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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZBTB33_CHD2
Z-value: 5.65
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Transcription factors associated with ZBTB33_CHD2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| CHD2 | hg19_v2_chr15_+_93443419_93443580 | -0.82 | 1.4e-53 | Click! |
| ZBTB33 | hg19_v2_chrX_+_119384607_119384720 | -0.71 | 1.1e-34 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZBTB33_CHD2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 15.0 | 689.5 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 4.1 | 536.3 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 14.2 | 455.0 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 8.8 | 237.4 | GO:0000470 | maturation of LSU-rRNA(GO:0000470) |
| 13.3 | 213.2 | GO:0090129 | positive regulation of synapse maturation(GO:0090129) |
| 23.9 | 191.3 | GO:1902255 | positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator(GO:1902255) |
| 36.7 | 183.6 | GO:0014835 | myoblast differentiation involved in skeletal muscle regeneration(GO:0014835) |
| 1.8 | 174.9 | GO:0006890 | retrograde vesicle-mediated transport, Golgi to ER(GO:0006890) |
| 5.5 | 171.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 16.9 | 169.1 | GO:1901409 | positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 7.7 | 781.6 | GO:0015935 | small ribosomal subunit(GO:0015935) |
| 21.2 | 381.4 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 3.5 | 379.9 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.8 | 311.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.7 | 266.9 | GO:0010008 | endosome membrane(GO:0010008) |
| 26.5 | 265.5 | GO:0000796 | condensin complex(GO:0000796) |
| 14.2 | 255.3 | GO:0034709 | methylosome(GO:0034709) |
| 2.8 | 239.8 | GO:0005840 | ribosome(GO:0005840) |
| 1.4 | 235.8 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 6.3 | 234.6 | GO:0016592 | mediator complex(GO:0016592) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.7 | 766.9 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 3.3 | 666.4 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.5 | 651.3 | GO:0003723 | RNA binding(GO:0003723) |
| 15.4 | 416.1 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
| 35.5 | 213.2 | GO:0010997 | anaphase-promoting complex binding(GO:0010997) |
| 1.8 | 197.1 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 19.6 | 195.6 | GO:0055104 | ligase inhibitor activity(GO:0055104) ubiquitin ligase inhibitor activity(GO:1990948) |
| 23.4 | 187.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 16.0 | 175.7 | GO:0051525 | NFAT protein binding(GO:0051525) |
| 5.0 | 169.1 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.0 | 671.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 4.9 | 317.3 | PID AURORA B PATHWAY | Aurora B signaling |
| 4.0 | 239.9 | PID PLK1 PATHWAY | PLK1 signaling events |
| 2.1 | 220.2 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 5.1 | 167.2 | PID NFKAPPAB ATYPICAL PATHWAY | Atypical NF-kappaB pathway |
| 2.9 | 145.5 | PID ATR PATHWAY | ATR signaling pathway |
| 2.0 | 108.1 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 1.9 | 95.0 | PID FOXM1 PATHWAY | FOXM1 transcription factor network |
| 3.1 | 91.9 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
| 1.1 | 89.0 | PID E2F PATHWAY | E2F transcription factor network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 18.7 | 692.8 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 7.1 | 537.6 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 4.6 | 480.4 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 18.4 | 424.3 | REACTOME FORMATION OF ATP BY CHEMIOSMOTIC COUPLING | Genes involved in Formation of ATP by chemiosmotic coupling |
| 10.8 | 303.1 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |
| 3.3 | 274.5 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.3 | 253.9 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 4.5 | 245.2 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 4.1 | 190.5 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 10.2 | 183.6 | REACTOME DSCAM INTERACTIONS | Genes involved in DSCAM interactions |