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averaged GNF SymAtlas + NCI-60 cancer cell lines, human (Su, 2004; Ross, 2000)

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Results for ZNF423

Z-value: 0.79

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Transcription factors associated with ZNF423

Gene Symbol Gene ID Gene Info
ZNF423
ENSG00000102935.7 zinc finger protein 423

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ZNF423hg19_v2_chr16_-_49890016_49890046-0.366.3e-08Click!

Activity profile of ZNF423 motif

Sorted Z-values of ZNF423 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_+_135385202 17.08 ENST00000514554.1
TGFBI
transforming growth factor, beta-induced, 68kDa
chrX_+_49028265 13.75 ENST00000376322.3
ENST00000376327.5
PLP2
proteolipid protein 2 (colonic epithelium-enriched)
chr10_+_124914285 12.57 ENST00000407911.2
BUB3
BUB3 mitotic checkpoint protein
chr3_-_195808980 11.41 ENST00000360110.4
TFRC
transferrin receptor
chr3_-_195808952 11.38 ENST00000540528.1
ENST00000392396.3
ENST00000535031.1
ENST00000420415.1
TFRC
transferrin receptor
chr3_-_69129501 11.34 ENST00000540295.1
ENST00000415609.2
ENST00000361055.4
ENST00000349511.4
UBA3
ubiquitin-like modifier activating enzyme 3
chr10_-_121296045 10.88 ENST00000392865.1
RGS10
regulator of G-protein signaling 10
chr11_-_64013663 10.15 ENST00000392210.2
PPP1R14B
protein phosphatase 1, regulatory (inhibitor) subunit 14B
chr9_+_112542591 9.21 ENST00000483909.1
ENST00000314527.4
ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
PALM2
PALM2-AKAP2
AKAP2
paralemmin 2
PALM2-AKAP2 readthrough
A kinase (PRKA) anchor protein 2
chr1_+_10459111 9.00 ENST00000541529.1
ENST00000270776.8
ENST00000483936.1
ENST00000538557.1
PGD
phosphogluconate dehydrogenase
chr10_+_124913930 8.71 ENST00000368858.5
BUB3
BUB3 mitotic checkpoint protein
chr9_+_112542572 8.44 ENST00000374530.3
PALM2-AKAP2
PALM2-AKAP2 readthrough
chr16_-_11681316 8.40 ENST00000571688.1
LITAF
lipopolysaccharide-induced TNF factor
chr15_-_59225758 8.21 ENST00000558486.1
ENST00000560682.1
ENST00000249736.7
ENST00000559880.1
ENST00000536328.1
SLTM
SAFB-like, transcription modulator
chr16_-_11681023 8.16 ENST00000570904.1
ENST00000574701.1
LITAF
lipopolysaccharide-induced TNF factor
chr17_-_73178599 7.11 ENST00000578238.1
SUMO2
small ubiquitin-like modifier 2
chr3_+_180630444 6.95 ENST00000491062.1
ENST00000468861.1
ENST00000445140.2
ENST00000484958.1
FXR1
fragile X mental retardation, autosomal homolog 1
chr2_+_171785012 6.85 ENST00000234160.4
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr2_+_46769798 6.62 ENST00000238738.4
RHOQ
ras homolog family member Q
chr10_+_17271266 6.58 ENST00000224237.5
VIM
vimentin
chr3_+_180630090 5.84 ENST00000357559.4
ENST00000305586.7
FXR1
fragile X mental retardation, autosomal homolog 1
chr10_+_124913793 5.77 ENST00000368865.4
ENST00000538238.1
ENST00000368859.2
BUB3
BUB3 mitotic checkpoint protein
chr19_+_14544099 5.67 ENST00000242783.6
ENST00000586557.1
ENST00000590097.1
PKN1
protein kinase N1
chr5_-_172756506 5.56 ENST00000265087.4
STC2
stanniocalcin 2
chr21_-_18985230 5.15 ENST00000457956.1
ENST00000348354.6
BTG3
BTG family, member 3
chr17_-_73179046 4.99 ENST00000314523.7
ENST00000420826.2
SUMO2
small ubiquitin-like modifier 2
chr8_-_103668114 4.81 ENST00000285407.6
KLF10
Kruppel-like factor 10
chr19_-_10450328 4.67 ENST00000160262.5
ICAM3
intercellular adhesion molecule 3
chr17_+_6347729 4.67 ENST00000572447.1
FAM64A
family with sequence similarity 64, member A
chr21_-_18985158 4.55 ENST00000339775.6
BTG3
BTG family, member 3
chr11_-_61658853 4.54 ENST00000525588.1
ENST00000540820.1
FADS3
fatty acid desaturase 3
chr17_+_6347761 4.51 ENST00000250056.8
ENST00000571373.1
ENST00000570337.2
ENST00000572595.2
ENST00000576056.1
FAM64A
family with sequence similarity 64, member A
chr2_+_171785824 4.36 ENST00000452526.2
GORASP2
golgi reassembly stacking protein 2, 55kDa
chr19_+_41770236 4.11 ENST00000392006.3
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr15_-_59225844 4.05 ENST00000380516.2
SLTM
SAFB-like, transcription modulator
chr19_+_41770349 3.74 ENST00000602130.1
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr22_+_35653445 3.65 ENST00000420166.1
ENST00000444518.2
ENST00000455359.1
ENST00000216106.5
HMGXB4
HMG box domain containing 4
chr1_+_155278625 3.63 ENST00000368356.4
ENST00000356657.6
FDPS
farnesyl diphosphate synthase
chr19_-_10450287 3.61 ENST00000589261.1
ENST00000590569.1
ENST00000589580.1
ENST00000589249.1
ICAM3
intercellular adhesion molecule 3
chr11_-_67120974 3.59 ENST00000539074.1
ENST00000312419.3
POLD4
polymerase (DNA-directed), delta 4, accessory subunit
chr20_+_43514320 3.43 ENST00000372839.3
ENST00000428262.1
ENST00000445830.1
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr4_+_74735102 3.42 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr1_-_35658736 3.32 ENST00000357214.5
SFPQ
splicing factor proline/glutamine-rich
chr19_-_11689752 3.24 ENST00000592659.1
ENST00000592828.1
ENST00000218758.5
ENST00000412435.2
ACP5
acid phosphatase 5, tartrate resistant
chr8_+_30241934 3.09 ENST00000538486.1
RBPMS
RNA binding protein with multiple splicing
chr11_-_61659006 3.04 ENST00000278829.2
FADS3
fatty acid desaturase 3
chr20_+_43514315 2.97 ENST00000353703.4
YWHAB
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
chr7_-_5570229 2.63 ENST00000331789.5
ACTB
actin, beta
chr12_-_57522813 2.61 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr15_+_41523335 2.48 ENST00000334660.5
CHP1
calcineurin-like EF-hand protein 1
chr8_+_22022800 2.34 ENST00000397814.3
BMP1
bone morphogenetic protein 1
chr12_-_125348329 2.26 ENST00000546215.1
ENST00000415380.2
ENST00000261693.6
ENST00000376788.1
ENST00000545493.1
SCARB1
scavenger receptor class B, member 1
chr15_-_66649010 2.22 ENST00000367709.4
ENST00000261881.4
TIPIN
TIMELESS interacting protein
chr10_-_75255668 1.98 ENST00000545874.1
PPP3CB
protein phosphatase 3, catalytic subunit, beta isozyme
chr19_+_41770269 1.91 ENST00000378215.4
HNRNPUL1
heterogeneous nuclear ribonucleoprotein U-like 1
chr12_-_125348448 1.91 ENST00000339570.5
SCARB1
scavenger receptor class B, member 1
chr11_-_44972418 1.88 ENST00000525680.1
ENST00000528290.1
ENST00000530035.1
TP53I11
tumor protein p53 inducible protein 11
chrX_-_48827976 1.85 ENST00000218176.3
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr1_+_26644441 1.64 ENST00000374213.2
CD52
CD52 molecule
chr6_+_33589161 1.63 ENST00000605930.1
ITPR3
inositol 1,4,5-trisphosphate receptor, type 3
chr7_+_101460882 1.60 ENST00000292535.7
ENST00000549414.2
ENST00000550008.2
ENST00000546411.2
ENST00000556210.1
CUX1
cut-like homeobox 1
chr7_-_30029367 1.51 ENST00000242059.5
SCRN1
secernin 1
chr12_-_118810688 1.44 ENST00000542532.1
ENST00000392533.3
TAOK3
TAO kinase 3
chr17_+_28705921 1.37 ENST00000225719.4
CPD
carboxypeptidase D
chr16_+_27325202 1.36 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R
interleukin 4 receptor
chr7_-_150754935 1.34 ENST00000297518.4
CDK5
cyclin-dependent kinase 5
chr15_+_100106244 1.34 ENST00000557942.1
MEF2A
myocyte enhancer factor 2A
chr8_+_22022653 1.33 ENST00000354870.5
ENST00000397816.3
ENST00000306349.8
BMP1
bone morphogenetic protein 1
chr9_-_35619539 1.24 ENST00000396757.1
CD72
CD72 molecule
chr6_-_32160622 1.12 ENST00000487761.1
ENST00000375040.3
GPSM3
G-protein signaling modulator 3
chr1_-_165414414 1.11 ENST00000359842.5
RXRG
retinoid X receptor, gamma
chr8_+_30241995 1.06 ENST00000397323.4
ENST00000339877.4
ENST00000320203.4
ENST00000287771.5
RBPMS
RNA binding protein with multiple splicing
chr12_+_52643077 1.04 ENST00000553310.2
ENST00000544024.1
KRT86
keratin 86
chr10_-_118032979 1.03 ENST00000355422.6
GFRA1
GDNF family receptor alpha 1
chr8_+_22022223 0.98 ENST00000306385.5
BMP1
bone morphogenetic protein 1
chr19_-_23941639 0.96 ENST00000395385.3
ENST00000531570.1
ENST00000528059.1
ZNF681
zinc finger protein 681
chr22_-_43045574 0.95 ENST00000352397.5
CYB5R3
cytochrome b5 reductase 3
chr6_+_30131318 0.89 ENST00000376688.1
TRIM15
tripartite motif containing 15
chrX_+_152760397 0.88 ENST00000331595.4
ENST00000431891.1
BGN
biglycan
chr19_-_23941680 0.80 ENST00000402377.3
ZNF681
zinc finger protein 681
chr8_-_42234745 0.74 ENST00000220812.2
DKK4
dickkopf WNT signaling pathway inhibitor 4
chr3_+_9958758 0.74 ENST00000383812.4
ENST00000438091.1
ENST00000295981.3
ENST00000436503.1
ENST00000403601.3
ENST00000416074.2
ENST00000455057.1
IL17RC
interleukin 17 receptor C
chr2_-_120980939 0.74 ENST00000426077.2
TMEM185B
transmembrane protein 185B
chr7_-_27219849 0.73 ENST00000396344.4
HOXA10
homeobox A10
chr8_+_22422749 0.70 ENST00000523900.1
SORBS3
sorbin and SH3 domain containing 3
chr9_-_16870704 0.68 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr6_-_35480705 0.65 ENST00000229771.6
TULP1
tubby like protein 1
chr1_-_155177677 0.62 ENST00000368378.3
ENST00000541990.1
ENST00000457183.2
THBS3
thrombospondin 3
chr6_+_30130969 0.55 ENST00000376694.4
TRIM15
tripartite motif containing 15
chr3_+_9958870 0.54 ENST00000413608.1
IL17RC
interleukin 17 receptor C
chr12_+_7037461 0.49 ENST00000396684.2
ATN1
atrophin 1
chr6_-_35480640 0.48 ENST00000428978.1
ENST00000322263.4
TULP1
tubby like protein 1
chr11_+_60691924 0.46 ENST00000544065.1
ENST00000453848.2
ENST00000005286.4
TMEM132A
transmembrane protein 132A
chr15_+_100106155 0.45 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
MEF2A
myocyte enhancer factor 2A
chr10_+_135340859 0.37 ENST00000252945.3
ENST00000421586.1
ENST00000418356.1
CYP2E1
cytochrome P450, family 2, subfamily E, polypeptide 1
chr8_+_22423219 0.37 ENST00000523965.1
ENST00000521554.1
SORBS3
sorbin and SH3 domain containing 3
chr11_-_44972390 0.36 ENST00000395648.3
ENST00000531928.2
TP53I11
tumor protein p53 inducible protein 11
chr11_-_47207950 0.34 ENST00000298838.6
ENST00000531226.1
ENST00000524509.1
ENST00000528201.1
ENST00000530513.1
PACSIN3
protein kinase C and casein kinase substrate in neurons 3
chr20_+_43029911 0.33 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
HNF4A
hepatocyte nuclear factor 4, alpha
chr6_+_42896865 0.33 ENST00000372836.4
ENST00000394142.3
CNPY3
canopy FGF signaling regulator 3
chr11_-_44972476 0.22 ENST00000527685.1
ENST00000308212.5
TP53I11
tumor protein p53 inducible protein 11
chr7_+_20370300 0.18 ENST00000537992.1
ITGB8
integrin, beta 8
chrX_-_1572629 0.13 ENST00000534940.1
ASMTL
acetylserotonin O-methyltransferase-like
chr16_+_3014269 0.08 ENST00000575885.1
ENST00000571007.1
ENST00000319500.6
KREMEN2
kringle containing transmembrane protein 2
chr2_+_62932779 0.08 ENST00000427809.1
ENST00000405482.1
ENST00000431489.1
EHBP1
EH domain binding protein 1
chrX_-_107019181 0.03 ENST00000315660.4
ENST00000372384.2
ENST00000502650.1
ENST00000506724.1
TSC22D3
TSC22 domain family, member 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ZNF423

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.8 11.3 GO:0007113 endomitotic cell cycle(GO:0007113)
3.0 9.0 GO:0009051 pentose-phosphate shunt, oxidative branch(GO:0009051)
1.4 4.2 GO:0015920 lipopolysaccharide transport(GO:0015920)
1.2 22.8 GO:0046852 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.9 5.7 GO:0035407 histone H3-T11 phosphorylation(GO:0035407)
0.7 3.6 GO:0033384 geranyl diphosphate metabolic process(GO:0033383) geranyl diphosphate biosynthetic process(GO:0033384) farnesyl diphosphate biosynthetic process(GO:0045337)
0.7 5.6 GO:2001256 regulation of store-operated calcium entry(GO:2001256)
0.7 27.1 GO:0007094 mitotic spindle assembly checkpoint(GO:0007094) spindle assembly checkpoint(GO:0071173)
0.7 2.6 GO:0002296 T-helper 1 cell lineage commitment(GO:0002296)
0.6 3.2 GO:0032929 negative regulation of superoxide anion generation(GO:0032929)
0.6 10.9 GO:0007213 G-protein coupled acetylcholine receptor signaling pathway(GO:0007213)
0.6 6.6 GO:0060020 Bergmann glial cell differentiation(GO:0060020)
0.6 12.8 GO:0060148 positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637)
0.6 3.3 GO:0045876 positive regulation of sister chromatid cohesion(GO:0045876)
0.5 1.6 GO:0050917 sensory perception of sweet taste(GO:0050916) sensory perception of umami taste(GO:0050917)
0.5 1.4 GO:0007500 mesodermal cell fate determination(GO:0007500) regulation of intracellular transport of viral material(GO:1901252) negative regulation of intracellular transport of viral material(GO:1901253)
0.4 16.6 GO:0042347 negative regulation of NF-kappaB import into nucleus(GO:0042347)
0.4 2.2 GO:0048478 replication fork protection(GO:0048478)
0.3 6.6 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.3 1.8 GO:0055005 ventricular cardiac myofibril assembly(GO:0055005)
0.3 1.4 GO:0045626 negative regulation of T-helper 1 cell differentiation(GO:0045626) response to odorant(GO:1990834)
0.3 2.1 GO:0070885 positive regulation of sodium:proton antiporter activity(GO:0032417) negative regulation of calcineurin-NFAT signaling cascade(GO:0070885)
0.3 4.1 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.2 12.1 GO:0070911 global genome nucleotide-excision repair(GO:0070911)
0.2 1.3 GO:0031914 negative regulation of synaptic plasticity(GO:0031914)
0.2 4.7 GO:0034380 high-density lipoprotein particle assembly(GO:0034380)
0.2 3.6 GO:0006296 nucleotide-excision repair, DNA incision, 5'-to lesion(GO:0006296)
0.2 1.3 GO:0097396 response to interleukin-17(GO:0097396) cellular response to interleukin-17(GO:0097398)
0.1 4.8 GO:0045672 positive regulation of osteoclast differentiation(GO:0045672)
0.1 6.4 GO:0035329 hippo signaling(GO:0035329)
0.1 3.4 GO:0090023 positive regulation of neutrophil chemotaxis(GO:0090023)
0.1 0.7 GO:0051799 negative regulation of hair follicle development(GO:0051799)
0.1 16.8 GO:0002062 chondrocyte differentiation(GO:0002062)
0.1 1.0 GO:0035860 glial cell-derived neurotrophic factor receptor signaling pathway(GO:0035860)
0.1 1.1 GO:0097500 receptor localization to nonmotile primary cilium(GO:0097500) protein localization to photoreceptor outer segment(GO:1903546)
0.1 1.3 GO:0001915 negative regulation of T cell mediated cytotoxicity(GO:0001915)
0.1 7.6 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.1 1.1 GO:1900017 positive regulation of cytokine production involved in inflammatory response(GO:1900017)
0.1 11.2 GO:0007030 Golgi organization(GO:0007030)
0.1 1.4 GO:0007095 mitotic G2 DNA damage checkpoint(GO:0007095)
0.1 0.4 GO:0010193 response to ozone(GO:0010193)
0.1 17.7 GO:0008360 regulation of cell shape(GO:0008360)
0.1 1.3 GO:0003416 endochondral bone growth(GO:0003416)
0.1 12.3 GO:0050684 regulation of mRNA processing(GO:0050684)
0.1 3.6 GO:0008333 endosome to lysosome transport(GO:0008333)
0.1 0.9 GO:0019852 L-ascorbic acid metabolic process(GO:0019852)
0.1 1.6 GO:0000301 retrograde transport, vesicle recycling within Golgi(GO:0000301)
0.1 1.6 GO:0045730 respiratory burst(GO:0045730)
0.0 0.3 GO:0051044 positive regulation of membrane protein ectodomain proteolysis(GO:0051044)
0.0 2.6 GO:0001895 retina homeostasis(GO:0001895)
0.0 0.9 GO:0019800 peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800)
0.0 0.3 GO:2000189 positive regulation of cholesterol homeostasis(GO:2000189)
0.0 6.0 GO:0002223 stimulatory C-type lectin receptor signaling pathway(GO:0002223)
0.0 1.1 GO:1901522 positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522)
0.0 0.7 GO:0060065 uterus development(GO:0060065)
0.0 8.2 GO:0000398 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398)
0.0 13.7 GO:0042330 chemotaxis(GO:0006935) taxis(GO:0042330)
0.0 2.3 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)
0.0 1.9 GO:0061337 cardiac conduction(GO:0061337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
9.0 27.1 GO:1990298 mitotic checkpoint complex(GO:0033597) bub1-bub3 complex(GO:1990298)
2.8 16.6 GO:0098560 cytoplasmic side of late endosome membrane(GO:0098560)
1.8 22.8 GO:1990712 HFE-transferrin receptor complex(GO:1990712)
0.9 3.6 GO:0043625 delta DNA polymerase complex(GO:0043625)
0.5 3.6 GO:0016589 NURF complex(GO:0016589)
0.4 3.3 GO:0042382 paraspeckles(GO:0042382)
0.3 1.3 GO:0016533 cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533)
0.3 12.8 GO:0043034 costamere(GO:0043034)
0.2 2.2 GO:0031298 replication fork protection complex(GO:0031298)
0.2 2.6 GO:0097433 dense body(GO:0097433)
0.1 4.2 GO:0031528 microvillus membrane(GO:0031528)
0.1 1.3 GO:0005955 calcineurin complex(GO:0005955)
0.1 16.8 GO:0005604 basement membrane(GO:0005604)
0.1 6.6 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 4.1 GO:0005685 U1 snRNP(GO:0005685)
0.1 1.6 GO:0031095 platelet dense tubular network membrane(GO:0031095)
0.1 12.1 GO:0016605 PML body(GO:0016605)
0.1 5.7 GO:0097610 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 0.9 GO:0005833 hemoglobin complex(GO:0005833)
0.1 7.6 GO:0005882 intermediate filament(GO:0005882)
0.1 6.4 GO:0017053 transcriptional repressor complex(GO:0017053)
0.1 10.9 GO:0043197 dendritic spine(GO:0043197)
0.0 3.4 GO:1904724 tertiary granule lumen(GO:1904724)
0.0 1.1 GO:0001917 photoreceptor inner segment(GO:0001917)
0.0 4.4 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.0 5.2 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 2.1 GO:0005793 endoplasmic reticulum-Golgi intermediate compartment(GO:0005793)
0.0 2.7 GO:0031225 anchored component of membrane(GO:0031225)
0.0 4.4 GO:0000790 nuclear chromatin(GO:0000790)
0.0 8.9 GO:0016604 nuclear body(GO:0016604)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
7.6 22.8 GO:0015091 ferric iron transmembrane transporter activity(GO:0015091) trivalent inorganic cation transmembrane transporter activity(GO:0072510)
3.0 9.0 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)
2.2 6.6 GO:0032427 GBD domain binding(GO:0032427)
1.4 11.3 GO:0019788 NEDD8 transferase activity(GO:0019788)
1.2 12.8 GO:0002151 G-quadruplex RNA binding(GO:0002151) RNA strand annealing activity(GO:0033592)
1.1 6.6 GO:1990254 keratin filament binding(GO:1990254)
1.0 4.2 GO:0034186 apolipoprotein A-I binding(GO:0034186)
1.0 12.1 GO:0031386 protein tag(GO:0031386)
0.9 5.7 GO:0035402 histone kinase activity (H3-T11 specific)(GO:0035402)
0.9 6.4 GO:0050815 phosphoserine binding(GO:0050815)
0.7 3.6 GO:0004161 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.6 4.1 GO:0035614 snRNA stem-loop binding(GO:0035614)
0.5 1.4 GO:0004913 interleukin-4 receptor activity(GO:0004913)
0.4 1.6 GO:0000822 inositol hexakisphosphate binding(GO:0000822) inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220)
0.4 13.7 GO:0019956 chemokine binding(GO:0019956)
0.4 16.6 GO:0050699 WW domain binding(GO:0050699)
0.4 10.9 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.3 1.1 GO:0004886 9-cis retinoic acid receptor activity(GO:0004886)
0.3 3.2 GO:0008199 ferric iron binding(GO:0008199)
0.2 17.3 GO:0050840 extracellular matrix binding(GO:0050840)
0.2 1.9 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.2 1.3 GO:0099602 acetylcholine receptor regulator activity(GO:0030548) neurotransmitter receptor regulator activity(GO:0099602)
0.2 10.2 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.2 3.4 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.2 2.6 GO:0030957 Tat protein binding(GO:0030957)
0.2 25.5 GO:0043130 ubiquitin binding(GO:0043130)
0.2 1.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.1 1.0 GO:0016167 glial cell-derived neurotrophic factor receptor activity(GO:0016167)
0.1 1.3 GO:0033192 calmodulin-dependent protein phosphatase activity(GO:0033192)
0.1 3.6 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.1 1.4 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.1 0.9 GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H(GO:0004128)
0.1 1.5 GO:0016805 dipeptidase activity(GO:0016805)
0.0 8.3 GO:0005178 integrin binding(GO:0005178)
0.0 1.1 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.0 4.7 GO:0004222 metalloendopeptidase activity(GO:0004222)
0.0 5.8 GO:0042826 histone deacetylase binding(GO:0042826)
0.0 7.7 GO:0001046 core promoter sequence-specific DNA binding(GO:0001046)
0.0 5.6 GO:0005179 hormone activity(GO:0005179)
0.0 2.1 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.3 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.0 0.4 GO:0017166 vinculin binding(GO:0017166)
0.0 0.4 GO:0008392 arachidonic acid monooxygenase activity(GO:0008391) arachidonic acid epoxygenase activity(GO:0008392)
0.0 0.5 GO:0004709 MAP kinase kinase kinase activity(GO:0004709)
0.0 1.1 GO:0005546 phosphatidylinositol-4,5-bisphosphate binding(GO:0005546)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 25.4 PID INTEGRIN2 PATHWAY Beta2 integrin cell surface interactions
0.5 11.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.3 13.0 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.3 23.1 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.3 5.7 PID P38 GAMMA DELTA PATHWAY Signaling mediated by p38-gamma and p38-delta
0.2 28.4 PID P73PATHWAY p73 transcription factor network
0.1 10.2 PID ILK PATHWAY Integrin-linked kinase signaling
0.1 13.4 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 6.6 PID AURORA B PATHWAY Aurora B signaling
0.1 2.6 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.1 3.4 PID IL23 PATHWAY IL23-mediated signaling events
0.1 2.2 PID ATR PATHWAY ATR signaling pathway
0.0 1.3 PID IL12 STAT4 PATHWAY IL12 signaling mediated by STAT4
0.0 1.6 ST MYOCYTE AD PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.
0.0 0.7 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway
0.0 1.1 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.7 PID HDAC CLASSIII PATHWAY Signaling events mediated by HDAC Class III
0.0 1.8 PID P38 ALPHA BETA DOWNSTREAM PATHWAY Signaling mediated by p38-alpha and p38-beta
0.0 0.9 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.0 1.0 PID RET PATHWAY Signaling events regulated by Ret tyrosine kinase
0.0 2.6 WNT SIGNALING Genes related to Wnt-mediated signal transduction
0.0 4.7 NABA ECM REGULATORS Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 27.1 REACTOME INHIBITION OF THE PROTEOLYTIC ACTIVITY OF APC C REQUIRED FOR THE ONSET OF ANAPHASE BY MITOTIC SPINDLE CHECKPOINT COMPONENTS Genes involved in Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components
0.7 22.8 REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING Genes involved in Transferrin endocytosis and recycling
0.5 6.4 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.4 8.8 REACTOME HDL MEDIATED LIPID TRANSPORT Genes involved in HDL-mediated lipid transport
0.3 3.6 REACTOME REMOVAL OF THE FLAP INTERMEDIATE FROM THE C STRAND Genes involved in Removal of the Flap Intermediate from the C-strand
0.2 17.1 REACTOME AMYLOIDS Genes involved in Amyloids
0.2 6.6 REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS Genes involved in Caspase-mediated cleavage of cytoskeletal proteins
0.1 1.6 REACTOME ELEVATION OF CYTOSOLIC CA2 LEVELS Genes involved in Elevation of cytosolic Ca2+ levels
0.1 3.6 REACTOME CHOLESTEROL BIOSYNTHESIS Genes involved in Cholesterol biosynthesis
0.1 8.3 REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
0.1 2.6 REACTOME PREFOLDIN MEDIATED TRANSFER OF SUBSTRATE TO CCT TRIC Genes involved in Prefoldin mediated transfer of substrate to CCT/TriC
0.1 9.8 REACTOME MRNA SPLICING Genes involved in mRNA Splicing
0.1 4.2 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.1 3.4 REACTOME CHEMOKINE RECEPTORS BIND CHEMOKINES Genes involved in Chemokine receptors bind chemokines
0.1 2.7 REACTOME DARPP 32 EVENTS Genes involved in DARPP-32 events
0.1 1.8 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 11.3 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 1.6 REACTOME SIGNALING BY FGFR1 FUSION MUTANTS Genes involved in Signaling by FGFR1 fusion mutants
0.0 0.9 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.0 2.6 REACTOME DOWNSTREAM SIGNAL TRANSDUCTION Genes involved in Downstream signal transduction
0.0 7.6 REACTOME METABOLISM OF CARBOHYDRATES Genes involved in Metabolism of carbohydrates
0.0 1.0 REACTOME NCAM1 INTERACTIONS Genes involved in NCAM1 interactions
0.0 1.2 REACTOME SEMA4D IN SEMAPHORIN SIGNALING Genes involved in Sema4D in semaphorin signaling
0.0 0.3 REACTOME TRAFFICKING AND PROCESSING OF ENDOSOMAL TLR Genes involved in Trafficking and processing of endosomal TLR
0.0 3.2 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 0.4 REACTOME XENOBIOTICS Genes involved in Xenobiotics
0.0 0.6 REACTOME SIGNALING BY PDGF Genes involved in Signaling by PDGF
0.0 0.3 REACTOME REGULATION OF GENE EXPRESSION IN BETA CELLS Genes involved in Regulation of gene expression in beta cells
0.0 1.4 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 1.1 REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY Genes involved in Nuclear Receptor transcription pathway