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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UCCCUUU

Z-value: 0.35

Motif logo

logo of

miRNA associated with seed UCCCUUU

NamemiRBASE accession
hsa-miR-204-5p
MIMAT0000265
hsa-miR-211-5p
MIMAT0000268

Activity profile of UCCCUUU motif

Sorted Z-values of UCCCUUU motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_66217911 2.38 ENST00000403681.2
HMGA2
high mobility group AT-hook 2
chr12_-_109125285 2.35 ENST00000552871.1
ENST00000261401.3
CORO1C
coronin, actin binding protein, 1C
chr1_-_70671216 2.15 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr13_+_98605902 2.07 ENST00000460070.1
ENST00000481455.1
ENST00000261574.5
ENST00000493281.1
ENST00000463157.1
ENST00000471898.1
ENST00000489058.1
ENST00000481689.1
IPO5
importin 5
chrX_-_20284958 2.04 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr11_-_6704513 1.89 ENST00000532203.1
ENST00000288937.6
MRPL17
mitochondrial ribosomal protein L17
chr7_+_56019486 1.73 ENST00000446692.1
ENST00000285298.4
ENST00000443449.1
GBAS
MRPS17
glioblastoma amplified sequence
mitochondrial ribosomal protein S17
chr1_-_154943212 1.49 ENST00000368445.5
ENST00000448116.2
ENST00000368449.4
SHC1
SHC (Src homology 2 domain containing) transforming protein 1
chr7_+_100797678 1.40 ENST00000337619.5
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr6_+_160390102 1.37 ENST00000356956.1
IGF2R
insulin-like growth factor 2 receptor
chr6_-_159239257 1.36 ENST00000337147.7
ENST00000392177.4
EZR
ezrin
chr4_-_111119804 1.36 ENST00000394607.3
ENST00000302274.3
ELOVL6
ELOVL fatty acid elongase 6
chr15_-_75230478 1.22 ENST00000322347.6
COX5A
cytochrome c oxidase subunit Va
chr11_+_63706444 1.12 ENST00000377793.4
ENST00000456907.2
ENST00000539656.1
NAA40
N(alpha)-acetyltransferase 40, NatD catalytic subunit
chr15_+_57210818 1.12 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr3_+_61547585 1.11 ENST00000295874.10
ENST00000474889.1
PTPRG
protein tyrosine phosphatase, receptor type, G
chr13_-_31736027 1.09 ENST00000380406.5
ENST00000320027.5
ENST00000380405.4
HSPH1
heat shock 105kDa/110kDa protein 1
chrX_+_28605516 1.02 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr19_+_34919257 1.02 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr8_-_122653630 1.01 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr6_+_15246501 1.00 ENST00000341776.2
JARID2
jumonji, AT rich interactive domain 2
chr2_+_201676256 0.99 ENST00000452206.1
ENST00000410110.2
ENST00000409600.1
BZW1
basic leucine zipper and W2 domains 1
chr16_+_67063036 0.95 ENST00000290858.6
ENST00000564034.1
CBFB
core-binding factor, beta subunit
chr10_+_60144782 0.95 ENST00000487519.1
TFAM
transcription factor A, mitochondrial
chr6_-_90062543 0.94 ENST00000435041.2
UBE2J1
ubiquitin-conjugating enzyme E2, J1
chr6_-_86352642 0.88 ENST00000355238.6
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr6_-_8102714 0.85 ENST00000502429.1
ENST00000429723.2
ENST00000507463.1
ENST00000379715.5
EEF1E1
eukaryotic translation elongation factor 1 epsilon 1
chr16_-_20911641 0.85 ENST00000564349.1
ENST00000324344.4
ERI2
DCUN1D3
ERI1 exoribonuclease family member 2
DCN1, defective in cullin neddylation 1, domain containing 3
chr2_-_200322723 0.83 ENST00000417098.1
SATB2
SATB homeobox 2
chr2_-_152684977 0.75 ENST00000428992.2
ENST00000295087.8
ARL5A
ADP-ribosylation factor-like 5A
chr12_+_4430371 0.75 ENST00000179259.4
C12orf5
chromosome 12 open reading frame 5
chr3_+_5229356 0.75 ENST00000256497.4
EDEM1
ER degradation enhancer, mannosidase alpha-like 1
chr4_+_99916765 0.72 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chr3_+_152017181 0.72 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr2_-_105946491 0.71 ENST00000393359.2
TGFBRAP1
transforming growth factor, beta receptor associated protein 1
chr2_+_208394616 0.69 ENST00000432329.2
ENST00000353267.3
ENST00000445803.1
CREB1
cAMP responsive element binding protein 1
chr1_+_65613217 0.68 ENST00000545314.1
AK4
adenylate kinase 4
chrX_+_70752917 0.67 ENST00000373719.3
OGT
O-linked N-acetylglucosamine (GlcNAc) transferase
chr9_+_112810878 0.66 ENST00000434623.2
ENST00000374525.1
AKAP2
A kinase (PRKA) anchor protein 2
chr7_+_138145076 0.66 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr6_+_7107999 0.64 ENST00000491191.1
ENST00000379938.2
ENST00000471433.1
RREB1
ras responsive element binding protein 1
chr4_-_23891693 0.61 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr11_-_57283159 0.61 ENST00000533263.1
ENST00000278426.3
SLC43A1
solute carrier family 43 (amino acid system L transporter), member 1
chr3_+_155588300 0.61 ENST00000496455.2
GMPS
guanine monphosphate synthase
chr17_-_66287257 0.60 ENST00000327268.4
SLC16A6
solute carrier family 16, member 6
chr2_+_96931834 0.59 ENST00000488633.1
CIAO1
cytosolic iron-sulfur protein assembly 1
chr7_-_127983877 0.59 ENST00000415472.2
ENST00000478061.1
ENST00000223073.2
ENST00000459726.1
RBM28
RNA binding motif protein 28
chr9_+_112542572 0.59 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr14_+_57735614 0.57 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr15_+_41523335 0.57 ENST00000334660.5
CHP1
calcineurin-like EF-hand protein 1
chr4_-_66536057 0.56 ENST00000273854.3
EPHA5
EPH receptor A5
chr8_-_57123815 0.54 ENST00000316981.3
ENST00000423799.2
ENST00000429357.2
PLAG1
pleiomorphic adenoma gene 1
chr22_+_40573921 0.54 ENST00000454349.2
ENST00000335727.9
TNRC6B
trinucleotide repeat containing 6B
chr12_+_27485823 0.52 ENST00000395901.2
ENST00000546179.1
ARNTL2
aryl hydrocarbon receptor nuclear translocator-like 2
chr20_+_56884752 0.51 ENST00000244040.3
RAB22A
RAB22A, member RAS oncogene family
chr1_+_90286562 0.50 ENST00000525774.1
ENST00000337338.5
LRRC8D
leucine rich repeat containing 8 family, member D
chr3_+_30648066 0.49 ENST00000359013.4
TGFBR2
transforming growth factor, beta receptor II (70/80kDa)
chr6_+_21593972 0.48 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chrX_-_131352152 0.48 ENST00000342983.2
RAP2C
RAP2C, member of RAS oncogene family
chr17_+_55162453 0.48 ENST00000575322.1
ENST00000337714.3
ENST00000314126.3
AKAP1
A kinase (PRKA) anchor protein 1
chr22_-_42017021 0.47 ENST00000263256.6
DESI1
desumoylating isopeptidase 1
chr1_+_193091080 0.46 ENST00000367435.3
CDC73
cell division cycle 73
chr3_-_138553594 0.45 ENST00000477593.1
ENST00000483968.1
PIK3CB
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
chr5_-_142783175 0.42 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr7_-_32529973 0.42 ENST00000410044.1
ENST00000409987.1
ENST00000409782.1
ENST00000450169.2
LSM5
LSM5 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr3_+_169940153 0.42 ENST00000295797.4
PRKCI
protein kinase C, iota
chrX_-_110655391 0.41 ENST00000356915.2
ENST00000356220.3
DCX
doublecortin
chr3_+_33155444 0.41 ENST00000320954.6
CRTAP
cartilage associated protein
chr11_+_34073195 0.39 ENST00000341394.4
CAPRIN1
cell cycle associated protein 1
chr2_-_68479614 0.39 ENST00000234310.3
PPP3R1
protein phosphatase 3, regulatory subunit B, alpha
chr7_+_107220422 0.39 ENST00000005259.4
BCAP29
B-cell receptor-associated protein 29
chr11_+_71498552 0.39 ENST00000346333.6
ENST00000359244.4
ENST00000426628.2
FAM86C1
family with sequence similarity 86, member C1
chr17_+_30469473 0.38 ENST00000333942.6
ENST00000358365.3
ENST00000583994.1
ENST00000545287.2
RHOT1
ras homolog family member T1
chr3_+_132136331 0.38 ENST00000260818.6
DNAJC13
DnaJ (Hsp40) homolog, subfamily C, member 13
chr2_-_131850951 0.38 ENST00000409185.1
ENST00000389915.3
FAM168B
family with sequence similarity 168, member B
chr4_-_68566832 0.37 ENST00000420827.2
ENST00000322244.5
UBA6
ubiquitin-like modifier activating enzyme 6
chr6_-_16761678 0.36 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr11_+_114270752 0.35 ENST00000540163.1
RBM7
RNA binding motif protein 7
chr15_+_52121822 0.35 ENST00000558455.1
ENST00000308580.7
TMOD3
tropomodulin 3 (ubiquitous)
chr5_+_95066823 0.35 ENST00000506817.1
ENST00000379982.3
RHOBTB3
Rho-related BTB domain containing 3
chr8_-_101965146 0.34 ENST00000395957.2
ENST00000395948.2
ENST00000457309.1
YWHAZ
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta
chr3_-_189838670 0.33 ENST00000319332.5
LEPREL1
leprecan-like 1
chr12_+_4382917 0.33 ENST00000261254.3
CCND2
cyclin D2
chr6_+_10556215 0.32 ENST00000316170.3
GCNT2
glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr17_-_79885576 0.30 ENST00000574686.1
ENST00000357736.4
MAFG
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog G
chr6_-_52441713 0.30 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr1_+_36348790 0.29 ENST00000373204.4
AGO1
argonaute RISC catalytic component 1
chrX_-_119694538 0.29 ENST00000371322.5
CUL4B
cullin 4B
chr11_-_75062730 0.28 ENST00000420843.2
ENST00000360025.3
ARRB1
arrestin, beta 1
chr18_+_49866496 0.28 ENST00000442544.2
DCC
deleted in colorectal carcinoma
chr5_-_127873659 0.28 ENST00000262464.4
FBN2
fibrillin 2
chr10_-_81965307 0.27 ENST00000537102.1
ENST00000372231.3
ENST00000438331.1
ENST00000422982.3
ENST00000360615.4
ENST00000265447.4
ANXA11
annexin A11
chr2_-_172017343 0.27 ENST00000431350.2
ENST00000360843.3
TLK1
tousled-like kinase 1
chr4_-_41750922 0.27 ENST00000226382.2
PHOX2B
paired-like homeobox 2b
chrX_-_15872914 0.26 ENST00000380291.1
ENST00000545766.1
ENST00000421527.2
ENST00000329235.2
AP1S2
adaptor-related protein complex 1, sigma 2 subunit
chr10_+_72575643 0.25 ENST00000373202.3
SGPL1
sphingosine-1-phosphate lyase 1
chr3_-_100120223 0.25 ENST00000284320.5
TOMM70A
translocase of outer mitochondrial membrane 70 homolog A (S. cerevisiae)
chr21_-_15755446 0.25 ENST00000544452.1
ENST00000285667.3
HSPA13
heat shock protein 70kDa family, member 13
chr1_+_32479430 0.25 ENST00000327300.7
ENST00000492989.1
KHDRBS1
KH domain containing, RNA binding, signal transduction associated 1
chr1_-_39325431 0.24 ENST00000373001.3
RRAGC
Ras-related GTP binding C
chr10_+_88516396 0.23 ENST00000372037.3
BMPR1A
bone morphogenetic protein receptor, type IA
chr10_+_93683519 0.23 ENST00000265990.6
BTAF1
BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa
chr1_+_2160134 0.23 ENST00000378536.4
SKI
v-ski avian sarcoma viral oncogene homolog
chr10_-_121356007 0.23 ENST00000369093.2
ENST00000436547.2
TIAL1
TIA1 cytotoxic granule-associated RNA binding protein-like 1
chr13_+_50571155 0.23 ENST00000420995.2
ENST00000378182.3
ENST00000356017.4
ENST00000457662.2
TRIM13
tripartite motif containing 13
chr3_-_52312636 0.22 ENST00000296490.3
WDR82
WD repeat domain 82
chr5_+_65222299 0.22 ENST00000284037.5
ERBB2IP
erbb2 interacting protein
chrX_+_49687216 0.21 ENST00000376088.3
CLCN5
chloride channel, voltage-sensitive 5
chr11_-_27494279 0.21 ENST00000379214.4
LGR4
leucine-rich repeat containing G protein-coupled receptor 4
chr6_+_50786414 0.21 ENST00000344788.3
ENST00000393655.3
ENST00000263046.4
TFAP2B
transcription factor AP-2 beta (activating enhancer binding protein 2 beta)
chr7_+_94285637 0.20 ENST00000482108.1
ENST00000488574.1
PEG10
paternally expressed 10
chr16_-_89007491 0.19 ENST00000327483.5
ENST00000564416.1
CBFA2T3
core-binding factor, runt domain, alpha subunit 2; translocated to, 3
chr1_+_147013182 0.19 ENST00000234739.3
BCL9
B-cell CLL/lymphoma 9
chr5_-_66492562 0.18 ENST00000256447.4
CD180
CD180 molecule
chr18_-_60987220 0.18 ENST00000398117.1
BCL2
B-cell CLL/lymphoma 2
chrX_-_111326004 0.17 ENST00000262839.2
TRPC5
transient receptor potential cation channel, subfamily C, member 5
chr3_+_11314099 0.17 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr3_+_183873098 0.17 ENST00000313143.3
DVL3
dishevelled segment polarity protein 3
chrX_-_24690771 0.15 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr7_+_145813453 0.14 ENST00000361727.3
CNTNAP2
contactin associated protein-like 2
chr12_-_123011536 0.14 ENST00000331738.7
ENST00000354654.2
RSRC2
arginine/serine-rich coiled-coil 2
chr16_+_68119440 0.14 ENST00000346183.3
ENST00000329524.4
NFATC3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3
chr6_+_99282570 0.13 ENST00000328345.5
POU3F2
POU class 3 homeobox 2
chr11_+_111957497 0.13 ENST00000375549.3
ENST00000528182.1
ENST00000528048.1
ENST00000528021.1
ENST00000526592.1
ENST00000525291.1
SDHD
succinate dehydrogenase complex, subunit D, integral membrane protein
chr12_-_57030115 0.11 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr16_-_71758602 0.11 ENST00000568954.1
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr7_+_28452130 0.11 ENST00000357727.2
CREB5
cAMP responsive element binding protein 5
chr1_-_22469459 0.11 ENST00000290167.6
WNT4
wingless-type MMTV integration site family, member 4
chr8_-_42751820 0.11 ENST00000526349.1
ENST00000527424.1
ENST00000534961.1
ENST00000319073.4
RNF170
ring finger protein 170
chr2_+_109335929 0.11 ENST00000283195.6
RANBP2
RAN binding protein 2
chr1_+_154377669 0.10 ENST00000368485.3
ENST00000344086.4
IL6R
interleukin 6 receptor
chr2_+_192542850 0.10 ENST00000410026.2
NABP1
nucleic acid binding protein 1
chr9_-_20622478 0.10 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr4_-_85887503 0.10 ENST00000509172.1
ENST00000322366.6
ENST00000295888.4
ENST00000502713.1
WDFY3
WD repeat and FYVE domain containing 3
chr16_-_73082274 0.09 ENST00000268489.5
ZFHX3
zinc finger homeobox 3
chr3_+_88188254 0.09 ENST00000309495.5
ZNF654
zinc finger protein 654
chr6_-_94129244 0.08 ENST00000369303.4
ENST00000369297.1
EPHA7
EPH receptor A7
chr22_-_37099555 0.08 ENST00000300105.6
CACNG2
calcium channel, voltage-dependent, gamma subunit 2
chr8_-_17270809 0.08 ENST00000180173.5
ENST00000521857.1
MTMR7
myotubularin related protein 7
chr4_-_140098339 0.08 ENST00000394235.2
ELF2
E74-like factor 2 (ets domain transcription factor)
chr7_-_129592700 0.08 ENST00000472396.1
ENST00000355621.3
UBE2H
ubiquitin-conjugating enzyme E2H
chr15_-_27018175 0.07 ENST00000311550.5
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr10_+_72164135 0.07 ENST00000373218.4
EIF4EBP2
eukaryotic translation initiation factor 4E binding protein 2
chr1_+_28995231 0.07 ENST00000373816.1
GMEB1
glucocorticoid modulatory element binding protein 1
chr6_+_114178512 0.06 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chr10_-_79686284 0.06 ENST00000372391.2
ENST00000372388.2
DLG5
discs, large homolog 5 (Drosophila)
chr13_-_42535214 0.06 ENST00000379310.3
ENST00000281496.6
VWA8
von Willebrand factor A domain containing 8
chr1_-_217262969 0.06 ENST00000361525.3
ESRRG
estrogen-related receptor gamma
chr4_-_89205879 0.06 ENST00000608933.1
ENST00000315194.4
ENST00000514204.1
PPM1K
protein phosphatase, Mg2+/Mn2+ dependent, 1K
chr19_+_10828724 0.06 ENST00000585892.1
ENST00000314646.5
ENST00000359692.6
DNM2
dynamin 2
chr20_+_56964169 0.06 ENST00000475243.1
VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr10_-_61666267 0.05 ENST00000263102.6
CCDC6
coiled-coil domain containing 6
chr11_+_35684288 0.05 ENST00000299413.5
TRIM44
tripartite motif containing 44
chr17_+_28705921 0.04 ENST00000225719.4
CPD
carboxypeptidase D
chr10_+_69644404 0.04 ENST00000212015.6
SIRT1
sirtuin 1
chr14_-_99737565 0.03 ENST00000357195.3
BCL11B
B-cell CLL/lymphoma 11B (zinc finger protein)
chr13_-_21476900 0.03 ENST00000400602.2
ENST00000255305.6
XPO4
exportin 4
chr1_+_78470530 0.02 ENST00000370763.5
DNAJB4
DnaJ (Hsp40) homolog, subfamily B, member 4
chr9_-_129885010 0.00 ENST00000373425.3
ANGPTL2
angiopoietin-like 2

Network of associatons between targets according to the STRING database.

First level regulatory network of UCCCUUU

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:2000685 mesodermal-endodermal cell signaling(GO:0003131) programmed DNA elimination(GO:0031049) chromosome breakage(GO:0031052) histone H2A-S139 phosphorylation(GO:0035978) positive regulation of cellular response to X-ray(GO:2000685)
0.3 1.4 GO:1900041 negative regulation of interleukin-2 secretion(GO:1900041) terminal web assembly(GO:1902896)
0.3 0.8 GO:0090526 regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526)
0.2 0.9 GO:0006391 transcription initiation from mitochondrial promoter(GO:0006391)
0.2 2.4 GO:0044387 negative regulation of protein kinase activity by regulation of protein phosphorylation(GO:0044387)
0.2 1.4 GO:0034626 fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, unsaturated fatty acid(GO:0019368) fatty acid elongation, monounsaturated fatty acid(GO:0034625) fatty acid elongation, polyunsaturated fatty acid(GO:0034626)
0.2 0.6 GO:0014878 response to electrical stimulus involved in regulation of muscle adaptation(GO:0014878) regulation of progesterone biosynthetic process(GO:2000182)
0.2 1.0 GO:0070295 renal water absorption(GO:0070295)
0.2 0.7 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
0.2 1.1 GO:1903385 regulation of homophilic cell adhesion(GO:1903385)
0.2 0.5 GO:0002514 B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663)
0.2 0.6 GO:1903691 positive regulation of wound healing, spreading of epidermal cells(GO:1903691)
0.1 2.1 GO:0006610 ribosomal protein import into nucleus(GO:0006610)
0.1 0.4 GO:1901873 regulation of post-translational protein modification(GO:1901873)
0.1 1.1 GO:1903751 negative regulation of establishment of protein localization to mitochondrion(GO:1903748) regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903750) negative regulation of intrinsic apoptotic signaling pathway in response to hydrogen peroxide(GO:1903751)
0.1 0.9 GO:0070862 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.1 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.7 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.1 0.5 GO:0035905 N-terminal peptidyl-lysine acetylation(GO:0018076) ascending aorta development(GO:0035905) ascending aorta morphogenesis(GO:0035910)
0.1 0.2 GO:0003186 tricuspid valve development(GO:0003175) tricuspid valve morphogenesis(GO:0003186)
0.1 0.7 GO:0034670 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.1 1.0 GO:0097105 presynaptic membrane assembly(GO:0097105)
0.1 0.7 GO:0046940 nucleoside monophosphate phosphorylation(GO:0046940)
0.1 0.6 GO:0006177 GMP biosynthetic process(GO:0006177)
0.1 0.4 GO:1902954 regulation of early endosome to recycling endosome transport(GO:1902954)
0.1 0.7 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
0.1 0.4 GO:0033031 positive regulation of neutrophil apoptotic process(GO:0033031)
0.1 0.9 GO:0021902 commitment of neuronal cell to specific neuron type in forebrain(GO:0021902)
0.1 1.1 GO:0006474 N-terminal protein amino acid acetylation(GO:0006474)
0.1 0.4 GO:0021764 amygdala development(GO:0021764)
0.1 1.0 GO:0051574 positive regulation of histone H3-K9 methylation(GO:0051574)
0.1 2.1 GO:0000002 mitochondrial genome maintenance(GO:0000002)
0.1 0.7 GO:0034058 endosomal vesicle fusion(GO:0034058)
0.1 0.6 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.1 2.0 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.3 GO:0033563 dorsal/ventral axon guidance(GO:0033563)
0.1 1.0 GO:0060252 positive regulation of glial cell proliferation(GO:0060252)
0.1 0.2 GO:0046833 positive regulation of RNA export from nucleus(GO:0046833)
0.1 0.9 GO:2000774 positive regulation of cellular senescence(GO:2000774)
0.1 0.8 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.1 1.2 GO:0006123 mitochondrial electron transport, cytochrome c to oxygen(GO:0006123)
0.1 0.2 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.1 0.2 GO:1902630 regulation of membrane hyperpolarization(GO:1902630)
0.1 0.8 GO:0010225 response to UV-C(GO:0010225)
0.1 0.3 GO:0048880 sensory system development(GO:0048880)
0.1 0.4 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.1 0.2 GO:0072204 cell-cell signaling involved in kidney development(GO:0060995) Wnt signaling pathway involved in kidney development(GO:0061289) canonical Wnt signaling pathway involved in metanephric kidney development(GO:0061290) cell-cell signaling involved in metanephros development(GO:0072204)
0.1 0.3 GO:0051694 pointed-end actin filament capping(GO:0051694)
0.0 0.1 GO:0071109 superior temporal gyrus development(GO:0071109)
0.0 0.2 GO:0046671 negative regulation of cellular pH reduction(GO:0032848) CD8-positive, alpha-beta T cell lineage commitment(GO:0043375) negative regulation of retinal cell programmed cell death(GO:0046671)
0.0 0.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.0 0.3 GO:0045048 protein insertion into ER membrane(GO:0045048)
0.0 0.1 GO:0006121 mitochondrial electron transport, succinate to ubiquinone(GO:0006121)
0.0 0.4 GO:0070973 protein localization to endoplasmic reticulum exit site(GO:0070973)
0.0 0.2 GO:0002322 B cell proliferation involved in immune response(GO:0002322)
0.0 0.1 GO:0002384 hepatic immune response(GO:0002384)
0.0 0.3 GO:0038030 non-canonical Wnt signaling pathway via MAPK cascade(GO:0038030)
0.0 1.0 GO:0050855 regulation of B cell receptor signaling pathway(GO:0050855)
0.0 0.5 GO:0001711 endodermal cell fate commitment(GO:0001711)
0.0 0.2 GO:0036438 maintenance of lens transparency(GO:0036438)
0.0 1.1 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
0.0 0.3 GO:0090240 positive regulation of smooth muscle cell apoptotic process(GO:0034393) positive regulation of histone H4 acetylation(GO:0090240)
0.0 1.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.0 0.3 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.0 0.3 GO:0001672 regulation of chromatin assembly or disassembly(GO:0001672)
0.0 0.0 GO:0046822 regulation of nucleocytoplasmic transport(GO:0046822)
0.0 0.1 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
0.0 0.6 GO:0031163 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 0.5 GO:0090557 establishment of endothelial intestinal barrier(GO:0090557)
0.0 0.2 GO:0072501 cellular divalent inorganic anion homeostasis(GO:0072501)
0.0 0.2 GO:1903715 regulation of aerobic respiration(GO:1903715)
0.0 0.1 GO:0035973 aggrephagy(GO:0035973)
0.0 1.7 GO:0070125 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.0 0.5 GO:0042753 positive regulation of circadian rhythm(GO:0042753)
0.0 0.1 GO:1904059 regulation of locomotor rhythm(GO:1904059)
0.0 0.3 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.4 GO:0071481 cellular response to X-ray(GO:0071481)
0.0 1.2 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.0 0.3 GO:0090168 Golgi reassembly(GO:0090168)
0.0 0.4 GO:0047497 establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497)
0.0 0.2 GO:0035562 negative regulation of chromatin binding(GO:0035562)
0.0 0.3 GO:0070914 UV-damage excision repair(GO:0070914)
0.0 0.1 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.0 0.3 GO:0032506 cytokinetic process(GO:0032506)
0.0 0.6 GO:0015804 neutral amino acid transport(GO:0015804)
0.0 0.4 GO:0061003 positive regulation of dendritic spine morphogenesis(GO:0061003)
0.0 0.2 GO:0006657 CDP-choline pathway(GO:0006657)
0.0 0.2 GO:1902187 negative regulation of viral release from host cell(GO:1902187)
0.0 0.4 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.2 GO:1903432 regulation of TORC1 signaling(GO:1903432)
0.0 0.4 GO:0033173 calcineurin-NFAT signaling cascade(GO:0033173)
0.0 0.2 GO:0032793 positive regulation of CREB transcription factor activity(GO:0032793)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0044393 microspike(GO:0044393)
0.3 1.0 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.2 1.5 GO:0070435 Shc-EGFR complex(GO:0070435)
0.2 2.4 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.2 1.4 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.2 2.4 GO:0016600 flotillin complex(GO:0016600)
0.1 0.7 GO:0033263 CORVET complex(GO:0033263)
0.1 0.7 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.9 GO:0097452 GAIT complex(GO:0097452)
0.1 0.7 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.1 0.6 GO:0071817 MMXD complex(GO:0071817)
0.1 1.4 GO:0005641 nuclear envelope lumen(GO:0005641)
0.1 1.2 GO:0005751 mitochondrial respiratory chain complex IV(GO:0005751)
0.1 0.4 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 1.7 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.1 0.4 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
0.1 0.3 GO:0097129 cyclin D2-CDK4 complex(GO:0097129)
0.1 0.4 GO:0071203 WASH complex(GO:0071203)
0.1 0.5 GO:0070022 transforming growth factor beta receptor homodimeric complex(GO:0070022)
0.0 1.9 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
0.0 0.5 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.0 0.9 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
0.0 0.2 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
0.0 1.0 GO:0035098 ESC/E(Z) complex(GO:0035098)
0.0 1.1 GO:0071682 endocytic vesicle lumen(GO:0071682)
0.0 0.3 GO:0035068 micro-ribonucleoprotein complex(GO:0035068)
0.0 0.3 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0045273 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 1.0 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.0 0.1 GO:0033553 rDNA heterochromatin(GO:0033553)
0.0 0.6 GO:0097440 apical dendrite(GO:0097440)
0.0 0.1 GO:0005896 interleukin-6 receptor complex(GO:0005896)
0.0 0.1 GO:0070876 SOSS complex(GO:0070876)
0.0 0.2 GO:0005955 calcineurin complex(GO:0005955)
0.0 0.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.0 0.4 GO:0043220 Schmidt-Lanterman incisure(GO:0043220)
0.0 0.1 GO:0033010 paranodal junction(GO:0033010)
0.0 1.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 2.2 GO:0005643 nuclear pore(GO:0005643)
0.0 0.2 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.0 0.9 GO:0009295 nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645)
0.0 0.1 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.0 0.3 GO:0005942 phosphatidylinositol 3-kinase complex(GO:0005942)
0.0 0.4 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.6 GO:0030119 AP-type membrane coat adaptor complex(GO:0030119)
0.0 0.2 GO:0046930 pore complex(GO:0046930)
0.0 1.6 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.3 GO:0031143 pseudopodium(GO:0031143)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 2.4 GO:0035501 MH1 domain binding(GO:0035501)
0.3 1.0 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.2 0.7 GO:0001069 regulatory region RNA binding(GO:0001069)
0.2 1.4 GO:0102338 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
0.2 1.1 GO:1990189 peptide-serine-N-acetyltransferase activity(GO:1990189)
0.2 0.7 GO:0016262 protein N-acetylglucosaminyltransferase activity(GO:0016262)
0.2 1.5 GO:0048408 epidermal growth factor binding(GO:0048408)
0.2 0.9 GO:0070363 mitochondrial light strand promoter sense binding(GO:0070363)
0.2 0.7 GO:0046899 nucleoside triphosphate adenylate kinase activity(GO:0046899)
0.1 1.0 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.1 1.4 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.1 0.5 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.5 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 2.1 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.1 0.3 GO:0031896 V2 vasopressin receptor binding(GO:0031896)
0.1 1.6 GO:0035497 cAMP response element binding(GO:0035497)
0.1 1.1 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
0.1 0.4 GO:0004883 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.1 1.6 GO:0044548 S100 protein binding(GO:0044548)
0.1 0.2 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 0.4 GO:0034046 poly(G) binding(GO:0034046)
0.1 0.7 GO:0004571 mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571)
0.1 0.4 GO:0035005 1-phosphatidylinositol-4-phosphate 3-kinase activity(GO:0035005)
0.1 1.0 GO:0019966 interleukin-1 binding(GO:0019966)
0.1 0.6 GO:0034056 estrogen response element binding(GO:0034056)
0.1 2.2 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.1 0.5 GO:0005225 volume-sensitive anion channel activity(GO:0005225)
0.0 0.6 GO:0005004 GPI-linked ephrin receptor activity(GO:0005004)
0.0 0.3 GO:0008109 N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109)
0.0 0.8 GO:0097602 cullin family protein binding(GO:0097602)
0.0 0.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.6 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 1.2 GO:0004129 cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676)
0.0 0.1 GO:0008177 succinate dehydrogenase (ubiquinone) activity(GO:0008177)
0.0 1.1 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.2 GO:0098821 BMP receptor activity(GO:0098821)
0.0 1.1 GO:0008143 poly(A) binding(GO:0008143)
0.0 0.1 GO:0019981 interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981)
0.0 0.3 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 2.5 GO:0048365 Rac GTPase binding(GO:0048365)
0.0 0.2 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.0 1.0 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.4 GO:0016018 calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) cyclosporin A binding(GO:0016018)
0.0 1.7 GO:0019843 rRNA binding(GO:0019843)
0.0 0.8 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.0 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.0 GO:0043398 HLH domain binding(GO:0043398)
0.0 0.2 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
0.0 0.1 GO:0033149 FFAT motif binding(GO:0033149)
0.0 0.4 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.6 GO:0015175 neutral amino acid transmembrane transporter activity(GO:0015175)
0.0 1.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.2 GO:0051434 BH3 domain binding(GO:0051434)
0.0 0.3 GO:0003924 GTPase activity(GO:0003924)
0.0 0.3 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.2 GO:0015279 store-operated calcium channel activity(GO:0015279)
0.0 0.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.0 0.2 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 1.5 GO:0008565 protein transporter activity(GO:0008565)
0.0 0.3 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 1.9 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 0.6 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.4 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.8 ST G ALPHA S PATHWAY G alpha s Pathway
0.0 1.8 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.7 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
0.0 1.7 PID ATF2 PATHWAY ATF-2 transcription factor network
0.0 0.6 PID EPHA FWDPATHWAY EPHA forward signaling
0.0 0.6 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.0 1.1 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 0.1 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.0 0.3 PID IL2 STAT5 PATHWAY IL2 signaling events mediated by STAT5
0.0 0.3 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway
0.0 0.4 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 0.3 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.7 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.1 1.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.1 1.4 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
0.1 2.7 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 1.0 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.7 REACTOME CALNEXIN CALRETICULIN CYCLE Genes involved in Calnexin/calreticulin cycle
0.0 0.6 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
0.0 0.4 REACTOME ROLE OF SECOND MESSENGERS IN NETRIN1 SIGNALING Genes involved in Role of second messengers in netrin-1 signaling
0.0 1.5 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 0.6 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
0.0 1.3 REACTOME NETRIN1 SIGNALING Genes involved in Netrin-1 signaling
0.0 0.4 REACTOME P75NTR RECRUITS SIGNALLING COMPLEXES Genes involved in p75NTR recruits signalling complexes
0.0 0.5 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.0 0.5 REACTOME TGF BETA RECEPTOR SIGNALING IN EMT EPITHELIAL TO MESENCHYMAL TRANSITION Genes involved in TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
0.0 0.9 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
0.0 0.7 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 1.6 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 0.4 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.0 0.3 REACTOME DESTABILIZATION OF MRNA BY KSRP Genes involved in Destabilization of mRNA by KSRP
0.0 1.3 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
0.0 0.6 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.0 0.1 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
0.0 2.1 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication