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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF143
Z-value: 4.86
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Transcription factors associated with ZNF143
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF143 | hg19_v2_chr11_+_9482551_9482604 | 0.68 | 4.4e-31 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF143
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 572.2 | GO:0008380 | RNA splicing(GO:0008380) |
| 39.0 | 234.0 | GO:0030423 | targeting of mRNA for destruction involved in RNA interference(GO:0030423) siRNA loading onto RISC involved in RNA interference(GO:0035087) |
| 78.0 | 233.9 | GO:0030474 | spindle pole body duplication(GO:0030474) spindle pole body organization(GO:0051300) spindle pole body localization(GO:0070631) establishment of spindle pole body localization(GO:0070632) spindle pole body localization to nuclear envelope(GO:0071789) establishment of spindle pole body localization to nuclear envelope(GO:0071790) |
| 4.3 | 198.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 1.0 | 198.2 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 16.5 | 197.9 | GO:0000463 | maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)(GO:0000463) |
| 2.1 | 195.0 | GO:0002181 | cytoplasmic translation(GO:0002181) |
| 2.6 | 189.6 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 15.7 | 188.0 | GO:0018206 | peptidyl-methionine modification(GO:0018206) |
| 26.2 | 183.6 | GO:0043985 | histone H4-R3 methylation(GO:0043985) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 16.5 | 297.5 | GO:0034709 | methylosome(GO:0034709) |
| 2.8 | 296.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 1.4 | 246.7 | GO:0005681 | spliceosomal complex(GO:0005681) |
| 3.7 | 236.8 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 78.0 | 233.9 | GO:0070762 | nuclear pore transmembrane ring(GO:0070762) |
| 27.4 | 219.5 | GO:0032133 | chromosome passenger complex(GO:0032133) |
| 2.8 | 206.4 | GO:0043657 | host(GO:0018995) host cell(GO:0043657) |
| 21.9 | 197.4 | GO:0035068 | micro-ribonucleoprotein complex(GO:0035068) |
| 1.5 | 187.4 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.1 | 181.1 | GO:0070062 | extracellular exosome(GO:0070062) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 634.9 | GO:0003723 | RNA binding(GO:0003723) |
| 2.1 | 436.8 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 6.0 | 287.9 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 9.5 | 274.7 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 21.9 | 197.4 | GO:0070883 | pre-miRNA binding(GO:0070883) |
| 6.0 | 185.2 | GO:0008574 | ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574) |
| 8.4 | 184.1 | GO:0000339 | RNA cap binding(GO:0000339) |
| 30.6 | 183.6 | GO:0044020 | histone methyltransferase activity (H4-R3 specific)(GO:0044020) |
| 1.2 | 171.6 | GO:0047485 | protein N-terminus binding(GO:0047485) |
| 2.1 | 169.4 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.2 | 335.8 | PID AURORA B PATHWAY | Aurora B signaling |
| 1.7 | 176.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 3.7 | 166.9 | PID HIF1A PATHWAY | Hypoxic and oxygen homeostasis regulation of HIF-1-alpha |
| 3.0 | 135.5 | PID MYC PATHWAY | C-MYC pathway |
| 3.6 | 106.7 | SA FAS SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.5 | 95.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.4 | 95.3 | PID P53 REGULATION PATHWAY | p53 pathway |
| 1.6 | 72.3 | PID BARD1 PATHWAY | BARD1 signaling events |
| 1.1 | 62.0 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 2.1 | 59.2 | PID DNA PK PATHWAY | DNA-PK pathway in nonhomologous end joining |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.9 | 548.3 | REACTOME 3 UTR MEDIATED TRANSLATIONAL REGULATION | Genes involved in 3' -UTR-mediated translational regulation |
| 3.8 | 309.2 | REACTOME VIF MEDIATED DEGRADATION OF APOBEC3G | Genes involved in Vif-mediated degradation of APOBEC3G |
| 2.3 | 242.2 | REACTOME APOPTOTIC EXECUTION PHASE | Genes involved in Apoptotic execution phase |
| 4.9 | 201.2 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 2.3 | 198.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 6.0 | 173.2 | REACTOME MICRORNA MIRNA BIOGENESIS | Genes involved in MicroRNA (miRNA) Biogenesis |
| 9.1 | 172.2 | REACTOME PROCESSIVE SYNTHESIS ON THE LAGGING STRAND | Genes involved in Processive synthesis on the lagging strand |
| 4.0 | 163.0 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 2.6 | 160.9 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 5.2 | 151.8 | REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS | Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components |