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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AACAGUC
Z-value: 0.36
Motif logo
miRNA associated with seed AACAGUC
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_98262240 Show fit | 6.15 |
ENST00000284049.3
|
chromodomain helicase DNA binding protein 1 |
|
| chr13_-_77900814 Show fit | 5.20 |
ENST00000544440.2
|
MYC binding protein 2, E3 ubiquitin protein ligase |
|
| chr6_+_111195973 Show fit | 4.37 |
ENST00000368885.3
ENST00000368882.3 ENST00000451850.2 ENST00000368877.5 |
adenosylmethionine decarboxylase 1 |
|
| chr8_-_103876965 Show fit | 4.28 |
ENST00000337198.5
|
antizyme inhibitor 1 |
|
| chr12_-_498620 Show fit | 4.04 |
ENST00000399788.2
ENST00000382815.4 |
lysine (K)-specific demethylase 5A |
|
| chr12_-_76953284 Show fit | 4.02 |
ENST00000547544.1
ENST00000393249.2 |
oxysterol binding protein-like 8 |
|
| chr5_-_111093406 Show fit | 3.99 |
ENST00000379671.3
|
neuronal regeneration related protein |
|
| chr10_+_89622870 Show fit | 3.59 |
ENST00000371953.3
|
phosphatase and tensin homolog |
|
| chr1_-_245027833 Show fit | 3.35 |
ENST00000444376.2
|
heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) |
|
| chr3_+_180630090 Show fit | 3.26 |
ENST00000357559.4
ENST00000305586.7 |
fragile X mental retardation, autosomal homolog 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AACAGUC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.1 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 1.5 | 4.4 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 1.1 | 4.3 | GO:0033387 | putrescine biosynthetic process from ornithine(GO:0033387) |
| 1.0 | 4.0 | GO:0031064 | negative regulation of histone deacetylation(GO:0031064) |
| 0.6 | 4.0 | GO:0090204 | protein localization to nuclear pore(GO:0090204) |
| 0.1 | 3.9 | GO:0000281 | mitotic cytokinesis(GO:0000281) |
| 0.9 | 3.6 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.9 | 3.6 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
| 0.5 | 3.4 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.1 | 3.3 | GO:2000637 | positive regulation of posttranscriptional gene silencing(GO:0060148) positive regulation of gene silencing by miRNA(GO:2000637) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.9 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.4 | 4.0 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.3 | 3.6 | GO:0035749 | myelin sheath adaxonal region(GO:0035749) |
| 0.3 | 3.4 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 3.4 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 3.3 | GO:0043034 | costamere(GO:0043034) |
| 0.3 | 3.2 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 3.1 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.2 | 2.8 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 2.8 | GO:0001650 | fibrillar center(GO:0001650) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.1 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 5.0 | GO:0031492 | nucleosomal DNA binding(GO:0031492) |
| 0.1 | 4.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
| 0.6 | 4.3 | GO:0042978 | ornithine decarboxylase activator activity(GO:0042978) |
| 1.0 | 4.0 | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) |
| 0.2 | 4.0 | GO:0070273 | phosphatidylinositol-4-phosphate binding(GO:0070273) |
| 0.1 | 3.7 | GO:0031490 | chromatin DNA binding(GO:0031490) |
| 1.2 | 3.6 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 3.5 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.1 | 3.4 | GO:0070034 | telomerase RNA binding(GO:0070034) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.1 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.1 | 4.4 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 2.7 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 2.6 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.0 | 2.2 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.0 | 2.0 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.0 | 1.9 | PID ERA GENOMIC PATHWAY | Validated nuclear estrogen receptor alpha network |
| 0.0 | 1.8 | PID P53 REGULATION PATHWAY | p53 pathway |
| 0.0 | 1.6 | PID AURORA A PATHWAY | Aurora A signaling |
| 0.0 | 1.6 | PID PLK1 PATHWAY | PLK1 signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.8 | REACTOME PROCESSING OF CAPPED INTRON CONTAINING PRE MRNA | Genes involved in Processing of Capped Intron-Containing Pre-mRNA |
| 0.1 | 5.3 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 0.2 | 4.4 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.4 | 3.5 | REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK | Genes involved in Negative regulation of the PI3K/AKT network |
| 0.1 | 3.5 | REACTOME DEADENYLATION OF MRNA | Genes involved in Deadenylation of mRNA |
| 0.1 | 3.3 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.1 | 2.6 | REACTOME IL1 SIGNALING | Genes involved in Interleukin-1 signaling |
| 0.0 | 2.4 | REACTOME RNA POL I PROMOTER OPENING | Genes involved in RNA Polymerase I Promoter Opening |
| 0.0 | 2.3 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 2.1 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |