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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AACACUG
Z-value: 0.49
Motif logo
miRNA associated with seed AACACUG
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_+_51701924 Show fit | 12.17 |
ENST00000242719.3
|
ring finger protein 11 |
|
| chr3_+_62304712 Show fit | 11.38 |
ENST00000494481.1
|
chromosome 3 open reading frame 14 |
|
| chr3_+_158991025 Show fit | 11.12 |
ENST00000337808.6
|
IQCJ-SCHIP1 readthrough |
|
| chr3_+_159557637 Show fit | 10.10 |
ENST00000445224.2
|
schwannomin interacting protein 1 |
|
| chrX_-_13956737 Show fit | 9.57 |
ENST00000454189.2
|
glycoprotein M6B |
|
| chr6_-_18265050 Show fit | 8.31 |
ENST00000397239.3
|
DEK oncogene |
|
| chr1_-_6453399 Show fit | 8.06 |
ENST00000608083.1
|
acyl-CoA thioesterase 7 |
|
| chr1_+_84543734 Show fit | 7.82 |
ENST00000370689.2
|
protein kinase, cAMP-dependent, catalytic, beta |
|
| chr17_-_8534067 Show fit | 7.61 |
ENST00000360416.3
ENST00000269243.4 |
myosin, heavy chain 10, non-muscle |
|
| chr3_-_33686743 Show fit | 7.54 |
ENST00000333778.6
ENST00000539981.1 |
cytoplasmic linker associated protein 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AACACUG
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 11.9 | GO:0051865 | protein autoubiquitination(GO:0051865) |
| 0.3 | 11.3 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.5 | 10.3 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
| 1.0 | 9.6 | GO:0051610 | negative regulation of neurotransmitter uptake(GO:0051581) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) |
| 0.6 | 9.6 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.3 | 8.6 | GO:0030208 | dermatan sulfate biosynthetic process(GO:0030208) |
| 0.8 | 8.3 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 2.0 | 8.1 | GO:1900533 | medium-chain fatty-acyl-CoA catabolic process(GO:0036114) long-chain fatty-acyl-CoA catabolic process(GO:0036116) palmitic acid metabolic process(GO:1900533) palmitic acid biosynthetic process(GO:1900535) |
| 1.6 | 7.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.8 | 7.5 | GO:1904259 | regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904259) positive regulation of basement membrane assembly involved in embryonic body morphogenesis(GO:1904261) basement membrane assembly involved in embryonic body morphogenesis(GO:2001197) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 17.8 | GO:0005819 | spindle(GO:0005819) |
| 0.1 | 13.4 | GO:0055037 | recycling endosome(GO:0055037) |
| 0.6 | 11.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 10.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.8 | 9.8 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
| 0.4 | 9.6 | GO:0032156 | septin cytoskeleton(GO:0032156) |
| 0.1 | 9.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 7.7 | GO:0031903 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 1.5 | 7.6 | GO:0097513 | myosin II filament(GO:0097513) |
| 0.8 | 7.5 | GO:0045180 | basal cortex(GO:0045180) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.7 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.4 | 10.1 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.3 | 9.8 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.3 | 9.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 9.5 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.2 | 9.0 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.0 | 8.3 | GO:0005525 | GTP binding(GO:0005525) |
| 0.8 | 8.1 | GO:0036042 | long-chain fatty acyl-CoA binding(GO:0036042) |
| 0.5 | 7.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.2 | 7.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 9.6 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.3 | 8.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 6.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.1 | 6.4 | PID ECADHERIN STABILIZATION PATHWAY | Stabilization and expansion of the E-cadherin adherens junction |
| 0.1 | 4.9 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.2 | 4.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.2 | 3.5 | SA G2 AND M PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.1 | 3.5 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 3.2 | PID INTEGRIN A4B1 PATHWAY | Alpha4 beta1 integrin signaling events |
| 0.1 | 3.0 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 13.4 | REACTOME TRANSFERRIN ENDOCYTOSIS AND RECYCLING | Genes involved in Transferrin endocytosis and recycling |
| 0.3 | 11.0 | REACTOME PKA MEDIATED PHOSPHORYLATION OF CREB | Genes involved in PKA-mediated phosphorylation of CREB |
| 0.4 | 9.6 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.5 | 8.6 | REACTOME ERKS ARE INACTIVATED | Genes involved in ERKs are inactivated |
| 0.2 | 7.9 | REACTOME SEMA4D INDUCED CELL MIGRATION AND GROWTH CONE COLLAPSE | Genes involved in Sema4D induced cell migration and growth-cone collapse |
| 0.1 | 7.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.3 | 6.9 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.4 | 6.5 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |
| 0.0 | 6.3 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |
| 0.2 | 5.5 | REACTOME CYCLIN A B1 ASSOCIATED EVENTS DURING G2 M TRANSITION | Genes involved in Cyclin A/B1 associated events during G2/M transition |