ENST00000522291.1
ENST00000521978.1
ENST00000520567.1
ENST00000264839.7
RIMS1
regulating synaptic membrane exocytosis 1
chr13_+_50571155 1.30 ENST00000420995.2
ENST00000378182.3
ENST00000356017.4
ENST00000457662.2
TRIM13
tripartite motif containing 13
chr5_+_55033845 1.24 ENST00000353507.5
ENST00000514278.2
ENST00000505374.1
ENST00000506511.1
DDX4
DEAD (Asp-Glu-Ala-Asp) box polypeptide 4
chr5_-_131132614 1.11 ENST00000307968.7
ENST00000307954.8
FNIP1
folliculin interacting protein 1
chr1_-_108507631 1.03 ENST00000527011.1
ENST00000370056.4
VAV3
vav 3 guanine nucleotide exchange factor
chr5_-_79287060 0.94 ENST00000512560.1
ENST00000509852.1
ENST00000512528.1
MTX3
metaxin 3
chr2_+_120517174 0.93 ENST00000263708.2
PTPN4
protein tyrosine phosphatase, non-receptor type 4 (megakaryocyte)
chr1_-_16678914 0.88 ENST00000375592.3
FBXO42
F-box protein 42
chr7_+_138916231 0.85 ENST00000473989.3
ENST00000288561.8
UBN2
ubinuclein 2
chr14_-_50698276 0.82 ENST00000216373.5
SOS2
son of sevenless homolog 2 (Drosophila)
chr7_-_105029329 0.79 ENST00000393651.3
ENST00000460391.1
SRPK2
SRSF protein kinase 2
chr9_+_82186872 0.71 ENST00000376544.3
ENST00000376520.4
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr7_+_65338230 0.67 ENST00000360768.3
VKORC1L1
vitamin K epoxide reductase complex, subunit 1-like 1
chr13_-_107220455 0.63 ENST00000400198.3
ARGLU1
arginine and glutamate rich 1
chr3_+_186501336 0.62 ENST00000323963.5
ENST00000440191.2
ENST00000356531.5
EIF4A2
eukaryotic translation initiation factor 4A2
chr8_+_42752053 0.60 ENST00000307602.4
HOOK3
hook microtubule-tethering protein 3
chr2_-_86564776 0.59 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
REEP1
receptor accessory protein 1
chr15_-_64648273 0.55 ENST00000607537.1
ENST00000303052.7
ENST00000303032.6
CSNK1G1
casein kinase 1, gamma 1
chr3_-_15374033 0.54 ENST00000253688.5
ENST00000383791.3
SH3BP5
SH3-domain binding protein 5 (BTK-associated)
chr8_+_11561660 0.53 ENST00000526716.1
ENST00000335135.4
ENST00000528027.1
GATA4
GATA binding protein 4
chr6_+_21593972 0.52 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr1_-_154842741 0.51 ENST00000271915.4
KCNN3
potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3
chr9_-_23821273 0.51 ENST00000380110.4
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr10_+_63661053 0.51 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr6_-_13711773 0.50 ENST00000011619.3
RANBP9
RAN binding protein 9
chr17_+_58677539 0.50 ENST00000305921.3
PPM1D
protein phosphatase, Mg2+/Mn2+ dependent, 1D
chr14_+_105781048 0.46 ENST00000458164.2
ENST00000447393.1
PACS2
phosphofurin acidic cluster sorting protein 2
chr11_-_128392085 0.40 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr12_-_42538657 0.40 ENST00000398675.3
GXYLT1
glucoside xylosyltransferase 1
chr8_+_58907104 0.39 ENST00000361488.3
FAM110B
family with sequence similarity 110, member B
chr17_+_29718642 0.38 ENST00000325874.8
RAB11FIP4
RAB11 family interacting protein 4 (class II)
chr2_-_208030647 0.38 ENST00000309446.6
KLF7
Kruppel-like factor 7 (ubiquitous)
chr3_-_72496035 0.34 ENST00000477973.2
RYBP
RING1 and YY1 binding protein
chr5_+_112312416 0.34 ENST00000389063.2
DCP2
decapping mRNA 2
chr19_-_7293942 0.33 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr6_+_37225540 0.32 ENST00000373491.3
TBC1D22B
TBC1 domain family, member 22B
chr20_+_51588873 0.32 ENST00000371497.5
TSHZ2
teashirt zinc finger homeobox 2
chr9_+_101867359 0.30 ENST00000374994.4
TGFBR1
transforming growth factor, beta receptor 1
chr12_+_68042495 0.29 ENST00000344096.3
DYRK2
dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 2
chr17_-_62050278 0.28 ENST00000578147.1
ENST00000435607.1
SCN4A
sodium channel, voltage-gated, type IV, alpha subunit
chr17_-_73775839 0.24 ENST00000592643.1
ENST00000591890.1
ENST00000587171.1
ENST00000254810.4
ENST00000589599.1
H3F3B
H3 histone, family 3B (H3.3B)
chr15_+_101142722 0.24 ENST00000332783.7
ENST00000558747.1
ENST00000343276.4
ASB7
ankyrin repeat and SOCS box containing 7
chr6_+_133562472 0.23 ENST00000430974.2
ENST00000367895.5
ENST00000355167.3
ENST00000355286.6
EYA4
eyes absent homolog 4 (Drosophila)
chr11_-_86666427 0.23 ENST00000531380.1
FZD4
frizzled family receptor 4
chr14_-_61116168 0.22 ENST00000247182.6
SIX1
SIX homeobox 1
chr15_-_45815005 0.22 ENST00000261867.4
SLC30A4
solute carrier family 30 (zinc transporter), member 4
chr4_+_139936905 0.21 ENST00000280614.2
CCRN4L
CCR4 carbon catabolite repression 4-like (S. cerevisiae)
chr2_+_228029281 0.21 ENST00000396578.3
COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
chr12_-_93323013 0.20 ENST00000322349.8
EEA1
early endosome antigen 1
chr2_+_176987088 0.18 ENST00000249499.6
HOXD9
homeobox D9
chr1_+_97187318 0.17 ENST00000609116.1
ENST00000370198.1
ENST00000370197.1
ENST00000426398.2
ENST00000394184.3
PTBP2
polypyrimidine tract binding protein 2
chr17_-_45266542 0.17 ENST00000531206.1
ENST00000527547.1
ENST00000446365.2
ENST00000575483.1
ENST00000066544.3
CDC27
cell division cycle 27
chr8_-_67579418 0.16 ENST00000310421.4
VCPIP1
valosin containing protein (p97)/p47 complex interacting protein 1
chr16_+_54964740 0.16 ENST00000394636.4
IRX5
iroquois homeobox 5
chr8_-_89339705 0.15 ENST00000286614.6
MMP16
matrix metallopeptidase 16 (membrane-inserted)
chr2_+_176981307 0.15 ENST00000249501.4
HOXD10
homeobox D10
chr2_+_42396472 0.14 ENST00000318522.5
ENST00000402711.2
EML4
echinoderm microtubule associated protein like 4
chr9_-_19786926 0.13 ENST00000341998.2
ENST00000286344.3
SLC24A2
solute carrier family 24 (sodium/potassium/calcium exchanger), member 2
chr1_-_21113105 0.13 ENST00000375000.1
ENST00000419490.1
ENST00000414993.1
ENST00000443615.1
ENST00000312239.5
HP1BP3
heterochromatin protein 1, binding protein 3
chr1_+_36396677 0.13 ENST00000373191.4
ENST00000397828.2
AGO3
argonaute RISC catalytic component 3
chr3_+_29322803 0.12 ENST00000396583.3
ENST00000383767.2
RBMS3
RNA binding motif, single stranded interacting protein 3
chr15_-_56535464 0.12 ENST00000559447.2
ENST00000422057.1
ENST00000317318.6
ENST00000423270.1
RFX7
regulatory factor X, 7
chr17_-_5389477 0.11 ENST00000572834.1
ENST00000570848.1
ENST00000571971.1
ENST00000158771.4
DERL2
derlin 2
chr22_+_21771656 0.11 ENST00000407464.2
HIC2
hypermethylated in cancer 2
chr7_-_44924939 0.11 ENST00000395699.2
PURB
purine-rich element binding protein B
chr2_-_71454185 0.11 ENST00000244221.8
PAIP2B
poly(A) binding protein interacting protein 2B
chr5_+_122110691 0.10 ENST00000379516.2
ENST00000505934.1
ENST00000514949.1
SNX2
sorting nexin 2
chr3_-_15563229 0.10 ENST00000383786.5
ENST00000383787.2
ENST00000383785.2
ENST00000383788.5
ENST00000603808.1
COLQ
collagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterase
chr17_+_38219063 0.10 ENST00000584985.1
ENST00000264637.4
ENST00000450525.2
THRA
thyroid hormone receptor, alpha
chr22_-_46933067 0.10 ENST00000262738.3
ENST00000395964.1
CELSR1
cadherin, EGF LAG seven-pass G-type receptor 1
chr5_-_76788317 0.09 ENST00000296679.4
WDR41
WD repeat domain 41
chr10_-_27149792 0.09 ENST00000376140.3
ENST00000376170.4
ABI1
abl-interactor 1
chr1_-_159684371 0.06 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
CRP
C-reactive protein, pentraxin-related
chr13_+_102104980 0.05 ENST00000545560.2
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_+_163835669 0.04 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI
QKI, KH domain containing, RNA binding
chrX_+_41192595 0.03 ENST00000399959.2
DDX3X
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr22_+_30279144 0.03 ENST00000401950.2
ENST00000333027.3
ENST00000445401.1
ENST00000323630.5
ENST00000351488.3
MTMR3
myotubularin related protein 3
chr3_+_89156674 0.02 ENST00000336596.2
EPHA3
EPH receptor A3
chr17_-_60142609 0.02 ENST00000397786.2
MED13
mediator complex subunit 13
chr1_+_50574585 0.00 ENST00000371824.1
ENST00000371823.4
ELAVL4
ELAV like neuron-specific RNA binding protein 4

Network of associatons between targets according to the STRING database.

First level regulatory network of UAAGACU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0060940 epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940)
0.4 1.4 GO:0021773 striatal medium spiny neuron differentiation(GO:0021773)
0.3 1.1 GO:0002904 positive regulation of B cell apoptotic process(GO:0002904)
0.2 1.0 GO:0003289 atrial septum primum morphogenesis(GO:0003289)
0.2 0.8 GO:0035063 nuclear speck organization(GO:0035063)
0.2 2.5 GO:0043374 CD8-positive, alpha-beta T cell differentiation(GO:0043374)
0.2 1.2 GO:0034587 piRNA metabolic process(GO:0034587)
0.2 0.6 GO:0022027 interkinetic nuclear migration(GO:0022027)
0.1 0.3 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)
0.1 0.4 GO:0030578 PML body organization(GO:0030578)
0.1 0.3 GO:1905075 proepicardium development(GO:0003342) septum transversum development(GO:0003343) occluding junction disassembly(GO:1905071) regulation of occluding junction disassembly(GO:1905073) positive regulation of occluding junction disassembly(GO:1905075)
0.1 0.2 GO:2000729 myotome development(GO:0061055) positive regulation of mesenchymal cell proliferation involved in ureter development(GO:2000729)
0.1 1.3 GO:0098828 positive regulation of inhibitory postsynaptic potential(GO:0097151) modulation of inhibitory postsynaptic potential(GO:0098828)
0.1 1.3 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.1 0.7 GO:0042373 vitamin K metabolic process(GO:0042373)
0.1 0.3 GO:0051534 negative regulation of NFAT protein import into nucleus(GO:0051534)
0.1 0.2 GO:0061304 extracellular matrix-cell signaling(GO:0035426) progesterone secretion(GO:0042701) retinal blood vessel morphogenesis(GO:0061304)
0.0 0.3 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
0.0 2.3 GO:0010501 RNA secondary structure unwinding(GO:0010501)
0.0 0.2 GO:0061088 regulation of sequestering of zinc ion(GO:0061088)
0.0 0.2 GO:0060040 retinal bipolar neuron differentiation(GO:0060040)
0.0 0.6 GO:0071786 endoplasmic reticulum tubular network organization(GO:0071786)
0.0 0.4 GO:0070314 G1 to G0 transition(GO:0070314)
0.0 0.1 GO:0045925 female courtship behavior(GO:0008050) positive regulation of female receptivity(GO:0045925)
0.0 0.1 GO:0060448 dichotomous subdivision of terminal units involved in lung branching(GO:0060448)
0.0 0.5 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.0 0.5 GO:0034497 protein localization to pre-autophagosomal structure(GO:0034497)
0.0 0.1 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.1 GO:0008582 regulation of synaptic growth at neuromuscular junction(GO:0008582)
0.0 0.2 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.9 GO:0043552 positive regulation of phosphatidylinositol 3-kinase activity(GO:0043552)
0.0 0.5 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
0.0 0.3 GO:0035518 histone H2A monoubiquitination(GO:0035518)
0.0 0.2 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0038063 collagen-activated tyrosine kinase receptor signaling pathway(GO:0038063)
0.0 0.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.0 0.5 GO:0016577 histone demethylation(GO:0016577)
0.0 0.5 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.7 GO:1904837 beta-catenin-TCF complex assembly(GO:1904837)
0.0 0.8 GO:0051057 positive regulation of small GTPase mediated signal transduction(GO:0051057)
0.0 1.4 GO:0021987 cerebral cortex development(GO:0021987)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.2 GO:0071546 pi-body(GO:0071546)
0.2 0.6 GO:0070695 FHF complex(GO:0070695)
0.1 1.3 GO:0097038 perinuclear endoplasmic reticulum(GO:0097038)
0.1 0.3 GO:0005899 insulin receptor complex(GO:0005899)
0.1 2.5 GO:0005720 nuclear heterochromatin(GO:0005720)
0.0 0.2 GO:0044308 axonal spine(GO:0044308)
0.0 0.3 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 0.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
0.0 0.6 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
0.0 0.5 GO:0031332 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 1.3 GO:0048786 presynaptic active zone(GO:0048786)
0.0 0.2 GO:0005587 collagen type IV trimer(GO:0005587)
0.0 0.1 GO:0030905 retromer, tubulation complex(GO:0030905)
0.0 0.1 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.1 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.2 0.7 GO:0016900 oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor(GO:0016900) vitamin-K-epoxide reductase (warfarin-sensitive) activity(GO:0047057)
0.1 1.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.1 0.5 GO:0016286 small conductance calcium-activated potassium channel activity(GO:0016286)
0.1 0.4 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 0.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.0 0.5 GO:0051525 NFAT protein binding(GO:0051525)
0.0 3.4 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 1.0 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.3 GO:0043559 insulin binding(GO:0043559)
0.0 0.3 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
0.0 1.1 GO:0071889 14-3-3 protein binding(GO:0071889)
0.0 0.3 GO:0005025 transforming growth factor beta receptor activity, type I(GO:0005025)
0.0 0.6 GO:0051959 dynein light intermediate chain binding(GO:0051959)
0.0 0.1 GO:0008273 calcium, potassium:sodium antiporter activity(GO:0008273)
0.0 0.2 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.4 GO:0030306 ADP-ribosylation factor binding(GO:0030306)
0.0 0.1 GO:1990460 leptin receptor binding(GO:1990460)
0.0 0.5 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.1 GO:0033265 choline binding(GO:0033265)
0.0 0.2 GO:0001223 transcription coactivator binding(GO:0001223)
0.0 0.2 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.5 GO:0051019 mitogen-activated protein kinase binding(GO:0051019)
0.0 0.8 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.5 GO:0008536 Ran GTPase binding(GO:0008536)
0.0 0.1 GO:0070324 thyroid hormone binding(GO:0070324)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 0.8 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.0 1.4 PID AURORA A PATHWAY Aurora A signaling
0.0 2.5 PID CASPASE PATHWAY Caspase cascade in apoptosis
0.0 0.5 PID WNT CANONICAL PATHWAY Canonical Wnt signaling pathway
0.0 1.6 PID MTOR 4PATHWAY mTOR signaling pathway
0.0 0.3 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 0.9 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)
0.0 0.3 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.0 0.8 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 0.5 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 2.5 REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS Genes involved in Apoptotic cleavage of cellular proteins
0.0 0.3 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
0.0 1.0 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.0 0.6 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
0.0 0.3 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.4 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.7 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription