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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for VENTX

Z-value: 0.59

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Transcription factors associated with VENTX

Gene Symbol Gene ID Gene Info
VENTX
ENSG00000151650.7 VENT homeobox

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
VENTXhg19_v2_chr10_+_135050908_1350509080.135.4e-02Click!

Activity profile of VENTX motif

Sorted Z-values of VENTX motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr4_-_84035905 11.28 ENST00000311507.4
PLAC8
placenta-specific 8
chr4_-_84035868 10.93 ENST00000426923.2
ENST00000509973.1
PLAC8
placenta-specific 8
chr12_+_25205568 6.98 ENST00000548766.1
ENST00000556887.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205666 6.46 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_25205446 6.17 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
LRMP
lymphoid-restricted membrane protein
chr6_-_39693111 5.53 ENST00000373215.3
ENST00000538893.1
ENST00000287152.7
ENST00000373216.3
KIF6
kinesin family member 6
chr6_-_99873145 3.84 ENST00000369239.5
ENST00000438806.1
PNISR
PNN-interacting serine/arginine-rich protein
chr1_+_226411319 3.63 ENST00000542034.1
ENST00000366810.5
MIXL1
Mix paired-like homeobox
chr6_-_49681235 3.38 ENST00000339139.4
CRISP2
cysteine-rich secretory protein 2
chr2_+_226265364 3.35 ENST00000272907.6
NYAP2
neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2
chr4_-_26492076 2.95 ENST00000295589.3
CCKAR
cholecystokinin A receptor
chr8_-_103424916 2.74 ENST00000220959.4
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr8_-_103424986 2.74 ENST00000521922.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr2_-_88285309 2.72 ENST00000420840.2
RGPD2
RANBP2-like and GRIP domain containing 2
chr11_-_72070206 2.61 ENST00000544382.1
CLPB
ClpB caseinolytic peptidase B homolog (E. coli)
chr17_+_47448102 2.58 ENST00000576461.1
RP11-81K2.1
Uncharacterized protein
chr2_+_87135076 2.44 ENST00000409776.2
RGPD1
RANBP2-like and GRIP domain containing 1
chr18_-_53253323 2.24 ENST00000540999.1
ENST00000563888.2
TCF4
transcription factor 4
chr18_-_74207146 2.19 ENST00000443185.2
ZNF516
zinc finger protein 516
chr1_+_153747746 2.08 ENST00000368661.3
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr18_-_53253112 2.05 ENST00000568673.1
ENST00000562847.1
ENST00000568147.1
TCF4
transcription factor 4
chr9_+_2159850 2.03 ENST00000416751.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr8_-_103425047 1.99 ENST00000520539.1
UBR5
ubiquitin protein ligase E3 component n-recognin 5
chr10_-_28571015 1.91 ENST00000375719.3
ENST00000375732.1
MPP7
membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)
chr11_+_75526212 1.88 ENST00000356136.3
UVRAG
UV radiation resistance associated
chrX_+_133733457 1.82 ENST00000440614.1
RP11-308B5.2
RP11-308B5.2
chr12_+_81110684 1.50 ENST00000228644.3
MYF5
myogenic factor 5
chr18_+_59000815 1.48 ENST00000262717.4
CDH20
cadherin 20, type 2
chr6_-_32157947 1.45 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr14_-_20801427 1.36 ENST00000557665.1
ENST00000358932.4
ENST00000353689.4
CCNB1IP1
cyclin B1 interacting protein 1, E3 ubiquitin protein ligase
chr12_+_52695617 1.35 ENST00000293525.5
KRT86
keratin 86
chr5_+_43121698 1.28 ENST00000505606.2
ENST00000509634.1
ENST00000509341.1
ZNF131
zinc finger protein 131
chr2_-_163008903 1.26 ENST00000418842.2
ENST00000375497.3
GCG
glucagon
chr1_+_168250194 1.19 ENST00000367821.3
TBX19
T-box 19
chr12_-_101604185 1.15 ENST00000536262.2
SLC5A8
solute carrier family 5 (sodium/monocarboxylate cotransporter), member 8
chr6_-_90529418 1.14 ENST00000439638.1
ENST00000369393.3
ENST00000428876.1
MDN1
MDN1, midasin homolog (yeast)
chr7_+_139025875 1.06 ENST00000297534.6
C7orf55
chromosome 7 open reading frame 55
chr20_-_50722183 1.06 ENST00000371523.4
ZFP64
ZFP64 zinc finger protein
chr19_-_49622348 0.99 ENST00000408991.2
C19orf73
chromosome 19 open reading frame 73
chr3_-_57233966 0.98 ENST00000473921.1
ENST00000295934.3
HESX1
HESX homeobox 1
chr10_+_74451883 0.97 ENST00000373053.3
ENST00000357157.6
MCU
mitochondrial calcium uniporter
chr17_-_7307358 0.96 ENST00000576017.1
ENST00000302422.3
ENST00000535512.1
TMEM256
TMEM256-PLSCR3
transmembrane protein 256
TMEM256-PLSCR3 readthrough (NMD candidate)
chr9_+_133539981 0.96 ENST00000253008.2
PRDM12
PR domain containing 12
chr12_+_56473910 0.93 ENST00000411731.2
ERBB3
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 3
chr16_-_67517716 0.91 ENST00000290953.2
AGRP
agouti related protein homolog (mouse)
chr7_+_120628731 0.90 ENST00000310396.5
CPED1
cadherin-like and PC-esterase domain containing 1
chr3_+_9834179 0.86 ENST00000498623.2
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr2_+_171034646 0.85 ENST00000409044.3
ENST00000408978.4
MYO3B
myosin IIIB
chr11_-_64684672 0.84 ENST00000377264.3
ENST00000421419.2
ATG2A
autophagy related 2A
chr9_-_23825956 0.83 ENST00000397312.2
ELAVL2
ELAV like neuron-specific RNA binding protein 2
chr7_+_18535346 0.82 ENST00000405010.3
ENST00000406451.4
ENST00000428307.2
HDAC9
histone deacetylase 9
chr4_-_105416039 0.80 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr3_+_134514093 0.78 ENST00000398015.3
EPHB1
EPH receptor B1
chr14_+_32798462 0.78 ENST00000280979.4
AKAP6
A kinase (PRKA) anchor protein 6
chr11_-_3859089 0.77 ENST00000396979.1
RHOG
ras homolog family member G
chr6_-_76203345 0.77 ENST00000393004.2
FILIP1
filamin A interacting protein 1
chr3_+_9834227 0.74 ENST00000287613.7
ENST00000397261.3
ARPC4
actin related protein 2/3 complex, subunit 4, 20kDa
chr9_+_116225999 0.73 ENST00000317613.6
RGS3
regulator of G-protein signaling 3
chr15_+_34261089 0.70 ENST00000383263.5
CHRM5
cholinergic receptor, muscarinic 5
chr19_-_15529790 0.69 ENST00000596195.1
ENST00000595067.1
ENST00000595465.2
ENST00000397410.5
ENST00000600247.1
AKAP8L
A kinase (PRKA) anchor protein 8-like
chr8_+_24298597 0.68 ENST00000380789.1
ADAM7
ADAM metallopeptidase domain 7
chr1_+_186265399 0.68 ENST00000367486.3
ENST00000367484.3
ENST00000533951.1
ENST00000367482.4
ENST00000367483.4
ENST00000367485.4
ENST00000445192.2
PRG4
proteoglycan 4
chr8_+_50824233 0.66 ENST00000522124.1
SNTG1
syntrophin, gamma 1
chr8_+_24298531 0.63 ENST00000175238.6
ADAM7
ADAM metallopeptidase domain 7
chr4_-_168155169 0.62 ENST00000534949.1
ENST00000535728.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chrX_-_130423200 0.62 ENST00000361420.3
IGSF1
immunoglobulin superfamily, member 1
chr20_+_42136308 0.58 ENST00000434666.1
ENST00000427442.2
ENST00000439769.1
ENST00000418998.1
L3MBTL1
l(3)mbt-like 1 (Drosophila)
chr12_-_6233828 0.57 ENST00000572068.1
ENST00000261405.5
VWF
von Willebrand factor
chr4_+_71458012 0.57 ENST00000449493.2
AMBN
ameloblastin (enamel matrix protein)
chr2_-_165698662 0.55 ENST00000194871.6
ENST00000445474.2
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr2_+_203776937 0.54 ENST00000402905.3
ENST00000414490.1
ENST00000431787.1
ENST00000444724.1
ENST00000414857.1
ENST00000430899.1
ENST00000445120.1
ENST00000441569.1
ENST00000432024.1
ENST00000443740.1
ENST00000414439.1
ENST00000428585.1
ENST00000545253.1
ENST00000545262.1
ENST00000447539.1
ENST00000456821.2
ENST00000434998.1
ENST00000320443.8
CARF
calcium responsive transcription factor
chr6_+_152011628 0.52 ENST00000404742.1
ENST00000440973.1
ESR1
estrogen receptor 1
chr22_-_40929812 0.52 ENST00000422851.1
MKL1
megakaryoblastic leukemia (translocation) 1
chr8_-_87755878 0.51 ENST00000320005.5
CNGB3
cyclic nucleotide gated channel beta 3
chr13_-_28545276 0.49 ENST00000381020.7
CDX2
caudal type homeobox 2
chr11_+_64018955 0.44 ENST00000279230.6
ENST00000540288.1
ENST00000325234.5
PLCB3
phospholipase C, beta 3 (phosphatidylinositol-specific)
chr12_-_51611477 0.43 ENST00000389243.4
POU6F1
POU class 6 homeobox 1
chr14_+_32798547 0.40 ENST00000557354.1
ENST00000557102.1
ENST00000557272.1
AKAP6
A kinase (PRKA) anchor protein 6
chr1_+_203651937 0.40 ENST00000341360.2
ATP2B4
ATPase, Ca++ transporting, plasma membrane 4
chr3_-_57260377 0.40 ENST00000495160.2
HESX1
HESX homeobox 1
chrX_+_135730297 0.40 ENST00000370629.2
CD40LG
CD40 ligand
chrX_-_153602991 0.38 ENST00000369850.3
ENST00000422373.1
FLNA
filamin A, alpha
chrX_+_135730373 0.38 ENST00000370628.2
CD40LG
CD40 ligand
chr8_+_31496809 0.37 ENST00000518104.1
ENST00000519301.1
NRG1
neuregulin 1
chr17_-_39222131 0.36 ENST00000394015.2
KRTAP2-4
keratin associated protein 2-4
chr22_+_39101728 0.36 ENST00000216044.5
ENST00000484657.1
GTPBP1
GTP binding protein 1
chr14_-_82000140 0.35 ENST00000555824.1
ENST00000557372.1
ENST00000336735.4
SEL1L
sel-1 suppressor of lin-12-like (C. elegans)
chr17_-_202579 0.32 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL
rabphilin 3A-like (without C2 domains)
chr1_+_153746683 0.32 ENST00000271857.2
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr12_-_102591604 0.31 ENST00000329406.4
PMCH
pro-melanin-concentrating hormone
chr4_+_71457970 0.31 ENST00000322937.6
AMBN
ameloblastin (enamel matrix protein)
chrX_-_130423240 0.31 ENST00000370910.1
ENST00000370901.4
IGSF1
immunoglobulin superfamily, member 1
chr12_-_86650045 0.30 ENST00000604798.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr2_-_165698521 0.29 ENST00000409184.3
ENST00000392717.2
ENST00000456693.1
COBLL1
cordon-bleu WH2 repeat protein-like 1
chr7_-_104909435 0.28 ENST00000357311.3
SRPK2
SRSF protein kinase 2
chr3_+_185303962 0.28 ENST00000296257.5
SENP2
SUMO1/sentrin/SMT3 specific peptidase 2
chr14_+_65171315 0.26 ENST00000394691.1
PLEKHG3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
chr5_-_142780280 0.26 ENST00000424646.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr2_+_169757750 0.23 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
G6PC2
glucose-6-phosphatase, catalytic, 2
chr4_+_169418255 0.22 ENST00000505667.1
ENST00000511948.1
PALLD
palladin, cytoskeletal associated protein
chr11_+_22359562 0.22 ENST00000263160.3
SLC17A6
solute carrier family 17 (vesicular glutamate transporter), member 6
chr11_+_46722368 0.21 ENST00000311764.2
ZNF408
zinc finger protein 408
chr3_+_171561127 0.21 ENST00000334567.5
ENST00000450693.1
TMEM212
transmembrane protein 212
chr12_-_86650077 0.20 ENST00000552808.2
ENST00000547225.1
MGAT4C
mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)
chr11_+_7618413 0.17 ENST00000528883.1
PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr2_+_45168875 0.15 ENST00000260653.3
SIX3
SIX homeobox 3
chr2_+_166152283 0.13 ENST00000375427.2
SCN2A
sodium channel, voltage-gated, type II, alpha subunit
chr17_-_10372875 0.13 ENST00000255381.2
MYH4
myosin, heavy chain 4, skeletal muscle
chr12_-_53994805 0.11 ENST00000328463.7
ATF7
activating transcription factor 7
chrX_-_139587225 0.09 ENST00000370536.2
SOX3
SRY (sex determining region Y)-box 3
chr8_+_107738240 0.09 ENST00000449762.2
ENST00000297447.6
OXR1
oxidation resistance 1
chr19_+_48949030 0.07 ENST00000253237.5
GRWD1
glutamate-rich WD repeat containing 1
chr9_+_136501478 0.06 ENST00000393056.2
ENST00000263611.2
DBH
dopamine beta-hydroxylase (dopamine beta-monooxygenase)
chr21_+_39644395 0.06 ENST00000398934.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chr10_-_49813090 0.04 ENST00000249601.4
ARHGAP22
Rho GTPase activating protein 22
chr12_-_53012343 0.02 ENST00000305748.3
KRT73
keratin 73
chr12_+_111471828 0.00 ENST00000261726.6
CUX2
cut-like homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of VENTX

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 22.2 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
1.1 7.5 GO:1901315 negative regulation of histone ubiquitination(GO:0033183) negative regulation of protein K63-linked ubiquitination(GO:1900045) regulation of histone H2A K63-linked ubiquitination(GO:1901314) negative regulation of histone H2A K63-linked ubiquitination(GO:1901315) negative regulation of protein polyubiquitination(GO:1902915)
1.0 2.9 GO:0038188 cholecystokinin signaling pathway(GO:0038188)
0.7 3.6 GO:2000382 positive regulation of mesoderm development(GO:2000382)
0.6 1.9 GO:0051684 maintenance of Golgi location(GO:0051684)
0.4 1.3 GO:0035948 positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter(GO:0035948)
0.3 1.2 GO:1902261 positive regulation of delayed rectifier potassium channel activity(GO:1902261)
0.3 1.9 GO:0071896 protein localization to adherens junction(GO:0071896)
0.3 0.8 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.3 0.8 GO:0048170 positive regulation of long-term neuronal synaptic plasticity(GO:0048170) trans-synaptic signaling by trans-synaptic complex(GO:0099545)
0.2 1.0 GO:1900109 regulation of histone H3-K9 dimethylation(GO:1900109)
0.2 0.9 GO:2000253 positive regulation of feeding behavior(GO:2000253)
0.2 5.2 GO:0000042 protein targeting to Golgi(GO:0000042)
0.2 1.0 GO:0036444 calcium ion transmembrane import into mitochondrion(GO:0036444)
0.2 19.6 GO:0006903 vesicle targeting(GO:0006903)
0.2 2.3 GO:0048742 regulation of skeletal muscle fiber development(GO:0048742)
0.2 1.4 GO:0051026 chiasma assembly(GO:0051026)
0.1 0.7 GO:0007197 adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197)
0.1 0.7 GO:0010793 regulation of mRNA export from nucleus(GO:0010793)
0.1 0.4 GO:2000283 regulation of cellular amine catabolic process(GO:0033241) negative regulation of cellular amine catabolic process(GO:0033242) negative regulation of the force of heart contraction(GO:0098736) regulation of arginine catabolic process(GO:1900081) negative regulation of arginine catabolic process(GO:1900082) regulation of citrulline biosynthetic process(GO:1903248) negative regulation of citrulline biosynthetic process(GO:1903249) negative regulation of cellular amino acid biosynthetic process(GO:2000283)
0.1 0.5 GO:0014807 regulation of somitogenesis(GO:0014807)
0.1 1.4 GO:0030916 otic vesicle formation(GO:0030916)
0.1 1.1 GO:0034356 NAD biosynthesis via nicotinamide riboside salvage pathway(GO:0034356)
0.1 0.5 GO:0060737 prostate epithelial cord elongation(GO:0060523) prostate gland morphogenetic growth(GO:0060737)
0.1 0.1 GO:0021798 forebrain dorsal/ventral pattern formation(GO:0021798)
0.1 0.5 GO:0010735 positive regulation of transcription via serum response element binding(GO:0010735)
0.1 0.4 GO:0016479 negative regulation of transcription from RNA polymerase I promoter(GO:0016479)
0.1 0.5 GO:0035865 cellular response to potassium ion(GO:0035865)
0.1 2.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.1 0.3 GO:0035063 nuclear speck organization(GO:0035063)
0.1 0.4 GO:0021840 directional guidance of interneurons involved in migration from the subpallium to the cortex(GO:0021840) chemorepulsion involved in interneuron migration from the subpallium to the cortex(GO:0021842)
0.1 0.8 GO:0051639 actin filament network formation(GO:0051639)
0.1 0.7 GO:0007154 cell communication(GO:0007154)
0.0 1.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.8 GO:2000353 positive regulation of endothelial cell apoptotic process(GO:2000353)
0.0 0.8 GO:0044804 nucleophagy(GO:0044804)
0.0 1.6 GO:0034314 Arp2/3 complex-mediated actin nucleation(GO:0034314)
0.0 0.3 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.0 1.1 GO:0000027 ribosomal large subunit assembly(GO:0000027)
0.0 0.6 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.8 GO:1900027 regulation of ruffle assembly(GO:1900027)
0.0 0.6 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.2 GO:0098700 neurotransmitter loading into synaptic vesicle(GO:0098700)
0.0 0.3 GO:1904380 endoplasmic reticulum mannose trimming(GO:1904380)
0.0 5.5 GO:0007018 microtubule-based movement(GO:0007018)
0.0 2.0 GO:0007286 spermatid development(GO:0007286)
0.0 0.8 GO:0021983 pituitary gland development(GO:0021983)
0.0 4.4 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 2.6 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.1 GO:0042421 norepinephrine biosynthetic process(GO:0042421)
0.0 1.7 GO:0031424 keratinization(GO:0031424)
0.0 0.9 GO:0042475 odontogenesis of dentin-containing tooth(GO:0042475)
0.0 0.7 GO:0006898 receptor-mediated endocytosis(GO:0006898)
0.0 0.4 GO:0007223 Wnt signaling pathway, calcium modulating pathway(GO:0007223)
0.0 2.3 GO:0014065 phosphatidylinositol 3-kinase signaling(GO:0014065)
0.0 0.1 GO:0008627 intrinsic apoptotic signaling pathway in response to osmotic stress(GO:0008627)
0.0 0.4 GO:0061014 positive regulation of mRNA catabolic process(GO:0061014)
0.0 0.6 GO:0045652 regulation of megakaryocyte differentiation(GO:0045652)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 5.5 GO:0001673 male germ cell nucleus(GO:0001673)
0.3 19.6 GO:0035577 azurophil granule membrane(GO:0035577)
0.2 1.0 GO:1990246 uniplex complex(GO:1990246)
0.2 20.8 GO:0035578 azurophil granule lumen(GO:0035578)
0.2 1.2 GO:0014701 junctional sarcoplasmic reticulum membrane(GO:0014701)
0.2 1.9 GO:0097025 MPP7-DLG1-LIN7 complex(GO:0097025)
0.1 1.9 GO:0030897 HOPS complex(GO:0030897)
0.1 0.4 GO:0031523 Myb complex(GO:0031523)
0.1 1.6 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.1 2.0 GO:0071564 npBAF complex(GO:0071564)
0.1 0.7 GO:0016013 syntrophin complex(GO:0016013)
0.1 0.3 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.1 1.4 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
0.0 0.5 GO:0033093 Weibel-Palade body(GO:0033093)
0.0 0.8 GO:0034045 pre-autophagosomal structure membrane(GO:0034045)
0.0 1.7 GO:0045095 keratin filament(GO:0045095)
0.0 0.7 GO:0030687 preribosome, large subunit precursor(GO:0030687)
0.0 0.4 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
0.0 4.2 GO:0032993 protein-DNA complex(GO:0032993)
0.0 0.8 GO:0035097 histone methyltransferase complex(GO:0035097)
0.0 0.4 GO:0097228 sperm principal piece(GO:0097228)
0.0 0.1 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.4 GO:0030673 axolemma(GO:0030673)
0.0 4.5 GO:0016607 nuclear speck(GO:0016607)
0.0 1.0 GO:0016459 myosin complex(GO:0016459)
0.0 1.3 GO:0045111 intermediate filament cytoskeleton(GO:0045111)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 2.9 GO:0004951 cholecystokinin receptor activity(GO:0004951)
0.5 7.5 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.3 4.3 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.3 0.8 GO:0005174 CD40 receptor binding(GO:0005174)
0.2 0.6 GO:0032093 SAM domain binding(GO:0032093)
0.2 2.4 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 0.7 GO:0016907 G-protein coupled acetylcholine receptor activity(GO:0016907)
0.1 0.4 GO:0036487 nitric-oxide synthase inhibitor activity(GO:0036487)
0.1 0.8 GO:0008046 axon guidance receptor activity(GO:0008046)
0.1 0.9 GO:0030345 extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345)
0.1 0.9 GO:0034711 inhibin binding(GO:0034711)
0.1 1.0 GO:1990226 histone methyltransferase binding(GO:1990226)
0.1 0.4 GO:0034988 Fc-gamma receptor I complex binding(GO:0034988)
0.1 0.5 GO:0001093 TFIIB-class transcription factor binding(GO:0001093)
0.1 3.6 GO:0001103 RNA polymerase II repressing transcription factor binding(GO:0001103)
0.1 1.9 GO:0034237 protein kinase A regulatory subunit binding(GO:0034237)
0.1 0.8 GO:0032041 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
0.1 0.5 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.1 0.5 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.1 0.3 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.1 5.5 GO:0003777 microtubule motor activity(GO:0003777)
0.1 0.2 GO:0050309 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.1 0.3 GO:0038051 glucocorticoid receptor activity(GO:0004883) glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity(GO:0038051)
0.0 2.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 2.6 GO:0001105 RNA polymerase II transcription coactivator activity(GO:0001105)
0.0 0.7 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 1.5 GO:0070888 E-box binding(GO:0070888)
0.0 24.4 GO:0003682 chromatin binding(GO:0003682)
0.0 0.4 GO:0005176 ErbB-2 class receptor binding(GO:0005176)
0.0 0.3 GO:0030274 LIM domain binding(GO:0030274)
0.0 1.8 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
0.0 0.9 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 0.6 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.0 1.9 GO:0032947 protein complex scaffold(GO:0032947)
0.0 0.4 GO:0004435 phosphatidylinositol phospholipase C activity(GO:0004435)
0.0 1.0 GO:0003774 motor activity(GO:0003774)
0.0 1.9 GO:0000149 SNARE binding(GO:0000149)
0.0 0.2 GO:0015172 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 1.3 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 0.3 GO:0071889 14-3-3 protein binding(GO:0071889)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 5.8 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 1.6 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
0.0 1.1 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 0.9 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.0 1.4 PID EPHRINB REV PATHWAY Ephrin B reverse signaling
0.0 2.0 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.0 0.5 PID CONE PATHWAY Visual signal transduction: Cones
0.0 1.6 PID RAC1 PATHWAY RAC1 signaling pathway
0.0 0.8 PID CD40 PATHWAY CD40/CD40L signaling
0.0 1.3 PID HNF3A PATHWAY FOXA1 transcription factor network
0.0 0.4 PID IL8 CXCR1 PATHWAY IL8- and CXCR1-mediated signaling events
0.0 0.5 PID RHOA PATHWAY RhoA signaling pathway
0.0 0.4 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.0 0.8 PID ILK PATHWAY Integrin-linked kinase signaling
0.0 0.6 NABA PROTEOGLYCANS Genes encoding proteoglycans

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 5.8 REACTOME MYOGENESIS Genes involved in Myogenesis
0.1 1.7 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GLP1 Genes involved in Synthesis, Secretion, and Inactivation of Glucagon-like Peptide-1 (GLP-1)
0.0 0.6 REACTOME PLATELET ADHESION TO EXPOSED COLLAGEN Genes involved in Platelet Adhesion to exposed collagen
0.0 1.4 REACTOME AMINO ACID AND OLIGOPEPTIDE SLC TRANSPORTERS Genes involved in Amino acid and oligopeptide SLC transporters
0.0 0.5 REACTOME N GLYCAN ANTENNAE ELONGATION Genes involved in N-Glycan antennae elongation
0.0 0.4 REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA Genes involved in G beta:gamma signalling through PLC beta
0.0 0.8 REACTOME GPVI MEDIATED ACTIVATION CASCADE Genes involved in GPVI-mediated activation cascade
0.0 3.8 REACTOME G ALPHA Q SIGNALLING EVENTS Genes involved in G alpha (q) signalling events
0.0 0.3 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.0 0.8 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.0 0.9 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4