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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AAGGCAC
Z-value: 0.17
Motif logo
miRNA associated with seed AAGGCAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-124-3p.1
|
MIMAT0000422 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr10_-_33246722 Show fit | 22.95 |
ENST00000437302.1
ENST00000396033.2 |
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) |
|
| chr10_+_17271266 Show fit | 22.55 |
ENST00000224237.5
|
vimentin |
|
| chr2_-_161350305 Show fit | 21.55 |
ENST00000348849.3
|
RNA binding motif, single stranded interacting protein 1 |
|
| chr1_+_182992545 Show fit | 17.40 |
ENST00000258341.4
|
laminin, gamma 1 (formerly LAMB2) |
|
| chr1_+_223900034 Show fit | 17.39 |
ENST00000295006.5
|
calpain 2, (m/II) large subunit |
|
| chr21_-_44846999 Show fit | 16.64 |
ENST00000270162.6
|
salt-inducible kinase 1 |
|
| chr22_-_50746027 Show fit | 16.45 |
ENST00000425954.1
ENST00000449103.1 |
plexin B2 |
|
| chr2_-_64881018 Show fit | 16.30 |
ENST00000313349.3
|
SERTA domain containing 2 |
|
| chr3_-_120170052 Show fit | 15.81 |
ENST00000295633.3
|
follistatin-like 1 |
|
| chr2_+_109204909 Show fit | 15.68 |
ENST00000393310.1
|
LIM and senescent cell antigen-like domains 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AAGGCAC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 31.8 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 4.6 | 23.0 | GO:0007161 | calcium-independent cell-matrix adhesion(GO:0007161) regulation of collagen catabolic process(GO:0010710) |
| 0.5 | 22.8 | GO:0034314 | Arp2/3 complex-mediated actin nucleation(GO:0034314) |
| 3.1 | 21.7 | GO:1904628 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.2 | 21.7 | GO:2000134 | negative regulation of G1/S transition of mitotic cell cycle(GO:2000134) |
| 0.6 | 20.5 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 1.9 | 20.4 | GO:0070307 | lens fiber cell development(GO:0070307) |
| 0.5 | 20.1 | GO:0046039 | GTP metabolic process(GO:0046039) |
| 0.6 | 19.7 | GO:0071526 | semaphorin-plexin signaling pathway(GO:0071526) |
| 3.7 | 18.5 | GO:0050428 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 80.4 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.4 | 59.3 | GO:0042579 | peroxisome(GO:0005777) microbody(GO:0042579) |
| 0.0 | 47.9 | GO:0005654 | nucleoplasm(GO:0005654) |
| 0.1 | 37.5 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.3 | 35.7 | GO:0035578 | azurophil granule lumen(GO:0035578) |
| 1.2 | 34.0 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 32.3 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.2 | 29.7 | GO:0001650 | fibrillar center(GO:0001650) |
| 0.2 | 28.1 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.1 | 26.2 | GO:0031965 | nuclear membrane(GO:0031965) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 41.8 | GO:0003713 | transcription coactivator activity(GO:0003713) |
| 0.3 | 31.5 | GO:0000979 | RNA polymerase II core promoter sequence-specific DNA binding(GO:0000979) |
| 0.3 | 25.7 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 1.0 | 24.8 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.1 | 24.8 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 1.4 | 24.4 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 4.0 | 24.3 | GO:1990254 | keratin filament binding(GO:1990254) |
| 0.6 | 23.1 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 4.6 | 23.0 | GO:0098639 | collagen binding involved in cell-matrix adhesion(GO:0098639) |
| 0.2 | 22.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 56.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 1.0 | 50.8 | PID LYMPH ANGIOGENESIS PATHWAY | VEGFR3 signaling in lymphatic endothelium |
| 0.6 | 44.5 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.6 | 38.3 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.6 | 34.7 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.6 | 30.4 | PID ERBB1 RECEPTOR PROXIMAL PATHWAY | EGF receptor (ErbB1) signaling pathway |
| 0.1 | 26.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.4 | 26.0 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.4 | 25.6 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.8 | 24.9 | PID SMAD2 3PATHWAY | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 38.6 | REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS | Genes involved in Cell-extracellular matrix interactions |
| 0.8 | 33.0 | REACTOME SIGNALING BY BMP | Genes involved in Signaling by BMP |
| 1.0 | 32.5 | REACTOME CASPASE MEDIATED CLEAVAGE OF CYTOSKELETAL PROTEINS | Genes involved in Caspase-mediated cleavage of cytoskeletal proteins |
| 0.3 | 30.6 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 1.2 | 24.1 | REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION | Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion |
| 0.9 | 24.1 | REACTOME TIE2 SIGNALING | Genes involved in Tie2 Signaling |
| 0.8 | 23.0 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.6 | 22.8 | REACTOME LYSOSOME VESICLE BIOGENESIS | Genes involved in Lysosome Vesicle Biogenesis |
| 0.2 | 22.8 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.9 | 22.3 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |