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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Z-value: 8.82
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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000065978.13 | Y-box binding protein 1 | |
| ENSG00000170345.5 | Fos proto-oncogene, AP-1 transcription factor subunit | |
| ENSG00000066136.15 | nuclear transcription factor Y subunit gamma | |
| ENSG00000001167.10 | nuclear transcription factor Y subunit alpha | |
| ENSG00000120837.3 | nuclear transcription factor Y subunit beta | |
| ENSG00000115816.9 | CCAAT enhancer binding protein zeta |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CEBPZ | hg19_v2_chr2_-_37458749_37458856 | 0.83 | 2.9e-56 | Click! |
| YBX1 | hg19_v2_chr1_+_43148625_43148710 | 0.78 | 1.9e-46 | Click! |
| NFYC | hg19_v2_chr1_+_41204506_41204541 | 0.69 | 5.4e-32 | Click! |
| NFYB | hg19_v2_chr12_-_104531945_104531996 | 0.54 | 4.1e-18 | Click! |
| FOS | hg19_v2_chr14_+_75745477_75745680 | -0.40 | 1.3e-09 | Click! |
| NFYA | hg19_v2_chr6_+_41040678_41040722 | -0.02 | 8.1e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_154947148 Show fit | 329.21 |
ENST00000368436.1
ENST00000308987.5 |
CDC28 protein kinase regulatory subunit 1B |
|
| chr1_+_154947126 Show fit | 313.29 |
ENST00000368439.1
|
CDC28 protein kinase regulatory subunit 1B |
|
| chr17_-_38574169 Show fit | 289.03 |
ENST00000423485.1
|
topoisomerase (DNA) II alpha 170kDa |
|
| chr14_+_54863739 Show fit | 287.52 |
ENST00000541304.1
|
cyclin-dependent kinase inhibitor 3 |
|
| chr14_+_54863667 Show fit | 279.35 |
ENST00000335183.6
|
cyclin-dependent kinase inhibitor 3 |
|
| chr14_+_54863682 Show fit | 269.87 |
ENST00000543789.2
ENST00000442975.2 ENST00000458126.2 ENST00000556102.2 |
cyclin-dependent kinase inhibitor 3 |
|
| chr1_-_197115818 Show fit | 252.56 |
ENST00000367409.4
ENST00000294732.7 |
asp (abnormal spindle) homolog, microcephaly associated (Drosophila) |
|
| chr4_-_174255536 Show fit | 244.96 |
ENST00000446922.2
|
high mobility group box 2 |
|
| chr9_+_91926103 Show fit | 243.06 |
ENST00000314355.6
|
CDC28 protein kinase regulatory subunit 2 |
|
| chr3_+_172468505 Show fit | 218.39 |
ENST00000427830.1
ENST00000417960.1 ENST00000428567.1 ENST00000366090.2 ENST00000426894.1 |
epithelial cell transforming sequence 2 oncogene |
Network of associatons between targets according to the STRING database.
First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.2 | 1173.9 | GO:0043044 | ATP-dependent chromatin remodeling(GO:0043044) |
| 16.0 | 1022.7 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) |
| 19.0 | 874.1 | GO:0045737 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) |
| 43.6 | 740.6 | GO:0006265 | DNA topological change(GO:0006265) |
| 92.5 | 740.3 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 10.3 | 615.8 | GO:0007077 | mitotic nuclear envelope disassembly(GO:0007077) |
| 16.5 | 610.6 | GO:2000816 | negative regulation of mitotic sister chromatid separation(GO:2000816) |
| 8.1 | 510.5 | GO:0032392 | DNA geometric change(GO:0032392) |
| 11.6 | 462.1 | GO:0042407 | cristae formation(GO:0042407) |
| 6.4 | 460.5 | GO:1902653 | cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 39.8 | 1194.7 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 16.5 | 923.5 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 30.4 | 639.1 | GO:0000812 | Swr1 complex(GO:0000812) |
| 125.0 | 625.2 | GO:0097125 | cyclin B1-CDK1 complex(GO:0097125) |
| 101.7 | 508.3 | GO:0097149 | centralspindlin complex(GO:0097149) |
| 29.1 | 494.4 | GO:0034709 | methylosome(GO:0034709) |
| 61.3 | 490.1 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 3.1 | 449.0 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 1.2 | 418.5 | GO:0005635 | nuclear envelope(GO:0005635) |
| 7.8 | 405.6 | GO:0005871 | kinesin complex(GO:0005871) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 175.5 | 1228.4 | GO:0061575 | cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575) |
| 18.9 | 869.3 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.9 | 836.9 | GO:0003723 | RNA binding(GO:0003723) |
| 17.3 | 776.3 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 14.6 | 644.6 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 15.0 | 556.4 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 1.4 | 458.9 | GO:0045296 | cadherin binding(GO:0045296) |
| 48.5 | 436.5 | GO:0035174 | histone serine kinase activity(GO:0035174) |
| 3.7 | 410.0 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 2.0 | 409.7 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 31.1 | 2116.0 | PID PLK1 PATHWAY | PLK1 signaling events |
| 24.0 | 1655.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 9.4 | 877.3 | PID E2F PATHWAY | E2F transcription factor network |
| 5.0 | 853.0 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 9.7 | 476.1 | PID FANCONI PATHWAY | Fanconi anemia pathway |
| 10.0 | 449.2 | PID AURORA B PATHWAY | Aurora B signaling |
| 11.0 | 430.9 | PID MYC PATHWAY | C-MYC pathway |
| 9.8 | 402.2 | PID AURORA A PATHWAY | Aurora A signaling |
| 12.3 | 318.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 4.8 | 312.4 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 49.0 | 1371.3 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 12.1 | 1092.8 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 7.6 | 1089.7 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 34.6 | 1074.0 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 89.2 | 624.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 8.4 | 596.6 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 12.6 | 590.3 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 29.2 | 583.8 | REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION | Genes involved in Apoptosis induced DNA fragmentation |
| 48.5 | 581.8 | REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND | Genes involved in Removal of the Flap Intermediate from the C-strand |
| 21.6 | 560.9 | REACTOME KINESINS | Genes involved in Kinesins |