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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZFX
Z-value: 3.02
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Transcription factors associated with ZFX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZFX | hg19_v2_chrX_+_24167828_24167907 | -0.71 | 4.0e-34 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZFX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 215.4 | GO:1904667 | negative regulation of ubiquitin protein ligase activity(GO:1904667) |
| 4.4 | 192.4 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 3.3 | 117.1 | GO:0050855 | regulation of B cell receptor signaling pathway(GO:0050855) |
| 2.5 | 105.7 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
| 1.7 | 77.4 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 3.0 | 71.2 | GO:0045899 | positive regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045899) |
| 0.3 | 70.2 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.3 | 69.4 | GO:0001844 | protein insertion into mitochondrial membrane involved in apoptotic signaling pathway(GO:0001844) |
| 1.6 | 69.3 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 1.3 | 66.3 | GO:0006369 | termination of RNA polymerase II transcription(GO:0006369) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 229.6 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 9.9 | 119.0 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 6.2 | 112.3 | GO:0034709 | methylosome(GO:0034709) |
| 3.7 | 111.1 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.7 | 102.2 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 1.8 | 99.7 | GO:0009295 | nucleoid(GO:0009295) mitochondrial nucleoid(GO:0042645) |
| 5.2 | 98.2 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.3 | 96.4 | GO:0019866 | organelle inner membrane(GO:0019866) |
| 0.8 | 88.0 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 6.9 | 82.9 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 472.6 | GO:0003723 | RNA binding(GO:0003723) |
| 4.3 | 199.6 | GO:0061650 | ubiquitin conjugating enzyme activity(GO:0061631) ubiquitin-like protein conjugating enzyme activity(GO:0061650) |
| 0.5 | 175.1 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.5 | 169.1 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.8 | 168.9 | GO:0003729 | mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822) |
| 4.5 | 134.6 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 1.5 | 111.1 | GO:0019003 | GDP binding(GO:0019003) |
| 0.5 | 96.0 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.6 | 92.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.7 | 78.1 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 197.4 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 1.9 | 167.6 | PID P53 REGULATION PATHWAY | p53 pathway |
| 3.0 | 156.7 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.7 | 139.5 | PID ATF2 PATHWAY | ATF-2 transcription factor network |
| 1.2 | 118.7 | PID AR PATHWAY | Coregulation of Androgen receptor activity |
| 1.1 | 83.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.9 | 64.6 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.7 | 57.2 | PID PTP1B PATHWAY | Signaling events mediated by PTP1B |
| 0.9 | 55.6 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 2.1 | 54.0 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.5 | 271.2 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 1.3 | 194.5 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 1.7 | 191.3 | REACTOME RESPIRATORY ELECTRON TRANSPORT ATP SYNTHESIS BY CHEMIOSMOTIC COUPLING AND HEAT PRODUCTION BY UNCOUPLING PROTEINS | Genes involved in Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. |
| 1.5 | 183.8 | REACTOME INFLUENZA LIFE CYCLE | Genes involved in Influenza Life Cycle |
| 1.7 | 133.1 | REACTOME ACTIVATION OF THE MRNA UPON BINDING OF THE CAP BINDING COMPLEX AND EIFS AND SUBSEQUENT BINDING TO 43S | Genes involved in Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S |
| 3.1 | 116.4 | REACTOME OXYGEN DEPENDENT PROLINE HYDROXYLATION OF HYPOXIA INDUCIBLE FACTOR ALPHA | Genes involved in Oxygen-dependent Proline Hydroxylation of Hypoxia-inducible Factor Alpha |
| 2.8 | 96.9 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 1.8 | 96.4 | REACTOME METABOLISM OF NON CODING RNA | Genes involved in Metabolism of non-coding RNA |
| 1.1 | 91.2 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 3.3 | 86.3 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |