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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZBTB12

Z-value: 1.10

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Transcription factors associated with ZBTB12

Gene Symbol Gene ID Gene Info
ZBTB12
ENSG00000204366.3 zinc finger and BTB domain containing 12

Activity profile of ZBTB12 motif

Sorted Z-values of ZBTB12 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr1_+_158979792 20.08 ENST00000359709.3
ENST00000430894.2
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979686 19.25 ENST00000368132.3
ENST00000295809.7
IFI16
interferon, gamma-inducible protein 16
chr1_+_158979680 19.19 ENST00000368131.4
ENST00000340979.6
IFI16
interferon, gamma-inducible protein 16
chr1_+_32757668 18.59 ENST00000373548.3
HDAC1
histone deacetylase 1
chr16_-_67969888 17.65 ENST00000574576.2
PSMB10
proteasome (prosome, macropain) subunit, beta type, 10
chr13_-_46716969 16.67 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr1_+_26644441 16.22 ENST00000374213.2
CD52
CD52 molecule
chr11_+_65769550 15.88 ENST00000312175.2
ENST00000445560.2
ENST00000530204.1
BANF1
barrier to autointegration factor 1
chr11_+_65769946 15.79 ENST00000533166.1
BANF1
barrier to autointegration factor 1
chr15_+_40453204 15.65 ENST00000287598.6
ENST00000412359.3
BUB1B
BUB1 mitotic checkpoint serine/threonine kinase B
chr1_+_155583012 14.06 ENST00000462250.2
MSTO1
misato 1, mitochondrial distribution and morphology regulator
chr12_-_7077125 14.04 ENST00000545555.2
PHB2
prohibitin 2
chr15_+_66797627 12.02 ENST00000565627.1
ENST00000564179.1
ZWILCH
zwilch kinetochore protein
chr15_-_55563072 11.95 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A
RAB27A, member RAS oncogene family
chr15_+_66797455 11.93 ENST00000446801.2
ZWILCH
zwilch kinetochore protein
chr15_-_55562479 11.87 ENST00000564609.1
RAB27A
RAB27A, member RAS oncogene family
chr10_+_76969909 11.69 ENST00000298468.5
ENST00000543351.1
VDAC2
voltage-dependent anion channel 2
chr20_+_36373032 11.16 ENST00000373473.1
CTNNBL1
catenin, beta like 1
chr14_-_74959978 10.79 ENST00000541064.1
NPC2
Niemann-Pick disease, type C2
chr1_+_45212074 10.57 ENST00000372217.1
KIF2C
kinesin family member 2C
chr22_+_22930626 10.41 ENST00000390302.2
IGLV2-33
immunoglobulin lambda variable 2-33 (non-functional)
chr14_-_74960030 9.86 ENST00000553490.1
ENST00000557510.1
NPC2
Niemann-Pick disease, type C2
chr12_+_53689309 9.74 ENST00000351500.3
ENST00000550846.1
ENST00000334478.4
ENST00000549759.1
PFDN5
prefoldin subunit 5
chr5_-_176778523 9.64 ENST00000513877.1
ENST00000515209.1
ENST00000514458.1
ENST00000502560.1
LMAN2
lectin, mannose-binding 2
chr15_-_55562582 9.23 ENST00000396307.2
RAB27A
RAB27A, member RAS oncogene family
chr14_-_54908043 9.22 ENST00000556113.1
ENST00000553660.1
ENST00000395573.4
ENST00000557690.1
ENST00000216416.4
CNIH1
cornichon family AMPA receptor auxiliary protein 1
chr11_-_104972158 9.13 ENST00000598974.1
ENST00000593315.1
ENST00000594519.1
ENST00000415981.2
ENST00000525374.1
ENST00000375707.1
CASP1
CARD16
CARD17
caspase 1, apoptosis-related cysteine peptidase
caspase recruitment domain family, member 16
caspase recruitment domain family, member 17
chr15_-_66797172 9.10 ENST00000569438.1
ENST00000569696.1
ENST00000307961.6
RPL4
ribosomal protein L4
chr4_-_10118348 9.01 ENST00000502702.1
WDR1
WD repeat domain 1
chr12_+_53848549 8.64 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2
poly(rC) binding protein 2
chr14_-_74959994 8.52 ENST00000238633.2
ENST00000434013.2
NPC2
Niemann-Pick disease, type C2
chr19_-_13227534 8.51 ENST00000588229.1
ENST00000357720.4
TRMT1
tRNA methyltransferase 1 homolog (S. cerevisiae)
chr17_+_36908984 8.49 ENST00000225426.4
ENST00000579088.1
PSMB3
proteasome (prosome, macropain) subunit, beta type, 3
chr1_+_45212051 8.22 ENST00000372222.3
KIF2C
kinesin family member 2C
chr4_-_99851766 8.14 ENST00000450253.2
EIF4E
eukaryotic translation initiation factor 4E
chr1_-_94344754 7.99 ENST00000436063.2
DNTTIP2
deoxynucleotidyltransferase, terminal, interacting protein 2
chr1_+_46016703 7.96 ENST00000481885.1
ENST00000351829.4
ENST00000471651.1
AKR1A1
aldo-keto reductase family 1, member A1 (aldehyde reductase)
chr20_-_33543546 7.67 ENST00000216951.2
GSS
glutathione synthetase
chr5_-_148929848 7.64 ENST00000504676.1
ENST00000515435.1
CSNK1A1
casein kinase 1, alpha 1
chr12_-_46766577 7.55 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr18_-_47018769 6.96 ENST00000583637.1
ENST00000578528.1
ENST00000578532.1
ENST00000580387.1
ENST00000579248.1
ENST00000581373.1
RPL17
ribosomal protein L17
chr6_-_114292449 6.56 ENST00000519065.1
HDAC2
histone deacetylase 2
chr5_-_96518907 6.55 ENST00000508447.1
ENST00000283109.3
RIOK2
RIO kinase 2
chrX_+_149861836 6.50 ENST00000542156.1
ENST00000370390.3
ENST00000490316.2
ENST00000445323.2
ENST00000544228.1
ENST00000451863.2
MTMR1
myotubularin related protein 1
chr17_+_73257945 6.36 ENST00000579002.1
MRPS7
mitochondrial ribosomal protein S7
chr17_-_46178527 6.35 ENST00000393408.3
CBX1
chromobox homolog 1
chr11_-_104905840 6.03 ENST00000526568.1
ENST00000393136.4
ENST00000531166.1
ENST00000534497.1
ENST00000527979.1
ENST00000446369.1
ENST00000353247.5
ENST00000528974.1
ENST00000533400.1
ENST00000525825.1
ENST00000436863.3
CASP1
caspase 1, apoptosis-related cysteine peptidase
chrX_-_102942961 5.98 ENST00000434230.1
ENST00000418819.1
ENST00000360458.1
MORF4L2
mortality factor 4 like 2
chr10_-_12084770 5.37 ENST00000357604.5
UPF2
UPF2 regulator of nonsense transcripts homolog (yeast)
chr5_-_176778803 4.99 ENST00000303127.7
LMAN2
lectin, mannose-binding 2
chr7_-_93520259 4.85 ENST00000222543.5
TFPI2
tissue factor pathway inhibitor 2
chr19_-_11688500 4.82 ENST00000433365.2
ACP5
acid phosphatase 5, tartrate resistant
chr14_-_91526462 4.74 ENST00000536315.2
RPS6KA5
ribosomal protein S6 kinase, 90kDa, polypeptide 5
chr7_-_102985035 4.65 ENST00000426036.2
ENST00000249270.7
ENST00000454277.1
ENST00000412522.1
DNAJC2
DnaJ (Hsp40) homolog, subfamily C, member 2
chr12_+_54378923 4.48 ENST00000303460.4
HOXC10
homeobox C10
chr11_+_74303575 4.40 ENST00000263681.2
POLD3
polymerase (DNA-directed), delta 3, accessory subunit
chr13_-_37633743 4.40 ENST00000497318.1
ENST00000475892.1
ENST00000356185.3
ENST00000350612.6
ENST00000542180.1
ENST00000360252.4
SUPT20H
suppressor of Ty 20 homolog (S. cerevisiae)
chr17_-_5487768 4.31 ENST00000269280.4
ENST00000345221.3
ENST00000262467.5
NLRP1
NLR family, pyrin domain containing 1
chr6_+_2988847 4.18 ENST00000380472.3
ENST00000605901.1
ENST00000454015.1
NQO2
LINC01011
NAD(P)H dehydrogenase, quinone 2
long intergenic non-protein coding RNA 1011
chr7_-_93520191 3.94 ENST00000545378.1
TFPI2
tissue factor pathway inhibitor 2
chr2_+_190722119 3.79 ENST00000452382.1
PMS1
PMS1 postmeiotic segregation increased 1 (S. cerevisiae)
chr7_-_142247606 3.75 ENST00000390361.3
TRBV7-3
T cell receptor beta variable 7-3
chr1_+_46049706 3.64 ENST00000527470.1
ENST00000525515.1
ENST00000537798.1
ENST00000402363.3
ENST00000528238.1
ENST00000350030.3
ENST00000470768.1
ENST00000372052.4
ENST00000351223.3
NASP
nuclear autoantigenic sperm protein (histone-binding)
chr10_+_5454505 3.48 ENST00000355029.4
NET1
neuroepithelial cell transforming 1
chr17_-_27405875 3.35 ENST00000359450.6
TIAF1
TGFB1-induced anti-apoptotic factor 1
chr14_-_50154921 3.30 ENST00000553805.2
ENST00000554396.1
ENST00000216367.5
ENST00000539565.2
POLE2
polymerase (DNA directed), epsilon 2, accessory subunit
chr8_+_1993173 3.20 ENST00000523438.1
MYOM2
myomesin 2
chr11_+_8704748 3.13 ENST00000526562.1
ENST00000525981.1
RPL27A
ribosomal protein L27a
chr2_+_89999259 3.10 ENST00000558026.1
IGKV2D-28
immunoglobulin kappa variable 2D-28
chr8_+_1993152 2.76 ENST00000262113.4
MYOM2
myomesin 2
chr17_-_39677971 2.71 ENST00000393976.2
KRT15
keratin 15
chr1_+_84873913 2.60 ENST00000370662.3
DNASE2B
deoxyribonuclease II beta
chr11_-_62323702 2.44 ENST00000530285.1
AHNAK
AHNAK nucleoprotein
chr20_-_8000426 2.37 ENST00000527925.1
ENST00000246024.2
TMX4
thioredoxin-related transmembrane protein 4
chr3_-_52804872 2.07 ENST00000535191.1
ENST00000461689.1
ENST00000383721.4
ENST00000233027.5
NEK4
NIMA-related kinase 4
chr22_-_42084863 2.05 ENST00000401959.1
ENST00000355257.3
NHP2L1
NHP2 non-histone chromosome protein 2-like 1 (S. cerevisiae)
chr15_+_81475047 1.98 ENST00000559388.1
IL16
interleukin 16
chr1_-_200992827 1.93 ENST00000332129.2
ENST00000422435.2
KIF21B
kinesin family member 21B
chr2_+_11674213 1.78 ENST00000381486.2
GREB1
growth regulation by estrogen in breast cancer 1
chr6_-_11232891 1.69 ENST00000379433.5
ENST00000379446.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr22_-_36236265 1.59 ENST00000414461.2
ENST00000416721.2
ENST00000449924.2
ENST00000262829.7
ENST00000397305.3
RBFOX2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr6_+_26158343 1.44 ENST00000377777.4
ENST00000289316.2
HIST1H2BD
histone cluster 1, H2bd
chrX_-_24690771 1.38 ENST00000379145.1
PCYT1B
phosphate cytidylyltransferase 1, choline, beta
chr17_-_61781750 1.25 ENST00000582026.1
STRADA
STE20-related kinase adaptor alpha
chr20_-_36793663 1.25 ENST00000536701.1
ENST00000536724.1
TGM2
transglutaminase 2
chr4_-_168155417 1.08 ENST00000511269.1
ENST00000506697.1
ENST00000512042.1
SPOCK3
sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3
chr5_-_88178964 1.06 ENST00000513252.1
ENST00000508569.1
ENST00000510942.1
ENST00000506554.1
MEF2C
myocyte enhancer factor 2C
chr5_+_54320078 1.06 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chrX_-_122866874 1.00 ENST00000245838.8
ENST00000355725.4
THOC2
THO complex 2
chr14_-_23877474 0.98 ENST00000405093.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr3_-_151047327 0.95 ENST00000325602.5
P2RY13
purinergic receptor P2Y, G-protein coupled, 13
chr8_+_110098850 0.88 ENST00000518632.1
TRHR
thyrotropin-releasing hormone receptor
chr1_-_157811588 0.81 ENST00000368174.4
CD5L
CD5 molecule-like
chr6_+_36097992 0.80 ENST00000211287.4
MAPK13
mitogen-activated protein kinase 13
chrX_+_101478829 0.74 ENST00000372763.1
ENST00000372758.1
NXF2
nuclear RNA export factor 2
chr15_-_34880646 0.72 ENST00000543376.1
GOLGA8A
golgin A8 family, member A
chr17_+_11501748 0.71 ENST00000262442.4
ENST00000579828.1
DNAH9
dynein, axonemal, heavy chain 9
chr19_+_52264449 0.67 ENST00000599326.1
ENST00000598953.1
FPR2
formyl peptide receptor 2
chrX_+_70338525 0.57 ENST00000374102.1
MED12
mediator complex subunit 12
chr1_+_113010056 0.57 ENST00000369686.5
WNT2B
wingless-type MMTV integration site family, member 2B
chr19_-_46148820 0.48 ENST00000587152.1
EML2
echinoderm microtubule associated protein like 2
chr17_+_46184911 0.48 ENST00000580219.1
ENST00000452859.2
ENST00000393405.2
ENST00000439357.2
ENST00000359238.2
SNX11
sorting nexin 11
chr1_+_200993071 0.38 ENST00000446333.1
ENST00000458003.1
RP11-168O16.1
RP11-168O16.1
chr14_-_23876801 0.33 ENST00000356287.3
MYH6
myosin, heavy chain 6, cardiac muscle, alpha
chr1_-_117210290 0.22 ENST00000369483.1
ENST00000369486.3
IGSF3
immunoglobulin superfamily, member 3
chr5_-_88179017 0.18 ENST00000514028.1
ENST00000514015.1
ENST00000503075.1
ENST00000437473.2
MEF2C
myocyte enhancer factor 2C
chr10_+_180405 0.08 ENST00000439456.1
ENST00000397962.3
ENST00000309776.4
ENST00000381602.4
ZMYND11
zinc finger, MYND-type containing 11

Network of associatons between targets according to the STRING database.

First level regulatory network of ZBTB12

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.3 29.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
5.5 33.0 GO:1903435 positive regulation of constitutive secretory pathway(GO:1903435)
5.0 25.1 GO:0061198 fungiform papilla formation(GO:0061198)
3.9 15.6 GO:0051754 meiotic sister chromatid cohesion, centromeric(GO:0051754)
3.8 15.2 GO:0050717 positive regulation of interleukin-1 alpha secretion(GO:0050717)
2.7 8.0 GO:0019853 L-ascorbic acid biosynthetic process(GO:0019853)
2.6 31.7 GO:0015074 DNA integration(GO:0015074)
2.3 9.0 GO:0042247 morphogenesis of follicular epithelium(GO:0016333) establishment or maintenance of polarity of follicular epithelium(GO:0016334) establishment of planar polarity of follicular epithelium(GO:0042247)
2.2 6.6 GO:2000234 positive regulation of ribosome biogenesis(GO:0090070) positive regulation of rRNA processing(GO:2000234)
2.0 14.0 GO:0033600 negative regulation of mammary gland epithelial cell proliferation(GO:0033600)
1.9 18.8 GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity(GO:0030951)
1.6 4.7 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
1.3 7.5 GO:0032328 alanine transport(GO:0032328)
1.2 62.8 GO:0032731 positive regulation of interleukin-1 beta production(GO:0032731)
1.1 7.6 GO:1904885 beta-catenin destruction complex assembly(GO:1904885)
1.0 16.7 GO:0051639 actin filament network formation(GO:0051639)
1.0 4.8 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.9 4.7 GO:0043988 histone H3-S28 phosphorylation(GO:0043988) histone H2A phosphorylation(GO:1990164)
0.8 14.1 GO:0048311 mitochondrion distribution(GO:0048311)
0.7 6.0 GO:0002074 extraocular skeletal muscle development(GO:0002074)
0.5 8.6 GO:0075522 IRES-dependent viral translational initiation(GO:0075522)
0.4 16.2 GO:0045730 respiratory burst(GO:0045730)
0.4 1.3 GO:0018153 isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine(GO:0018153) isopeptide cross-linking(GO:0018262)
0.4 3.6 GO:0006335 DNA replication-dependent nucleosome assembly(GO:0006335) DNA replication-dependent nucleosome organization(GO:0034723)
0.3 7.7 GO:0006750 glutathione biosynthetic process(GO:0006750)
0.3 6.4 GO:0000028 ribosomal small subunit assembly(GO:0000028)
0.3 3.5 GO:0051451 myoblast migration(GO:0051451)
0.3 26.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)
0.2 7.7 GO:0032201 telomere maintenance via semi-conservative replication(GO:0032201)
0.2 7.7 GO:0071498 cellular response to fluid shear stress(GO:0071498)
0.2 14.6 GO:0050766 positive regulation of phagocytosis(GO:0050766)
0.2 11.7 GO:1903959 regulation of anion transmembrane transport(GO:1903959)
0.2 6.5 GO:0046856 phosphatidylinositol dephosphorylation(GO:0046856)
0.2 5.9 GO:0030488 tRNA methylation(GO:0030488)
0.2 6.0 GO:0043968 histone H2A acetylation(GO:0043968)
0.2 0.6 GO:0060492 foregut regionalization(GO:0060423) lung field specification(GO:0060424) lung induction(GO:0060492)
0.2 23.9 GO:0007062 sister chromatid cohesion(GO:0007062)
0.2 1.0 GO:0046784 viral mRNA export from host cell nucleus(GO:0046784)
0.2 4.5 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.2 1.3 GO:0003228 atrial cardiac muscle tissue development(GO:0003228) atrial cardiac muscle tissue morphogenesis(GO:0055009)
0.2 8.1 GO:0071549 cellular response to dexamethasone stimulus(GO:0071549)
0.2 11.2 GO:0016445 somatic diversification of immunoglobulins(GO:0016445)
0.2 3.8 GO:0006298 mismatch repair(GO:0006298)
0.1 4.2 GO:1904707 positive regulation of vascular smooth muscle cell proliferation(GO:1904707)
0.1 2.1 GO:0001302 replicative cell aging(GO:0001302)
0.1 19.2 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.1 1.4 GO:0006657 CDP-choline pathway(GO:0006657)
0.1 0.6 GO:0090245 axis elongation involved in somitogenesis(GO:0090245)
0.1 10.4 GO:0002377 immunoglobulin production(GO:0002377)
0.1 9.2 GO:0048208 vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208)
0.1 2.6 GO:0006309 apoptotic DNA fragmentation(GO:0006309)
0.1 0.7 GO:0032930 positive regulation of superoxide anion generation(GO:0032930)
0.1 2.0 GO:0050930 induction of positive chemotaxis(GO:0050930)
0.1 5.4 GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay(GO:0000184)
0.1 9.7 GO:0090090 negative regulation of canonical Wnt signaling pathway(GO:0090090)
0.1 0.9 GO:0035589 G-protein coupled purinergic nucleotide receptor signaling pathway(GO:0035589)
0.1 1.1 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 2.4 GO:1901385 regulation of voltage-gated calcium channel activity(GO:1901385)
0.0 0.7 GO:0016973 poly(A)+ mRNA export from nucleus(GO:0016973)
0.0 0.5 GO:0010968 regulation of microtubule nucleation(GO:0010968)
0.0 2.4 GO:0045454 cell redox homeostasis(GO:0045454)
0.0 3.1 GO:0030449 regulation of complement activation(GO:0030449)
0.0 0.2 GO:0032808 lacrimal gland development(GO:0032808)
0.0 4.4 GO:0007369 gastrulation(GO:0007369)
0.0 2.7 GO:0070268 cornification(GO:0070268)
0.0 0.7 GO:0003341 cilium movement(GO:0003341)
0.0 1.3 GO:0006611 protein export from nucleus(GO:0006611)
0.0 1.4 GO:0006334 nucleosome assembly(GO:0006334)
0.0 3.4 GO:0007249 I-kappaB kinase/NF-kappaB signaling(GO:0007249)
0.0 0.8 GO:0050729 positive regulation of inflammatory response(GO:0050729)
0.0 1.7 GO:0051017 actin filament bundle assembly(GO:0051017) actin filament bundle organization(GO:0061572)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
6.0 23.9 GO:1990423 RZZ complex(GO:1990423)
3.2 19.5 GO:0072558 NLRP1 inflammasome complex(GO:0072558)
2.8 33.0 GO:0033093 Weibel-Palade body(GO:0033093)
2.2 17.7 GO:1990111 spermatoproteasome complex(GO:1990111)
1.8 9.0 GO:0042643 actomyosin, actin portion(GO:0042643)
1.4 9.7 GO:0016272 prefoldin complex(GO:0016272)
1.3 15.6 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)
1.3 6.3 GO:0001940 male pronucleus(GO:0001940)
1.1 4.4 GO:0043625 delta DNA polymerase complex(GO:0043625)
1.0 25.1 GO:0016580 Sin3 complex(GO:0016580)
0.9 8.5 GO:0019774 proteasome core complex, beta-subunit complex(GO:0019774)
0.8 16.7 GO:0001891 phagocytic cup(GO:0001891)
0.8 6.6 GO:0030688 preribosome, small subunit precursor(GO:0030688)
0.7 8.1 GO:0033391 chromatoid body(GO:0033391)
0.7 3.3 GO:0008622 epsilon DNA polymerase complex(GO:0008622)
0.6 7.6 GO:0005847 mRNA cleavage and polyadenylation specificity factor complex(GO:0005847)
0.6 18.8 GO:0035371 microtubule plus-end(GO:0035371)
0.5 11.2 GO:0000974 Prp19 complex(GO:0000974)
0.5 4.5 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.5 11.7 GO:0046930 pore complex(GO:0046930)
0.5 3.8 GO:0032389 MutLalpha complex(GO:0032389)
0.3 4.4 GO:0000124 SAGA complex(GO:0000124)
0.3 7.3 GO:0032982 myosin filament(GO:0032982)
0.3 29.2 GO:0035578 azurophil granule lumen(GO:0035578)
0.3 23.8 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)
0.2 6.4 GO:0005763 organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763)
0.2 6.0 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267) H4/H2A histone acetyltransferase complex(GO:0043189) H4 histone acetyltransferase complex(GO:1902562)
0.2 5.4 GO:0035145 exon-exon junction complex(GO:0035145)
0.1 0.7 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.1 31.7 GO:0000793 condensed chromosome(GO:0000793)
0.1 1.0 GO:0000445 THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445)
0.1 27.2 GO:0005741 mitochondrial outer membrane(GO:0005741)
0.1 51.1 GO:0016607 nuclear speck(GO:0016607)
0.1 11.4 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.1 16.2 GO:0031225 anchored component of membrane(GO:0031225)
0.1 2.4 GO:0043034 costamere(GO:0043034)
0.1 7.5 GO:0005903 brush border(GO:0005903)
0.0 1.9 GO:0005871 kinesin complex(GO:0005871)
0.0 2.7 GO:0005882 intermediate filament(GO:0005882)
0.0 9.4 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 0.6 GO:0016592 mediator complex(GO:0016592)
0.0 0.7 GO:0030286 dynein complex(GO:0030286)
0.0 8.2 GO:0005925 focal adhesion(GO:0005925)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
2.1 8.5 GO:0004809 tRNA (guanine-N2-)-methyltransferase activity(GO:0004809)
1.9 18.8 GO:0019237 centromeric DNA binding(GO:0019237)
1.8 25.1 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041)
1.4 8.6 GO:1990829 C-rich single-stranded DNA binding(GO:1990829)
1.3 11.7 GO:0015288 porin activity(GO:0015288)
1.3 33.0 GO:0031489 myosin V binding(GO:0031489)
1.1 15.2 GO:0050700 CARD domain binding(GO:0050700)
1.0 4.2 GO:1904408 dihydronicotinamide riboside quinone reductase activity(GO:0001512) melatonin binding(GO:1904408)
1.0 8.1 GO:0000340 RNA 7-methylguanosine cap binding(GO:0000340)
0.9 8.0 GO:0004032 alditol:NADP+ 1-oxidoreductase activity(GO:0004032)
0.9 26.1 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.9 2.6 GO:0004531 deoxyribonuclease II activity(GO:0004531)
0.8 4.7 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.7 14.6 GO:0005537 mannose binding(GO:0005537)
0.7 6.3 GO:1990226 histone methyltransferase binding(GO:1990226)
0.5 7.7 GO:0016594 glycine binding(GO:0016594)
0.5 29.2 GO:0015485 cholesterol binding(GO:0015485)
0.5 6.5 GO:0052629 phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity(GO:0052629)
0.4 4.8 GO:0008199 ferric iron binding(GO:0008199)
0.4 8.4 GO:0097493 structural molecule activity conferring elasticity(GO:0097493)
0.3 48.8 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.3 1.4 GO:0004105 choline-phosphate cytidylyltransferase activity(GO:0004105)
0.3 45.7 GO:0047485 protein N-terminus binding(GO:0047485)
0.3 7.7 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.2 3.8 GO:0030983 mismatched DNA binding(GO:0030983)
0.2 1.3 GO:0017018 myosin phosphatase activity(GO:0017018)
0.2 3.5 GO:0017049 GTP-Rho binding(GO:0017049)
0.2 0.7 GO:0005124 scavenger receptor binding(GO:0005124)
0.2 1.3 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.1 25.6 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 2.4 GO:0003756 protein disulfide isomerase activity(GO:0003756) intramolecular oxidoreductase activity, transposing S-S bonds(GO:0016864)
0.1 25.7 GO:0051015 actin filament binding(GO:0051015)
0.1 5.4 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 8.8 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.1 2.0 GO:0042609 CD4 receptor binding(GO:0042609)
0.1 7.5 GO:0015171 amino acid transmembrane transporter activity(GO:0015171)
0.1 3.6 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 31.1 GO:0004674 protein serine/threonine kinase activity(GO:0004674)
0.1 4.3 GO:0097110 scaffold protein binding(GO:0097110)
0.0 0.9 GO:0001608 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 1.1 GO:0008191 metalloendopeptidase inhibitor activity(GO:0008191)
0.0 0.7 GO:0008569 ATP-dependent microtubule motor activity, minus-end-directed(GO:0008569)
0.0 0.6 GO:0042809 vitamin D receptor binding(GO:0042809)
0.0 5.0 GO:0051082 unfolded protein binding(GO:0051082)
0.0 1.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 9.8 GO:0003924 GTPase activity(GO:0003924)
0.0 0.6 GO:0005109 frizzled binding(GO:0005109)
0.0 3.1 GO:0003823 antigen binding(GO:0003823)
0.0 0.8 GO:0005044 scavenger receptor activity(GO:0005044)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 18.6 PID RANBP2 PATHWAY Sumoylation by RanBP2 regulates transcriptional repression
0.6 15.8 PID ANTHRAX PATHWAY Cellular roles of Anthrax toxin
0.3 18.8 PID AURORA B PATHWAY Aurora B signaling
0.3 7.6 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.3 15.6 PID PLK1 PATHWAY PLK1 signaling events
0.2 4.7 PID LPA4 PATHWAY LPA4-mediated signaling events
0.2 8.1 ST ERK1 ERK2 MAPK PATHWAY ERK1/ERK2 MAPK Pathway
0.2 15.8 PID ERA GENOMIC PATHWAY Validated nuclear estrogen receptor alpha network
0.1 6.6 PID HEDGEHOG GLI PATHWAY Hedgehog signaling events mediated by Gli proteins
0.1 0.8 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.1 9.7 PID P73PATHWAY p73 transcription factor network
0.0 3.5 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.3 PID INTEGRIN A9B1 PATHWAY Alpha9 beta1 integrin signaling events
0.0 1.1 NABA PROTEOGLYCANS Genes encoding proteoglycans
0.0 1.3 PID LKB1 PATHWAY LKB1 signaling events
0.0 0.7 PID UPA UPAR PATHWAY Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
3.5 31.7 REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION Genes involved in APOBEC3G mediated resistance to HIV-1 infection
1.3 33.0 REACTOME INSULIN SYNTHESIS AND PROCESSING Genes involved in Insulin Synthesis and Processing
0.8 15.2 REACTOME THE NLRP3 INFLAMMASOME Genes involved in The NLRP3 inflammasome
0.8 7.6 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.8 18.8 REACTOME KINESINS Genes involved in Kinesins
0.6 18.6 REACTOME G0 AND EARLY G1 Genes involved in G0 and Early G1
0.5 15.6 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.5 7.7 REACTOME REPAIR SYNTHESIS FOR GAP FILLING BY DNA POL IN TC NER Genes involved in Repair synthesis for gap-filling by DNA polymerase in TC-NER
0.4 8.1 REACTOME MTORC1 MEDIATED SIGNALLING Genes involved in mTORC1-mediated signalling
0.4 26.1 REACTOME AUTODEGRADATION OF CDH1 BY CDH1 APC C Genes involved in Autodegradation of Cdh1 by Cdh1:APC/C
0.4 4.3 REACTOME INFLAMMASOMES Genes involved in Inflammasomes
0.3 7.5 REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Glutamate Neurotransmitter Release Cycle
0.2 9.7 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.2 20.2 REACTOME MITOTIC PROMETAPHASE Genes involved in Mitotic Prometaphase
0.2 7.7 REACTOME GLUTATHIONE CONJUGATION Genes involved in Glutathione conjugation
0.2 8.6 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 6.5 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 24.6 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex
0.1 4.7 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.1 6.6 REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION Genes involved in NOTCH1 Intracellular Domain Regulates Transcription
0.1 4.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 9.0 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 3.5 REACTOME NRAGE SIGNALS DEATH THROUGH JNK Genes involved in NRAGE signals death through JNK
0.1 1.3 REACTOME REGULATION OF AMPK ACTIVITY VIA LKB1 Genes involved in Regulation of AMPK activity via LKB1
0.1 1.4 REACTOME SYNTHESIS OF PC Genes involved in Synthesis of PC
0.1 0.8 REACTOME DSCAM INTERACTIONS Genes involved in DSCAM interactions
0.0 0.9 REACTOME P2Y RECEPTORS Genes involved in P2Y receptors
0.0 1.3 REACTOME STRIATED MUSCLE CONTRACTION Genes involved in Striated Muscle Contraction
0.0 0.7 REACTOME MRNA SPLICING MINOR PATHWAY Genes involved in mRNA Splicing - Minor Pathway