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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)
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Results for ZNF263
Z-value: 1.66
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Transcription factors associated with ZNF263
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ZNF263 | hg19_v2_chr16_+_3313791_3313834 | -0.16 | 1.8e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ZNF263
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 39.9 | GO:0034465 | response to carbon monoxide(GO:0034465) |
| 2.9 | 34.6 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 4.3 | 34.1 | GO:0097116 | gephyrin clustering involved in postsynaptic density assembly(GO:0097116) |
| 4.5 | 27.2 | GO:0036166 | phenotypic switching(GO:0036166) regulation of phenotypic switching(GO:1900239) |
| 3.8 | 26.9 | GO:2000124 | regulation of endocannabinoid signaling pathway(GO:2000124) |
| 8.7 | 26.0 | GO:0050720 | regulation of interleukin-1 biosynthetic process(GO:0045360) positive regulation of interleukin-1 biosynthetic process(GO:0045362) interleukin-1 beta biosynthetic process(GO:0050720) response to interleukin-8(GO:0098758) cellular response to interleukin-8(GO:0098759) regulation of progesterone biosynthetic process(GO:2000182) |
| 0.2 | 22.2 | GO:0030516 | regulation of axon extension(GO:0030516) |
| 0.2 | 20.2 | GO:0007626 | locomotory behavior(GO:0007626) |
| 0.2 | 19.7 | GO:0042795 | snRNA transcription(GO:0009301) snRNA transcription from RNA polymerase II promoter(GO:0042795) |
| 0.8 | 19.3 | GO:0022010 | central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 61.9 | GO:0031226 | intrinsic component of plasma membrane(GO:0031226) |
| 0.0 | 52.8 | GO:0005615 | extracellular space(GO:0005615) |
| 0.5 | 46.4 | GO:0005901 | caveola(GO:0005901) |
| 0.4 | 38.0 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.1 | 36.6 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 34.9 | GO:0043204 | perikaryon(GO:0043204) |
| 2.5 | 34.6 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.6 | 25.7 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
| 0.3 | 24.9 | GO:0016459 | myosin complex(GO:0016459) |
| 0.3 | 22.0 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 72.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 47.7 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 5.7 | 39.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 2.1 | 34.1 | GO:0097109 | neuroligin family protein binding(GO:0097109) |
| 0.1 | 30.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.3 | 27.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 27.1 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 2.1 | 26.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 5.2 | 26.0 | GO:0044729 | hemi-methylated DNA-binding(GO:0044729) |
| 0.2 | 25.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 69.6 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.2 | 52.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 35.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.6 | 33.7 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 30.6 | NABA SECRETED FACTORS | Genes encoding secreted soluble factors |
| 0.8 | 27.8 | PID PRL SIGNALING EVENTS PATHWAY | Signaling events mediated by PRL |
| 0.6 | 26.3 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.3 | 26.2 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.2 | 25.5 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.4 | 14.6 | PID LIS1 PATHWAY | Lissencephaly gene (LIS1) in neuronal migration and development |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 69.0 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 1.7 | 46.8 | REACTOME CRMPS IN SEMA3A SIGNALING | Genes involved in CRMPs in Sema3A signaling |
| 1.4 | 36.9 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.9 | 26.9 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.6 | 24.8 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 0.5 | 24.7 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.1 | 22.7 | REACTOME G ALPHA I SIGNALLING EVENTS | Genes involved in G alpha (i) signalling events |
| 0.4 | 18.1 | REACTOME LIPID DIGESTION MOBILIZATION AND TRANSPORT | Genes involved in Lipid digestion, mobilization, and transport |
| 1.3 | 17.9 | REACTOME ROLE OF DCC IN REGULATING APOPTOSIS | Genes involved in Role of DCC in regulating apoptosis |
| 1.1 | 16.9 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |