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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AAGGUGC

Z-value: 0.15

Motif logo

logo of

miRNA associated with seed AAGGUGC

NamemiRBASE accession
hsa-miR-18a-5p
MIMAT0000072
hsa-miR-18b-5p
MIMAT0001412
hsa-miR-4735-3p
MIMAT0019861

Activity profile of AAGGUGC motif

Sorted Z-values of AAGGUGC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr2_+_235860616 8.48 ENST00000392011.2
SH3BP4
SH3-domain binding protein 4
chr3_-_123603137 8.40 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr3_+_107241783 6.11 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
BBX
bobby sox homolog (Drosophila)
chr6_-_132272504 4.69 ENST00000367976.3
CTGF
connective tissue growth factor
chr3_-_114790179 4.58 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr2_+_36582857 4.54 ENST00000280527.2
CRIM1
cysteine rich transmembrane BMP regulator 1 (chordin-like)
chr7_-_121036337 4.41 ENST00000426156.1
ENST00000359943.3
ENST00000412653.1
FAM3C
family with sequence similarity 3, member C
chr21_-_18985158 4.07 ENST00000339775.6
BTG3
BTG family, member 3
chr15_+_39873268 3.74 ENST00000397591.2
ENST00000260356.5
THBS1
thrombospondin 1
chr3_+_171758344 3.60 ENST00000336824.4
ENST00000423424.1
FNDC3B
fibronectin type III domain containing 3B
chr22_+_38093005 3.32 ENST00000406386.3
TRIOBP
TRIO and F-actin binding protein
chr3_+_187930719 2.83 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chr5_-_142783175 2.72 ENST00000231509.3
ENST00000394464.2
NR3C1
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
chr19_+_3572925 2.71 ENST00000333651.6
ENST00000417382.1
ENST00000453933.1
ENST00000262949.7
HMG20B
high mobility group 20B
chr2_-_26101374 2.63 ENST00000435504.4
ASXL2
additional sex combs like 2 (Drosophila)
chr6_+_39760783 2.47 ENST00000398904.2
ENST00000538976.1
DAAM2
dishevelled associated activator of morphogenesis 2
chr15_-_56209306 2.46 ENST00000506154.1
ENST00000338963.2
ENST00000508342.1
NEDD4
neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase
chr4_-_157892498 2.43 ENST00000502773.1
PDGFC
platelet derived growth factor C
chr3_+_105085734 2.40 ENST00000306107.5
ALCAM
activated leukocyte cell adhesion molecule
chr7_+_66386204 2.26 ENST00000341567.4
ENST00000607045.1
TMEM248
transmembrane protein 248
chr9_-_74383799 2.14 ENST00000377044.4
TMEM2
transmembrane protein 2
chr2_+_12857015 2.03 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr3_-_185542817 2.02 ENST00000382199.2
IGF2BP2
insulin-like growth factor 2 mRNA binding protein 2
chr6_-_16761678 1.98 ENST00000244769.4
ENST00000436367.1
ATXN1
ataxin 1
chr17_-_40306934 1.89 ENST00000592574.1
ENST00000550406.1
ENST00000547517.1
ENST00000393860.3
ENST00000346213.4
CTD-2132N18.3
RAB5C
Uncharacterized protein
RAB5C, member RAS oncogene family
chr2_+_85198216 1.84 ENST00000456682.1
ENST00000409785.4
KCMF1
potassium channel modulatory factor 1
chr4_-_186877502 1.81 ENST00000431902.1
ENST00000284776.7
ENST00000415274.1
SORBS2
sorbin and SH3 domain containing 2
chr1_+_36621529 1.67 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chrX_+_13707235 1.63 ENST00000464506.1
RAB9A
RAB9A, member RAS oncogene family
chr17_+_46985731 1.61 ENST00000360943.5
UBE2Z
ubiquitin-conjugating enzyme E2Z
chr1_-_120612240 1.48 ENST00000256646.2
NOTCH2
notch 2
chr18_-_45456930 1.37 ENST00000262160.6
ENST00000587269.1
SMAD2
SMAD family member 2
chr12_+_12764773 1.34 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr1_-_161993616 1.28 ENST00000294794.3
OLFML2B
olfactomedin-like 2B
chr3_+_152017181 1.26 ENST00000498502.1
ENST00000324196.5
ENST00000545754.1
ENST00000357472.3
MBNL1
muscleblind-like splicing regulator 1
chr6_-_11232891 1.23 ENST00000379433.5
ENST00000379446.5
NEDD9
neural precursor cell expressed, developmentally down-regulated 9
chr9_+_125703282 1.19 ENST00000373647.4
ENST00000402311.1
RABGAP1
RAB GTPase activating protein 1
chr2_+_46926048 1.18 ENST00000306503.5
SOCS5
suppressor of cytokine signaling 5
chr1_-_51425902 1.17 ENST00000396153.2
FAF1
Fas (TNFRSF6) associated factor 1
chr4_+_183164574 1.07 ENST00000511685.1
TENM3
teneurin transmembrane protein 3
chr10_-_735553 1.07 ENST00000280886.6
ENST00000423550.1
DIP2C
DIP2 disco-interacting protein 2 homolog C (Drosophila)
chr3_-_113465065 1.03 ENST00000497255.1
ENST00000478020.1
ENST00000240922.3
ENST00000493900.1
NAA50
N(alpha)-acetyltransferase 50, NatE catalytic subunit
chr1_+_173684047 0.92 ENST00000546011.1
ENST00000209884.4
KLHL20
kelch-like family member 20
chr6_+_134274322 0.92 ENST00000367871.1
ENST00000237264.4
TBPL1
TBP-like 1
chr5_-_73937244 0.90 ENST00000302351.4
ENST00000510316.1
ENST00000508331.1
ENC1
ectodermal-neural cortex 1 (with BTB domain)
chr10_-_119806085 0.89 ENST00000355624.3
RAB11FIP2
RAB11 family interacting protein 2 (class I)
chr6_-_86352642 0.88 ENST00000355238.6
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr1_-_20812690 0.84 ENST00000375078.3
CAMK2N1
calcium/calmodulin-dependent protein kinase II inhibitor 1
chr12_-_44200052 0.83 ENST00000548315.1
ENST00000552521.1
ENST00000546662.1
ENST00000548403.1
ENST00000546506.1
TWF1
twinfilin actin-binding protein 1
chr1_+_87794150 0.78 ENST00000370544.5
LMO4
LIM domain only 4
chr20_+_56884752 0.70 ENST00000244040.3
RAB22A
RAB22A, member RAS oncogene family
chr1_-_95007193 0.64 ENST00000370207.4
ENST00000334047.7
F3
coagulation factor III (thromboplastin, tissue factor)
chr3_+_37903432 0.63 ENST00000443503.2
CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr10_-_81205373 0.62 ENST00000372336.3
ZCCHC24
zinc finger, CCHC domain containing 24
chr12_+_56360550 0.60 ENST00000266970.4
CDK2
cyclin-dependent kinase 2
chr1_+_84543734 0.59 ENST00000370689.2
PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr9_-_127952032 0.57 ENST00000456642.1
ENST00000373546.3
ENST00000373547.4
PPP6C
protein phosphatase 6, catalytic subunit
chr14_+_52456327 0.55 ENST00000556760.1
C14orf166
chromosome 14 open reading frame 166
chr16_-_85722530 0.51 ENST00000253462.3
GINS2
GINS complex subunit 2 (Psf2 homolog)
chr20_+_30865429 0.47 ENST00000375712.3
KIF3B
kinesin family member 3B
chr12_+_109535373 0.47 ENST00000242576.2
UNG
uracil-DNA glycosylase
chr9_+_91003271 0.43 ENST00000375859.3
ENST00000541629.1
SPIN1
spindlin 1
chr4_+_154125565 0.42 ENST00000338700.5
TRIM2
tripartite motif containing 2
chr6_-_111136513 0.41 ENST00000368911.3
CDK19
cyclin-dependent kinase 19
chr9_+_96338860 0.40 ENST00000375376.4
PHF2
PHD finger protein 2
chr10_-_71930222 0.38 ENST00000458634.2
ENST00000373239.2
ENST00000373242.2
ENST00000373241.4
SAR1A
SAR1 homolog A (S. cerevisiae)
chr17_+_48423453 0.38 ENST00000017003.2
ENST00000509778.1
ENST00000507602.1
XYLT2
xylosyltransferase II
chr10_+_72575643 0.37 ENST00000373202.3
SGPL1
sphingosine-1-phosphate lyase 1
chr17_-_62340581 0.32 ENST00000258991.3
ENST00000583738.1
ENST00000584379.1
TEX2
testis expressed 2
chr1_-_109506036 0.32 ENST00000369976.1
ENST00000356970.2
ENST00000369971.2
ENST00000415331.1
ENST00000357393.4
CLCC1
AKNAD1
chloride channel CLIC-like 1
AKNA domain containing 1
chr11_+_94822968 0.29 ENST00000278505.4
ENDOD1
endonuclease domain containing 1
chr1_-_38325256 0.26 ENST00000373036.4
MTF1
metal-regulatory transcription factor 1
chr11_-_34379546 0.22 ENST00000435224.2
ABTB2
ankyrin repeat and BTB (POZ) domain containing 2
chr14_+_55518349 0.18 ENST00000395468.4
MAPK1IP1L
mitogen-activated protein kinase 1 interacting protein 1-like
chr4_+_6784401 0.18 ENST00000425103.1
ENST00000307659.5
KIAA0232
KIAA0232
chr17_-_1395954 0.18 ENST00000359786.5
MYO1C
myosin IC
chr3_-_33481835 0.17 ENST00000283629.3
UBP1
upstream binding protein 1 (LBP-1a)
chr16_-_17564738 0.16 ENST00000261381.6
XYLT1
xylosyltransferase I
chr4_-_185395672 0.16 ENST00000393593.3
IRF2
interferon regulatory factor 2
chr6_+_16238786 0.15 ENST00000259727.4
GMPR
guanosine monophosphate reductase
chr1_+_22379120 0.13 ENST00000400259.1
ENST00000344548.3
CDC42
cell division cycle 42
chr18_+_20513782 0.11 ENST00000399722.2
ENST00000399725.2
ENST00000399721.2
ENST00000583594.1
RBBP8
retinoblastoma binding protein 8
chr1_+_100435315 0.11 ENST00000370155.3
ENST00000465289.1
SLC35A3
solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3
chr16_-_74640986 0.10 ENST00000422840.2
ENST00000565260.1
ENST00000447066.2
ENST00000205061.5
GLG1
golgi glycoprotein 1
chr12_+_49212514 0.09 ENST00000301050.2
ENST00000548279.1
ENST00000547230.1
CACNB3
calcium channel, voltage-dependent, beta 3 subunit
chr7_+_90225796 0.09 ENST00000380050.3
CDK14
cyclin-dependent kinase 14
chr2_+_28615669 0.08 ENST00000379619.1
ENST00000264716.4
FOSL2
FOS-like antigen 2
chr4_+_55524085 0.08 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chr16_+_30960375 0.06 ENST00000318663.4
ENST00000566237.1
ENST00000562699.1
ORAI3
ORAI calcium release-activated calcium modulator 3
chr8_-_18871159 0.06 ENST00000327040.8
ENST00000440756.2
PSD3
pleckstrin and Sec7 domain containing 3
chr5_+_102594403 0.04 ENST00000319933.2
C5orf30
chromosome 5 open reading frame 30
chrX_+_108780062 0.02 ENST00000372106.1
NXT2
nuclear transport factor 2-like export factor 2
chr7_-_111846435 0.01 ENST00000437633.1
ENST00000428084.1
DOCK4
dedicator of cytokinesis 4

Network of associatons between targets according to the STRING database.

First level regulatory network of AAGGUGC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.6 4.7 GO:0070318 positive regulation of G0 to G1 transition(GO:0070318)
1.2 3.7 GO:0002605 negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002581) negative regulation of dendritic cell antigen processing and presentation(GO:0002605)
1.0 8.4 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.8 4.2 GO:0030047 actin modification(GO:0030047)
0.6 2.5 GO:0044111 development involved in symbiotic interaction(GO:0044111)
0.5 1.4 GO:1900224 positive regulation of nodal signaling pathway involved in determination of lateral mesoderm left/right asymmetry(GO:1900224)
0.4 2.0 GO:0042091 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.3 2.7 GO:0043402 glucocorticoid mediated signaling pathway(GO:0043402)
0.3 1.6 GO:0052405 negative regulation by host of symbiont molecular function(GO:0052405)
0.2 2.6 GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway(GO:0035360)
0.2 0.9 GO:0009212 dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212)
0.2 8.5 GO:0043090 amino acid import(GO:0043090)
0.2 0.6 GO:0002541 activation of plasma proteins involved in acute inflammatory response(GO:0002541)
0.2 1.2 GO:0045629 negative regulation of T-helper 2 cell differentiation(GO:0045629)
0.2 1.0 GO:0070601 centromeric sister chromatid cohesion(GO:0070601)
0.1 1.5 GO:0002315 marginal zone B cell differentiation(GO:0002315)
0.1 1.9 GO:0048227 plasma membrane to endosome transport(GO:0048227)
0.1 2.7 GO:0033234 negative regulation of protein sumoylation(GO:0033234)
0.1 0.4 GO:0061188 negative regulation of chromatin silencing at rDNA(GO:0061188)
0.1 0.9 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.1 0.6 GO:0097338 response to clozapine(GO:0097338)
0.1 0.6 GO:0030174 regulation of DNA-dependent DNA replication initiation(GO:0030174)
0.1 0.9 GO:0010499 proteasomal ubiquitin-independent protein catabolic process(GO:0010499)
0.1 2.4 GO:0007171 activation of transmembrane receptor protein tyrosine kinase activity(GO:0007171)
0.1 4.6 GO:0032728 positive regulation of interferon-beta production(GO:0032728)
0.1 0.8 GO:0097264 self proteolysis(GO:0097264)
0.1 4.4 GO:0048009 insulin-like growth factor receptor signaling pathway(GO:0048009)
0.1 0.8 GO:0042659 regulation of cell fate specification(GO:0042659)
0.1 2.4 GO:1902284 axon extension involved in axon guidance(GO:0048846) neuron projection extension involved in neuron projection guidance(GO:1902284)
0.1 2.1 GO:0030214 hyaluronan catabolic process(GO:0030214)
0.1 1.2 GO:0007253 cytoplasmic sequestering of NF-kappaB(GO:0007253)
0.1 0.5 GO:0000727 double-strand break repair via break-induced replication(GO:0000727)
0.1 1.8 GO:0003298 physiological muscle hypertrophy(GO:0003298) physiological cardiac muscle hypertrophy(GO:0003301) cell growth involved in cardiac muscle cell development(GO:0061049)
0.0 0.5 GO:0072383 plus-end-directed vesicle transport along microtubule(GO:0072383)
0.0 0.6 GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388)
0.0 0.9 GO:0006895 Golgi to endosome transport(GO:0006895)
0.0 0.4 GO:0033327 Leydig cell differentiation(GO:0033327)
0.0 0.5 GO:0045008 depyrimidination(GO:0045008)
0.0 0.4 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.0 0.1 GO:0051835 positive regulation of synapse structural plasticity(GO:0051835)
0.0 0.2 GO:1900748 positive regulation of vascular endothelial growth factor signaling pathway(GO:1900748)
0.0 6.3 GO:0060348 bone development(GO:0060348)
0.0 1.3 GO:0046326 positive regulation of glucose import(GO:0046326)
0.0 4.7 GO:0002576 platelet degranulation(GO:0002576)
0.0 0.4 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.0 2.0 GO:0042035 regulation of cytokine biosynthetic process(GO:0042035)
0.0 0.9 GO:0003091 renal water homeostasis(GO:0003091)
0.0 1.4 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.2 GO:0031338 regulation of vesicle fusion(GO:0031338)
0.0 0.1 GO:0045002 DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002)
0.0 0.1 GO:0090481 pyrimidine nucleotide-sugar transmembrane transport(GO:0090481)
0.0 1.1 GO:0045445 myoblast differentiation(GO:0045445)
0.0 0.2 GO:0015012 heparan sulfate proteoglycan biosynthetic process(GO:0015012)
0.0 0.4 GO:0009303 rRNA transcription(GO:0009303)
0.0 0.1 GO:0098903 regulation of membrane repolarization during action potential(GO:0098903)
0.0 0.2 GO:0097237 cellular response to toxic substance(GO:0097237)
0.0 4.0 GO:0045930 negative regulation of mitotic cell cycle(GO:0045930)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.0 GO:0042272 nuclear RNA export factor complex(GO:0042272)
0.3 3.7 GO:0005577 fibrinogen complex(GO:0005577)
0.2 4.4 GO:0031089 platelet dense granule lumen(GO:0031089)
0.2 0.6 GO:0097134 Y chromosome(GO:0000806) cyclin A2-CDK2 complex(GO:0097124) cyclin E1-CDK2 complex(GO:0097134)
0.2 1.4 GO:0071144 SMAD2-SMAD3 protein complex(GO:0071144)
0.2 0.5 GO:0005873 plus-end kinesin complex(GO:0005873)
0.1 1.0 GO:0031415 NatA complex(GO:0031415)
0.1 0.5 GO:0000811 GINS complex(GO:0000811)
0.1 0.9 GO:0097452 GAIT complex(GO:0097452)
0.1 8.4 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.1 1.2 GO:0034098 VCP-NPL4-UFD1 AAA ATPase complex(GO:0034098)
0.1 0.6 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.1 4.7 GO:0005801 cis-Golgi network(GO:0005801)
0.1 8.5 GO:0005905 clathrin-coated pit(GO:0005905)
0.1 2.4 GO:0042101 T cell receptor complex(GO:0042101)
0.1 2.5 GO:0016327 apicolateral plasma membrane(GO:0016327)
0.0 0.2 GO:0045160 myosin I complex(GO:0045160)
0.0 0.1 GO:0000308 cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.6 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 2.3 GO:0030670 phagocytic vesicle membrane(GO:0030670)
0.0 1.8 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 0.2 GO:1902560 GMP reductase complex(GO:1902560)
0.0 1.9 GO:0005811 lipid particle(GO:0005811)
0.0 3.5 GO:0030496 midbody(GO:0030496)
0.0 0.4 GO:0030127 COPII vesicle coat(GO:0030127)
0.0 5.3 GO:0005819 spindle(GO:0005819)
0.0 0.9 GO:0010494 cytoplasmic stress granule(GO:0010494)
0.0 0.4 GO:0016592 mediator complex(GO:0016592)
0.0 0.6 GO:0055038 recycling endosome membrane(GO:0055038)
0.0 1.2 GO:0005875 microtubule associated complex(GO:0005875)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.7 8.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.2 3.7 GO:0070052 collagen V binding(GO:0070052)
0.7 4.2 GO:0038049 transcription factor activity, ligand-activated RNA polymerase II transcription factor binding(GO:0038049)
0.4 1.3 GO:0001069 regulatory region RNA binding(GO:0001069)
0.4 2.0 GO:0034046 poly(G) binding(GO:0034046)
0.4 2.5 GO:0050815 phosphoserine binding(GO:0050815)
0.3 8.5 GO:0005092 GDP-dissociation inhibitor activity(GO:0005092)
0.3 0.9 GO:0019961 interferon binding(GO:0019961)
0.3 3.3 GO:0045159 myosin II binding(GO:0045159)
0.2 9.2 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.2 2.1 GO:0004415 hyalurononglucosaminidase activity(GO:0004415)
0.2 2.6 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.2 0.5 GO:0030158 protein xylosyltransferase activity(GO:0030158)
0.1 0.8 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.1 2.0 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 2.4 GO:0005161 platelet-derived growth factor receptor binding(GO:0005161)
0.1 1.4 GO:0030618 transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) type I transforming growth factor beta receptor binding(GO:0034713)
0.1 1.0 GO:0004596 peptide alpha-N-acetyltransferase activity(GO:0004596)
0.1 1.8 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.1 2.0 GO:0048027 mRNA 5'-UTR binding(GO:0048027)
0.1 0.5 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.1 4.2 GO:0019003 GDP binding(GO:0019003)
0.0 0.1 GO:0032427 GBD domain binding(GO:0032427)
0.0 2.3 GO:0004407 histone deacetylase activity(GO:0004407)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.6 GO:0061631 ubiquitin conjugating enzyme activity(GO:0061631)
0.0 0.5 GO:0043138 3'-5' DNA helicase activity(GO:0043138)
0.0 0.9 GO:0008143 poly(A) binding(GO:0008143)
0.0 1.0 GO:0051059 NF-kappaB binding(GO:0051059)
0.0 2.9 GO:0017048 Rho GTPase binding(GO:0017048)
0.0 4.6 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.2 GO:0003920 GMP reductase activity(GO:0003920) oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor(GO:0016657)
0.0 0.4 GO:0032454 histone demethylase activity (H3-K9 specific)(GO:0032454)
0.0 0.6 GO:0035173 histone kinase activity(GO:0035173)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 1.1 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.0 0.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.4 GO:0016832 aldehyde-lyase activity(GO:0016832)
0.0 4.4 GO:0005125 cytokine activity(GO:0005125)
0.0 0.2 GO:0017160 Ral GTPase binding(GO:0017160)
0.0 0.1 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.0 1.8 GO:0017137 Rab GTPase binding(GO:0017137)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 8.5 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 4.7 PID AMB2 NEUTROPHILS PATHWAY amb2 Integrin signaling
0.1 3.7 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.0 2.7 PID ECADHERIN STABILIZATION PATHWAY Stabilization and expansion of the E-cadherin adherens junction
0.0 1.4 PID GLYPICAN 1PATHWAY Glypican 1 network
0.0 2.5 PID PS1 PATHWAY Presenilin action in Notch and Wnt signaling
0.0 2.2 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.0 0.9 PID ECADHERIN NASCENT AJ PATHWAY E-cadherin signaling in the nascent adherens junction
0.0 0.6 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.0 1.6 PID NOTCH PATHWAY Notch signaling pathway
0.0 4.5 NABA ECM GLYCOPROTEINS Genes encoding structural ECM glycoproteins
0.0 0.6 PID INTEGRIN A4B1 PATHWAY Alpha4 beta1 integrin signaling events
0.0 0.8 PID IL6 7 PATHWAY IL6-mediated signaling events
0.0 1.2 PID IL4 2PATHWAY IL4-mediated signaling events
0.0 0.4 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.0 0.6 PID BMP PATHWAY BMP receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 REACTOME RECEPTOR LIGAND BINDING INITIATES THE SECOND PROTEOLYTIC CLEAVAGE OF NOTCH RECEPTOR Genes involved in Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor
0.1 8.4 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.1 2.4 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.1 4.6 REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression
0.1 1.8 REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression
0.0 1.4 REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING Genes involved in Downregulation of TGF-beta receptor signaling
0.0 0.5 REACTOME UNWINDING OF DNA Genes involved in Unwinding of DNA
0.0 3.7 REACTOME INTEGRIN CELL SURFACE INTERACTIONS Genes involved in Integrin cell surface interactions
0.0 4.2 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 2.5 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 1.9 REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS Genes involved in Golgi Associated Vesicle Biogenesis
0.0 0.9 REACTOME REGULATION OF WATER BALANCE BY RENAL AQUAPORINS Genes involved in Regulation of Water Balance by Renal Aquaporins
0.0 0.6 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.0 2.1 REACTOME L1CAM INTERACTIONS Genes involved in L1CAM interactions
0.0 0.4 REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS Genes involved in Sphingolipid de novo biosynthesis