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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for UUGUUCG

Z-value: 0.37

Motif logo

logo of

miRNA associated with seed UUGUUCG

NamemiRBASE accession
hsa-miR-375
MIMAT0000728

Activity profile of UUGUUCG motif

Sorted Z-values of UUGUUCG motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr17_+_38599693 4.42 ENST00000542955.1
ENST00000269593.4
IGFBP4
insulin-like growth factor binding protein 4
chr2_+_204192942 2.01 ENST00000295851.5
ENST00000261017.5
ABI2
abl-interactor 2
chr3_-_114790179 1.95 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr10_-_126849068 1.66 ENST00000494626.2
ENST00000337195.5
CTBP2
C-terminal binding protein 2
chr18_+_19749386 1.45 ENST00000269216.3
GATA6
GATA binding protein 6
chr13_+_73632897 1.43 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr4_-_40631859 1.33 ENST00000295971.7
ENST00000319592.4
RBM47
RNA binding motif protein 47
chr1_-_225840747 1.32 ENST00000366843.2
ENST00000366844.3
ENAH
enabled homolog (Drosophila)
chr11_+_101981169 1.15 ENST00000526343.1
ENST00000282441.5
ENST00000537274.1
ENST00000345877.2
YAP1
Yes-associated protein 1
chr9_-_16870704 1.10 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr9_-_110251836 1.09 ENST00000374672.4
KLF4
Kruppel-like factor 4 (gut)
chr4_-_157892498 1.09 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr12_-_76425368 1.06 ENST00000602540.1
PHLDA1
pleckstrin homology-like domain, family A, member 1
chr5_+_95997918 0.99 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
CAST
calpastatin
chr13_-_79177673 0.93 ENST00000377208.5
POU4F1
POU class 4 homeobox 1
chr12_+_56211703 0.88 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORMDL2
ORM1-like 2 (S. cerevisiae)
chr15_+_81071684 0.85 ENST00000220244.3
ENST00000394685.3
ENST00000356249.5
KIAA1199
KIAA1199
chr12_-_14133053 0.85 ENST00000609686.1
GRIN2B
glutamate receptor, ionotropic, N-methyl D-aspartate 2B
chr7_-_27183263 0.84 ENST00000222726.3
HOXA5
homeobox A5
chr15_+_57210818 0.79 ENST00000438423.2
ENST00000267811.5
ENST00000452095.2
ENST00000559609.1
ENST00000333725.5
TCF12
transcription factor 12
chr7_+_17338239 0.79 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr16_+_56965960 0.79 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr11_+_68080077 0.76 ENST00000294304.7
LRP5
low density lipoprotein receptor-related protein 5
chr2_+_178257372 0.70 ENST00000264167.4
ENST00000409888.1
AGPS
alkylglycerone phosphate synthase
chr18_+_18943554 0.69 ENST00000580732.2
GREB1L
growth regulation by estrogen in breast cancer-like
chr1_+_43148059 0.68 ENST00000321358.7
ENST00000332220.6
YBX1
Y box binding protein 1
chr1_-_100231349 0.67 ENST00000287474.5
ENST00000414213.1
FRRS1
ferric-chelate reductase 1
chr14_+_67707826 0.66 ENST00000261681.4
MPP5
membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5)
chr11_-_86666427 0.64 ENST00000531380.1
FZD4
frizzled family receptor 4
chr9_-_38069208 0.63 ENST00000377707.3
ENST00000377700.4
SHB
Src homology 2 domain containing adaptor protein B
chr9_-_127533519 0.59 ENST00000487099.2
ENST00000344523.4
ENST00000373584.3
NR6A1
nuclear receptor subfamily 6, group A, member 1
chr2_+_46926048 0.58 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr1_+_224544552 0.57 ENST00000465271.1
ENST00000366858.3
CNIH4
cornichon family AMPA receptor auxiliary protein 4
chr11_+_12695944 0.55 ENST00000361905.4
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr4_+_184020398 0.54 ENST00000403733.3
ENST00000378925.3
WWC2
WW and C2 domain containing 2
chr12_-_120806960 0.54 ENST00000257552.2
MSI1
musashi RNA-binding protein 1
chr3_-_128369643 0.53 ENST00000296255.3
RPN1
ribophorin I
chr9_+_26956371 0.52 ENST00000380062.5
ENST00000518614.1
IFT74
intraflagellar transport 74 homolog (Chlamydomonas)
chr20_-_524455 0.50 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr17_+_55162453 0.49 ENST00000575322.1
ENST00000337714.3
ENST00000314126.3
AKAP1
A kinase (PRKA) anchor protein 1
chr14_-_30396948 0.48 ENST00000331968.5
PRKD1
protein kinase D1
chr8_+_61591337 0.47 ENST00000423902.2
CHD7
chromodomain helicase DNA binding protein 7
chr15_-_101792137 0.47 ENST00000254190.3
CHSY1
chondroitin sulfate synthase 1
chr19_-_7293942 0.46 ENST00000341500.5
ENST00000302850.5
INSR
insulin receptor
chr8_-_122653630 0.46 ENST00000303924.4
HAS2
hyaluronan synthase 2
chr14_+_74486043 0.45 ENST00000464394.1
ENST00000394009.3
CCDC176
coiled-coil domain containing 176
chrX_+_73641286 0.45 ENST00000587091.1
SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter)
chr1_+_2985760 0.44 ENST00000378391.2
ENST00000514189.1
ENST00000270722.5
PRDM16
PR domain containing 16
chr9_+_115983808 0.44 ENST00000374210.6
ENST00000374212.4
SLC31A1
solute carrier family 31 (copper transporter), member 1
chrX_+_56259316 0.42 ENST00000468660.1
KLF8
Kruppel-like factor 8
chr16_+_69458428 0.42 ENST00000512062.1
ENST00000307892.8
CYB5B
cytochrome b5 type B (outer mitochondrial membrane)
chr19_+_19496624 0.41 ENST00000494516.2
ENST00000360315.3
ENST00000252577.5
GATAD2A
GATA zinc finger domain containing 2A
chr16_+_86544113 0.40 ENST00000262426.4
FOXF1
forkhead box F1
chr8_-_65711310 0.39 ENST00000310193.3
CYP7B1
cytochrome P450, family 7, subfamily B, polypeptide 1
chr13_-_72441315 0.38 ENST00000305425.4
ENST00000313174.7
ENST00000354591.4
DACH1
dachshund homolog 1 (Drosophila)
chr6_+_149068464 0.38 ENST00000367463.4
UST
uronyl-2-sulfotransferase
chr12_+_53774423 0.37 ENST00000426431.2
SP1
Sp1 transcription factor
chr8_-_116681221 0.36 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr22_-_42017021 0.36 ENST00000263256.6
DESI1
desumoylating isopeptidase 1
chr12_+_20522179 0.36 ENST00000359062.3
PDE3A
phosphodiesterase 3A, cGMP-inhibited
chr1_-_57045228 0.35 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr16_+_2587998 0.35 ENST00000441549.3
ENST00000268673.7
PDPK1
3-phosphoinositide dependent protein kinase-1
chr1_-_67896095 0.35 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr7_-_44924939 0.35 ENST00000395699.2
PURB
purine-rich element binding protein B
chr15_-_72410109 0.34 ENST00000564571.1
MYO9A
myosin IXA
chr19_-_663277 0.34 ENST00000292363.5
RNF126
ring finger protein 126
chr20_+_20348740 0.34 ENST00000310227.1
INSM1
insulinoma-associated 1
chr2_+_118846008 0.34 ENST00000245787.4
INSIG2
insulin induced gene 2
chr17_-_42143963 0.33 ENST00000585388.1
ENST00000293406.3
LSM12
LSM12 homolog (S. cerevisiae)
chr10_+_102222798 0.33 ENST00000343737.5
WNT8B
wingless-type MMTV integration site family, member 8B
chr1_-_120612240 0.32 ENST00000256646.2
NOTCH2
notch 2
chr1_-_205601064 0.32 ENST00000357992.4
ENST00000289703.4
ELK4
ELK4, ETS-domain protein (SRF accessory protein 1)
chr4_+_113152881 0.31 ENST00000274000.5
AP1AR
adaptor-related protein complex 1 associated regulatory protein
chr2_+_155554797 0.31 ENST00000295101.2
KCNJ3
potassium inwardly-rectifying channel, subfamily J, member 3
chr1_+_2160134 0.31 ENST00000378536.4
SKI
v-ski avian sarcoma viral oncogene homolog
chr17_+_27369918 0.30 ENST00000323372.4
PIPOX
pipecolic acid oxidase
chr7_+_100797678 0.30 ENST00000337619.5
AP1S1
adaptor-related protein complex 1, sigma 1 subunit
chr20_+_306221 0.30 ENST00000342665.2
SOX12
SRY (sex determining region Y)-box 12
chrX_-_18690210 0.29 ENST00000379984.3
RS1
retinoschisin 1
chr9_+_77112244 0.28 ENST00000376896.3
RORB
RAR-related orphan receptor B
chrX_+_95939711 0.28 ENST00000373049.4
ENST00000324765.8
DIAPH2
diaphanous-related formin 2
chr1_-_149982624 0.27 ENST00000417191.1
ENST00000369135.4
OTUD7B
OTU domain containing 7B
chr4_-_120550146 0.27 ENST00000354960.3
PDE5A
phosphodiesterase 5A, cGMP-specific
chr1_+_62902308 0.27 ENST00000339950.4
USP1
ubiquitin specific peptidase 1
chr5_+_174905398 0.26 ENST00000321442.5
SFXN1
sideroflexin 1
chr11_+_44117741 0.25 ENST00000395673.3
ENST00000343631.3
EXT2
exostosin glycosyltransferase 2
chrX_+_24483338 0.25 ENST00000379162.4
ENST00000441463.2
PDK3
pyruvate dehydrogenase kinase, isozyme 3
chr8_+_106330920 0.24 ENST00000407775.2
ZFPM2
zinc finger protein, FOG family member 2
chr2_+_242641442 0.24 ENST00000313552.6
ENST00000406941.1
ING5
inhibitor of growth family, member 5
chr11_+_120207787 0.24 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_-_213189108 0.23 ENST00000535388.1
ANGEL2
angel homolog 2 (Drosophila)
chr9_-_100935043 0.23 ENST00000343933.5
CORO2A
coronin, actin binding protein, 2A
chr7_-_128695147 0.22 ENST00000482320.1
ENST00000393245.1
ENST00000471234.1
TNPO3
transportin 3
chr19_+_47421933 0.22 ENST00000404338.3
ARHGAP35
Rho GTPase activating protein 35
chr7_-_105517021 0.22 ENST00000318724.4
ENST00000419735.3
ATXN7L1
ataxin 7-like 1
chrX_-_100604184 0.22 ENST00000372902.3
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr19_+_34919257 0.22 ENST00000246548.4
ENST00000590048.2
UBA2
ubiquitin-like modifier activating enzyme 2
chr4_-_83295103 0.21 ENST00000313899.7
ENST00000352301.4
ENST00000509107.1
ENST00000353341.4
ENST00000541060.1
HNRNPD
heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa)
chr9_-_23821273 0.21 ENST00000380110.4
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr1_-_240775447 0.21 ENST00000318160.4
GREM2
gremlin 2, DAN family BMP antagonist
chr3_+_137483579 0.20 ENST00000306087.1
SOX14
SRY (sex determining region Y)-box 14
chr5_+_56111361 0.20 ENST00000399503.3
MAP3K1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
chr3_+_185303962 0.19 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr2_-_74405929 0.19 ENST00000396049.4
MOB1A
MOB kinase activator 1A
chr14_-_70883708 0.18 ENST00000256366.4
SYNJ2BP
synaptojanin 2 binding protein
chr4_-_139163491 0.17 ENST00000280612.5
SLC7A11
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11
chr1_+_15853308 0.17 ENST00000375838.1
ENST00000375847.3
ENST00000375849.1
DNAJC16
DnaJ (Hsp40) homolog, subfamily C, member 16
chr17_-_3749515 0.15 ENST00000158149.3
ENST00000389005.4
C17orf85
chromosome 17 open reading frame 85
chr18_+_42260861 0.15 ENST00000282030.5
SETBP1
SET binding protein 1
chr1_+_199996702 0.15 ENST00000367362.3
NR5A2
nuclear receptor subfamily 5, group A, member 2
chr13_-_95364389 0.15 ENST00000376945.2
SOX21
SRY (sex determining region Y)-box 21
chr5_-_59189545 0.15 ENST00000340635.6
PDE4D
phosphodiesterase 4D, cAMP-specific
chr14_-_68283291 0.15 ENST00000555452.1
ENST00000347230.4
ZFYVE26
zinc finger, FYVE domain containing 26
chr17_+_28804380 0.14 ENST00000225724.5
ENST00000451249.2
ENST00000467337.2
ENST00000581721.1
ENST00000414833.2
GOSR1
golgi SNAP receptor complex member 1
chr19_-_6279932 0.14 ENST00000252674.7
MLLT1
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1
chr9_+_4985228 0.14 ENST00000381652.3
JAK2
Janus kinase 2
chr2_-_178937478 0.13 ENST00000286063.6
PDE11A
phosphodiesterase 11A
chr21_-_38362497 0.12 ENST00000427746.1
ENST00000336648.4
HLCS
holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase)
chr10_+_102505468 0.12 ENST00000361791.3
ENST00000355243.3
ENST00000428433.1
ENST00000370296.2
PAX2
paired box 2
chr1_-_10856694 0.12 ENST00000377022.3
ENST00000344008.5
CASZ1
castor zinc finger 1
chr9_+_140513438 0.11 ENST00000462484.1
ENST00000334856.6
ENST00000460843.1
EHMT1
euchromatic histone-lysine N-methyltransferase 1
chr10_-_71930222 0.11 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
SAR1A
SAR1 homolog A (S. cerevisiae)
chr8_-_117768023 0.11 ENST00000518949.1
ENST00000522453.1
ENST00000521861.1
ENST00000518995.1
EIF3H
eukaryotic translation initiation factor 3, subunit H
chr17_-_60142609 0.11 ENST00000397786.2
MED13
mediator complex subunit 13
chr12_-_51420128 0.11 ENST00000262051.7
ENST00000547732.1
ENST00000262052.5
ENST00000546488.1
ENST00000550714.1
ENST00000548193.1
ENST00000547579.1
ENST00000546743.1
SLC11A2
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
chr15_+_68346501 0.09 ENST00000249636.6
PIAS1
protein inhibitor of activated STAT, 1
chr13_+_31191920 0.09 ENST00000255304.4
USPL1
ubiquitin specific peptidase like 1
chr8_+_77593448 0.07 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr17_-_49198216 0.07 ENST00000262013.7
ENST00000357122.4
SPAG9
sperm associated antigen 9
chr16_-_12897642 0.07 ENST00000433677.2
ENST00000261660.4
ENST00000381774.4
CPPED1
calcineurin-like phosphoesterase domain containing 1
chr3_+_150126101 0.06 ENST00000361875.3
ENST00000361136.2
TSC22D2
TSC22 domain family, member 2
chr7_-_558876 0.06 ENST00000354513.5
ENST00000402802.3
PDGFA
platelet-derived growth factor alpha polypeptide
chr17_-_38020392 0.06 ENST00000346872.3
ENST00000439167.2
ENST00000377945.3
ENST00000394189.2
ENST00000377944.3
ENST00000377958.2
ENST00000535189.1
ENST00000377952.2
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr14_-_96830207 0.06 ENST00000359933.4
ATG2B
autophagy related 2B
chrX_+_69664706 0.06 ENST00000194900.4
ENST00000374360.3
DLG3
discs, large homolog 3 (Drosophila)
chr9_+_4679555 0.05 ENST00000381858.1
ENST00000381854.3
CDC37L1
cell division cycle 37-like 1
chr12_+_56401268 0.05 ENST00000262032.5
IKZF4
IKAROS family zinc finger 4 (Eos)
chr17_-_617949 0.05 ENST00000401468.3
ENST00000574029.1
ENST00000291074.5
ENST00000571805.1
ENST00000437048.2
ENST00000446250.2
VPS53
vacuolar protein sorting 53 homolog (S. cerevisiae)
chr11_+_33563821 0.04 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
KIAA1549L
KIAA1549-like
chr2_+_133174147 0.04 ENST00000329321.3
GPR39
G protein-coupled receptor 39
chr2_-_172750733 0.04 ENST00000392592.4
ENST00000422440.2
SLC25A12
solute carrier family 25 (aspartate/glutamate carrier), member 12
chr6_+_4021554 0.04 ENST00000337659.6
PRPF4B
pre-mRNA processing factor 4B
chr13_+_51483814 0.03 ENST00000336617.3
ENST00000422660.1
RNASEH2B
ribonuclease H2, subunit B
chr6_-_91006461 0.02 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr3_-_135914615 0.01 ENST00000309993.2
MSL2
male-specific lethal 2 homolog (Drosophila)
chr17_-_7832753 0.00 ENST00000303790.2
KCNAB3
potassium voltage-gated channel, shaker-related subfamily, beta member 3
chr1_+_180601139 0.00 ENST00000367590.4
ENST00000367589.3
XPR1
xenotropic and polytropic retrovirus receptor 1

Network of associatons between targets according to the STRING database.

First level regulatory network of UUGUUCG

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.4 GO:0032911 negative regulation of transforming growth factor beta1 production(GO:0032911)
0.4 1.1 GO:0071409 negative regulation of muscle hyperplasia(GO:0014740) cellular response to cycloheximide(GO:0071409)
0.4 1.1 GO:0045210 FasL biosynthetic process(GO:0045210)
0.3 1.4 GO:0061304 extracellular matrix-cell signaling(GO:0035426) retinal blood vessel morphogenesis(GO:0061304)
0.3 0.9 GO:0021986 epithalamus development(GO:0021538) habenula development(GO:0021986)
0.3 0.9 GO:0090155 negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
0.3 0.8 GO:0060535 trachea cartilage morphogenesis(GO:0060535)
0.2 0.7 GO:0003221 right ventricular cardiac muscle tissue morphogenesis(GO:0003221)
0.2 0.7 GO:0008611 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
0.2 1.3 GO:0016554 cytidine to uridine editing(GO:0016554)
0.2 4.4 GO:0044342 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) type B pancreatic cell proliferation(GO:0044342)
0.2 2.0 GO:2000601 positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601)
0.2 1.7 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.2 1.4 GO:0032534 regulation of microvillus assembly(GO:0032534)
0.2 0.6 GO:0060283 negative regulation of oocyte development(GO:0060283) negative regulation of oocyte maturation(GO:1900194)
0.1 0.4 GO:0048611 ectodermal digestive tract development(GO:0007439) embryonic ectodermal digestive tract development(GO:0048611)
0.1 1.1 GO:1902459 positive regulation of stem cell population maintenance(GO:1902459)
0.1 0.5 GO:1990535 transformation of host cell by virus(GO:0019087) neuron projection maintenance(GO:1990535)
0.1 0.5 GO:0070295 renal water absorption(GO:0070295)
0.1 0.6 GO:0060282 positive regulation of oocyte development(GO:0060282)
0.1 0.3 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
0.1 0.3 GO:0019477 L-lysine catabolic process to acetyl-CoA(GO:0019474) L-lysine catabolic process(GO:0019477) L-lysine metabolic process(GO:0046440)
0.1 0.6 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.1 0.7 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.5 GO:0035331 negative regulation of hippo signaling(GO:0035331)
0.1 0.3 GO:0031064 negative regulation of histone deacetylation(GO:0031064)
0.1 0.4 GO:0072719 cellular response to cisplatin(GO:0072719)
0.1 0.2 GO:1901355 response to rapamycin(GO:1901355)
0.1 1.0 GO:2000675 negative regulation of type B pancreatic cell apoptotic process(GO:2000675)
0.1 0.5 GO:0089700 protein kinase D signaling(GO:0089700)
0.1 0.2 GO:0038098 sequestering of BMP from receptor via BMP binding(GO:0038098)
0.1 0.1 GO:0010512 negative regulation of phosphatidylinositol biosynthetic process(GO:0010512)
0.1 0.4 GO:0090336 positive regulation of brown fat cell differentiation(GO:0090336)
0.1 0.4 GO:0036166 phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239)
0.1 0.1 GO:0021650 vestibulocochlear nerve formation(GO:0021650)
0.1 0.7 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
0.1 0.8 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.1 0.2 GO:0003358 noradrenergic neuron development(GO:0003358)
0.1 0.3 GO:0035881 amacrine cell differentiation(GO:0035881)
0.1 0.2 GO:0030950 establishment or maintenance of actin cytoskeleton polarity(GO:0030950)
0.0 0.4 GO:0060244 negative regulation of cell proliferation involved in contact inhibition(GO:0060244)
0.0 0.3 GO:0048263 determination of dorsal identity(GO:0048263)
0.0 0.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.2 GO:0035329 hippo signaling(GO:0035329)
0.0 1.1 GO:0043586 tongue development(GO:0043586)
0.0 0.4 GO:0035754 B cell chemotaxis(GO:0035754)
0.0 1.1 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.0 0.4 GO:0006477 protein sulfation(GO:0006477)
0.0 0.1 GO:0070781 response to biotin(GO:0070781)
0.0 0.3 GO:1990416 cellular response to brain-derived neurotrophic factor stimulus(GO:1990416)
0.0 0.3 GO:0043487 regulation of RNA stability(GO:0043487) regulation of mRNA stability(GO:0043488)
0.0 1.9 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.0 0.3 GO:0097411 hypoxia-inducible factor-1alpha signaling pathway(GO:0097411)
0.0 0.3 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.5 GO:0070327 thyroid hormone transport(GO:0070327)
0.0 0.3 GO:0035871 protein K11-linked deubiquitination(GO:0035871)
0.0 0.3 GO:0060363 cranial suture morphogenesis(GO:0060363)
0.0 0.3 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.0 0.2 GO:0061113 pancreas morphogenesis(GO:0061113)
0.0 0.3 GO:0098914 membrane repolarization during atrial cardiac muscle cell action potential(GO:0098914)
0.0 0.3 GO:0009642 response to light intensity(GO:0009642)
0.0 0.5 GO:0033630 positive regulation of cell adhesion mediated by integrin(GO:0033630)
0.0 0.5 GO:0051923 sulfation(GO:0051923)
0.0 0.3 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
0.0 0.1 GO:0015692 lead ion transport(GO:0015692)
0.0 0.2 GO:0048312 intracellular distribution of mitochondria(GO:0048312)
0.0 0.3 GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162)
0.0 0.3 GO:0070932 histone H3 deacetylation(GO:0070932)
0.0 0.1 GO:0086024 adrenergic receptor signaling pathway involved in positive regulation of heart rate(GO:0086024)
0.0 0.1 GO:0060992 response to fungicide(GO:0060992)
0.0 0.6 GO:1902895 positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895)
0.0 0.2 GO:0009649 entrainment of circadian clock(GO:0009649)
0.0 0.5 GO:0010738 regulation of protein kinase A signaling(GO:0010738)
0.0 0.0 GO:0043490 malate-aspartate shuttle(GO:0043490)
0.0 0.8 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.5 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.0 0.2 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.0 0.1 GO:0046069 cGMP catabolic process(GO:0046069)
0.0 0.1 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.0 0.2 GO:0089711 L-glutamate transmembrane transport(GO:0089711)
0.0 0.2 GO:0051170 nuclear import(GO:0051170) single-organism nuclear import(GO:1902593)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.7 GO:0071148 TEAD-1-YAP complex(GO:0071148)
0.3 0.8 GO:1990851 Wnt-Frizzled-LRP5/6 complex(GO:1990851)
0.2 0.9 GO:0017059 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
0.2 0.8 GO:0034751 aryl hydrocarbon receptor complex(GO:0034751)
0.1 2.0 GO:0031209 SCAR complex(GO:0031209)
0.1 0.8 GO:1990037 Lewy body core(GO:1990037)
0.1 1.7 GO:0097470 ribbon synapse(GO:0097470)
0.1 0.2 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 0.5 GO:0005899 insulin receptor complex(GO:0005899)
0.1 0.7 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
0.1 0.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.1 0.5 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.3 GO:0043541 UDP-N-acetylglucosamine transferase complex(GO:0043541)
0.1 0.8 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.1 0.7 GO:0035749 myelin sheath adaxonal region(GO:0035749) lateral loop(GO:0043219)
0.1 0.2 GO:0031510 SUMO activating enzyme complex(GO:0031510)
0.0 0.5 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.0 0.3 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 1.1 GO:0005719 nuclear euchromatin(GO:0005719)
0.0 0.2 GO:0070776 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.0 0.5 GO:0030992 intraciliary transport particle B(GO:0030992)
0.0 0.3 GO:0005662 DNA replication factor A complex(GO:0005662)
0.0 0.3 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0070826 paraferritin complex(GO:0070826)
0.0 1.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.4 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
0.0 0.9 GO:0016235 aggresome(GO:0016235)
0.0 5.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 0.0 GO:1990745 EARP complex(GO:1990745)
0.0 0.4 GO:0000421 autophagosome membrane(GO:0000421)
0.0 0.1 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
0.0 0.6 GO:0030669 clathrin-coated endocytic vesicle membrane(GO:0030669)
0.0 1.3 GO:0030175 filopodium(GO:0030175)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 4.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 1.7 GO:0016618 hydroxypyruvate reductase activity(GO:0016618) glyoxylate reductase (NADP) activity(GO:0030267)
0.2 1.1 GO:0001010 transcription factor activity, sequence-specific DNA binding transcription factor recruiting(GO:0001010)
0.2 0.8 GO:0004874 aryl hydrocarbon receptor activity(GO:0004874)
0.2 1.0 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.2 0.5 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
0.2 0.5 GO:0050501 hyaluronan synthase activity(GO:0050501)
0.1 0.4 GO:0004119 cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119)
0.1 0.4 GO:0004676 3-phosphoinositide-dependent protein kinase activity(GO:0004676)
0.1 0.7 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.1 0.3 GO:0035033 histone deacetylase regulator activity(GO:0035033)
0.1 3.2 GO:0070064 proline-rich region binding(GO:0070064)
0.1 0.8 GO:0071936 coreceptor activity involved in Wnt signaling pathway(GO:0071936)
0.1 0.8 GO:0004972 NMDA glutamate receptor activity(GO:0004972)
0.1 0.3 GO:0035650 AP-1 adaptor complex binding(GO:0035650)
0.1 0.3 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 0.3 GO:0004740 pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740)
0.1 0.6 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
0.1 0.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.1 0.5 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.3 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.1 0.5 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.3 GO:0086089 voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization(GO:0086089)
0.1 0.3 GO:0016647 oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor(GO:0016647)
0.0 1.1 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.0 1.2 GO:0071837 HMG box domain binding(GO:0071837)
0.0 0.2 GO:0070137 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.0 0.3 GO:1990380 Lys48-specific deubiquitinase activity(GO:1990380)
0.0 1.4 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.0 0.6 GO:0001134 transcription factor activity, transcription factor recruiting(GO:0001134)
0.0 0.2 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.0 0.6 GO:0042813 Wnt-activated receptor activity(GO:0042813)
0.0 0.3 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
0.0 1.3 GO:0050699 WW domain binding(GO:0050699)
0.0 0.4 GO:0001075 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075)
0.0 0.2 GO:0044388 small protein activating enzyme binding(GO:0044388)
0.0 0.7 GO:0071949 FAD binding(GO:0071949)
0.0 0.1 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
0.0 0.1 GO:0004118 cGMP-stimulated cyclic-nucleotide phosphodiesterase activity(GO:0004118)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 0.5 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.0 0.9 GO:0001205 transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001205)
0.0 0.5 GO:0004697 protein kinase C activity(GO:0004697)
0.0 0.1 GO:0061665 SUMO ligase activity(GO:0061665)
0.0 0.2 GO:0003680 AT DNA binding(GO:0003680)
0.0 2.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.9 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.1 GO:0005143 interleukin-12 receptor binding(GO:0005143)
0.0 0.2 GO:0036122 BMP binding(GO:0036122)
0.0 0.5 GO:1990841 promoter-specific chromatin binding(GO:1990841)
0.0 0.3 GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555)
0.0 0.6 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 0.1 GO:0009374 biotin binding(GO:0009374)
0.0 1.0 GO:0098531 RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding(GO:0004879) transcription factor activity, direct ligand regulated sequence-specific DNA binding(GO:0098531)
0.0 0.5 GO:0048487 beta-tubulin binding(GO:0048487)
0.0 0.4 GO:0008395 steroid hydroxylase activity(GO:0008395)
0.0 0.5 GO:0051879 Hsp90 protein binding(GO:0051879)
0.0 0.4 GO:0018024 histone-lysine N-methyltransferase activity(GO:0018024)
0.0 0.3 GO:0005109 frizzled binding(GO:0005109)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 5.8 PID WNT SIGNALING PATHWAY Wnt signaling network
0.0 2.1 PID ERBB4 PATHWAY ErbB4 signaling events
0.0 1.3 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 1.1 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 2.2 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 1.3 PID HES HEY PATHWAY Notch-mediated HES/HEY network
0.0 0.4 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.0 0.5 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 1.1 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 1.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 0.1 ST JAK STAT PATHWAY Jak-STAT Pathway
0.0 0.2 PID EPHA2 FWD PATHWAY EPHA2 forward signaling
0.0 1.0 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.5 ST GA13 PATHWAY G alpha 13 Pathway
0.0 0.3 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.9 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.4 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.1 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
0.1 1.1 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.0 1.7 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.0 0.8 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.0 0.4 REACTOME SYNTHESIS OF BILE ACIDS AND BILE SALTS Genes involved in Synthesis of bile acids and bile salts
0.0 0.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.0 0.8 REACTOME ACTIVATION OF GENES BY ATF4 Genes involved in Activation of Genes by ATF4
0.0 1.3 REACTOME SIGNALING BY ROBO RECEPTOR Genes involved in Signaling by Robo receptor
0.0 0.5 REACTOME SIGNAL ATTENUATION Genes involved in Signal attenuation
0.0 0.3 REACTOME NEF MEDIATED DOWNREGULATION OF MHC CLASS I COMPLEX CELL SURFACE EXPRESSION Genes involved in Nef mediated downregulation of MHC class I complex cell surface expression
0.0 0.5 REACTOME HYALURONAN METABOLISM Genes involved in Hyaluronan metabolism
0.0 0.3 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
0.0 0.7 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.0 0.7 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis
0.0 0.8 REACTOME CGMP EFFECTS Genes involved in cGMP effects
0.0 0.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
0.0 1.4 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 0.7 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.0 0.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.0 0.4 REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS Genes involved in CREB phosphorylation through the activation of Ras
0.0 0.4 REACTOME CHONDROITIN SULFATE DERMATAN SULFATE METABOLISM Genes involved in Chondroitin sulfate/dermatan sulfate metabolism
0.0 0.3 REACTOME REGULATION OF PYRUVATE DEHYDROGENASE PDH COMPLEX Genes involved in Regulation of pyruvate dehydrogenase (PDH) complex
0.0 2.3 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 0.5 REACTOME SIGNALING BY BMP Genes involved in Signaling by BMP
0.0 1.0 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway
0.0 0.5 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1