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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Z-value: 8.82

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Transcription factors associated with YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

Gene Symbol Gene ID Gene Info
ENSG00000065978.13 Y-box binding protein 1
ENSG00000170345.5 Fos proto-oncogene, AP-1 transcription factor subunit
ENSG00000066136.15 nuclear transcription factor Y subunit gamma
ENSG00000001167.10 nuclear transcription factor Y subunit alpha
ENSG00000120837.3 nuclear transcription factor Y subunit beta
ENSG00000115816.9 CCAAT enhancer binding protein zeta

Activity-expression correlation:

Activity profile of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Sorted Z-values of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ motif

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_154947148 329.21 ENST00000368436.1
ENST00000308987.5
CDC28 protein kinase regulatory subunit 1B
chr1_+_154947126 313.29 ENST00000368439.1
CDC28 protein kinase regulatory subunit 1B
chr17_-_38574169 289.03 ENST00000423485.1
topoisomerase (DNA) II alpha 170kDa
chr14_+_54863739 287.52 ENST00000541304.1
cyclin-dependent kinase inhibitor 3
chr14_+_54863667 279.35 ENST00000335183.6
cyclin-dependent kinase inhibitor 3
chr14_+_54863682 269.87 ENST00000543789.2
ENST00000442975.2
ENST00000458126.2
ENST00000556102.2
cyclin-dependent kinase inhibitor 3
chr1_-_197115818 252.56 ENST00000367409.4
ENST00000294732.7
asp (abnormal spindle) homolog, microcephaly associated (Drosophila)
chr4_-_174255536 244.96 ENST00000446922.2
high mobility group box 2
chr9_+_91926103 243.06 ENST00000314355.6
CDC28 protein kinase regulatory subunit 2
chr3_+_172468505 218.39 ENST00000427830.1
ENST00000417960.1
ENST00000428567.1
ENST00000366090.2
ENST00000426894.1
epithelial cell transforming sequence 2 oncogene
chr1_-_153643442 209.73 ENST00000368681.1
ENST00000361891.4
interleukin enhancer binding factor 2
chr3_+_172468472 201.12 ENST00000232458.5
ENST00000392692.3
epithelial cell transforming sequence 2 oncogene
chr17_+_26646175 197.63 ENST00000583381.1
ENST00000582113.1
ENST00000582384.1
transmembrane protein 97
chr19_-_55919087 189.78 ENST00000587845.1
ENST00000589978.1
ENST00000264552.9
ubiquitin-conjugating enzyme E2S
chr2_-_61765315 169.78 ENST00000406957.1
ENST00000401558.2
exportin 1 (CRM1 homolog, yeast)
chr17_-_8113886 164.90 ENST00000577833.1
ENST00000534871.1
ENST00000583915.1
ENST00000316199.6
ENST00000581511.1
ENST00000585124.1
aurora kinase B
chr10_+_124914285 162.69 ENST00000407911.2
BUB3 mitotic checkpoint protein
chr5_+_151151471 160.78 ENST00000394123.3
ENST00000543466.1
GTPase activating protein (SH3 domain) binding protein 1
chr5_+_137514834 159.24 ENST00000508792.1
ENST00000504621.1
kinesin family member 20A
chr5_+_177631523 158.60 ENST00000506339.1
ENST00000355836.5
ENST00000514633.1
ENST00000515193.1
ENST00000506259.1
ENST00000504898.1
heterogeneous nuclear ribonucleoprotein A/B
chr20_+_44441271 155.85 ENST00000335046.3
ENST00000243893.6
ubiquitin-conjugating enzyme E2C
chr5_+_151151504 155.37 ENST00000356245.3
ENST00000507878.2
GTPase activating protein (SH3 domain) binding protein 1
chr14_-_21737551 154.73 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr15_+_59397275 153.42 ENST00000288207.2
cyclin B2
chr20_+_47662805 151.59 ENST00000262982.2
ENST00000542325.1
CSE1 chromosome segregation 1-like (yeast)
chr15_-_64673630 151.23 ENST00000558008.1
ENST00000559519.1
ENST00000380258.2
KIAA0101
chr10_+_62538089 150.83 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
cyclin-dependent kinase 1
chr5_+_177631497 149.44 ENST00000358344.3
heterogeneous nuclear ribonucleoprotein A/B
chr17_-_8113542 148.71 ENST00000578549.1
ENST00000535053.1
ENST00000582368.1
aurora kinase B
chr11_+_63953691 148.59 ENST00000543847.1
stress-induced-phosphoprotein 1
chr2_+_10262442 148.24 ENST00000360566.2
ribonucleotide reductase M2
chr1_+_43824577 148.21 ENST00000310955.6
cell division cycle 20
chr1_+_43824669 146.76 ENST00000372462.1
cell division cycle 20
chr5_+_137514687 145.03 ENST00000394894.3
kinesin family member 20A
chr15_+_59397298 143.71 ENST00000559622.1
cyclin B2
chr14_-_21737610 143.65 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chrX_+_154444643 142.23 ENST00000286428.5
von Hippel-Lindau binding protein 1
chr17_+_26646121 142.19 ENST00000226230.6
transmembrane protein 97
chr4_-_174256276 137.28 ENST00000296503.5
high mobility group box 2
chr12_+_104324112 135.19 ENST00000299767.5
heat shock protein 90kDa beta (Grp94), member 1
chr1_+_62902308 135.11 ENST00000339950.4
ubiquitin specific peptidase 1
chr20_+_44441626 134.26 ENST00000372568.4
ubiquitin-conjugating enzyme E2C
chr20_+_44441304 132.30 ENST00000352551.5
ubiquitin-conjugating enzyme E2C
chr1_+_110881945 131.87 ENST00000602849.1
ENST00000487146.2
RNA binding motif protein 15
chr20_-_5100591 131.63 ENST00000379143.5
proliferating cell nuclear antigen
chr10_+_62538248 131.55 ENST00000448257.2
cyclin-dependent kinase 1
chr17_-_76183111 130.84 ENST00000405273.1
ENST00000590862.1
ENST00000590430.1
ENST00000586613.1
thymidine kinase 1, soluble
chr12_+_56211703 128.47 ENST00000243045.5
ENST00000552672.1
ENST00000550836.1
ORM1-like 2 (S. cerevisiae)
chr20_+_44441215 128.08 ENST00000356455.4
ENST00000405520.1
ubiquitin-conjugating enzyme E2C
chr1_+_62901968 126.84 ENST00000452143.1
ENST00000442679.1
ENST00000371146.1
ubiquitin specific peptidase 1
chr5_+_159848807 125.26 ENST00000352433.5
pituitary tumor-transforming 1
chr5_+_68462837 121.18 ENST00000256442.5
cyclin B1
chr3_+_179280668 120.89 ENST00000429709.2
ENST00000450518.2
ENST00000392662.1
ENST00000490364.1
actin-like 6A
chr5_+_145826867 120.61 ENST00000296702.5
ENST00000394421.2
transcription elongation regulator 1
chr2_+_10262857 119.99 ENST00000304567.5
ribonucleotide reductase M2
chr1_+_38158090 116.67 ENST00000373055.1
ENST00000327331.2
cell division cycle associated 8
chr1_-_150669500 114.22 ENST00000271732.3
golgi phosphoprotein 3-like
chr5_+_68462944 113.95 ENST00000506572.1
cyclin B1
chr5_+_162864575 111.30 ENST00000512163.1
ENST00000393929.1
ENST00000340828.2
ENST00000511683.2
ENST00000510097.1
ENST00000511490.2
ENST00000510664.1
cyclin G1
chr19_+_50180317 111.28 ENST00000534465.1
protein arginine methyltransferase 1
chr15_+_41624892 109.30 ENST00000260359.6
ENST00000450318.1
ENST00000450592.2
ENST00000559596.1
ENST00000414849.2
ENST00000560747.1
ENST00000560177.1
nucleolar and spindle associated protein 1
chr5_+_68463043 107.74 ENST00000508407.1
ENST00000505500.1
cyclin B1
chr20_-_48770174 106.90 ENST00000341698.2
TMEM189-UBE2V1 readthrough
chr4_-_1713977 105.89 ENST00000318386.4
stem-loop binding protein
chr7_+_73097890 104.58 ENST00000265758.2
ENST00000423166.2
ENST00000423497.1
Williams Beuren syndrome chromosome region 22
chr20_-_48770244 102.77 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
transmembrane protein 189
chr7_-_99699538 100.90 ENST00000343023.6
ENST00000303887.5
minichromosome maintenance complex component 7
chr5_+_74633036 100.35 ENST00000343975.5
3-hydroxy-3-methylglutaryl-CoA reductase
chr11_+_63953587 100.27 ENST00000305218.4
ENST00000538945.1
stress-induced-phosphoprotein 1
chr17_+_6347729 99.76 ENST00000572447.1
family with sequence similarity 64, member A
chr14_+_58711539 99.11 ENST00000216455.4
ENST00000412908.2
ENST00000557508.1
proteasome (prosome, macropain) subunit, alpha type, 3
chr10_+_124913930 98.58 ENST00000368858.5
BUB3 mitotic checkpoint protein
chr1_+_41174988 98.38 ENST00000372652.1
nuclear transcription factor Y, gamma
chr8_+_11660227 98.25 ENST00000443614.2
ENST00000525900.1
farnesyl-diphosphate farnesyltransferase 1
chr6_+_24775153 98.22 ENST00000356509.3
ENST00000230056.3
geminin, DNA replication inhibitor
chr2_+_27008865 98.17 ENST00000335756.4
ENST00000233505.8
centromere protein A
chr17_+_6347761 96.97 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
family with sequence similarity 64, member A
chr2_-_96874553 96.72 ENST00000337288.5
ENST00000443962.1
StAR-related lipid transfer (START) domain containing 7
chr1_+_155278539 95.62 ENST00000447866.1
farnesyl diphosphate synthase
chr9_-_95056010 95.38 ENST00000443024.2
isoleucyl-tRNA synthetase
chr20_-_54967187 95.28 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
aurora kinase A
chr5_+_162887556 94.76 ENST00000393915.4
ENST00000432118.2
ENST00000358715.3
hyaluronan-mediated motility receptor (RHAMM)
chr1_-_150208498 92.60 ENST00000314136.8
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr5_+_74632993 91.86 ENST00000287936.4
3-hydroxy-3-methylglutaryl-CoA reductase
chr9_+_140135665 91.59 ENST00000340384.4
tubulin, beta 4B class IVb
chr12_-_102513843 91.32 ENST00000551744.2
ENST00000552283.1
nucleoporin 37kDa
chr8_-_25315905 90.93 ENST00000221200.4
potassium channel tetramerization domain containing 9
chr4_+_166248775 90.28 ENST00000261507.6
ENST00000507013.1
ENST00000393766.2
ENST00000504317.1
methylsterol monooxygenase 1
chr19_+_13049413 90.28 ENST00000316448.5
ENST00000588454.1
calreticulin
chr1_-_150208412 89.74 ENST00000532744.1
ENST00000369114.5
ENST00000369115.2
ENST00000369116.4
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr9_-_35103105 89.47 ENST00000452248.2
ENST00000356493.5
stomatin (EPB72)-like 2
chr19_-_8070474 89.00 ENST00000407627.2
ENST00000593807.1
ELAV like RNA binding protein 1
chr6_+_80714318 88.82 ENST00000369798.2
TTK protein kinase
chr17_+_45727204 88.64 ENST00000290158.4
karyopherin (importin) beta 1
chr1_+_155278625 88.48 ENST00000368356.4
ENST00000356657.6
farnesyl diphosphate synthase
chr17_-_5323480 88.27 ENST00000573584.1
nucleoporin 88kDa
chr8_+_11660120 88.25 ENST00000220584.4
farnesyl-diphosphate farnesyltransferase 1
chr9_-_128003606 88.04 ENST00000324460.6
heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
chr17_-_79818354 87.68 ENST00000576541.1
ENST00000576380.1
ENST00000571617.1
ENST00000576052.1
ENST00000576390.1
ENST00000573778.2
ENST00000439918.2
ENST00000574914.1
ENST00000331483.4
prolyl 4-hydroxylase, beta polypeptide
chr14_-_55658252 87.07 ENST00000395425.2
discs, large (Drosophila) homolog-associated protein 5
chr6_-_18265050 86.79 ENST00000397239.3
DEK oncogene
chr1_-_150208363 86.76 ENST00000436748.2
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr12_-_49075941 86.65 ENST00000553086.1
ENST00000548304.1
KAT8 regulatory NSL complex subunit 2
chr1_+_181057638 86.64 ENST00000367577.4
immediate early response 5
chr7_-_30544405 86.21 ENST00000409390.1
ENST00000409144.1
ENST00000005374.6
ENST00000409436.1
ENST00000275428.4
gamma-glutamylcyclotransferase
chr17_+_1733276 86.09 ENST00000254719.5
replication protein A1, 70kDa
chr5_+_159848854 85.78 ENST00000517480.1
ENST00000520452.1
ENST00000393964.1
pituitary tumor-transforming 1
chr19_+_3572925 85.77 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
high mobility group 20B
chr14_-_23398565 84.88 ENST00000397440.4
ENST00000538452.1
ENST00000421938.2
ENST00000554867.1
ENST00000556616.1
ENST00000216350.8
ENST00000553550.1
ENST00000397441.2
ENST00000553897.1
protein arginine methyltransferase 5
chr6_+_160183492 84.86 ENST00000541436.1
acetyl-CoA acetyltransferase 2
chr3_+_37034823 84.27 ENST00000231790.2
ENST00000456676.2
mutL homolog 1
chr19_+_45394477 83.47 ENST00000252487.5
ENST00000405636.2
ENST00000592434.1
ENST00000426677.2
ENST00000589649.1
translocase of outer mitochondrial membrane 40 homolog (yeast)
chr7_-_7680601 83.11 ENST00000396682.2
replication protein A3, 14kDa
chr8_-_66546439 82.61 ENST00000276569.3
armadillo repeat containing 1
chrX_+_150151752 81.57 ENST00000325307.7
high mobility group box 3
chr4_+_1723197 81.56 ENST00000485989.2
ENST00000313288.4
transforming, acidic coiled-coil containing protein 3
chr10_-_58120996 81.55 ENST00000361148.6
ENST00000395405.1
ENST00000373944.3
ZW10 interacting kinetochore protein
chr6_+_32146131 81.33 ENST00000375094.3
ring finger protein 5, E3 ubiquitin protein ligase
chr10_+_14880157 81.07 ENST00000378372.3
heat shock 70kDa protein 14
chr7_-_148725733 80.62 ENST00000286091.4
protein disulfide isomerase family A, member 4
chr2_+_191745560 80.60 ENST00000338435.4
glutaminase
chr19_-_18433875 80.56 ENST00000252816.6
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr19_+_49497121 80.07 ENST00000413176.2
RuvB-like AAA ATPase 2
chr14_-_55658323 79.62 ENST00000554067.1
ENST00000247191.2
discs, large (Drosophila) homolog-associated protein 5
chr15_-_41624685 79.54 ENST00000560640.1
ENST00000220514.3
Opa interacting protein 5
chr19_+_49496705 79.50 ENST00000595090.1
RuvB-like AAA ATPase 2
chr5_-_137878887 78.88 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
eukaryotic translation termination factor 1
chr20_+_30327063 78.40 ENST00000300403.6
ENST00000340513.4
TPX2, microtubule-associated
chr1_-_35658736 78.15 ENST00000357214.5
splicing factor proline/glutamine-rich
chr14_+_52456327 77.95 ENST00000556760.1
chromosome 14 open reading frame 166
chr4_-_100871506 77.64 ENST00000296417.5
H2A histone family, member Z
chr6_-_52149475 77.23 ENST00000419835.2
ENST00000229854.7
ENST00000596288.1
minichromosome maintenance complex component 3
chr5_+_44809027 76.78 ENST00000507110.1
mitochondrial ribosomal protein S30
chr19_-_18433910 75.83 ENST00000594828.3
ENST00000593829.1
LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)
chr11_-_46867780 75.47 ENST00000529230.1
ENST00000415402.1
ENST00000312055.5
cytoskeleton associated protein 5
chr8_+_6565854 74.68 ENST00000285518.6
1-acylglycerol-3-phosphate O-acyltransferase 5
chr2_-_111435610 74.48 ENST00000447014.1
ENST00000420328.1
ENST00000535254.1
ENST00000409311.1
ENST00000302759.6
BUB1 mitotic checkpoint serine/threonine kinase
chr22_+_19467261 74.34 ENST00000455750.1
ENST00000437685.2
ENST00000263201.1
ENST00000404724.3
cell division cycle 45
chr1_+_52082751 74.33 ENST00000447887.1
ENST00000435686.2
ENST00000428468.1
ENST00000453295.1
oxysterol binding protein-like 9
chr17_-_43025005 74.11 ENST00000587309.1
ENST00000593135.1
ENST00000339151.4
kinesin family member 18B
chr2_+_74425689 74.08 ENST00000394053.2
ENST00000409804.1
ENST00000264090.4
ENST00000394050.3
ENST00000409601.1
methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase
chr1_-_27816641 73.52 ENST00000430629.2
WAS protein family, member 2
chr17_-_5322786 73.27 ENST00000225696.4
nucleoporin 88kDa
chr12_+_56618102 73.04 ENST00000267023.4
ENST00000380198.2
ENST00000341463.5
nucleic acid binding protein 2
chrX_-_100662881 72.55 ENST00000218516.3
galactosidase, alpha
chr20_+_3869423 72.39 ENST00000497424.1
pantothenate kinase 2
chr21_-_40720974 72.38 ENST00000380748.1
high mobility group nucleosome binding domain 1
chr1_+_10459111 72.27 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
phosphogluconate dehydrogenase
chr12_+_109535373 72.02 ENST00000242576.2
uracil-DNA glycosylase
chr13_+_53029564 71.22 ENST00000468284.1
ENST00000378034.3
ENST00000258607.5
ENST00000378037.5
cytoskeleton associated protein 2
chr12_-_49076002 71.20 ENST00000357861.3
ENST00000550347.1
ENST00000420613.2
ENST00000550931.1
ENST00000550870.1
KAT8 regulatory NSL complex subunit 2
chr3_-_141868293 71.13 ENST00000317104.7
ENST00000494358.1
transcription factor Dp-2 (E2F dimerization partner 2)
chr7_+_12727250 71.06 ENST00000404894.1
ADP-ribosylation factor-like 4A
chr16_+_69458537 71.04 ENST00000515314.1
ENST00000561792.1
ENST00000568237.1
cytochrome b5 type B (outer mitochondrial membrane)
chr11_+_57480046 70.97 ENST00000378312.4
ENST00000278422.4
thioredoxin-related transmembrane protein 2
chr4_-_1714037 70.80 ENST00000488267.1
ENST00000429429.2
ENST00000480936.1
stem-loop binding protein
chr11_+_95523621 70.51 ENST00000325542.5
ENST00000325486.5
ENST00000544522.1
ENST00000541365.1
centrosomal protein 57kDa
chr14_+_39644387 70.34 ENST00000553331.1
ENST00000216832.4
pinin, desmosome associated protein
chr17_-_79980734 70.05 ENST00000584600.1
ENST00000584347.1
ENST00000580435.1
ENST00000306704.6
ENST00000392359.3
stimulated by retinoic acid 13
chrX_+_48432892 69.64 ENST00000376759.3
ENST00000430348.2
RNA binding motif (RNP1, RRM) protein 3
chr13_-_31040060 69.31 ENST00000326004.4
ENST00000341423.5
high mobility group box 1
chr5_-_89705537 69.25 ENST00000522864.1
ENST00000522083.1
ENST00000522565.1
ENST00000522842.1
ENST00000283122.3
centrin, EF-hand protein, 3
chr17_+_18759612 69.24 ENST00000432893.2
ENST00000414602.1
ENST00000574522.1
ENST00000570450.1
ENST00000419071.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chr1_+_214776516 69.22 ENST00000366955.3
centromere protein F, 350/400kDa
chr16_+_69458428 69.04 ENST00000512062.1
ENST00000307892.8
cytochrome b5 type B (outer mitochondrial membrane)
chr12_+_121124921 68.75 ENST00000412616.2
malectin
chr1_-_28241226 68.51 ENST00000373912.3
ENST00000373909.3
replication protein A2, 32kDa
chr19_+_16222439 68.16 ENST00000300935.3
RAB8A, member RAS oncogene family
chr12_+_109535923 68.16 ENST00000336865.2
uracil-DNA glycosylase
chr11_-_64546202 68.12 ENST00000377390.3
ENST00000227503.9
ENST00000377394.3
ENST00000422298.2
ENST00000334944.5
splicing factor 1
chr20_+_35807449 67.95 ENST00000237530.6
ribophorin II
chr10_+_124913793 67.81 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3 mitotic checkpoint protein
chr6_+_27114861 67.72 ENST00000377459.1
histone cluster 1, H2ah
chr2_-_234763147 67.48 ENST00000411486.2
ENST00000432087.1
ENST00000441687.1
ENST00000414924.1
Holliday junction recognition protein
chr21_-_40720995 67.17 ENST00000380749.5
high mobility group nucleosome binding domain 1
chr20_-_5107180 67.09 ENST00000379160.3
proliferating cell nuclear antigen
chr7_-_151217166 66.93 ENST00000496004.1
Ras homolog enriched in brain
chr12_+_6603253 66.72 ENST00000382457.4
ENST00000545962.1
non-SMC condensin I complex, subunit D2
chr15_+_80351910 66.57 ENST00000261749.6
ENST00000561060.1
zinc finger, AN1-type domain 6
chr11_-_64545941 66.28 ENST00000377387.1
splicing factor 1
chr1_+_33116765 66.12 ENST00000544435.1
ENST00000373485.1
ENST00000458695.2
ENST00000490500.1
ENST00000445722.2
retinoblastoma binding protein 4
chr2_+_75061108 65.90 ENST00000290573.2
hexokinase 2
chr2_-_128784846 65.68 ENST00000259235.3
ENST00000357702.5
ENST00000424298.1
Sin3A-associated protein, 130kDa
chr14_+_52456193 65.64 ENST00000261700.3
chromosome 14 open reading frame 166
chrX_+_48380205 65.51 ENST00000446158.1
ENST00000414061.1
emopamil binding protein (sterol isomerase)
chr1_-_150208291 65.43 ENST00000533654.1
acidic (leucine-rich) nuclear phosphoprotein 32 family, member E
chr3_+_51422478 64.82 ENST00000528157.1
mesencephalic astrocyte-derived neurotrophic factor
chr6_-_27114577 64.43 ENST00000356950.1
ENST00000396891.4
histone cluster 1, H2bk
chr1_+_33116743 64.30 ENST00000414241.3
ENST00000373493.5
retinoblastoma binding protein 4
chr1_-_225615599 64.17 ENST00000421383.1
ENST00000272163.4
lamin B receptor
chr5_-_31532160 64.11 ENST00000511367.2
ENST00000513349.1
drosha, ribonuclease type III
chr1_-_149814478 64.04 ENST00000369161.3
histone cluster 2, H2aa3
chr13_+_73302047 63.79 ENST00000377814.2
ENST00000377815.3
ENST00000390667.5
bora, aurora kinase A activator
chr19_+_41770236 63.58 ENST00000392006.3
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_-_64673665 63.38 ENST00000300035.4
KIAA0101
chr1_+_32757668 63.32 ENST00000373548.3
histone deacetylase 1
chr15_+_80351977 63.16 ENST00000559157.1
ENST00000561012.1
ENST00000564367.1
ENST00000558494.1
zinc finger, AN1-type domain 6
chr4_-_122744998 63.12 ENST00000274026.5
cyclin A2
chr11_-_66056596 63.08 ENST00000471387.2
ENST00000359461.6
ENST00000376901.4
Yip1 interacting factor homolog A (S. cerevisiae)
chr14_+_97263641 63.04 ENST00000216639.3
vaccinia related kinase 1

Network of associatons between targets according to the STRING database.

First level regulatory network of YBX1_FOS_NFYC_NFYA_NFYB_CEBPZ

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
114.3 342.9 GO:2000775 regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031660) positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle(GO:0031662) response to DDT(GO:0046680) histone H3-S10 phosphorylation involved in chromosome condensation(GO:2000775)
104.5 313.6 GO:0044878 mitotic cytokinesis checkpoint(GO:0044878)
92.5 740.3 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
61.2 306.0 GO:0016321 female meiosis chromosome segregation(GO:0016321)
54.1 216.5 GO:0090579 transcriptional activation by promoter-enhancer looping(GO:0071733) gene looping(GO:0090202) dsDNA loop formation(GO:0090579)
52.2 313.2 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
51.7 206.6 GO:0006272 leading strand elongation(GO:0006272)
48.8 293.0 GO:0014038 regulation of Schwann cell differentiation(GO:0014038)
48.0 383.8 GO:0090306 spindle assembly involved in meiosis(GO:0090306)
47.8 334.6 GO:0000056 ribosomal small subunit export from nucleus(GO:0000056)
47.2 330.7 GO:0016128 phytosteroid metabolic process(GO:0016128) phytosteroid biosynthetic process(GO:0016129)
46.7 140.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
46.1 138.3 GO:0006267 pre-replicative complex assembly involved in nuclear cell cycle DNA replication(GO:0006267) pre-replicative complex assembly(GO:0036388) pre-replicative complex assembly involved in cell cycle DNA replication(GO:1902299)
43.6 740.6 GO:0006265 DNA topological change(GO:0006265)
43.0 301.3 GO:0043985 histone H4-R3 methylation(GO:0043985)
42.8 128.5 GO:0090155 negative regulation of sphingolipid biosynthetic process(GO:0090155) negative regulation of ceramide biosynthetic process(GO:1900060)
35.5 35.5 GO:1903405 protein localization to nuclear body(GO:1903405) protein localization to Cajal body(GO:1904867) regulation of protein localization to Cajal body(GO:1904869) positive regulation of protein localization to Cajal body(GO:1904871) protein localization to nucleoplasm(GO:1990173)
33.0 165.1 GO:0045338 farnesyl diphosphate metabolic process(GO:0045338)
33.0 164.9 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
32.7 130.8 GO:0046104 thymidine metabolic process(GO:0046104) pyrimidine deoxyribonucleoside metabolic process(GO:0046125)
31.7 380.8 GO:0051988 regulation of attachment of spindle microtubules to kinetochore(GO:0051988)
31.4 94.1 GO:0033489 cholesterol biosynthetic process via desmosterol(GO:0033489) cholesterol biosynthetic process via lathosterol(GO:0033490)
31.3 156.5 GO:0000389 mRNA 3'-splice site recognition(GO:0000389)
29.6 88.7 GO:0072334 UDP-galactose transport(GO:0015785) UDP-galactose transmembrane transport(GO:0072334)
29.3 88.0 GO:0021589 hindbrain structural organization(GO:0021577) cerebellum structural organization(GO:0021589)
28.5 114.1 GO:0071163 DNA replication preinitiation complex assembly(GO:0071163)
27.3 54.6 GO:0005997 xylulose metabolic process(GO:0005997)
27.0 81.1 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
25.5 25.5 GO:1903181 regulation of dopamine biosynthetic process(GO:1903179) positive regulation of dopamine biosynthetic process(GO:1903181)
25.2 75.5 GO:1903526 negative regulation of membrane tubulation(GO:1903526)
24.3 72.9 GO:2000374 regulation of oxygen metabolic process(GO:2000374)
24.3 97.1 GO:0019322 pentose biosynthetic process(GO:0019322)
24.2 363.3 GO:0034975 protein folding in endoplasmic reticulum(GO:0034975)
23.7 47.5 GO:0051088 PMA-inducible membrane protein ectodomain proteolysis(GO:0051088)
23.4 23.4 GO:1904815 negative regulation of protein localization to chromosome, telomeric region(GO:1904815)
22.7 113.7 GO:1903377 negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903377)
22.4 269.1 GO:0035520 monoubiquitinated protein deubiquitination(GO:0035520)
22.4 89.5 GO:0090296 regulation of mitochondrial DNA replication(GO:0090296)
21.5 364.8 GO:0000920 cell separation after cytokinesis(GO:0000920)
21.3 63.8 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
21.1 105.6 GO:0000973 posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery(GO:0000973)
20.9 20.9 GO:0031047 gene silencing by RNA(GO:0031047)
20.6 206.1 GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus(GO:0061179)
20.3 142.1 GO:0007221 positive regulation of transcription of Notch receptor target(GO:0007221)
20.0 20.0 GO:0060623 regulation of chromosome condensation(GO:0060623)
19.8 59.4 GO:1903926 signal transduction involved in intra-S DNA damage checkpoint(GO:0072428) response to bisphenol A(GO:1903925) cellular response to bisphenol A(GO:1903926)
19.7 296.1 GO:0016446 somatic hypermutation of immunoglobulin genes(GO:0016446)
19.4 58.3 GO:1903630 regulation of aminoacyl-tRNA ligase activity(GO:1903630)
19.4 154.9 GO:0010032 meiotic chromosome condensation(GO:0010032)
19.3 192.8 GO:0006268 DNA unwinding involved in DNA replication(GO:0006268)
19.0 874.1 GO:0045737 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737)
18.9 94.6 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
18.6 18.6 GO:1904429 regulation of t-circle formation(GO:1904429) positive regulation of t-circle formation(GO:1904431)
18.3 55.0 GO:0071109 superior temporal gyrus development(GO:0071109)
18.3 182.9 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
17.4 104.6 GO:0030581 intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708)
17.3 52.0 GO:0006425 glutaminyl-tRNA aminoacylation(GO:0006425)
17.2 292.3 GO:0090129 positive regulation of synapse maturation(GO:0090129)
16.6 49.9 GO:0044210 'de novo' CTP biosynthetic process(GO:0044210)
16.6 49.8 GO:0036333 hepatocyte homeostasis(GO:0036333) response to tetrachloromethane(GO:1904772)
16.5 33.1 GO:0043137 DNA replication, removal of RNA primer(GO:0043137)
16.5 610.6 GO:2000816 negative regulation of mitotic sister chromatid separation(GO:2000816)
16.5 49.5 GO:0007290 spermatid nucleus elongation(GO:0007290)
16.3 162.7 GO:0007091 metaphase/anaphase transition of mitotic cell cycle(GO:0007091)
16.2 81.1 GO:0031120 snRNA pseudouridine synthesis(GO:0031120)
16.2 113.5 GO:0070562 regulation of vitamin D receptor signaling pathway(GO:0070562)
16.2 48.5 GO:0044209 AMP salvage(GO:0044209)
16.0 1022.7 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079)
15.8 47.3 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
15.7 31.5 GO:0009211 pyrimidine deoxyribonucleoside triphosphate metabolic process(GO:0009211) dTTP metabolic process(GO:0046075)
15.7 47.1 GO:1901301 regulation of cargo loading into COPII-coated vesicle(GO:1901301)
15.6 156.5 GO:0015939 pantothenate metabolic process(GO:0015939)
15.6 78.2 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
15.5 46.6 GO:1904247 positive regulation of polynucleotide adenylyltransferase activity(GO:1904247)
15.5 93.1 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
15.5 31.0 GO:0009133 ADP biosynthetic process(GO:0006172) nucleoside diphosphate biosynthetic process(GO:0009133) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
15.4 46.3 GO:0048478 replication fork protection(GO:0048478)
15.4 184.7 GO:0007080 mitotic metaphase plate congression(GO:0007080)
15.2 76.2 GO:1904764 late endosomal microautophagy(GO:0061738) negative regulation of fibril organization(GO:1902904) chaperone-mediated autophagy translocation complex disassembly(GO:1904764)
15.2 1173.9 GO:0043044 ATP-dependent chromatin remodeling(GO:0043044)
15.1 75.3 GO:2000035 regulation of stem cell division(GO:2000035)
15.0 30.0 GO:0035927 RNA import into mitochondrion(GO:0035927) rRNA import into mitochondrion(GO:0035928)
14.9 311.9 GO:0009263 deoxyribonucleotide biosynthetic process(GO:0009263)
14.7 383.1 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
14.6 29.2 GO:0000912 assembly of actomyosin apparatus involved in cytokinesis(GO:0000912) actomyosin contractile ring assembly(GO:0000915) actomyosin contractile ring organization(GO:0044837)
14.2 28.5 GO:0000965 mitochondrial RNA 3'-end processing(GO:0000965)
13.9 55.6 GO:2001166 regulation of histone H2B ubiquitination(GO:2001166) positive regulation of histone H2B ubiquitination(GO:2001168)
13.8 69.1 GO:0002084 protein depalmitoylation(GO:0002084) negative regulation of Golgi to plasma membrane protein transport(GO:0042997)
13.7 123.3 GO:0050847 progesterone receptor signaling pathway(GO:0050847)
13.6 40.9 GO:0070638 nicotinamide riboside catabolic process(GO:0006738) inosine metabolic process(GO:0046102) nicotinamide riboside metabolic process(GO:0046495) pyridine nucleoside metabolic process(GO:0070637) pyridine nucleoside catabolic process(GO:0070638)
13.2 39.5 GO:0006106 fumarate metabolic process(GO:0006106)
13.0 39.1 GO:0070510 regulation of histone H4-K20 methylation(GO:0070510) positive regulation of histone H4-K20 methylation(GO:0070512)
12.9 64.4 GO:1903588 negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis(GO:1903588)
12.9 102.9 GO:0042761 fatty acid elongation(GO:0030497) very long-chain fatty acid biosynthetic process(GO:0042761)
12.6 188.7 GO:0030150 protein import into mitochondrial matrix(GO:0030150)
12.5 50.1 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
12.2 48.9 GO:0002317 plasma cell differentiation(GO:0002317)
12.1 12.1 GO:0019046 release from viral latency(GO:0019046)
12.0 108.3 GO:1903297 regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903297) negative regulation of hypoxia-induced intrinsic apoptotic signaling pathway(GO:1903298)
12.0 143.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
11.8 47.1 GO:0098905 regulation of bundle of His cell action potential(GO:0098905)
11.7 81.8 GO:0090224 regulation of spindle organization(GO:0090224)
11.6 34.9 GO:1901355 response to rapamycin(GO:1901355)
11.6 81.1 GO:0010606 positive regulation of cytoplasmic mRNA processing body assembly(GO:0010606)
11.6 34.7 GO:0043490 malate-aspartate shuttle(GO:0043490)
11.6 462.1 GO:0042407 cristae formation(GO:0042407)
11.1 77.7 GO:0072656 maintenance of protein location in mitochondrion(GO:0072656)
11.1 55.3 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
10.7 85.7 GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline(GO:0018401)
10.5 189.4 GO:0007021 tubulin complex assembly(GO:0007021)
10.5 31.5 GO:0072237 isoleucine catabolic process(GO:0006550) proximal convoluted tubule development(GO:0072019) metanephric proximal convoluted tubule development(GO:0072229) metanephric proximal tubule development(GO:0072237)
10.3 51.6 GO:0006543 glutamine catabolic process(GO:0006543)
10.3 615.8 GO:0007077 mitotic nuclear envelope disassembly(GO:0007077)
10.1 80.7 GO:0016139 glycoside catabolic process(GO:0016139)
10.0 49.9 GO:1905098 negative regulation of guanyl-nucleotide exchange factor activity(GO:1905098)
9.9 29.7 GO:0051066 dihydrobiopterin metabolic process(GO:0051066)
9.8 29.5 GO:0035087 targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087)
9.8 108.1 GO:2000576 positive regulation of microtubule motor activity(GO:2000576) regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000580) positive regulation of ATP-dependent microtubule motor activity, plus-end-directed(GO:2000582)
9.7 58.3 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
9.5 47.6 GO:2000781 positive regulation of double-strand break repair(GO:2000781)
9.5 37.8 GO:0006842 tricarboxylic acid transport(GO:0006842) citrate transport(GO:0015746)
9.4 56.5 GO:1903758 regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903756) negative regulation of transcription from RNA polymerase II promoter by histone modification(GO:1903758)
9.3 259.9 GO:0006270 DNA replication initiation(GO:0006270)
9.2 64.6 GO:0090650 response to oxygen-glucose deprivation(GO:0090649) cellular response to oxygen-glucose deprivation(GO:0090650)
9.2 27.6 GO:0019511 peptidyl-proline hydroxylation(GO:0019511)
9.2 27.6 GO:1901873 regulation of post-translational protein modification(GO:1901873)
9.1 45.5 GO:0070647 protein modification by small protein conjugation or removal(GO:0070647)
9.0 35.9 GO:0071681 response to indole-3-methanol(GO:0071680) cellular response to indole-3-methanol(GO:0071681)
9.0 89.7 GO:1902455 negative regulation of stem cell population maintenance(GO:1902455)
9.0 80.6 GO:0006552 leucine catabolic process(GO:0006552)
8.9 71.1 GO:0048194 Golgi vesicle budding(GO:0048194)
8.9 26.6 GO:0021678 fourth ventricle development(GO:0021592) third ventricle development(GO:0021678)
8.9 70.9 GO:2000628 regulation of miRNA metabolic process(GO:2000628)
8.7 26.1 GO:0032765 lymphotoxin A production(GO:0032641) positive regulation of mast cell cytokine production(GO:0032765) lymphotoxin A biosynthetic process(GO:0042109)
8.7 43.4 GO:0032380 regulation of intracellular lipid transport(GO:0032377) regulation of intracellular sterol transport(GO:0032380) regulation of intracellular cholesterol transport(GO:0032383)
8.6 129.4 GO:0060965 negative regulation of gene silencing by miRNA(GO:0060965)
8.6 333.5 GO:0000281 mitotic cytokinesis(GO:0000281)
8.5 59.2 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
8.4 33.6 GO:0010730 negative regulation of hydrogen peroxide biosynthetic process(GO:0010730)
8.4 386.0 GO:0000387 spliceosomal snRNP assembly(GO:0000387)
8.3 24.8 GO:0045658 regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659)
8.1 32.4 GO:0043456 regulation of pentose-phosphate shunt(GO:0043456)
8.1 510.5 GO:0032392 DNA geometric change(GO:0032392)
8.1 129.0 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
8.0 143.8 GO:0070200 establishment of protein localization to telomere(GO:0070200)
7.9 71.3 GO:0061732 mitochondrial acetyl-CoA biosynthetic process from pyruvate(GO:0061732)
7.8 31.2 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
7.7 77.3 GO:0002480 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent(GO:0002480)
7.7 23.1 GO:0070901 mitochondrial tRNA methylation(GO:0070901)
7.7 46.0 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
7.6 38.2 GO:0042816 vitamin B6 metabolic process(GO:0042816)
7.6 15.2 GO:0075528 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by symbiont of host defense response(GO:0052031) induction by organism of defense response of other organism involved in symbiotic interaction(GO:0052251) modulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052255) positive regulation by symbiont of host defense response(GO:0052509) positive regulation by organism of defense response of other organism involved in symbiotic interaction(GO:0052510) modulation by organism of immune response of other organism involved in symbiotic interaction(GO:0052552) modulation by symbiont of host immune response(GO:0052553) modulation by virus of host immune response(GO:0075528)
7.6 189.1 GO:0032786 positive regulation of DNA-templated transcription, elongation(GO:0032786)
7.5 60.4 GO:0045723 positive regulation of fatty acid biosynthetic process(GO:0045723)
7.5 7.5 GO:0090116 C-5 methylation of cytosine(GO:0090116)
7.5 89.7 GO:0006449 regulation of translational termination(GO:0006449)
7.4 133.9 GO:0061157 mRNA destabilization(GO:0061157)
7.4 52.0 GO:0003415 chondrocyte hypertrophy(GO:0003415)
7.4 88.4 GO:0071712 ER-associated misfolded protein catabolic process(GO:0071712)
7.3 14.6 GO:0070314 G1 to G0 transition(GO:0070314)
7.3 131.8 GO:1900363 regulation of mRNA polyadenylation(GO:1900363)
7.3 29.1 GO:0070131 positive regulation of mitochondrial translation(GO:0070131)
7.2 28.7 GO:0006556 S-adenosylmethionine biosynthetic process(GO:0006556)
7.0 105.1 GO:0016024 CDP-diacylglycerol biosynthetic process(GO:0016024)
7.0 147.0 GO:0002192 IRES-dependent translational initiation(GO:0002192)
7.0 14.0 GO:0045900 negative regulation of translational elongation(GO:0045900)
6.9 20.7 GO:0032773 regulation of monophenol monooxygenase activity(GO:0032771) positive regulation of monophenol monooxygenase activity(GO:0032773) negative regulation of catagen(GO:0051796) regulation of hair cycle by canonical Wnt signaling pathway(GO:0060901) positive regulation of melanosome transport(GO:1902910)
6.8 20.5 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
6.8 13.5 GO:0051295 establishment of meiotic spindle localization(GO:0051295)
6.8 33.8 GO:0033591 response to L-ascorbic acid(GO:0033591)
6.8 33.8 GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032)
6.8 101.3 GO:0043982 histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982)
6.7 20.2 GO:0046900 tetrahydrofolylpolyglutamate metabolic process(GO:0046900)
6.7 20.0 GO:0030860 regulation of polarized epithelial cell differentiation(GO:0030860)
6.6 72.7 GO:0045835 negative regulation of meiotic nuclear division(GO:0045835)
6.6 26.4 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
6.6 39.6 GO:0042866 pyruvate biosynthetic process(GO:0042866)
6.5 39.3 GO:2000324 positive regulation of glucocorticoid receptor signaling pathway(GO:2000324)
6.5 26.0 GO:0008616 queuosine biosynthetic process(GO:0008616) queuosine metabolic process(GO:0046116)
6.4 19.3 GO:0006258 UDP-glucose catabolic process(GO:0006258) galactose catabolic process via UDP-galactose(GO:0033499)
6.4 460.5 GO:1902653 cholesterol biosynthetic process(GO:0006695) secondary alcohol biosynthetic process(GO:1902653)
6.4 25.4 GO:0072367 regulation of lipid transport by regulation of transcription from RNA polymerase II promoter(GO:0072367)
6.3 31.5 GO:0031507 heterochromatin assembly(GO:0031507)
6.3 6.3 GO:0051595 response to methylglyoxal(GO:0051595)
6.3 31.4 GO:0051490 negative regulation of filopodium assembly(GO:0051490)
6.3 162.7 GO:0072663 protein targeting to peroxisome(GO:0006625) protein localization to peroxisome(GO:0072662) establishment of protein localization to peroxisome(GO:0072663)
6.2 236.3 GO:0070979 protein K11-linked ubiquitination(GO:0070979)
6.2 18.5 GO:0039534 negative regulation of MDA-5 signaling pathway(GO:0039534)
6.2 18.5 GO:0030327 prenylated protein catabolic process(GO:0030327)
6.2 135.7 GO:0006465 signal peptide processing(GO:0006465)
6.2 43.1 GO:0090343 positive regulation of cell aging(GO:0090343) positive regulation of cellular senescence(GO:2000774)
6.1 6.1 GO:0040031 snRNA modification(GO:0040031)
6.1 24.3 GO:0002880 chronic inflammatory response to non-antigenic stimulus(GO:0002545) regulation of chronic inflammatory response to non-antigenic stimulus(GO:0002880)
6.0 6.0 GO:0006286 base-excision repair, base-free sugar-phosphate removal(GO:0006286)
6.0 23.9 GO:0017198 N-terminal peptidyl-serine acetylation(GO:0017198) N-terminal peptidyl-glutamic acid acetylation(GO:0018002) peptidyl-serine acetylation(GO:0030920)
6.0 29.8 GO:1990834 response to odorant(GO:1990834)
5.9 41.5 GO:2001032 regulation of double-strand break repair via nonhomologous end joining(GO:2001032)
5.9 52.9 GO:0009113 purine nucleobase biosynthetic process(GO:0009113)
5.8 5.8 GO:0042118 endothelial cell activation(GO:0042118)
5.8 23.2 GO:1903288 positive regulation of potassium ion import(GO:1903288)
5.7 109.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
5.7 5.7 GO:0061031 endodermal digestive tract morphogenesis(GO:0061031)
5.6 311.8 GO:0018279 protein N-linked glycosylation via asparagine(GO:0018279)
5.6 22.3 GO:0048496 maintenance of organ identity(GO:0048496)
5.6 22.2 GO:0072308 negative regulation by virus of viral protein levels in host cell(GO:0046725) negative regulation of nephron tubule epithelial cell differentiation(GO:0072183) negative regulation of metanephric nephron tubule epithelial cell differentiation(GO:0072308) negative regulation of epithelial cell differentiation involved in kidney development(GO:2000697)
5.5 160.9 GO:0006301 postreplication repair(GO:0006301)
5.5 16.6 GO:0002731 negative regulation of dendritic cell cytokine production(GO:0002731) negative regulation of intracellular transport of viral material(GO:1901253)
5.5 16.6 GO:0042369 vitamin D catabolic process(GO:0042369)
5.5 22.1 GO:2000042 negative regulation of double-strand break repair via homologous recombination(GO:2000042)
5.5 33.1 GO:0006499 N-terminal protein myristoylation(GO:0006499)
5.5 121.2 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
5.4 16.3 GO:1902303 regulation of heart rate by hormone(GO:0003064) negative regulation of potassium ion export(GO:1902303)
5.3 10.6 GO:0035166 post-embryonic hemopoiesis(GO:0035166)
5.3 21.2 GO:0097680 double-strand break repair via classical nonhomologous end joining(GO:0097680)
5.3 21.2 GO:0060751 epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750) branch elongation involved in mammary gland duct branching(GO:0060751)
5.2 36.5 GO:2000074 regulation of type B pancreatic cell development(GO:2000074)
5.2 36.4 GO:0042791 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797)
5.2 15.5 GO:1902031 regulation of NADP metabolic process(GO:1902031)
5.1 15.3 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
5.1 71.4 GO:0046602 regulation of mitotic centrosome separation(GO:0046602)
5.1 15.3 GO:0072282 metanephric nephron tubule morphogenesis(GO:0072282)
5.0 5.0 GO:0036506 maintenance of unfolded protein(GO:0036506) maintenance of unfolded protein involved in ERAD pathway(GO:1904378)
5.0 65.4 GO:0043248 proteasome assembly(GO:0043248)
5.0 24.9 GO:0033299 secretion of lysosomal enzymes(GO:0033299)
5.0 34.8 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
5.0 19.8 GO:1903224 regulation of endodermal cell differentiation(GO:1903224)
4.9 34.4 GO:0097577 intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577)
4.9 9.8 GO:0002331 pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331)
4.9 38.9 GO:0032417 positive regulation of sodium:proton antiporter activity(GO:0032417)
4.8 48.5 GO:0071578 zinc II ion transmembrane import(GO:0071578)
4.8 23.8 GO:0003069 age-dependent response to oxidative stress(GO:0001306) age-dependent response to reactive oxygen species(GO:0001315) regulation of systemic arterial blood pressure by acetylcholine(GO:0003068) vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure(GO:0003069) regulation of systemic arterial blood pressure by neurotransmitter(GO:0003070) age-dependent general metabolic decline(GO:0007571)
4.7 14.2 GO:0051305 chromosome movement towards spindle pole(GO:0051305)
4.7 9.4 GO:1901503 ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503)
4.7 42.3 GO:0043968 histone H2A acetylation(GO:0043968)
4.7 56.3 GO:0006107 oxaloacetate metabolic process(GO:0006107)
4.7 271.9 GO:0006342 chromatin silencing(GO:0006342)
4.5 340.9 GO:0042632 cholesterol homeostasis(GO:0042632) sterol homeostasis(GO:0055092)
4.4 22.2 GO:0009438 methylglyoxal metabolic process(GO:0009438)
4.4 13.3 GO:0016260 selenocysteine biosynthetic process(GO:0016260)
4.4 17.7 GO:0060762 regulation of branching involved in mammary gland duct morphogenesis(GO:0060762)
4.4 8.8 GO:0006864 pyrimidine nucleotide transport(GO:0006864) mitochondrial pyrimidine nucleotide import(GO:1990519)
4.4 22.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
4.4 8.8 GO:1903626 positive regulation of DNA catabolic process(GO:1903626)
4.4 26.2 GO:0000290 deadenylation-dependent decapping of nuclear-transcribed mRNA(GO:0000290)
4.4 56.7 GO:0019054 modulation by virus of host process(GO:0019054)
4.3 260.0 GO:0051439 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051436) regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle(GO:0051439)
4.3 34.0 GO:0006689 ganglioside catabolic process(GO:0006689)
4.2 63.5 GO:0000338 protein deneddylation(GO:0000338)
4.2 274.1 GO:0006120 mitochondrial electron transport, NADH to ubiquinone(GO:0006120)
4.2 29.4 GO:0060155 platelet dense granule organization(GO:0060155)
4.1 12.4 GO:0072719 cellular response to cisplatin(GO:0072719)
4.1 24.8 GO:0048096 chromatin-mediated maintenance of transcription(GO:0048096)
4.1 28.9 GO:0010507 negative regulation of autophagy(GO:0010507)
4.1 93.7 GO:0030214 hyaluronan catabolic process(GO:0030214)
4.0 36.3 GO:0045008 depyrimidination(GO:0045008)
4.0 40.2 GO:1900034 regulation of cellular response to heat(GO:1900034)
4.0 20.0 GO:0000733 DNA strand renaturation(GO:0000733)
4.0 12.0 GO:0006627 protein processing involved in protein targeting to mitochondrion(GO:0006627)
4.0 43.8 GO:1903800 regulation of production of small RNA involved in gene silencing by RNA(GO:0070920) regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903798) positive regulation of production of miRNAs involved in gene silencing by miRNA(GO:1903800)
4.0 43.8 GO:0006337 nucleosome disassembly(GO:0006337)
3.9 15.7 GO:0007144 female meiosis I(GO:0007144)
3.9 62.7 GO:1903540 neurotransmitter receptor transport to plasma membrane(GO:0098877) neurotransmitter receptor transport to postsynaptic membrane(GO:0098969) establishment of protein localization to postsynaptic membrane(GO:1903540)
3.9 19.5 GO:0030047 actin modification(GO:0030047)
3.8 61.2 GO:0051639 actin filament network formation(GO:0051639)
3.8 30.5 GO:0009249 protein lipoylation(GO:0009249)
3.8 3.8 GO:1990144 intrinsic apoptotic signaling pathway in response to hypoxia(GO:1990144)
3.8 18.9 GO:0051299 mitotic centrosome separation(GO:0007100) centrosome separation(GO:0051299)
3.8 60.6 GO:0042113 B cell activation(GO:0042113)
3.8 135.7 GO:0006656 phosphatidylcholine biosynthetic process(GO:0006656)
3.8 75.0 GO:0035855 megakaryocyte development(GO:0035855)
3.7 30.0 GO:0017183 peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183)
3.7 7.4 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
3.7 22.0 GO:0070836 caveola assembly(GO:0070836)
3.7 3.7 GO:0031291 Ran protein signal transduction(GO:0031291)
3.6 50.8 GO:0006703 estrogen biosynthetic process(GO:0006703)
3.6 3.6 GO:2000465 regulation of glycogen (starch) synthase activity(GO:2000465) positive regulation of glycogen (starch) synthase activity(GO:2000467)
3.6 10.8 GO:0043132 FAD transport(GO:0015883) FAD transmembrane transport(GO:0035350) NAD transport(GO:0043132)
3.6 180.3 GO:1900739 regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900739) positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:1900740)
3.6 25.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
3.5 56.0 GO:0032802 low-density lipoprotein particle receptor catabolic process(GO:0032802)
3.5 10.5 GO:0034982 mitochondrial protein processing(GO:0034982)
3.4 10.3 GO:0051135 positive regulation of NK T cell activation(GO:0051135)
3.4 51.2 GO:0045116 protein neddylation(GO:0045116)
3.4 249.1 GO:0070125 mitochondrial translational elongation(GO:0070125)
3.4 6.8 GO:0090427 activation of meiosis(GO:0090427)
3.4 70.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
3.2 45.1 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
3.2 12.7 GO:0014894 response to inactivity(GO:0014854) response to muscle inactivity(GO:0014870) response to muscle inactivity involved in regulation of muscle adaptation(GO:0014877) response to denervation involved in regulation of muscle adaptation(GO:0014894)
3.2 22.2 GO:0061099 negative regulation of protein tyrosine kinase activity(GO:0061099)
3.1 6.2 GO:0046449 creatinine metabolic process(GO:0046449)
3.1 9.3 GO:0002326 B cell lineage commitment(GO:0002326) immunoglobulin V(D)J recombination(GO:0033152)
3.0 6.0 GO:0070541 response to platinum ion(GO:0070541)
3.0 33.0 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
3.0 33.0 GO:0006370 7-methylguanosine mRNA capping(GO:0006370)
3.0 211.1 GO:0045454 cell redox homeostasis(GO:0045454)
3.0 8.9 GO:0072718 response to cisplatin(GO:0072718)
2.9 8.8 GO:1904526 regulation of microtubule binding(GO:1904526)
2.9 23.2 GO:0061042 vascular wound healing(GO:0061042)
2.9 8.7 GO:1904504 regulation of lipophagy(GO:1904502) positive regulation of lipophagy(GO:1904504)
2.8 8.5 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
2.8 14.1 GO:1902268 negative regulation of polyamine transmembrane transport(GO:1902268)
2.7 10.9 GO:1903826 arginine transmembrane transport(GO:1903826)
2.7 147.7 GO:0071349 interleukin-12-mediated signaling pathway(GO:0035722) cellular response to interleukin-12(GO:0071349)
2.7 21.8 GO:0010569 regulation of double-strand break repair via homologous recombination(GO:0010569)
2.7 10.9 GO:0036510 trimming of terminal mannose on C branch(GO:0036510)
2.7 10.8 GO:0043967 histone H4 acetylation(GO:0043967)
2.7 2.7 GO:0006624 vacuolar protein processing(GO:0006624)
2.7 10.7 GO:0018242 protein O-linked glycosylation via serine(GO:0018242)
2.7 37.2 GO:0045814 negative regulation of gene expression, epigenetic(GO:0045814)
2.6 7.9 GO:0019626 short-chain fatty acid catabolic process(GO:0019626)
2.6 31.8 GO:0035372 protein localization to microtubule(GO:0035372)
2.6 5.2 GO:0090502 RNA phosphodiester bond hydrolysis, endonucleolytic(GO:0090502)
2.6 10.5 GO:0009439 cyanate metabolic process(GO:0009439) cyanate catabolic process(GO:0009440)
2.6 15.6 GO:0031087 nuclear-transcribed mRNA catabolic process, deadenylation-independent decay(GO:0031086) deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
2.6 20.8 GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899)
2.6 5.2 GO:0060696 regulation of phospholipid catabolic process(GO:0060696)
2.6 72.3 GO:0007176 regulation of epidermal growth factor-activated receptor activity(GO:0007176)
2.6 59.2 GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia(GO:0061418)
2.5 30.5 GO:0043651 linoleic acid metabolic process(GO:0043651)
2.5 35.6 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
2.5 5.1 GO:0036260 7-methylguanosine RNA capping(GO:0009452) RNA capping(GO:0036260)
2.5 32.8 GO:0000478 endonucleolytic cleavage involved in rRNA processing(GO:0000478)
2.5 148.3 GO:0042267 natural killer cell mediated cytotoxicity(GO:0042267)
2.5 12.5 GO:0070574 cadmium ion transport(GO:0015691) lead ion transport(GO:0015692) cadmium ion transmembrane transport(GO:0070574)
2.5 7.4 GO:0071043 CUT catabolic process(GO:0071034) CUT metabolic process(GO:0071043) polyadenylation-dependent snoRNA 3'-end processing(GO:0071051)
2.5 12.4 GO:0015862 uridine transport(GO:0015862)
2.5 73.8 GO:0045739 positive regulation of DNA repair(GO:0045739)
2.5 14.7 GO:1901164 negative regulation of trophoblast cell migration(GO:1901164)
2.5 9.8 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
2.4 16.9 GO:0006868 glutamine transport(GO:0006868)
2.4 7.3 GO:0006597 spermine biosynthetic process(GO:0006597)
2.4 55.1 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
2.4 4.8 GO:0051084 'de novo' posttranslational protein folding(GO:0051084) chaperone mediated protein folding requiring cofactor(GO:0051085)
2.4 26.3 GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c(GO:0006122)
2.4 30.7 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
2.3 18.8 GO:0032287 peripheral nervous system myelin maintenance(GO:0032287)
2.3 49.0 GO:0035435 phosphate ion transmembrane transport(GO:0035435)
2.3 11.6 GO:0000160 phosphorelay signal transduction system(GO:0000160)
2.3 6.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
2.2 38.2 GO:0071451 removal of superoxide radicals(GO:0019430) cellular response to oxygen radical(GO:0071450) cellular response to superoxide(GO:0071451)
2.2 35.7 GO:0040015 negative regulation of multicellular organism growth(GO:0040015)
2.2 24.5 GO:0033197 response to vitamin E(GO:0033197)
2.2 4.4 GO:0006059 hexitol metabolic process(GO:0006059)
2.1 4.3 GO:0031441 negative regulation of mRNA 3'-end processing(GO:0031441)
2.1 40.6 GO:0043928 exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928)
2.1 8.5 GO:1901727 protein kinase D signaling(GO:0089700) positive regulation of histone deacetylase activity(GO:1901727)
2.1 27.5 GO:0010811 positive regulation of cell-substrate adhesion(GO:0010811)
2.1 8.3 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
2.1 16.6 GO:0010917 negative regulation of mitochondrial membrane potential(GO:0010917)
2.1 8.3 GO:0002268 follicular dendritic cell differentiation(GO:0002268)
2.1 4.1 GO:0070141 response to UV-A(GO:0070141) cellular response to UV-A(GO:0071492)
2.0 12.1 GO:1900864 mitochondrial tRNA modification(GO:0070900) mitochondrial RNA modification(GO:1900864)
2.0 24.2 GO:0090527 actin filament reorganization(GO:0090527)
2.0 48.3 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
2.0 12.0 GO:0070933 histone H4 deacetylation(GO:0070933)
2.0 10.0 GO:0010756 positive regulation of plasminogen activation(GO:0010756)
2.0 6.0 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
2.0 9.9 GO:0006011 UDP-glucose metabolic process(GO:0006011)
2.0 58.9 GO:0000060 protein import into nucleus, translocation(GO:0000060)
1.9 1.9 GO:0051182 coenzyme transport(GO:0051182)
1.9 438.4 GO:0000377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
1.9 5.8 GO:0060178 regulation of exocyst assembly(GO:0001928) regulation of exocyst localization(GO:0060178)
1.9 17.5 GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148)
1.9 21.4 GO:0051451 myoblast migration(GO:0051451)
1.9 57.2 GO:0043388 positive regulation of DNA binding(GO:0043388)
1.9 30.3 GO:0018345 protein palmitoylation(GO:0018345)
1.8 7.4 GO:0070302 regulation of stress-activated MAPK cascade(GO:0032872) regulation of stress-activated protein kinase signaling cascade(GO:0070302)
1.8 34.9 GO:0006359 regulation of transcription from RNA polymerase III promoter(GO:0006359)
1.8 146.8 GO:0006353 DNA-templated transcription, termination(GO:0006353)
1.8 23.8 GO:0038003 opioid receptor signaling pathway(GO:0038003)
1.8 18.3 GO:0036258 multivesicular body organization(GO:0036257) multivesicular body assembly(GO:0036258)
1.8 21.8 GO:0045727 positive regulation of cellular amide metabolic process(GO:0034250) positive regulation of translation(GO:0045727)
1.8 21.6 GO:0035518 histone H2A monoubiquitination(GO:0035518)
1.8 33.7 GO:0046475 glycerophospholipid catabolic process(GO:0046475)
1.8 17.7 GO:0044728 DNA methylation or demethylation(GO:0044728)
1.8 14.1 GO:2000001 regulation of DNA damage checkpoint(GO:2000001)
1.7 73.0 GO:0006611 protein export from nucleus(GO:0006611)
1.7 10.4 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
1.7 46.7 GO:0000462 maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000462)
1.7 5.2 GO:0051697 protein delipidation(GO:0051697)
1.7 42.8 GO:0030212 hyaluronan metabolic process(GO:0030212)
1.7 8.6 GO:0030316 osteoclast differentiation(GO:0030316)
1.7 6.8 GO:0044821 meiotic telomere tethering at nuclear periphery(GO:0044821) meiotic attachment of telomere to nuclear envelope(GO:0070197) chromosome attachment to the nuclear envelope(GO:0097240)
1.7 8.4 GO:0034637 cellular carbohydrate biosynthetic process(GO:0034637)
1.7 15.0 GO:0006024 aminoglycan biosynthetic process(GO:0006023) glycosaminoglycan biosynthetic process(GO:0006024)
1.6 8.2 GO:0060022 hard palate development(GO:0060022)
1.6 8.2 GO:0048254 snoRNA localization(GO:0048254)
1.6 4.8 GO:0010641 positive regulation of platelet-derived growth factor receptor signaling pathway(GO:0010641)
1.6 7.9 GO:1905146 lysosomal protein catabolic process(GO:1905146)
1.6 3.2 GO:0060266 negative regulation of respiratory burst involved in inflammatory response(GO:0060266)
1.6 14.1 GO:0001886 endothelial cell morphogenesis(GO:0001886)
1.6 9.4 GO:0006013 mannose metabolic process(GO:0006013)
1.5 27.6 GO:0036010 protein localization to endosome(GO:0036010)
1.5 13.7 GO:0051599 response to hydrostatic pressure(GO:0051599)
1.5 4.5 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
1.5 10.3 GO:0007258 JUN phosphorylation(GO:0007258)
1.5 11.8 GO:0051660 establishment of centrosome localization(GO:0051660)
1.5 38.1 GO:0031648 protein destabilization(GO:0031648)
1.4 1.4 GO:0032757 positive regulation of interleukin-8 production(GO:0032757)
1.4 1.4 GO:0070828 heterochromatin organization(GO:0070828)
1.4 4.2 GO:0048203 vesicle targeting, trans-Golgi to endosome(GO:0048203)
1.4 56.9 GO:0046513 ceramide biosynthetic process(GO:0046513)
1.4 8.3 GO:0060736 prostate gland growth(GO:0060736)
1.4 15.2 GO:0051195 negative regulation of glycolytic process(GO:0045820) negative regulation of cofactor metabolic process(GO:0051195) negative regulation of coenzyme metabolic process(GO:0051198)
1.4 2.7 GO:0021812 neuronal-glial interaction involved in cerebral cortex radial glia guided migration(GO:0021812)
1.4 13.6 GO:0031639 plasminogen activation(GO:0031639)
1.4 98.6 GO:0006890 retrograde vesicle-mediated transport, Golgi to ER(GO:0006890)
1.3 8.1 GO:0090161 Golgi ribbon formation(GO:0090161)
1.3 5.3 GO:1902513 regulation of organelle transport along microtubule(GO:1902513)
1.3 2.7 GO:0071609 chemokine (C-C motif) ligand 5 production(GO:0071609)
1.3 47.9 GO:0035306 positive regulation of dephosphorylation(GO:0035306) positive regulation of protein dephosphorylation(GO:0035307)
1.3 13.3 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
1.3 21.2 GO:0006491 N-glycan processing(GO:0006491)
1.3 13.2 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500)
1.3 3.9 GO:0070272 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
1.3 3.9 GO:0015888 thiamine transport(GO:0015888) thiamine transmembrane transport(GO:0071934)
1.3 1.3 GO:0051030 snRNA transport(GO:0051030)
1.3 2.6 GO:2000491 hepatic stellate cell activation(GO:0035733) regulation of hepatic stellate cell activation(GO:2000489) positive regulation of hepatic stellate cell activation(GO:2000491)
1.3 3.9 GO:0031548 regulation of brain-derived neurotrophic factor receptor signaling pathway(GO:0031548)
1.3 5.1 GO:1902766 skeletal muscle satellite cell migration(GO:1902766)
1.3 7.6 GO:0042262 DNA protection(GO:0042262)
1.3 3.8 GO:1903313 positive regulation of mRNA metabolic process(GO:1903313)
1.2 8.7 GO:0001916 positive regulation of T cell mediated cytotoxicity(GO:0001916)
1.2 3.7 GO:0044275 cellular carbohydrate catabolic process(GO:0044275)
1.2 2.5 GO:0042938 dipeptide transport(GO:0042938)
1.2 33.2 GO:0006505 GPI anchor metabolic process(GO:0006505) GPI anchor biosynthetic process(GO:0006506)
1.2 3.7 GO:0019418 sulfide oxidation(GO:0019418) sulfide oxidation, using sulfide:quinone oxidoreductase(GO:0070221)
1.2 16.8 GO:0002021 response to dietary excess(GO:0002021)
1.2 3.6 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
1.2 4.7 GO:0097278 complement-dependent cytotoxicity(GO:0097278) regulation of complement-dependent cytotoxicity(GO:1903659)
1.2 24.8 GO:0030488 tRNA methylation(GO:0030488)
1.2 14.1 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
1.2 7.0 GO:0008295 spermidine biosynthetic process(GO:0008295)
1.2 2.3 GO:0046946 hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947)
1.2 24.3 GO:0009226 nucleotide-sugar biosynthetic process(GO:0009226)
1.2 6.9 GO:0044030 regulation of DNA methylation(GO:0044030)
1.2 9.2 GO:0046618 drug export(GO:0046618)
1.1 3.4 GO:0014886 transition between slow and fast fiber(GO:0014886)
1.1 16.7 GO:1902857 positive regulation of nonmotile primary cilium assembly(GO:1902857)
1.1 4.4 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
1.1 3.3 GO:1903348 positive regulation of bicellular tight junction assembly(GO:1903348)
1.1 13.0 GO:0006450 regulation of translational fidelity(GO:0006450)
1.1 74.1 GO:0007098 centrosome cycle(GO:0007098)
1.0 19.8 GO:0050892 intestinal absorption(GO:0050892)
1.0 6.1 GO:0040016 embryonic cleavage(GO:0040016)
1.0 1.0 GO:2000696 regulation of epithelial cell differentiation involved in kidney development(GO:2000696)
1.0 1.0 GO:0060648 mammary gland bud morphogenesis(GO:0060648)
1.0 8.7 GO:1900037 regulation of cellular response to hypoxia(GO:1900037)
0.9 2.8 GO:0002353 kinin cascade(GO:0002254) plasma kallikrein-kinin cascade(GO:0002353)
0.9 28.0 GO:0006582 melanin metabolic process(GO:0006582) melanin biosynthetic process(GO:0042438)
0.9 7.4 GO:0002230 positive regulation of defense response to virus by host(GO:0002230)
0.9 11.1 GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568)
0.9 15.4 GO:0014904 myotube cell development(GO:0014904)
0.9 14.4 GO:0032780 negative regulation of ATPase activity(GO:0032780)
0.9 3.6 GO:1901838 regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901836) positive regulation of transcription of nuclear large rRNA transcript from RNA polymerase I promoter(GO:1901838)
0.9 0.9 GO:0030948 negative regulation of vascular endothelial growth factor receptor signaling pathway(GO:0030948)
0.9 21.4 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.9 3.5 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.9 1.7 GO:0007518 myoblast fate determination(GO:0007518)
0.9 43.1 GO:0050829 defense response to Gram-negative bacterium(GO:0050829)
0.8 41.6 GO:0042273 ribosomal large subunit biogenesis(GO:0042273)
0.8 8.2 GO:0018026 peptidyl-lysine monomethylation(GO:0018026)
0.8 2.4 GO:0030252 growth hormone secretion(GO:0030252)
0.8 6.4 GO:0002441 histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553)
0.8 47.0 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.8 11.9 GO:0031424 keratinization(GO:0031424)
0.8 3.2 GO:1902527 positive regulation of protein monoubiquitination(GO:1902527)
0.8 7.1 GO:0006568 tryptophan metabolic process(GO:0006568)
0.8 1.5 GO:0031118 rRNA pseudouridine synthesis(GO:0031118)
0.7 6.0 GO:0006787 porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) pigment catabolic process(GO:0046149)
0.7 7.4 GO:0072643 interferon-gamma secretion(GO:0072643)
0.7 96.9 GO:0006613 cotranslational protein targeting to membrane(GO:0006613)
0.7 2.2 GO:0050894 determination of affect(GO:0050894)
0.7 13.2 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)
0.7 11.0 GO:0051569 regulation of histone H3-K4 methylation(GO:0051569)
0.7 3.6 GO:0044351 macropinocytosis(GO:0044351)
0.7 9.2 GO:0046686 response to cadmium ion(GO:0046686)
0.7 6.4 GO:0001778 plasma membrane repair(GO:0001778)
0.7 6.2 GO:0031293 membrane protein intracellular domain proteolysis(GO:0031293)
0.7 8.3 GO:1901687 glutathione derivative metabolic process(GO:1901685) glutathione derivative biosynthetic process(GO:1901687)
0.7 2.7 GO:0060671 epithelial cell differentiation involved in embryonic placenta development(GO:0060671) epithelial cell morphogenesis involved in placental branching(GO:0060672)
0.7 4.0 GO:0006907 pinocytosis(GO:0006907)
0.7 5.3 GO:0051601 exocyst localization(GO:0051601)
0.6 82.3 GO:0071466 cellular response to xenobiotic stimulus(GO:0071466)
0.6 29.4 GO:0001541 ovarian follicle development(GO:0001541)
0.6 9.2 GO:0006959 humoral immune response(GO:0006959)
0.6 1.2 GO:0006054 N-acetylneuraminate metabolic process(GO:0006054)
0.6 1.2 GO:0044805 late nucleophagy(GO:0044805)
0.6 3.5 GO:1902669 positive regulation of axon guidance(GO:1902669)
0.6 9.9 GO:0046676 negative regulation of insulin secretion(GO:0046676)
0.6 20.5 GO:0000413 protein peptidyl-prolyl isomerization(GO:0000413)
0.6 4.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.6 5.6 GO:0060124 positive regulation of growth hormone secretion(GO:0060124)
0.6 1.7 GO:0002703 regulation of leukocyte mediated immunity(GO:0002703)
0.6 4.4 GO:0030100 regulation of endocytosis(GO:0030100)
0.5 1.6 GO:1901162 isoquinoline alkaloid metabolic process(GO:0033076) serotonin biosynthetic process(GO:0042427) phytoalexin metabolic process(GO:0052314) primary amino compound biosynthetic process(GO:1901162)
0.5 21.1 GO:0045214 sarcomere organization(GO:0045214)
0.5 1.6 GO:0050859 negative regulation of B cell receptor signaling pathway(GO:0050859)
0.5 17.7 GO:0006891 intra-Golgi vesicle-mediated transport(GO:0006891)
0.5 1.6 GO:0032785 negative regulation of DNA-templated transcription, elongation(GO:0032785) negative regulation of transcription elongation from RNA polymerase II promoter(GO:0034244)
0.5 74.5 GO:0002576 platelet degranulation(GO:0002576)
0.5 1.0 GO:0071494 cellular response to UV-C(GO:0071494)
0.5 37.7 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.5 3.0 GO:0070863 positive regulation of protein exit from endoplasmic reticulum(GO:0070863)
0.5 12.6 GO:0009235 cobalamin metabolic process(GO:0009235)
0.5 1.5 GO:0050917 sensory perception of umami taste(GO:0050917)
0.5 3.3 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.5 4.6 GO:0006044 N-acetylglucosamine metabolic process(GO:0006044)
0.5 23.9 GO:0051452 pH reduction(GO:0045851) intracellular pH reduction(GO:0051452)
0.5 2.7 GO:1903003 positive regulation of protein deubiquitination(GO:1903003) positive regulation of ubiquitin-specific protease activity(GO:2000158)
0.4 6.7 GO:0072673 lamellipodium morphogenesis(GO:0072673)
0.4 2.7 GO:0048873 homeostasis of number of cells within a tissue(GO:0048873)
0.4 0.9 GO:0021558 trochlear nerve development(GO:0021558)
0.4 2.2 GO:0090181 regulation of cholesterol metabolic process(GO:0090181)
0.4 3.4 GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771)
0.4 0.8 GO:1902994 regulation of phospholipid efflux(GO:1902994) positive regulation of phospholipid efflux(GO:1902995)
0.4 8.8 GO:0050832 defense response to fungus(GO:0050832)
0.4 2.7 GO:0008218 bioluminescence(GO:0008218)
0.4 0.8 GO:0032304 negative regulation of icosanoid secretion(GO:0032304)
0.4 0.4 GO:0002580 regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002580) negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) regulation of antigen processing and presentation of peptide antigen via MHC class II(GO:0002586)
0.4 47.1 GO:0006888 ER to Golgi vesicle-mediated transport(GO:0006888)
0.4 17.2 GO:0071357 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.4 41.2 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.4 1.4 GO:0046836 glycolipid transport(GO:0046836)
0.4 2.5 GO:0046007 negative regulation of activated T cell proliferation(GO:0046007)
0.3 20.6 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.3 5.2 GO:0001682 tRNA 5'-leader removal(GO:0001682)
0.3 2.7 GO:1904776 protein localization to cell cortex(GO:0072697) regulation of protein localization to cell cortex(GO:1904776) positive regulation of protein localization to cell cortex(GO:1904778)
0.3 2.0 GO:0060135 maternal process involved in female pregnancy(GO:0060135)
0.3 5.0 GO:1990542 mitochondrial transmembrane transport(GO:1990542)
0.3 1.7 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.3 1.0 GO:0021979 hypothalamus cell differentiation(GO:0021979)
0.3 2.6 GO:0060576 intestinal epithelial cell development(GO:0060576)
0.3 1.6 GO:0009650 UV protection(GO:0009650)
0.3 2.8 GO:0007517 muscle organ development(GO:0007517) muscle structure development(GO:0061061)
0.3 2.1 GO:0048069 eye pigmentation(GO:0048069)
0.3 1.2 GO:0043376 regulation of CD8-positive, alpha-beta T cell differentiation(GO:0043376)
0.3 4.1 GO:0030520 intracellular estrogen receptor signaling pathway(GO:0030520)
0.3 12.0 GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157)
0.3 3.4 GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis(GO:0090190)
0.3 1.1 GO:0010626 regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626)
0.3 1.9 GO:1903204 negative regulation of oxidative stress-induced neuron death(GO:1903204)
0.3 3.6 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway(GO:0031664)
0.3 4.6 GO:0048268 clathrin coat assembly(GO:0048268)
0.3 2.4 GO:0051923 sulfation(GO:0051923)
0.3 1.8 GO:1990564 protein ufmylation(GO:0071569) protein polyufmylation(GO:1990564) protein K69-linked ufmylation(GO:1990592)
0.2 2.2 GO:0035583 sequestering of TGFbeta in extracellular matrix(GO:0035583)
0.2 4.8 GO:0006308 DNA catabolic process(GO:0006308)
0.2 1.1 GO:1900016 negative regulation of cytokine production involved in inflammatory response(GO:1900016)
0.2 0.9 GO:0048702 embryonic neurocranium morphogenesis(GO:0048702)
0.2 2.7 GO:0030728 ovulation(GO:0030728)
0.2 1.6 GO:0035873 lactate transport(GO:0015727) lactate transmembrane transport(GO:0035873)
0.2 2.8 GO:0009128 purine nucleoside monophosphate catabolic process(GO:0009128) ribonucleoside monophosphate catabolic process(GO:0009158) purine ribonucleoside monophosphate catabolic process(GO:0009169)
0.2 1.7 GO:0045793 positive regulation of cell size(GO:0045793)
0.2 0.9 GO:0006049 UDP-N-acetylglucosamine catabolic process(GO:0006049)
0.2 0.2 GO:0003166 bundle of His development(GO:0003166) cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.2 1.2 GO:0060056 mammary gland involution(GO:0060056)
0.2 1.0 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.2 2.3 GO:0046688 response to copper ion(GO:0046688)
0.2 3.6 GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein(GO:0042531)
0.2 0.2 GO:1902805 positive regulation of synaptic vesicle transport(GO:1902805) positive regulation of synaptic vesicle exocytosis(GO:2000302)
0.2 3.8 GO:0050690 regulation of defense response to virus by virus(GO:0050690)
0.2 1.4 GO:0046051 UTP biosynthetic process(GO:0006228) UTP metabolic process(GO:0046051)
0.2 0.6 GO:2001286 regulation of caveolin-mediated endocytosis(GO:2001286) positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 0.6 GO:0060346 bone trabecula formation(GO:0060346)
0.1 1.3 GO:0031282 regulation of guanylate cyclase activity(GO:0031282)
0.1 1.0 GO:0060134 prepulse inhibition(GO:0060134)
0.1 2.7 GO:0007229 integrin-mediated signaling pathway(GO:0007229)
0.1 1.0 GO:0071243 cellular response to arsenic-containing substance(GO:0071243)
0.1 0.2 GO:0006566 threonine metabolic process(GO:0006566)
0.1 0.6 GO:0052695 cellular glucuronidation(GO:0052695)
0.1 3.0 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.1 0.7 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.1 0.7 GO:0030091 protein repair(GO:0030091)
0.1 0.3 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 0.3 GO:0001820 serotonin secretion(GO:0001820) regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.1 1.0 GO:0043011 myeloid dendritic cell differentiation(GO:0043011)
0.1 0.6 GO:0042420 dopamine catabolic process(GO:0042420)
0.1 0.3 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 0.7 GO:0090102 cochlea development(GO:0090102)
0.1 0.4 GO:0030210 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 0.7 GO:0035641 locomotory exploration behavior(GO:0035641)
0.1 0.6 GO:0035024 negative regulation of Rho protein signal transduction(GO:0035024)
0.0 1.0 GO:0051931 regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931)
0.0 0.3 GO:0051764 actin crosslink formation(GO:0051764)
0.0 1.4 GO:0022904 respiratory electron transport chain(GO:0022904)
0.0 0.7 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.6 GO:0001580 detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580)
0.0 0.2 GO:0030238 male sex determination(GO:0030238)
0.0 0.2 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386)
0.0 0.1 GO:0060481 lobar bronchus epithelium development(GO:0060481)
0.0 0.1 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.0 1.1 GO:0051341 regulation of oxidoreductase activity(GO:0051341)
0.0 2.3 GO:0070268 cornification(GO:0070268)
0.0 0.4 GO:0050869 negative regulation of B cell activation(GO:0050869)
0.0 0.5 GO:0030101 natural killer cell activation(GO:0030101)
0.0 0.1 GO:0019509 L-methionine biosynthetic process from methylthioadenosine(GO:0019509)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
125.0 625.2 GO:0097125 cyclin B1-CDK1 complex(GO:0097125)
109.7 329.1 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
101.7 508.3 GO:0097149 centralspindlin complex(GO:0097149)
96.3 289.0 GO:0009330 DNA topoisomerase complex (ATP-hydrolyzing)(GO:0009330)
67.1 268.2 GO:0005971 ribonucleoside-diphosphate reductase complex(GO:0005971)
66.2 198.7 GO:0070557 PCNA-p21 complex(GO:0070557)
61.3 490.1 GO:0032133 chromosome passenger complex(GO:0032133)
52.7 158.0 GO:0005715 late recombination nodule(GO:0005715)
46.1 138.3 GO:0036387 nuclear pre-replicative complex(GO:0005656) pre-replicative complex(GO:0036387)
44.6 133.7 GO:0000942 condensed nuclear chromosome outer kinetochore(GO:0000942)
42.1 126.2 GO:0000939 condensed chromosome inner kinetochore(GO:0000939)
41.7 166.6 GO:0031211 serine C-palmitoyltransferase complex(GO:0017059) endoplasmic reticulum palmitoyltransferase complex(GO:0031211)
40.8 163.2 GO:0032301 MutSalpha complex(GO:0032301)
39.8 1194.7 GO:0005680 anaphase-promoting complex(GO:0005680)
38.7 154.9 GO:0000799 nuclear condensin complex(GO:0000799)
32.6 130.5 GO:0033186 CAF-1 complex(GO:0033186)
30.4 639.1 GO:0000812 Swr1 complex(GO:0000812)
29.5 235.9 GO:0071204 histone pre-mRNA 3'end processing complex(GO:0071204)
29.2 87.7 GO:0016222 procollagen-proline 4-dioxygenase complex(GO:0016222)
29.1 494.4 GO:0034709 methylosome(GO:0034709)
28.6 85.7 GO:0097124 cyclin A2-CDK2 complex(GO:0097124)
27.9 195.0 GO:0036449 microtubule minus-end(GO:0036449)
26.7 320.3 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
26.6 26.6 GO:0005687 U4 snRNP(GO:0005687)
26.6 345.2 GO:0042555 MCM complex(GO:0042555)
26.2 104.6 GO:0036502 Derlin-1-VIMP complex(GO:0036502)
25.7 179.7 GO:0061617 MICOS complex(GO:0061617)
23.8 190.5 GO:0042382 paraspeckles(GO:0042382)
23.1 322.9 GO:0005662 DNA replication factor A complex(GO:0005662)
22.9 389.5 GO:0034663 endoplasmic reticulum chaperone complex(GO:0034663)
22.5 45.0 GO:0031262 Ndc80 complex(GO:0031262)
22.2 155.6 GO:0016272 prefoldin complex(GO:0016272)
21.4 64.1 GO:0031298 replication fork protection complex(GO:0031298)
20.5 143.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
19.6 137.4 GO:0005787 signal peptidase complex(GO:0005787)
18.3 292.2 GO:0031080 nuclear pore outer ring(GO:0031080)
18.3 73.0 GO:0070876 SOSS complex(GO:0070876)
17.9 196.9 GO:0005688 U6 snRNP(GO:0005688)
17.3 69.2 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
17.3 69.2 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
16.7 200.1 GO:0005642 annulate lamellae(GO:0005642)
16.5 923.5 GO:0019005 SCF ubiquitin ligase complex(GO:0019005)
16.3 81.4 GO:1905202 3-methylcrotonyl-CoA carboxylase complex, mitochondrial(GO:0002169) methylcrotonoyl-CoA carboxylase complex(GO:1905202)
16.3 97.6 GO:0001740 Barr body(GO:0001740)
16.0 63.9 GO:0071598 neuronal ribonucleoprotein granule(GO:0071598)
15.8 31.5 GO:0005677 chromatin silencing complex(GO:0005677)
15.7 47.1 GO:0097447 dendritic tree(GO:0097447)
14.8 74.1 GO:0000235 astral microtubule(GO:0000235) aster(GO:0005818)
14.4 43.2 GO:0005826 actomyosin contractile ring(GO:0005826)
14.1 155.0 GO:0098799 outer mitochondrial membrane protein complex(GO:0098799)
13.8 290.6 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
13.7 164.1 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
13.6 54.5 GO:0000811 GINS complex(GO:0000811)
13.5 81.1 GO:0072588 box H/ACA snoRNP complex(GO:0031429) box H/ACA RNP complex(GO:0072588) box H/ACA scaRNP complex(GO:0072589) box H/ACA telomerase RNP complex(GO:0090661)
13.5 54.0 GO:0043625 delta DNA polymerase complex(GO:0043625)
12.6 301.3 GO:0005697 telomerase holoenzyme complex(GO:0005697)
12.5 112.4 GO:0031616 spindle pole centrosome(GO:0031616)
12.4 123.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
12.4 61.8 GO:0033503 HULC complex(GO:0033503)
12.2 73.5 GO:0070435 Shc-EGFR complex(GO:0070435)
12.0 59.8 GO:0097422 tubular endosome(GO:0097422)
11.6 58.0 GO:0005726 perichromatin fibrils(GO:0005726)
11.4 22.8 GO:1903349 omegasome membrane(GO:1903349)
11.3 90.3 GO:0042824 MHC class I peptide loading complex(GO:0042824)
11.1 44.3 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
11.1 33.2 GO:0033565 ESCRT-0 complex(GO:0033565)
10.9 76.2 GO:0098575 lumenal side of lysosomal membrane(GO:0098575)
9.8 39.1 GO:0031436 BRCA1-BARD1 complex(GO:0031436)
9.7 174.7 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)
9.6 28.7 GO:0048269 methionine adenosyltransferase complex(GO:0048269)
9.2 110.0 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
8.3 24.9 GO:0030904 retromer complex(GO:0030904)
8.1 56.7 GO:0070531 BRCA1-A complex(GO:0070531)
8.0 80.1 GO:0044233 ER-mitochondrion membrane contact site(GO:0044233)
7.8 86.2 GO:0016602 CCAAT-binding factor complex(GO:0016602)
7.8 405.6 GO:0005871 kinesin complex(GO:0005871)
7.8 46.5 GO:0071817 MMXD complex(GO:0071817)
7.8 147.3 GO:0043189 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
7.5 37.7 GO:0034457 Mpp10 complex(GO:0034457)
7.4 44.6 GO:0005784 Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256)
7.4 88.4 GO:0005732 small nucleolar ribonucleoprotein complex(GO:0005732)
7.2 14.5 GO:1990726 Lsm1-7-Pat1 complex(GO:1990726)
7.1 163.3 GO:0005685 U1 snRNP(GO:0005685)
7.0 77.3 GO:0042612 MHC class I protein complex(GO:0042612)
6.7 13.5 GO:0000438 core TFIIH complex portion of holo TFIIH complex(GO:0000438)
6.5 26.2 GO:0035061 interchromatin granule(GO:0035061)
6.5 45.5 GO:0036513 Derlin-1 retrotranslocation complex(GO:0036513)
6.5 38.9 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
6.4 121.4 GO:0071782 endoplasmic reticulum tubular network(GO:0071782)
6.2 99.6 GO:0005814 centriole(GO:0005814)
6.2 56.0 GO:0071439 clathrin complex(GO:0071439)
6.2 93.0 GO:0070822 Sin3-type complex(GO:0070822)
6.1 354.3 GO:0010494 cytoplasmic stress granule(GO:0010494)
6.1 24.3 GO:1990730 VCP-NSFL1C complex(GO:1990730)
5.9 29.6 GO:0005869 dynactin complex(GO:0005869)
5.8 122.3 GO:0035098 ESC/E(Z) complex(GO:0035098)
5.8 34.6 GO:1990635 proximal dendrite(GO:1990635)
5.5 72.1 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
5.5 11.1 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
5.5 16.6 GO:0035189 Rb-E2F complex(GO:0035189)
5.5 54.9 GO:0008541 proteasome regulatory particle, lid subcomplex(GO:0008541)
5.4 81.4 GO:0005916 fascia adherens(GO:0005916)
5.3 73.8 GO:0031209 SCAR complex(GO:0031209)
5.2 183.4 GO:0005876 spindle microtubule(GO:0005876)
5.2 125.7 GO:0000930 gamma-tubulin complex(GO:0000930)
5.2 26.1 GO:0032449 CBM complex(GO:0032449) lipopolysaccharide receptor complex(GO:0046696)
5.2 36.4 GO:0000127 transcription factor TFIIIC complex(GO:0000127)
5.0 60.6 GO:0090543 Flemming body(GO:0090543)
5.0 54.5 GO:0097550 transcriptional preinitiation complex(GO:0097550)
5.0 168.3 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
4.9 138.3 GO:0005640 nuclear outer membrane(GO:0005640)
4.9 9.8 GO:0097135 cyclin E2-CDK2 complex(GO:0097135)
4.8 28.8 GO:1990131 EGO complex(GO:0034448) Gtr1-Gtr2 GTPase complex(GO:1990131)
4.7 236.3 GO:0008180 COP9 signalosome(GO:0008180)
4.7 14.0 GO:0005785 signal recognition particle receptor complex(GO:0005785)
4.6 23.2 GO:0071008 U2-type post-mRNA release spliceosomal complex(GO:0071008)
4.5 31.4 GO:0071203 WASH complex(GO:0071203)
4.4 71.0 GO:0005639 integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453)
4.4 22.1 GO:0071004 U2-type prespliceosome(GO:0071004)
4.3 282.9 GO:0030964 mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271)
4.3 21.4 GO:0031226 intrinsic component of plasma membrane(GO:0031226)
4.2 58.9 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
4.2 58.7 GO:0005641 nuclear envelope lumen(GO:0005641)
4.1 28.5 GO:1990391 DNA repair complex(GO:1990391)
4.0 32.3 GO:0072546 ER membrane protein complex(GO:0072546)
4.0 48.1 GO:0002199 zona pellucida receptor complex(GO:0002199)
3.9 27.6 GO:0000275 mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
3.9 74.2 GO:0001891 phagocytic cup(GO:0001891)
3.8 376.4 GO:0035578 azurophil granule lumen(GO:0035578)
3.8 280.3 GO:0035580 specific granule lumen(GO:0035580)
3.8 61.3 GO:0030014 CCR4-NOT complex(GO:0030014)
3.8 26.3 GO:0031415 NatA complex(GO:0031415)
3.7 7.4 GO:1990075 periciliary membrane compartment(GO:1990075)
3.7 32.9 GO:0005664 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
3.6 3.6 GO:1990462 omegasome(GO:1990462)
3.6 32.1 GO:0042405 nuclear inclusion body(GO:0042405)
3.6 35.6 GO:1990909 Wnt signalosome(GO:1990909)
3.5 179.2 GO:0000786 nucleosome(GO:0000786)
3.4 20.4 GO:0008537 proteasome activator complex(GO:0008537)
3.4 272.2 GO:0005758 mitochondrial intermembrane space(GO:0005758)
3.3 73.3 GO:0000776 kinetochore(GO:0000776)
3.3 66.4 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
3.3 69.2 GO:1902555 endoribonuclease complex(GO:1902555)
3.3 16.3 GO:1902937 inward rectifier potassium channel complex(GO:1902937)
3.3 16.3 GO:0009368 endopeptidase Clp complex(GO:0009368)
3.2 38.9 GO:0005689 U12-type spliceosomal complex(GO:0005689)
3.2 50.6 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
3.2 79.0 GO:0005666 DNA-directed RNA polymerase III complex(GO:0005666)
3.1 12.4 GO:0031414 N-terminal protein acetyltransferase complex(GO:0031414)
3.1 9.3 GO:0031515 tRNA (m1A) methyltransferase complex(GO:0031515)
3.1 449.0 GO:0005681 spliceosomal complex(GO:0005681)
3.1 268.9 GO:0005643 nuclear pore(GO:0005643)
2.9 11.6 GO:0030905 retromer, tubulation complex(GO:0030905)
2.9 11.5 GO:0070545 PeBoW complex(GO:0070545)
2.8 25.1 GO:0043203 axon hillock(GO:0043203)
2.8 8.3 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
2.7 38.4 GO:0009898 cytoplasmic side of plasma membrane(GO:0009898)
2.7 21.8 GO:0030688 preribosome, small subunit precursor(GO:0030688)
2.7 8.2 GO:0070761 pre-snoRNP complex(GO:0070761)
2.7 18.8 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
2.6 7.9 GO:0031166 integral component of vacuolar membrane(GO:0031166)
2.6 52.6 GO:0016281 eukaryotic translation initiation factor 4F complex(GO:0016281)
2.6 93.1 GO:0030173 integral component of Golgi membrane(GO:0030173)
2.5 22.9 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
2.5 22.5 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
2.5 12.5 GO:0070826 paraferritin complex(GO:0070826)
2.5 54.9 GO:0030687 preribosome, large subunit precursor(GO:0030687)
2.5 17.4 GO:0016600 flotillin complex(GO:0016600)
2.5 12.4 GO:0043564 Ku70:Ku80 complex(GO:0043564)
2.5 166.2 GO:0005791 rough endoplasmic reticulum(GO:0005791)
2.5 19.8 GO:0036056 filtration diaphragm(GO:0036056) slit diaphragm(GO:0036057)
2.5 24.5 GO:0035749 myelin sheath adaxonal region(GO:0035749)
2.4 64.8 GO:0070971 endoplasmic reticulum exit site(GO:0070971)
2.4 391.3 GO:0000793 condensed chromosome(GO:0000793)
2.3 44.3 GO:0016581 NuRD complex(GO:0016581) CHD-type complex(GO:0090545)
2.3 34.7 GO:0000109 nucleotide-excision repair complex(GO:0000109)
2.3 20.7 GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m(GO:0071541)
2.3 4.6 GO:0034657 GID complex(GO:0034657)
2.3 61.3 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
2.2 84.7 GO:0005762 organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762)
2.2 171.7 GO:0005778 peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903)
2.1 33.3 GO:0000177 cytoplasmic exosome (RNase complex)(GO:0000177)
2.1 8.3 GO:0033257 Bcl3/NF-kappaB2 complex(GO:0033257)
2.1 10.3 GO:0002193 MAML1-RBP-Jkappa- ICN1 complex(GO:0002193)
2.0 14.2 GO:0045252 oxoglutarate dehydrogenase complex(GO:0045252)
1.9 149.1 GO:0032580 Golgi cisterna membrane(GO:0032580)
1.9 40.1 GO:0032040 small-subunit processome(GO:0032040)
1.9 35.6 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
1.9 14.9 GO:0045254 pyruvate dehydrogenase complex(GO:0045254)
1.8 9.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)
1.8 16.0 GO:0005955 calcineurin complex(GO:0005955)
1.7 17.1 GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
1.7 35.5 GO:0005838 proteasome regulatory particle(GO:0005838)
1.6 7.9 GO:0030894 replisome(GO:0030894)
1.6 6.3 GO:0097454 Schwann cell microvillus(GO:0097454)
1.5 166.9 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
1.4 20.2 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
1.4 4.3 GO:0070288 intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288)
1.4 12.9 GO:0017119 Golgi transport complex(GO:0017119)
1.4 17.2 GO:0097225 sperm midpiece(GO:0097225)
1.4 184.9 GO:0048770 melanosome(GO:0042470) pigment granule(GO:0048770)
1.4 15.6 GO:0051233 spindle midzone(GO:0051233)
1.4 50.8 GO:0016592 mediator complex(GO:0016592)
1.4 12.6 GO:0034464 BBSome(GO:0034464)
1.4 147.8 GO:0015934 large ribosomal subunit(GO:0015934)
1.3 239.4 GO:0044798 nuclear transcription factor complex(GO:0044798)
1.3 18.4 GO:0031519 PcG protein complex(GO:0031519)
1.3 9.1 GO:0043240 Fanconi anaemia nuclear complex(GO:0043240)
1.3 18.1 GO:0071339 MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339)
1.3 304.8 GO:0005694 chromosome(GO:0005694)
1.3 47.8 GO:0030496 midbody(GO:0030496)
1.2 418.5 GO:0005635 nuclear envelope(GO:0005635)
1.2 4.7 GO:0043073 germ cell nucleus(GO:0043073)
1.1 8.0 GO:0005832 chaperonin-containing T-complex(GO:0005832)
1.1 12.0 GO:0005750 mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275)
1.1 110.9 GO:0031093 platelet alpha granule lumen(GO:0031093)
1.0 10.8 GO:0097524 sperm plasma membrane(GO:0097524)
0.9 28.9 GO:0042582 primary lysosome(GO:0005766) azurophil granule(GO:0042582)
0.9 46.0 GO:0055038 recycling endosome membrane(GO:0055038)
0.9 3.7 GO:0097431 mitotic spindle pole(GO:0097431)
0.9 2.7 GO:0005607 laminin-2 complex(GO:0005607)
0.9 9.1 GO:0044322 endoplasmic reticulum quality control compartment(GO:0044322)
0.8 51.0 GO:0005902 microvillus(GO:0005902)
0.8 2.5 GO:0005960 glycine cleavage complex(GO:0005960)
0.8 29.9 GO:0045171 intercellular bridge(GO:0045171)
0.8 9.1 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.8 42.9 GO:0005811 lipid particle(GO:0005811)
0.7 87.7 GO:0034774 secretory granule lumen(GO:0034774)
0.7 14.5 GO:0016459 myosin complex(GO:0016459)
0.7 49.0 GO:0000922 spindle pole(GO:0000922)
0.7 75.4 GO:0035579 specific granule membrane(GO:0035579)
0.7 11.1 GO:0000145 exocyst(GO:0000145)
0.7 52.6 GO:0016605 PML body(GO:0016605)
0.7 10.0 GO:0032059 bleb(GO:0032059)
0.7 26.0 GO:0045095 keratin filament(GO:0045095)
0.6 74.4 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.6 12.8 GO:0017053 transcriptional repressor complex(GO:0017053)
0.6 6.7 GO:0005929 cilium(GO:0005929)
0.6 21.6 GO:0015030 Cajal body(GO:0015030)
0.6 1.1 GO:0035869 ciliary transition zone(GO:0035869)
0.6 150.0 GO:0019866 mitochondrial inner membrane(GO:0005743) organelle inner membrane(GO:0019866)
0.5 45.3 GO:0005905 clathrin-coated pit(GO:0005905)
0.5 3.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.5 23.8 GO:0043198 dendritic shaft(GO:0043198)
0.5 11.0 GO:0016363 nuclear matrix(GO:0016363)
0.5 4.4 GO:0061574 ASAP complex(GO:0061574)
0.5 2.3 GO:0032389 MutLalpha complex(GO:0032389)
0.4 1.8 GO:0000322 storage vacuole(GO:0000322)
0.4 38.0 GO:0019898 extrinsic component of membrane(GO:0019898)
0.4 2.2 GO:0032021 NELF complex(GO:0032021)
0.4 2.1 GO:0032039 integrator complex(GO:0032039)
0.4 3.4 GO:0070187 telosome(GO:0070187)
0.4 2.2 GO:0045239 tricarboxylic acid cycle enzyme complex(GO:0045239)
0.4 3.3 GO:0035748 myelin sheath abaxonal region(GO:0035748)
0.4 9.2 GO:0042101 T cell receptor complex(GO:0042101)
0.3 3.2 GO:0030127 COPII vesicle coat(GO:0030127)
0.3 0.6 GO:0071159 NF-kappaB complex(GO:0071159)
0.3 1.2 GO:0005797 Golgi medial cisterna(GO:0005797)
0.3 7.5 GO:0031941 filamentous actin(GO:0031941)
0.3 75.2 GO:0016607 nuclear speck(GO:0016607)
0.3 1.1 GO:0071818 BAT3 complex(GO:0071818) ER membrane insertion complex(GO:0072379)
0.3 1.0 GO:0005795 Golgi stack(GO:0005795)
0.3 2.6 GO:0035985 senescence-associated heterochromatin focus(GO:0035985)
0.3 1.0 GO:0097179 protease inhibitor complex(GO:0097179)
0.2 4.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.2 1.2 GO:0000407 pre-autophagosomal structure(GO:0000407)
0.2 0.8 GO:0005736 DNA-directed RNA polymerase I complex(GO:0005736)
0.2 0.7 GO:0030684 preribosome(GO:0030684)
0.2 22.6 GO:0005874 microtubule(GO:0005874)
0.2 2.2 GO:0017146 NMDA selective glutamate receptor complex(GO:0017146)
0.2 10.1 GO:0043292 contractile fiber(GO:0043292)
0.2 9.0 GO:0030315 T-tubule(GO:0030315)
0.1 5.2 GO:0005903 brush border(GO:0005903)
0.1 65.7 GO:0042175 nuclear outer membrane-endoplasmic reticulum membrane network(GO:0042175)
0.1 0.9 GO:0032433 filopodium tip(GO:0032433)
0.1 1.0 GO:0001518 voltage-gated sodium channel complex(GO:0001518)
0.1 3.8 GO:0044439 microbody part(GO:0044438) peroxisomal part(GO:0044439)
0.1 5.7 GO:0045335 phagocytic vesicle(GO:0045335)
0.1 2.2 GO:0043205 microfibril(GO:0001527) fibril(GO:0043205)
0.1 2.2 GO:0071564 npBAF complex(GO:0071564)
0.1 19.0 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 238.2 GO:0005829 cytosol(GO:0005829)
0.1 1.1 GO:0070821 tertiary granule membrane(GO:0070821)
0.0 1.4 GO:0072562 blood microparticle(GO:0072562)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
175.5 1228.4 GO:0061575 cyclin-dependent protein serine/threonine kinase activator activity(GO:0061575)
96.4 385.5 GO:0044378 non-sequence-specific DNA binding, bending(GO:0044378)
96.3 289.0 GO:0003918 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
67.1 268.2 GO:0016728 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731)
61.8 309.1 GO:0032139 dinucleotide insertion or deletion binding(GO:0032139)
55.0 330.3 GO:0010997 anaphase-promoting complex binding(GO:0010997)
52.5 209.8 GO:0004310 farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996)
50.2 301.3 GO:0044020 histone methyltransferase activity (H4-R3 specific)(GO:0044020)
48.5 436.5 GO:0035174 histone serine kinase activity(GO:0035174)
46.7 140.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
43.6 130.8 GO:0004797 thymidine kinase activity(GO:0004797)
42.2 210.9 GO:0032137 guanine/thymine mispair binding(GO:0032137)
38.0 228.1 GO:0043141 ATP-dependent 5'-3' DNA helicase activity(GO:0043141)
35.3 176.7 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
34.1 102.2 GO:0004487 methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) methylenetetrahydrofolate dehydrogenase (NAD+) activity(GO:0004487) methylenetetrahydrofolate dehydrogenase (NADP+) activity(GO:0004488)
33.4 133.7 GO:0004594 pantothenate kinase activity(GO:0004594)
33.0 165.1 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
32.9 32.9 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
32.0 320.3 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
31.0 340.7 GO:0005049 nuclear export signal receptor activity(GO:0005049)
29.6 88.7 GO:0005459 UDP-galactose transmembrane transporter activity(GO:0005459)
29.1 116.3 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
27.6 82.9 GO:0097158 pre-mRNA intronic pyrimidine-rich binding(GO:0097158)
24.8 248.5 GO:0098505 G-rich strand telomeric DNA binding(GO:0098505)
24.3 73.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
23.6 70.9 GO:0070273 phosphatidylinositol-4-phosphate binding(GO:0070273)
23.0 298.4 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
22.9 68.8 GO:0050613 delta14-sterol reductase activity(GO:0050613)
21.8 65.5 GO:0004769 steroid delta-isomerase activity(GO:0004769)
21.3 63.8 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
19.2 76.9 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
18.9 869.3 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
18.3 329.8 GO:0035173 histone kinase activity(GO:0035173)
18.3 146.2 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
18.1 72.5 GO:0016936 galactoside binding(GO:0016936)
18.1 36.3 GO:0008263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity(GO:0008263)
18.1 90.3 GO:0001849 complement component C1q binding(GO:0001849)
17.5 87.7 GO:0019798 procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)
17.3 52.0 GO:0004819 glutamine-tRNA ligase activity(GO:0004819)
17.3 776.3 GO:0008138 protein tyrosine/serine/threonine phosphatase activity(GO:0008138)
16.6 49.9 GO:0003883 CTP synthase activity(GO:0003883)
16.6 66.2 GO:0031871 proteinase activated receptor binding(GO:0031871)
16.3 81.4 GO:0004485 methylcrotonoyl-CoA carboxylase activity(GO:0004485)
15.1 256.4 GO:0003688 DNA replication origin binding(GO:0003688)
15.0 556.4 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
15.0 74.8 GO:0061676 importin-alpha family protein binding(GO:0061676)
14.9 29.8 GO:0030984 kininogen binding(GO:0030984)
14.6 644.6 GO:0031492 nucleosomal DNA binding(GO:0031492)
13.9 69.3 GO:0000405 bubble DNA binding(GO:0000405)
13.6 40.9 GO:0004731 purine-nucleoside phosphorylase activity(GO:0004731)
13.6 54.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
13.6 27.1 GO:0046979 TAP2 binding(GO:0046979)
13.5 135.4 GO:0042731 PH domain binding(GO:0042731)
13.5 81.1 GO:0034513 box H/ACA snoRNA binding(GO:0034513)
13.4 40.2 GO:0016509 long-chain-3-hydroxyacyl-CoA dehydrogenase activity(GO:0016509)
13.1 52.4 GO:0071987 WD40-repeat domain binding(GO:0071987)
13.1 65.5 GO:0004525 ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296)
12.9 142.1 GO:0015266 protein channel activity(GO:0015266)
12.8 140.3 GO:0046790 virion binding(GO:0046790)
12.7 38.1 GO:0016454 serine C-palmitoyltransferase activity(GO:0004758) C-palmitoyltransferase activity(GO:0016454)
12.1 36.4 GO:0001002 polymerase III regulatory region sequence-specific DNA binding(GO:0000992) RNA polymerase III type 1 promoter sequence-specific DNA binding(GO:0001002) RNA polymerase III type 2 promoter sequence-specific DNA binding(GO:0001003)
11.9 47.6 GO:0005087 Ran guanyl-nucleotide exchange factor activity(GO:0005087)
11.9 35.7 GO:0031859 platelet activating factor receptor binding(GO:0031859)
11.5 69.2 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
11.3 135.6 GO:0031386 protein tag(GO:0031386)
11.3 135.5 GO:0046972 histone acetyltransferase activity (H4-K5 specific)(GO:0043995) histone acetyltransferase activity (H4-K8 specific)(GO:0043996) histone acetyltransferase activity (H4-K16 specific)(GO:0046972)
11.1 55.3 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
11.0 33.0 GO:0004609 phosphatidylserine decarboxylase activity(GO:0004609)
10.9 43.5 GO:0015319 sodium:inorganic phosphate symporter activity(GO:0015319)
10.9 65.2 GO:0102337 fatty acid elongase activity(GO:0009922) 3-oxo-arachidoyl-CoA synthase activity(GO:0102336) 3-oxo-cerotoyl-CoA synthase activity(GO:0102337) 3-oxo-lignoceronyl-CoA synthase activity(GO:0102338)
10.8 97.3 GO:0004784 superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721)
10.8 32.4 GO:0070538 oleic acid binding(GO:0070538)
10.7 42.8 GO:0004743 pyruvate kinase activity(GO:0004743)
10.6 31.9 GO:0042134 rRNA primary transcript binding(GO:0042134)
10.6 10.6 GO:0070404 NADH binding(GO:0070404)
10.6 31.7 GO:0048030 disaccharide binding(GO:0048030)
10.5 73.5 GO:0048408 epidermal growth factor binding(GO:0048408)
10.5 41.9 GO:0033981 D-dopachrome decarboxylase activity(GO:0033981)
10.3 51.7 GO:0032795 heterotrimeric G-protein binding(GO:0032795)
10.3 71.9 GO:0035614 snRNA stem-loop binding(GO:0035614)
10.2 194.6 GO:0016864 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
10.0 50.0 GO:0030060 L-malate dehydrogenase activity(GO:0030060)
10.0 39.8 GO:0004466 long-chain-acyl-CoA dehydrogenase activity(GO:0004466)
9.9 89.5 GO:1901612 cardiolipin binding(GO:1901612)
9.9 29.7 GO:0019238 cyclohydrolase activity(GO:0019238)
9.9 49.4 GO:0004359 glutaminase activity(GO:0004359)
9.7 77.7 GO:0004396 glucokinase activity(GO:0004340) hexokinase activity(GO:0004396) fructokinase activity(GO:0008865) mannokinase activity(GO:0019158)
9.5 293.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
9.5 37.8 GO:0015142 citrate transmembrane transporter activity(GO:0015137) tricarboxylic acid transmembrane transporter activity(GO:0015142)
9.3 204.0 GO:0070402 NADPH binding(GO:0070402)
9.1 127.7 GO:1990825 sequence-specific mRNA binding(GO:1990825)
9.0 315.0 GO:0008139 nuclear localization sequence binding(GO:0008139)
9.0 63.0 GO:0050815 phosphoserine binding(GO:0050815)
8.9 17.8 GO:0061650 ubiquitin-like protein conjugating enzyme activity(GO:0061650)
8.8 26.3 GO:0045155 electron transporter, transferring electrons from CoQH2-cytochrome c reductase complex and cytochrome c oxidase complex activity(GO:0045155)
8.6 69.1 GO:0008474 palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599)
8.6 34.5 GO:0052795 exo-alpha-(2->3)-sialidase activity(GO:0052794) exo-alpha-(2->6)-sialidase activity(GO:0052795) exo-alpha-(2->8)-sialidase activity(GO:0052796)
8.6 77.1 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
8.4 25.3 GO:0016846 carbon-sulfur lyase activity(GO:0016846)
8.3 191.5 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
8.3 33.1 GO:0004523 RNA-DNA hybrid ribonuclease activity(GO:0004523)
8.1 32.4 GO:0046538 bisphosphoglycerate mutase activity(GO:0004082) phosphoglycerate mutase activity(GO:0004619) 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase activity(GO:0046538)
7.8 23.5 GO:0004727 prenylated protein tyrosine phosphatase activity(GO:0004727)
7.8 39.1 GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912)
7.8 46.9 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
7.7 46.3 GO:0003998 acylphosphatase activity(GO:0003998)
7.6 53.4 GO:0061133 endopeptidase activator activity(GO:0061133)
7.6 259.5 GO:0042288 MHC class I protein binding(GO:0042288)
7.5 44.7 GO:0050291 sphingosine N-acyltransferase activity(GO:0050291)
7.2 28.7 GO:0008889 glycerophosphodiester phosphodiesterase activity(GO:0008889)
7.1 276.4 GO:0036002 pre-mRNA binding(GO:0036002)
7.0 21.0 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
7.0 208.7 GO:0070003 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
6.9 132.0 GO:0097602 cullin family protein binding(GO:0097602)
6.9 34.7 GO:0015183 L-aspartate transmembrane transporter activity(GO:0015183)
6.8 27.2 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
6.8 81.3 GO:1904264 ubiquitin protein ligase activity involved in ERAD pathway(GO:1904264)
6.7 67.2 GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding(GO:0036312)
6.7 33.6 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
6.6 359.1 GO:0019212 phosphatase inhibitor activity(GO:0019212)
6.6 124.8 GO:0051787 misfolded protein binding(GO:0051787)
6.5 38.9 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
6.3 132.1 GO:0008301 DNA binding, bending(GO:0008301)
6.3 100.2 GO:0035925 mRNA 3'-UTR AU-rich region binding(GO:0035925)
6.3 31.3 GO:0008483 transaminase activity(GO:0008483)
6.2 24.8 GO:0016744 transferase activity, transferring aldehyde or ketonic groups(GO:0016744)
6.2 31.0 GO:0004017 adenylate kinase activity(GO:0004017)
6.2 18.6 GO:0017108 5'-flap endonuclease activity(GO:0017108)
6.2 148.3 GO:0016628 oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628)
6.2 86.3 GO:0070064 proline-rich region binding(GO:0070064)
6.1 24.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
6.0 23.9 GO:1990190 peptide-glutamate-N-acetyltransferase activity(GO:1990190)
5.9 35.5 GO:0044547 DNA topoisomerase binding(GO:0044547)
5.8 63.4 GO:0034056 estrogen response element binding(GO:0034056)
5.7 17.2 GO:0048039 quinone binding(GO:0048038) ubiquinone binding(GO:0048039)
5.5 22.2 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
5.5 49.9 GO:0035497 cAMP response element binding(GO:0035497)
5.5 44.3 GO:0004738 pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase [NAD(P)+] activity(GO:0034603) pyruvate dehydrogenase (NAD+) activity(GO:0034604)
5.5 5.5 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
5.5 307.6 GO:0003777 microtubule motor activity(GO:0003777)
5.4 308.7 GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor(GO:0016655)
5.4 21.5 GO:0061649 ubiquitinated histone binding(GO:0061649)
5.3 26.6 GO:0070990 snRNP binding(GO:0070990)
5.3 63.4 GO:0032050 clathrin heavy chain binding(GO:0032050)
5.2 57.4 GO:0008253 5'-nucleotidase activity(GO:0008253)
5.2 281.5 GO:0097472 cyclin-dependent protein kinase activity(GO:0097472)
5.2 26.0 GO:0008479 queuine tRNA-ribosyltransferase activity(GO:0008479)
5.2 41.4 GO:0019103 pyrimidine nucleotide binding(GO:0019103)
5.2 242.8 GO:0030544 Hsp70 protein binding(GO:0030544)
5.1 15.3 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
5.0 139.4 GO:0000993 RNA polymerase II core binding(GO:0000993)
4.9 24.3 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
4.8 33.8 GO:0004046 aminoacylase activity(GO:0004046)
4.8 23.8 GO:0070905 serine binding(GO:0070905)
4.7 14.0 GO:0005047 signal recognition particle binding(GO:0005047)
4.6 59.7 GO:0005095 GTPase inhibitor activity(GO:0005095)
4.6 13.7 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
4.5 139.9 GO:0043015 gamma-tubulin binding(GO:0043015)
4.4 13.3 GO:0016781 selenide, water dikinase activity(GO:0004756) phosphotransferase activity, paired acceptors(GO:0016781)
4.4 44.1 GO:0016829 lyase activity(GO:0016829)
4.4 158.8 GO:0004407 histone deacetylase activity(GO:0004407)
4.4 52.6 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
4.4 69.9 GO:0031491 nucleosome binding(GO:0031491)
4.3 25.7 GO:0031543 peptidyl-proline dioxygenase activity(GO:0031543)
4.3 12.8 GO:0051185 coenzyme transporter activity(GO:0051185)
4.3 63.8 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
4.2 4.2 GO:0008413 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity(GO:0008413) 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity(GO:0035539)
4.2 25.3 GO:0034452 dynactin binding(GO:0034452)
4.2 8.3 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
4.0 20.0 GO:0036310 annealing helicase activity(GO:0036310)
4.0 95.8 GO:0034236 protein kinase A catalytic subunit binding(GO:0034236)
4.0 16.0 GO:0016018 cyclosporin A binding(GO:0016018)
4.0 79.6 GO:0000339 RNA cap binding(GO:0000339)
4.0 19.8 GO:0050145 nucleoside phosphate kinase activity(GO:0050145)
4.0 39.6 GO:0055104 ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948)
3.9 78.9 GO:0034185 apolipoprotein binding(GO:0034185)
3.9 50.6 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
3.9 66.1 GO:0005537 mannose binding(GO:0005537)
3.9 147.3 GO:0031593 polyubiquitin binding(GO:0031593)
3.9 46.5 GO:0000774 adenyl-nucleotide exchange factor activity(GO:0000774)
3.8 38.4 GO:0019784 NEDD8-specific protease activity(GO:0019784)
3.8 11.4 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
3.8 15.1 GO:0005471 ATP:ADP antiporter activity(GO:0005471) adenine transmembrane transporter activity(GO:0015207)
3.7 82.4 GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841)
3.7 130.6 GO:0001106 RNA polymerase II transcription corepressor activity(GO:0001106)
3.7 40.5 GO:0042169 SH2 domain binding(GO:0042169)
3.7 410.0 GO:0017048 Rho GTPase binding(GO:0017048)
3.6 101.4 GO:0005540 hyaluronic acid binding(GO:0005540)
3.6 28.9 GO:0030170 pyridoxal phosphate binding(GO:0030170)
3.6 3.6 GO:0000253 3-keto sterol reductase activity(GO:0000253)
3.6 21.4 GO:0004565 beta-galactosidase activity(GO:0004565)
3.5 10.4 GO:0016749 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
3.5 48.5 GO:0019206 nucleoside kinase activity(GO:0019206)
3.4 79.0 GO:0001056 RNA polymerase III activity(GO:0001056)
3.4 133.3 GO:0046966 thyroid hormone receptor binding(GO:0046966)
3.4 50.8 GO:0070567 cytidylyltransferase activity(GO:0070567)
3.4 27.0 GO:0050833 pyruvate transmembrane transporter activity(GO:0050833)
3.3 26.8 GO:0004176 ATP-dependent peptidase activity(GO:0004176)
3.3 6.6 GO:0030898 actin-dependent ATPase activity(GO:0030898)
3.3 62.6 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
3.3 291.3 GO:0003725 double-stranded RNA binding(GO:0003725)
3.2 25.8 GO:0010485 H4 histone acetyltransferase activity(GO:0010485)
3.2 15.8 GO:0016670 oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670)
3.1 6.2 GO:0051033 nucleic acid transmembrane transporter activity(GO:0051032) RNA transmembrane transporter activity(GO:0051033)
3.1 40.2 GO:0045294 alpha-catenin binding(GO:0045294)
3.1 9.3 GO:0016426 tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429)
3.1 49.2 GO:0009931 calcium-dependent protein serine/threonine kinase activity(GO:0009931)
3.1 15.3 GO:0008420 CTD phosphatase activity(GO:0008420)
3.0 18.1 GO:0071889 14-3-3 protein binding(GO:0071889)
3.0 30.0 GO:0008097 5S rRNA binding(GO:0008097)
3.0 17.9 GO:0090599 alpha-glucosidase activity(GO:0090599)
2.9 26.1 GO:0005131 growth hormone receptor binding(GO:0005131)
2.9 214.7 GO:0004869 cysteine-type endopeptidase inhibitor activity(GO:0004869)
2.8 8.5 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
2.8 16.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
2.8 14.1 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
2.8 24.9 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
2.8 19.3 GO:0070569 uridylyltransferase activity(GO:0070569)
2.7 8.2 GO:0046975 histone methyltransferase activity (H3-K36 specific)(GO:0046975)
2.7 10.9 GO:0015181 arginine transmembrane transporter activity(GO:0015181)
2.7 16.3 GO:0000155 phosphorelay sensor kinase activity(GO:0000155) protein histidine kinase activity(GO:0004673)
2.7 43.3 GO:0017056 structural constituent of nuclear pore(GO:0017056)
2.7 24.0 GO:0031730 CCR5 chemokine receptor binding(GO:0031730)
2.6 31.6 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
2.6 10.5 GO:0016784 3-mercaptopyruvate sulfurtransferase activity(GO:0016784)
2.6 15.5 GO:0008948 malate dehydrogenase (decarboxylating) (NAD+) activity(GO:0004471) malate dehydrogenase (decarboxylating) (NADP+) activity(GO:0004473) oxaloacetate decarboxylase activity(GO:0008948)
2.5 35.5 GO:0070628 proteasome binding(GO:0070628)
2.5 10.0 GO:0004047 aminomethyltransferase activity(GO:0004047)
2.5 7.4 GO:0033867 Fas-activated serine/threonine kinase activity(GO:0033867)
2.5 12.3 GO:0016882 cyclo-ligase activity(GO:0016882)
2.4 44.0 GO:0004535 poly(A)-specific ribonuclease activity(GO:0004535)
2.4 12.1 GO:0008440 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440)
2.4 33.9 GO:0051537 2 iron, 2 sulfur cluster binding(GO:0051537)
2.4 58.9 GO:0003899 DNA-directed RNA polymerase activity(GO:0003899)
2.3 7.0 GO:0004766 spermidine synthase activity(GO:0004766)
2.3 11.6 GO:1990460 leptin receptor binding(GO:1990460)
2.3 18.5 GO:0089720 caspase binding(GO:0089720)
2.3 13.9 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
2.3 6.9 GO:0015616 DNA translocase activity(GO:0015616)
2.3 139.5 GO:0043130 ubiquitin binding(GO:0043130)
2.3 6.8 GO:0008859 exoribonuclease II activity(GO:0008859)
2.2 40.1 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
2.2 17.7 GO:0016863 intramolecular oxidoreductase activity, transposing C=C bonds(GO:0016863)
2.2 109.2 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
2.1 131.0 GO:0005507 copper ion binding(GO:0005507)
2.1 42.8 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
2.1 2.1 GO:0008309 double-stranded DNA exodeoxyribonuclease activity(GO:0008309)
2.1 173.2 GO:0003697 single-stranded DNA binding(GO:0003697)
2.1 36.0 GO:0043422 protein kinase B binding(GO:0043422)
2.1 6.3 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
2.1 195.9 GO:0032947 protein complex scaffold(GO:0032947)
2.1 115.6 GO:0002039 p53 binding(GO:0002039)
2.1 65.9 GO:0008308 voltage-gated anion channel activity(GO:0008308)
2.1 16.5 GO:0036042 long-chain fatty acyl-CoA binding(GO:0036042)
2.1 22.6 GO:0001158 enhancer sequence-specific DNA binding(GO:0001158)
2.0 409.7 GO:0003735 structural constituent of ribosome(GO:0003735)
2.0 8.2 GO:0001094 TFIID-class transcription factor binding(GO:0001094)
2.0 48.4 GO:0080025 phosphatidylinositol-3,5-bisphosphate binding(GO:0080025)
1.9 27.2 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
1.9 23.2 GO:0055103 ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106)
1.9 3.8 GO:0004090 carbonyl reductase (NADPH) activity(GO:0004090)
1.9 7.6 GO:0033265 choline binding(GO:0033265)
1.9 56.0 GO:0017025 TBP-class protein binding(GO:0017025)
1.9 9.3 GO:0070644 vitamin D response element binding(GO:0070644)
1.8 9.2 GO:0015307 drug:proton antiporter activity(GO:0015307)
1.8 11.0 GO:0008240 tripeptidyl-peptidase activity(GO:0008240)
1.8 23.8 GO:0004985 opioid receptor activity(GO:0004985)
1.8 51.2 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
1.8 5.3 GO:0050510 N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510)
1.7 13.9 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
1.7 5.2 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
1.7 10.3 GO:0004705 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
1.7 8.6 GO:0070576 vitamin D 24-hydroxylase activity(GO:0070576)
1.7 61.8 GO:0043531 ADP binding(GO:0043531)
1.7 17.1 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
1.7 22.0 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
1.7 25.3 GO:0008536 Ran GTPase binding(GO:0008536)
1.7 35.4 GO:0050811 GABA receptor binding(GO:0050811)
1.7 33.6 GO:0004549 tRNA-specific ribonuclease activity(GO:0004549)
1.7 38.0 GO:0031489 myosin V binding(GO:0031489)
1.6 75.4 GO:0016859 cis-trans isomerase activity(GO:0016859)
1.6 34.0 GO:0019894 kinesin binding(GO:0019894)
1.6 4.8 GO:0000033 alpha-1,3-mannosyltransferase activity(GO:0000033)
1.6 191.5 GO:0042393 histone binding(GO:0042393)
1.6 6.4 GO:0015563 uptake transmembrane transporter activity(GO:0015563)
1.6 9.5 GO:0050733 RS domain binding(GO:0050733)
1.6 18.8 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
1.5 9.1 GO:0016421 CoA carboxylase activity(GO:0016421)
1.5 58.5 GO:0050681 androgen receptor binding(GO:0050681)
1.5 26.8 GO:0030331 estrogen receptor binding(GO:0030331)
1.5 3.0 GO:0046974 histone methyltransferase activity (H3-K9 specific)(GO:0046974)
1.5 11.7 GO:0050072 m7G(5')pppN diphosphatase activity(GO:0050072)
1.5 17.5 GO:0035251 UDP-glucosyltransferase activity(GO:0035251)
1.5 11.6 GO:0008172 S-methyltransferase activity(GO:0008172)
1.4 37.5 GO:0004713 protein tyrosine kinase activity(GO:0004713)
1.4 4.3 GO:0016724 ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724)
1.4 9.9 GO:0008199 ferric iron binding(GO:0008199)
1.4 15.5 GO:0070182 DNA polymerase binding(GO:0070182)
1.4 5.5 GO:0043262 adenosine-diphosphatase activity(GO:0043262)
1.4 458.9 GO:0045296 cadherin binding(GO:0045296)
1.3 18.6 GO:0030881 beta-2-microglobulin binding(GO:0030881)
1.3 3.9 GO:0005169 neurotrophin TRKB receptor binding(GO:0005169)
1.3 97.9 GO:0004386 helicase activity(GO:0004386)
1.3 5.0 GO:0003886 DNA (cytosine-5-)-methyltransferase activity(GO:0003886)
1.2 185.6 GO:0003729 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
1.2 95.3 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
1.2 7.3 GO:0046527 glucosyltransferase activity(GO:0046527)
1.2 23.1 GO:0016500 protein-hormone receptor activity(GO:0016500)
1.2 4.8 GO:0016888 endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888)
1.2 23.9 GO:0016505 peptidase activator activity involved in apoptotic process(GO:0016505)
1.2 11.8 GO:0001135 transcription factor activity, RNA polymerase II transcription factor recruiting(GO:0001135)
1.2 11.5 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.1 4.5 GO:0050509 N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
1.1 19.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
1.1 3.4 GO:1904047 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809) S-adenosyl-L-methionine binding(GO:1904047)
1.1 11.2 GO:0008641 small protein activating enzyme activity(GO:0008641)
1.1 4.4 GO:0004335 galactokinase activity(GO:0004335)
1.1 8.6 GO:0032182 ubiquitin-like protein binding(GO:0032182)
1.1 7.4 GO:0008312 7S RNA binding(GO:0008312)
1.0 41.4 GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen(GO:0016709)
1.0 2.1 GO:0010314 phosphatidylinositol-5-phosphate binding(GO:0010314)
1.0 6.1 GO:0004521 endoribonuclease activity(GO:0004521)
1.0 13.1 GO:0047372 acylglycerol lipase activity(GO:0047372)
1.0 33.9 GO:0050699 WW domain binding(GO:0050699)
0.9 3.8 GO:0005114 type II transforming growth factor beta receptor binding(GO:0005114)
0.9 1.9 GO:0004033 aldo-keto reductase (NADP) activity(GO:0004033)
0.9 13.0 GO:0052744 phosphatidylinositol-3-phosphatase activity(GO:0004438) phosphatidylinositol monophosphate phosphatase activity(GO:0052744)
0.9 41.9 GO:0004364 glutathione transferase activity(GO:0004364)
0.9 11.0 GO:0004659 prenyltransferase activity(GO:0004659)
0.9 27.3 GO:0005080 protein kinase C binding(GO:0005080)
0.9 34.6 GO:0033613 activating transcription factor binding(GO:0033613)
0.9 836.9 GO:0003723 RNA binding(GO:0003723)
0.9 92.0 GO:0047485 protein N-terminus binding(GO:0047485)
0.9 31.8 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.9 12.8 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.8 12.4 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)
0.8 2.4 GO:0008424 glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921)
0.8 2.4 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.8 3.9 GO:0070840 dynein complex binding(GO:0070840)
0.7 5.2 GO:0016290 palmitoyl-CoA hydrolase activity(GO:0016290)
0.7 4.5 GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.7 2.2 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.7 1.5 GO:0000035 acyl binding(GO:0000035)
0.7 9.4 GO:0071949 FAD binding(GO:0071949)
0.7 2.9 GO:0070139 ubiquitin-like protein-specific endopeptidase activity(GO:0070137) SUMO-specific endopeptidase activity(GO:0070139)
0.7 3.6 GO:0038187 signaling pattern recognition receptor activity(GO:0008329) pattern recognition receptor activity(GO:0038187)
0.7 3.5 GO:0004994 somatostatin receptor activity(GO:0004994)
0.7 3.3 GO:0005294 neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294)
0.7 4.6 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.7 2.7 GO:0004771 sterol esterase activity(GO:0004771)
0.6 6.9 GO:0051721 protein phosphatase 2A binding(GO:0051721)
0.6 9.2 GO:0034483 heparan sulfate sulfotransferase activity(GO:0034483)
0.6 7.8 GO:0015248 sterol transporter activity(GO:0015248)
0.6 1.8 GO:0005254 chloride channel activity(GO:0005254) chloride transmembrane transporter activity(GO:0015108)
0.6 5.1 GO:0003995 acyl-CoA dehydrogenase activity(GO:0003995)
0.6 9.1 GO:0015923 alpha-mannosidase activity(GO:0004559) mannosidase activity(GO:0015923)
0.6 5.0 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005)
0.5 4.2 GO:0047499 calcium-independent phospholipase A2 activity(GO:0047499)
0.5 16.9 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.5 1.6 GO:0015129 lactate transmembrane transporter activity(GO:0015129)
0.5 1.0 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.5 11.6 GO:0005504 fatty acid binding(GO:0005504)
0.5 7.0 GO:0019707 protein-cysteine S-palmitoyltransferase activity(GO:0019706) protein-cysteine S-acyltransferase activity(GO:0019707)
0.5 2.0 GO:0004977 melanocortin receptor activity(GO:0004977)
0.5 3.3 GO:0002162 dystroglycan binding(GO:0002162)
0.5 4.6 GO:0019869 chloride channel inhibitor activity(GO:0019869)
0.5 4.6 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.4 2.2 GO:0050436 microfibril binding(GO:0050436)
0.4 6.5 GO:0016209 antioxidant activity(GO:0016209)
0.4 2.2 GO:0004465 lipoprotein lipase activity(GO:0004465)
0.4 20.5 GO:0042826 histone deacetylase binding(GO:0042826)
0.4 1.7 GO:0004348 glucosylceramidase activity(GO:0004348)
0.4 0.8 GO:0030226 apolipoprotein receptor activity(GO:0030226) apolipoprotein A-I receptor activity(GO:0034188) phosphatidylserine-translocating ATPase activity(GO:0090556)
0.4 0.8 GO:0008252 nucleotidase activity(GO:0008252)
0.4 0.8 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.4 5.5 GO:0015114 phosphate ion transmembrane transporter activity(GO:0015114)
0.4 5.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.4 28.1 GO:0005516 calmodulin binding(GO:0005516)
0.4 31.5 GO:0030165 PDZ domain binding(GO:0030165)
0.4 1.5 GO:0004052 arachidonate 12-lipoxygenase activity(GO:0004052)
0.4 1.1 GO:0045127 N-acetylglucosamine kinase activity(GO:0045127)
0.4 1.4 GO:0017089 glycolipid transporter activity(GO:0017089)
0.3 0.3 GO:0015925 galactosidase activity(GO:0015925)
0.3 1.6 GO:0008237 metallopeptidase activity(GO:0008237)
0.3 54.5 GO:0031625 ubiquitin protein ligase binding(GO:0031625)
0.3 3.9 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.3 2.4 GO:0019534 toxin transporter activity(GO:0019534)
0.3 12.4 GO:0015485 cholesterol binding(GO:0015485)
0.3 26.1 GO:0004721 phosphoprotein phosphatase activity(GO:0004721)
0.3 1.7 GO:0008553 hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553)
0.3 1.9 GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454)
0.3 2.1 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.2 0.2 GO:0016453 C-acetyltransferase activity(GO:0016453)
0.2 2.5 GO:0035256 G-protein coupled glutamate receptor binding(GO:0035256)
0.2 0.9 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.2 0.6 GO:0008195 phosphatidate phosphatase activity(GO:0008195)
0.2 0.2 GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508)
0.2 1.4 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.2 1.0 GO:0098821 BMP receptor activity(GO:0098821)
0.2 0.9 GO:0008048 calcium sensitive guanylate cyclase activator activity(GO:0008048)
0.2 2.0 GO:0031701 angiotensin receptor binding(GO:0031701) type 1 angiotensin receptor binding(GO:0031702)
0.2 0.5 GO:0019237 centromeric DNA binding(GO:0019237)
0.2 3.6 GO:0043021 ribonucleoprotein complex binding(GO:0043021)
0.2 0.9 GO:0050294 steroid sulfotransferase activity(GO:0050294)
0.1 1.9 GO:0019213 deacetylase activity(GO:0019213)
0.1 1.2 GO:0008175 tRNA methyltransferase activity(GO:0008175)
0.1 0.4 GO:0010851 cyclase regulator activity(GO:0010851) guanylate cyclase regulator activity(GO:0030249)
0.1 0.7 GO:0018479 benzaldehyde dehydrogenase (NAD+) activity(GO:0018479)
0.1 0.6 GO:0022889 L-serine transmembrane transporter activity(GO:0015194) serine transmembrane transporter activity(GO:0022889)
0.1 0.9 GO:0060002 plus-end directed microfilament motor activity(GO:0060002)
0.1 1.4 GO:0033130 acetylcholine receptor binding(GO:0033130)
0.1 0.6 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.1 4.9 GO:0005044 scavenger receptor activity(GO:0005044)
0.1 1.8 GO:0042974 retinoic acid receptor binding(GO:0042974)
0.1 2.3 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.1 2.0 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.3 GO:0004461 lactose synthase activity(GO:0004461)
0.1 0.9 GO:0042287 MHC protein binding(GO:0042287)
0.1 0.6 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.6 GO:0033038 bitter taste receptor activity(GO:0033038)
0.1 0.6 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.0 2.7 GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds(GO:0004553)
0.0 0.9 GO:0031072 heat shock protein binding(GO:0031072)
0.0 1.9 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.1 GO:0015556 C4-dicarboxylate transmembrane transporter activity(GO:0015556)
0.0 0.3 GO:0005112 Notch binding(GO:0005112)
0.0 0.1 GO:0052650 NADP-retinol dehydrogenase activity(GO:0052650)
0.0 0.1 GO:0005124 scavenger receptor binding(GO:0005124)
0.0 0.5 GO:0003774 motor activity(GO:0003774)
0.0 0.0 GO:0070087 chromo shadow domain binding(GO:0070087)
0.0 0.2 GO:0019992 diacylglycerol binding(GO:0019992)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
31.1 2116.0 PID PLK1 PATHWAY PLK1 signaling events
24.0 1655.0 PID FOXM1 PATHWAY FOXM1 transcription factor network
19.8 19.8 ST T CELL SIGNAL TRANSDUCTION T Cell Signal Transduction
15.6 234.3 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
12.3 318.7 PID BARD1 PATHWAY BARD1 signaling events
11.0 430.9 PID MYC PATHWAY C-MYC pathway
10.0 449.2 PID AURORA B PATHWAY Aurora B signaling
9.8 402.2 PID AURORA A PATHWAY Aurora A signaling
9.7 476.1 PID FANCONI PATHWAY Fanconi anemia pathway
9.4 877.3 PID E2F PATHWAY E2F transcription factor network
6.9 179.3 PID ATR PATHWAY ATR signaling pathway
5.1 219.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
5.0 853.0 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
4.9 24.5 SA PROGRAMMED CELL DEATH Programmed cell death, or apoptosis, eliminates damaged or unneeded cells.
4.8 312.4 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
3.9 125.4 PID SMAD2 3PATHWAY Regulation of cytoplasmic and nuclear SMAD2/3 signaling
3.7 41.1 PID IL3 PATHWAY IL3-mediated signaling events
3.6 14.4 PID MAPK TRK PATHWAY Trk receptor signaling mediated by the MAPK pathway
3.3 229.5 PID P73PATHWAY p73 transcription factor network
3.3 192.9 PID TELOMERASE PATHWAY Regulation of Telomerase
3.2 22.2 ST INTERFERON GAMMA PATHWAY Interferon gamma pathway.
3.0 30.0 ST STAT3 PATHWAY STAT3 Pathway
3.0 77.5 PID HIF1A PATHWAY Hypoxic and oxygen homeostasis regulation of HIF-1-alpha
2.8 121.8 PID IL6 7 PATHWAY IL6-mediated signaling events
2.7 128.7 PID FOXO PATHWAY FoxO family signaling
2.7 69.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
2.5 53.1 PID PRL SIGNALING EVENTS PATHWAY Signaling events mediated by PRL
2.5 32.5 PID NFKAPPAB ATYPICAL PATHWAY Atypical NF-kappaB pathway
2.5 235.2 PID CMYB PATHWAY C-MYB transcription factor network
2.5 72.2 PID HDAC CLASSII PATHWAY Signaling events mediated by HDAC Class II
2.2 140.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
2.2 138.1 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
2.1 177.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
2.0 36.0 SA FAS SIGNALING The TNF-type receptor Fas induces apoptosis on ligand binding.
1.9 102.4 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
1.8 23.0 SA G1 AND S PHASES Cdk2, 4, and 6 bind cyclin D in G1, while cdk2/cyclin E promotes the G1/S transition.
1.7 36.4 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
1.6 75.7 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
1.6 54.5 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
1.6 98.4 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
1.4 32.0 PID RHOA PATHWAY RhoA signaling pathway
1.4 20.8 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
1.3 17.5 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
1.2 14.8 PID HIF2PATHWAY HIF-2-alpha transcription factor network
1.2 20.9 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.9 42.8 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.9 29.9 PID AR TF PATHWAY Regulation of Androgen receptor activity
0.9 14.0 PID ANGIOPOIETIN RECEPTOR PATHWAY Angiopoietin receptor Tie2-mediated signaling
0.8 23.5 PID TAP63 PATHWAY Validated transcriptional targets of TAp63 isoforms
0.8 0.8 SA PTEN PATHWAY PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate.
0.8 42.0 PID AJDISS 2PATHWAY Posttranslational regulation of adherens junction stability and dissassembly
0.8 14.6 PID RAS PATHWAY Regulation of Ras family activation
0.7 46.2 ST INTEGRIN SIGNALING PATHWAY Integrin Signaling Pathway
0.7 16.8 PID HNF3A PATHWAY FOXA1 transcription factor network
0.7 21.5 PID AVB3 INTEGRIN PATHWAY Integrins in angiogenesis
0.7 14.7 PID HIV NEF PATHWAY HIV-1 Nef: Negative effector of Fas and TNF-alpha
0.6 23.4 PID ILK PATHWAY Integrin-linked kinase signaling
0.6 10.6 PID WNT NONCANONICAL PATHWAY Noncanonical Wnt signaling pathway
0.5 23.1 PID CD8 TCR PATHWAY TCR signaling in naïve CD8+ T cells
0.5 22.0 PID ARF6 PATHWAY Arf6 signaling events
0.5 23.9 PID SYNDECAN 1 PATHWAY Syndecan-1-mediated signaling events
0.4 12.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.4 7.3 PID P38 MK2 PATHWAY p38 signaling mediated by MAPKAP kinases
0.4 6.2 PID SYNDECAN 3 PATHWAY Syndecan-3-mediated signaling events
0.4 6.5 ST TUMOR NECROSIS FACTOR PATHWAY Tumor Necrosis Factor Pathway.
0.3 3.4 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.3 6.8 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.3 2.7 PID INTEGRIN4 PATHWAY Alpha6 beta4 integrin-ligand interactions
0.2 3.9 PID ATM PATHWAY ATM pathway
0.2 2.7 PID SYNDECAN 2 PATHWAY Syndecan-2-mediated signaling events
0.2 15.2 PID RHOA REG PATHWAY Regulation of RhoA activity
0.2 34.1 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.1 4.9 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.3 PID ARF 3PATHWAY Arf1 pathway
0.1 1.5 PID TGFBR PATHWAY TGF-beta receptor signaling
0.0 1.0 PID CDC42 PATHWAY CDC42 signaling events
0.0 1.6 PID PTP1B PATHWAY Signaling events mediated by PTP1B
0.0 0.7 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
89.2 624.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
50.1 50.1 REACTOME APC CDC20 MEDIATED DEGRADATION OF NEK2A Genes involved in APC-Cdc20 mediated degradation of Nek2A
49.0 1371.3 REACTOME PHOSPHORYLATION OF THE APC C Genes involved in Phosphorylation of the APC/C
48.5 581.8 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
34.6 1074.0 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
32.9 32.9 REACTOME CDC6 ASSOCIATION WITH THE ORC ORIGIN COMPLEX Genes involved in CDC6 association with the ORC:origin complex
32.7 523.3 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
29.2 583.8 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
25.8 541.6 REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION Genes involved in Cyclin A/B1 associated events during G2/M transition
21.6 560.9 REACTOME KINESINS Genes involved in Kinesins
20.0 320.7 REACTOME SLBP DEPENDENT PROCESSING OF REPLICATION DEPENDENT HISTONE PRE MRNAS Genes involved in SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
19.6 156.9 REACTOME ASSOCIATION OF LICENSING FACTORS WITH THE PRE REPLICATIVE COMPLEX Genes involved in Association of licensing factors with the pre-replicative complex
18.5 259.2 REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA Genes involved in Activation of Chaperone Genes by ATF6-alpha
17.5 332.3 REACTOME G1 S SPECIFIC TRANSCRIPTION Genes involved in G1/S-Specific Transcription
16.7 149.9 REACTOME REGULATION OF THE FANCONI ANEMIA PATHWAY Genes involved in Regulation of the Fanconi anemia pathway
14.9 223.1 REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE Genes involved in mRNA Decay by 5' to 3' Exoribonuclease
14.1 226.2 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
14.0 266.2 REACTOME N GLYCAN TRIMMING IN THE ER AND CALNEXIN CALRETICULIN CYCLE Genes involved in N-glycan trimming in the ER and Calnexin/Calreticulin cycle
12.6 590.3 REACTOME G1 PHASE Genes involved in G1 Phase
12.5 312.2 REACTOME EXTENSION OF TELOMERES Genes involved in Extension of Telomeres
12.1 1092.8 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
11.9 94.9 REACTOME MICRORNA MIRNA BIOGENESIS Genes involved in MicroRNA (miRNA) Biogenesis
11.8 423.0 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
11.4 159.0 REACTOME VITAMIN B5 PANTOTHENATE METABOLISM Genes involved in Vitamin B5 (pantothenate) metabolism
11.2 547.2 REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere
10.6 413.5 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
9.4 93.9 REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY Genes involved in Post-chaperonin tubulin folding pathway
8.9 106.9 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
8.8 202.3 REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING Genes involved in Formation of ATP by chemiosmotic coupling
8.6 232.3 REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS Genes involved in Transport of Ribonucleoproteins into the Host Nucleus
8.5 59.4 REACTOME G2 M DNA DAMAGE CHECKPOINT Genes involved in G2/M DNA damage checkpoint
8.4 596.6 REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
8.3 99.1 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
8.0 136.5 REACTOME SYNTHESIS SECRETION AND DEACYLATION OF GHRELIN Genes involved in Synthesis, Secretion, and Deacylation of Ghrelin
7.6 1089.7 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
7.3 73.3 REACTOME ENDOSOMAL VACUOLAR PATHWAY Genes involved in Endosomal/Vacuolar pathway
7.3 131.5 REACTOME GAP JUNCTION DEGRADATION Genes involved in Gap junction degradation
7.1 78.1 REACTOME SHC1 EVENTS IN EGFR SIGNALING Genes involved in SHC1 events in EGFR signaling
6.9 145.9 REACTOME SYNTHESIS OF VERY LONG CHAIN FATTY ACYL COAS Genes involved in Synthesis of very long-chain fatty acyl-CoAs
6.9 220.3 REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha
6.9 41.2 REACTOME FATTY ACYL COA BIOSYNTHESIS Genes involved in Fatty Acyl-CoA Biosynthesis
6.8 392.1 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
6.7 74.1 REACTOME PURINE CATABOLISM Genes involved in Purine catabolism
6.4 63.8 REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC Genes involved in Regulation of ornithine decarboxylase (ODC)
6.4 108.1 REACTOME ACTIVATION OF BH3 ONLY PROTEINS Genes involved in Activation of BH3-only proteins
5.9 70.3 REACTOME RNA POL III CHAIN ELONGATION Genes involved in RNA Polymerase III Chain Elongation
5.8 92.0 REACTOME METABOLISM OF NON CODING RNA Genes involved in Metabolism of non-coding RNA
5.1 142.9 REACTOME ENOS ACTIVATION AND REGULATION Genes involved in eNOS activation and regulation
5.0 130.8 REACTOME PYRIMIDINE METABOLISM Genes involved in Pyrimidine metabolism
4.9 93.7 REACTOME HYALURONAN UPTAKE AND DEGRADATION Genes involved in Hyaluronan uptake and degradation
4.7 93.9 REACTOME ADVANCED GLYCOSYLATION ENDPRODUCT RECEPTOR SIGNALING Genes involved in Advanced glycosylation endproduct receptor signaling
4.4 70.7 REACTOME CITRIC ACID CYCLE TCA CYCLE Genes involved in Citric acid cycle (TCA cycle)
4.3 93.8 REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT Genes involved in Chylomicron-mediated lipid transport
4.2 41.7 REACTOME COPI MEDIATED TRANSPORT Genes involved in COPI Mediated Transport
4.1 146.0 REACTOME LYSOSOME VESICLE BIOGENESIS Genes involved in Lysosome Vesicle Biogenesis
4.0 32.2 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 2 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 2 Promoter
3.9 62.6 REACTOME ZINC TRANSPORTERS Genes involved in Zinc transporters
3.8 56.8 REACTOME ALPHA LINOLENIC ACID ALA METABOLISM Genes involved in alpha-linolenic acid (ALA) metabolism
3.7 78.0 REACTOME TRIGLYCERIDE BIOSYNTHESIS Genes involved in Triglyceride Biosynthesis
3.6 64.6 REACTOME IL 6 SIGNALING Genes involved in Interleukin-6 signaling
3.5 300.5 REACTOME RESPIRATORY ELECTRON TRANSPORT Genes involved in Respiratory electron transport
3.5 52.5 REACTOME HOMOLOGOUS RECOMBINATION REPAIR OF REPLICATION INDEPENDENT DOUBLE STRAND BREAKS Genes involved in Homologous recombination repair of replication-independent double-strand breaks
3.5 93.5 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
3.4 57.7 REACTOME GLUCOSE TRANSPORT Genes involved in Glucose transport
3.1 89.2 REACTOME MEIOTIC RECOMBINATION Genes involved in Meiotic Recombination
3.1 21.5 REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION Genes involved in Influenza Viral RNA Transcription and Replication
3.0 61.0 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
2.9 140.9 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
2.8 33.3 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter
2.7 13.4 REACTOME ACTIVATION OF THE PRE REPLICATIVE COMPLEX Genes involved in Activation of the pre-replicative complex
2.5 86.1 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
2.3 160.8 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
2.3 66.4 REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB Genes involved in PKA-mediated phosphorylation of CREB
2.3 11.3 REACTOME ERKS ARE INACTIVATED Genes involved in ERKs are inactivated
2.2 116.6 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
2.1 34.3 REACTOME DEADENYLATION OF MRNA Genes involved in Deadenylation of mRNA
2.1 48.5 REACTOME PURINE SALVAGE Genes involved in Purine salvage
2.1 90.4 REACTOME GLYCOSPHINGOLIPID METABOLISM Genes involved in Glycosphingolipid metabolism
2.1 58.0 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
2.1 138.2 REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES Genes involved in Loss of Nlp from mitotic centrosomes
2.0 13.9 REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
2.0 82.6 REACTOME REGULATION OF MRNA STABILITY BY PROTEINS THAT BIND AU RICH ELEMENTS Genes involved in Regulation of mRNA Stability by Proteins that Bind AU-rich Elements
2.0 33.2 REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION Genes involved in Mitochondrial Fatty Acid Beta-Oxidation
1.9 262.0 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.8 422.1 REACTOME TRANSLATION Genes involved in Translation
1.8 49.3 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
1.7 39.9 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
1.6 27.0 REACTOME PURINE RIBONUCLEOSIDE MONOPHOSPHATE BIOSYNTHESIS Genes involved in Purine ribonucleoside monophosphate biosynthesis
1.6 50.8 REACTOME METABOLISM OF NUCLEOTIDES Genes involved in Metabolism of nucleotides
1.6 12.4 REACTOME METAL ION SLC TRANSPORTERS Genes involved in Metal ion SLC transporters
1.5 30.6 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
1.4 8.3 REACTOME RIP MEDIATED NFKB ACTIVATION VIA DAI Genes involved in RIP-mediated NFkB activation via DAI
1.4 17.9 REACTOME FORMATION OF THE HIV1 EARLY ELONGATION COMPLEX Genes involved in Formation of the HIV-1 Early Elongation Complex
1.3 36.5 REACTOME ACTIVATED NOTCH1 TRANSMITS SIGNAL TO THE NUCLEUS Genes involved in Activated NOTCH1 Transmits Signal to the Nucleus
1.3 21.5 REACTOME SIGNALING BY HIPPO Genes involved in Signaling by Hippo
1.2 25.4 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
1.1 26.6 REACTOME NUCLEOTIDE LIKE PURINERGIC RECEPTORS Genes involved in Nucleotide-like (purinergic) receptors
1.0 5.1 REACTOME BINDING AND ENTRY OF HIV VIRION Genes involved in Binding and entry of HIV virion
1.0 17.4 REACTOME APOPTOTIC CLEAVAGE OF CELL ADHESION PROTEINS Genes involved in Apoptotic cleavage of cell adhesion proteins
0.9 9.1 REACTOME SYNTHESIS OF PIPS AT THE LATE ENDOSOME MEMBRANE Genes involved in Synthesis of PIPs at the late endosome membrane
0.9 104.9 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.9 53.2 REACTOME PHASE II CONJUGATION Genes involved in Phase II conjugation
0.9 10.3 REACTOME NOTCH HLH TRANSCRIPTION PATHWAY Genes involved in Notch-HLH transcription pathway
0.9 29.0 REACTOME BASIGIN INTERACTIONS Genes involved in Basigin interactions
0.8 12.0 REACTOME ACTIVATION OF NF KAPPAB IN B CELLS Genes involved in Activation of NF-kappaB in B Cells
0.8 6.3 REACTOME INTERACTIONS OF VPR WITH HOST CELLULAR PROTEINS Genes involved in Interactions of Vpr with host cellular proteins
0.8 12.5 REACTOME NEPHRIN INTERACTIONS Genes involved in Nephrin interactions
0.7 10.3 REACTOME JNK C JUN KINASES PHOSPHORYLATION AND ACTIVATION MEDIATED BY ACTIVATED HUMAN TAK1 Genes involved in JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
0.7 30.7 REACTOME GLYCOLYSIS Genes involved in Glycolysis
0.6 5.1 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.6 10.9 REACTOME TIE2 SIGNALING Genes involved in Tie2 Signaling
0.6 3.6 REACTOME ACTIVATED TAK1 MEDIATES P38 MAPK ACTIVATION Genes involved in activated TAK1 mediates p38 MAPK activation
0.6 12.8 REACTOME METABOLISM OF POLYAMINES Genes involved in Metabolism of polyamines
0.5 16.7 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.5 21.6 REACTOME LATE PHASE OF HIV LIFE CYCLE Genes involved in Late Phase of HIV Life Cycle
0.5 15.5 REACTOME POST TRANSLATIONAL MODIFICATION SYNTHESIS OF GPI ANCHORED PROTEINS Genes involved in Post-translational modification: synthesis of GPI-anchored proteins
0.4 5.8 REACTOME P38MAPK EVENTS Genes involved in p38MAPK events
0.4 14.7 REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX Genes involved in Degradation of the extracellular matrix
0.4 16.7 REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES Genes involved in Transport of vitamins, nucleosides, and related molecules
0.3 3.4 REACTOME TELOMERE MAINTENANCE Genes involved in Telomere Maintenance
0.3 16.2 REACTOME TRANS GOLGI NETWORK VESICLE BUDDING Genes involved in trans-Golgi Network Vesicle Budding
0.3 11.4 REACTOME TIGHT JUNCTION INTERACTIONS Genes involved in Tight junction interactions
0.3 6.6 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.3 14.0 REACTOME TRANSPORT TO THE GOLGI AND SUBSEQUENT MODIFICATION Genes involved in Transport to the Golgi and subsequent modification
0.3 10.1 REACTOME O LINKED GLYCOSYLATION OF MUCINS Genes involved in O-linked glycosylation of mucins
0.3 21.3 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.2 7.0 REACTOME REGULATION OF COMPLEMENT CASCADE Genes involved in Regulation of Complement cascade
0.2 2.3 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.1 6.4 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.1 22.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.1 11.5 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 1.6 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.1 1.2 REACTOME GLOBAL GENOMIC NER GG NER Genes involved in Global Genomic NER (GG-NER)
0.1 1.5 REACTOME RNA POL I TRANSCRIPTION TERMINATION Genes involved in RNA Polymerase I Transcription Termination
0.1 1.9 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.0 0.4 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events