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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UGACCUA

Z-value: 0.17

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miRNA associated with seed UGACCUA

NamemiRBASE accession
hsa-miR-192-5p
MIMAT0000222
hsa-miR-215-5p
MIMAT0000272

Activity profile of UGACCUA motif

Sorted Z-values of UGACCUA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chrX_+_119737806 1.03 ENST00000371317.5
MCTS1
malignant T cell amplified sequence 1
chrX_+_64887512 0.77 ENST00000360270.5
MSN
moesin
chr1_+_62902308 0.71 ENST00000339950.4
USP1
ubiquitin specific peptidase 1
chr2_-_235405679 0.69 ENST00000390645.2
ARL4C
ADP-ribosylation factor-like 4C
chr15_-_34394119 0.67 ENST00000256545.4
EMC7
ER membrane protein complex subunit 7
chr3_+_171758344 0.62 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr8_+_48920960 0.57 ENST00000523111.2
ENST00000523432.1
ENST00000521346.1
ENST00000517630.1
UBE2V2
ubiquitin-conjugating enzyme E2 variant 2
chr3_+_105085734 0.48 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr10_+_70661014 0.48 ENST00000373585.3
DDX50
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50
chr2_+_109204909 0.45 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr14_+_57735614 0.44 ENST00000261558.3
AP5M1
adaptor-related protein complex 5, mu 1 subunit
chr1_+_181057638 0.43 ENST00000367577.4
IER5
immediate early response 5
chr19_-_49576198 0.43 ENST00000221444.1
KCNA7
potassium voltage-gated channel, shaker-related subfamily, member 7
chr20_-_36156125 0.40 ENST00000397135.1
ENST00000397137.1
BLCAP
bladder cancer associated protein
chr6_+_146864829 0.40 ENST00000367495.3
RAB32
RAB32, member RAS oncogene family
chr1_+_150122034 0.40 ENST00000025469.6
ENST00000369124.4
PLEKHO1
pleckstrin homology domain containing, family O member 1
chr8_+_61591337 0.35 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr16_+_67596310 0.33 ENST00000264010.4
ENST00000401394.1
CTCF
CCCTC-binding factor (zinc finger protein)
chr1_+_84543734 0.32 ENST00000370689.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr2_-_26101374 0.32 ENST00000435504.4
ASXL2
additional sex combs like 2 (Drosophila)
chr1_+_10271674 0.31 ENST00000377086.1
KIF1B
kinesin family member 1B
chr8_+_110346546 0.31 ENST00000521662.1
ENST00000521688.1
ENST00000520147.1
ENY2
enhancer of yellow 2 homolog (Drosophila)
chr11_+_35684288 0.30 ENST00000299413.5
TRIM44
tripartite motif containing 44
chr3_-_42846021 0.29 ENST00000321331.7
HIGD1A
HIG1 hypoxia inducible domain family, member 1A
chr18_-_33709268 0.29 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
SLC39A6
solute carrier family 39 (zinc transporter), member 6
chr3_-_113465065 0.28 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_+_63833261 0.26 ENST00000371108.4
ALG6
ALG6, alpha-1,3-glucosyltransferase
chr3_-_160283348 0.25 ENST00000334256.4
KPNA4
karyopherin alpha 4 (importin alpha 3)
chr3_-_32022733 0.25 ENST00000438237.2
ENST00000396556.2
OSBPL10
oxysterol binding protein-like 10
chr22_-_50746027 0.24 ENST00000425954.1
ENST00000449103.1
PLXNB2
plexin B2
chr4_+_184020398 0.20 ENST00000403733.3
ENST00000378925.3
WWC2
WW and C2 domain containing 2
chr1_+_179262905 0.15 ENST00000539888.1
ENST00000540564.1
ENST00000535686.1
ENST00000367619.3
SOAT1
sterol O-acyltransferase 1
chr10_-_79686284 0.15 ENST00000372391.2
ENST00000372388.2
DLG5
discs, large homolog 5 (Drosophila)
chr7_+_77469439 0.14 ENST00000450574.1
ENST00000416283.2
ENST00000248550.7
PHTF2
putative homeodomain transcription factor 2
chr1_+_179851410 0.13 ENST00000271583.3
ENST00000606911.2
TOR1AIP1
torsin A interacting protein 1
chr9_+_137533615 0.13 ENST00000371817.3
COL5A1
collagen, type V, alpha 1
chr5_-_73937244 0.13 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1
ectodermal-neural cortex 1 (with BTB domain)
chr17_+_2699697 0.11 ENST00000254695.8
ENST00000366401.4
ENST00000542807.1
RAP1GAP2
RAP1 GTPase activating protein 2
chr3_+_101292939 0.11 ENST00000265260.3
ENST00000469941.1
ENST00000296024.5
PCNP
PEST proteolytic signal containing nuclear protein
chr20_+_42086525 0.10 ENST00000244020.3
SRSF6
serine/arginine-rich splicing factor 6
chr15_+_89631381 0.09 ENST00000352732.5
ABHD2
abhydrolase domain containing 2
chr8_+_42010464 0.09 ENST00000518421.1
ENST00000174653.3
ENST00000396926.3
ENST00000521280.1
ENST00000522288.1
AP3M2
adaptor-related protein complex 3, mu 2 subunit
chr9_+_12693336 0.08 ENST00000381137.2
ENST00000388918.5
TYRP1
tyrosinase-related protein 1
chrX_+_23352133 0.08 ENST00000379361.4
PTCHD1
patched domain containing 1
chr18_+_54318616 0.07 ENST00000254442.3
WDR7
WD repeat domain 7
chr17_-_56595196 0.07 ENST00000579921.1
ENST00000579925.1
ENST00000323456.5
MTMR4
myotubularin related protein 4
chr5_+_49961727 0.06 ENST00000505697.2
ENST00000503750.2
ENST00000514342.2
PARP8
poly (ADP-ribose) polymerase family, member 8
chr1_+_233749739 0.06 ENST00000366621.3
KCNK1
potassium channel, subfamily K, member 1
chr3_+_11314099 0.05 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr1_-_9970227 0.05 ENST00000377263.1
CTNNBIP1
catenin, beta interacting protein 1
chr12_-_14133053 0.04 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr6_-_116381918 0.04 ENST00000606080.1
FRK
fyn-related kinase
chr20_-_58515344 0.04 ENST00000370996.3
PPP1R3D
protein phosphatase 1, regulatory subunit 3D
chr5_+_36876833 0.03 ENST00000282516.8
ENST00000448238.2
NIPBL
Nipped-B homolog (Drosophila)
chr3_-_123603137 0.02 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr20_+_46130601 0.02 ENST00000341724.6
NCOA3
nuclear receptor coactivator 3
chr12_+_85673868 0.01 ENST00000316824.3
ALX1
ALX homeobox 1
chr3_-_114790179 0.01 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr14_+_100705322 0.00 ENST00000262238.4
YY1
YY1 transcription factor
chr12_+_862089 0.00 ENST00000315939.6
ENST00000537687.1
ENST00000447667.2
WNK1
WNK lysine deficient protein kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of UGACCUA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.0 GO:0002188 translation reinitiation(GO:0002188)
0.1 0.8 GO:0022614 membrane to membrane docking(GO:0022614)
0.1 0.4 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.1 0.3 GO:0070602 regulation of centromeric sister chromatid cohesion(GO:0070602)
0.1 0.3 GO:1904647 response to rotenone(GO:1904647)
0.1 0.3 GO:0097338 response to clozapine(GO:0097338)
0.1 0.7 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.1 0.4 GO:1903232 melanosome assembly(GO:1903232)
0.1 0.3 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.0 0.3 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.1 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
0.0 0.4 GO:0051451 myoblast migration(GO:0051451)
0.0 0.3 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
0.0 0.3 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.0 0.3 GO:0071578 zinc II ion transmembrane import(GO:0071578)
0.0 0.6 GO:0000729 DNA double-strand break processing(GO:0000729)
0.0 0.1 GO:0090298 late nucleophagy(GO:0044805) negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859) single-organism membrane invagination(GO:1902534)
0.0 0.5 GO:0048846 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.0 0.3 GO:0006488 dolichol-linked oligosaccharide biosynthetic process(GO:0006488)
0.0 0.1 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.0 0.1 GO:0071763 nuclear membrane organization(GO:0071763)
0.0 0.5 GO:0051894 positive regulation of focal adhesion assembly(GO:0051894)
0.0 0.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 0.5 GO:0032456 endocytic recycling(GO:0032456)
0.0 0.2 GO:0036150 phosphatidylserine acyl-chain remodeling(GO:0036150)
0.0 0.2 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0031372 UBC13-MMS2 complex(GO:0031372)
0.1 0.4 GO:0036195 muscle cell projection(GO:0036194) muscle cell projection membrane(GO:0036195)
0.1 0.4 GO:0031905 early endosome lumen(GO:0031905)
0.1 0.7 GO:0072546 ER membrane protein complex(GO:0072546)
0.0 0.1 GO:0005588 collagen type V trimer(GO:0005588)
0.0 0.3 GO:0031415 NatA complex(GO:0031415)
0.0 0.8 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.0 0.3 GO:0000124 SAGA complex(GO:0000124)
0.0 0.3 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.5 GO:0042101 T cell receptor complex(GO:0042101)
0.0 1.0 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.0 0.4 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 0.1 GO:1902937 inward rectifier potassium channel complex(GO:1902937)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0035651 AP-1 adaptor complex binding(GO:0035650) AP-3 adaptor complex binding(GO:0035651)
0.0 0.3 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.3 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.0 0.7 GO:0043014 alpha-tubulin binding(GO:0043014)
0.0 0.3 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.3 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 0.3 GO:0046527 glucosyltransferase activity(GO:0046527)
0.0 1.0 GO:0003743 translation initiation factor activity(GO:0003743)
0.0 0.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.7 PID FANCONI PATHWAY Fanconi anemia pathway
0.0 0.8 PID ER NONGENOMIC PATHWAY Plasma membrane estrogen receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.7 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.3 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
0.0 0.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.0 0.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.0 0.3 REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
0.0 0.3 REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein