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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AACGGAA

Z-value: 0.17

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miRNA associated with seed AACGGAA

NamemiRBASE accession
hsa-miR-191-5p
MIMAT0000440

Activity profile of AACGGAA motif

Sorted Z-values of AACGGAA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr10_-_81205373 0.53 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr3_+_115342159 0.52 ENST00000305124.6
GAP43
growth associated protein 43
chr6_+_116601265 0.38 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr7_-_108096822 0.32 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM
neuronal cell adhesion molecule
chr8_-_134115118 0.29 ENST00000395352.3
ENST00000338087.5
SLA
Src-like-adaptor
chr17_-_46623441 0.25 ENST00000330070.4
HOXB2
homeobox B2
chr7_-_71801980 0.24 ENST00000329008.5
CALN1
calneuron 1
chr9_+_133454943 0.13 ENST00000319725.9
FUBP3
far upstream element (FUSE) binding protein 3
chr5_+_149887672 0.13 ENST00000261797.6
NDST1
N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
chr12_+_122242597 0.11 ENST00000267197.5
SETD1B
SET domain containing 1B
chrX_-_41782249 0.09 ENST00000442742.2
ENST00000421587.2
ENST00000378166.4
ENST00000318588.9
ENST00000361962.4
CASK
calcium/calmodulin-dependent serine protein kinase (MAGUK family)
chrX_-_109561294 0.09 ENST00000372059.2
ENST00000262844.5
AMMECR1
Alport syndrome, mental retardation, midface hypoplasia and elliptocytosis chromosomal region gene 1
chr2_-_208634287 0.08 ENST00000295417.3
FZD5
frizzled family receptor 5
chr19_-_15560730 0.08 ENST00000389282.4
ENST00000263381.7
WIZ
widely interspaced zinc finger motifs
chr3_-_18466787 0.07 ENST00000338745.6
ENST00000450898.1
SATB1
SATB homeobox 1
chr18_+_32558208 0.07 ENST00000436190.2
MAPRE2
microtubule-associated protein, RP/EB family, member 2
chr16_-_4897266 0.06 ENST00000591451.1
ENST00000436648.5
ENST00000381983.3
ENST00000588297.1
ENST00000321919.9
GLYR1
glyoxylate reductase 1 homolog (Arabidopsis)
chr7_-_17980091 0.04 ENST00000409389.1
ENST00000409604.1
ENST00000428135.3
SNX13
sorting nexin 13
chr3_-_52090461 0.03 ENST00000296483.6
ENST00000495880.1
DUSP7
dual specificity phosphatase 7
chr2_+_27193480 0.02 ENST00000233121.2
ENST00000405074.3
MAPRE3
microtubule-associated protein, RP/EB family, member 3
chr19_+_3359561 0.02 ENST00000589123.1
ENST00000346156.5
ENST00000395111.3
ENST00000586919.1
NFIC
nuclear factor I/C (CCAAT-binding transcription factor)
chr6_+_21593972 0.02 ENST00000244745.1
ENST00000543472.1
SOX4
SRY (sex determining region Y)-box 4
chr9_-_3525968 0.00 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)

Network of associatons between targets according to the STRING database.

First level regulatory network of AACGGAA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.3 GO:0021569 rhombomere 3 development(GO:0021569)
0.1 0.3 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.1 0.5 GO:0016198 axon choice point recognition(GO:0016198)
0.0 0.1 GO:0060061 Spemann organizer formation(GO:0060061)
0.0 0.5 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0032584 growth cone membrane(GO:0032584)
0.0 0.3 GO:0043194 axon initial segment(GO:0043194)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0047757 chondroitin-glucuronate 5-epimerase activity(GO:0047757)
0.1 0.5 GO:0035727 lysophosphatidic acid binding(GO:0035727)
0.0 0.1 GO:0050119 N-acetylglucosamine deacetylase activity(GO:0050119)
0.0 0.1 GO:0070984 SET domain binding(GO:0070984)
0.0 0.3 GO:0086080 protein binding involved in heterotypic cell-cell adhesion(GO:0086080)
0.0 0.1 GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616)