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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AAUCUCA

Z-value: 0.33

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miRNA associated with seed AAUCUCA

NamemiRBASE accession
hsa-miR-216a-5p
MIMAT0000273

Activity profile of AAUCUCA motif

Sorted Z-values of AAUCUCA motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr13_-_31038370 2.33 ENST00000399489.1
ENST00000339872.4
HMGB1
high mobility group box 1
chr4_+_99916765 2.13 ENST00000296411.6
METAP1
methionyl aminopeptidase 1
chrX_-_20284958 2.11 ENST00000379565.3
RPS6KA3
ribosomal protein S6 kinase, 90kDa, polypeptide 3
chr1_-_67896095 1.89 ENST00000370994.4
SERBP1
SERPINE1 mRNA binding protein 1
chr10_+_11206925 1.20 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2
CUGBP, Elav-like family member 2
chr2_+_231921574 1.14 ENST00000308696.6
ENST00000373635.4
ENST00000440838.1
ENST00000409643.1
PSMD1
proteasome (prosome, macropain) 26S subunit, non-ATPase, 1
chr4_-_105416039 1.02 ENST00000394767.2
CXXC4
CXXC finger protein 4
chr2_-_242212227 0.91 ENST00000427007.1
ENST00000458564.1
ENST00000452065.1
ENST00000427183.2
ENST00000426343.1
ENST00000422080.1
ENST00000449504.1
ENST00000449864.1
ENST00000391975.1
HDLBP
high density lipoprotein binding protein
chrX_+_23352133 0.87 ENST00000379361.4
PTCHD1
patched domain containing 1
chr1_-_67519782 0.86 ENST00000235345.5
SLC35D1
solute carrier family 35 (UDP-GlcA/UDP-GalNAc transporter), member D1
chr7_-_139876812 0.84 ENST00000397560.2
JHDM1D
lysine (K)-specific demethylase 7A
chr6_+_42749759 0.74 ENST00000314073.5
GLTSCR1L
GLTSCR1-like
chr9_-_20622478 0.73 ENST00000355930.6
ENST00000380338.4
MLLT3
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3
chr17_+_30677136 0.73 ENST00000394670.4
ENST00000321233.6
ENST00000394673.2
ENST00000341711.6
ENST00000579634.1
ENST00000580759.1
ENST00000342555.6
ENST00000577908.1
ENST00000394679.5
ENST00000582165.1
ZNF207
zinc finger protein 207
chr7_+_12250886 0.70 ENST00000444443.1
ENST00000396667.3
TMEM106B
transmembrane protein 106B
chr5_-_178054105 0.66 ENST00000316308.4
CLK4
CDC-like kinase 4
chr20_-_524455 0.65 ENST00000349736.5
ENST00000217244.3
CSNK2A1
casein kinase 2, alpha 1 polypeptide
chr1_-_53793584 0.63 ENST00000354412.3
ENST00000347547.2
ENST00000306052.6
LRP8
low density lipoprotein receptor-related protein 8, apolipoprotein e receptor
chr11_+_111945011 0.45 ENST00000532163.1
ENST00000280352.9
ENST00000530104.1
ENST00000526879.1
ENST00000393047.3
ENST00000525785.1
C11orf57
chromosome 11 open reading frame 57
chr12_+_50344516 0.42 ENST00000199280.3
ENST00000550862.1
AQP2
aquaporin 2 (collecting duct)
chr15_+_40733387 0.36 ENST00000416165.1
BAHD1
bromo adjacent homology domain containing 1
chr12_-_57030115 0.26 ENST00000379441.3
ENST00000179765.5
ENST00000551812.1
BAZ2A
bromodomain adjacent to zinc finger domain, 2A
chr4_-_113437328 0.20 ENST00000313341.3
NEUROG2
neurogenin 2
chr11_-_32452357 0.17 ENST00000379079.2
ENST00000530998.1
WT1
Wilms tumor 1
chr3_+_126707437 0.16 ENST00000393409.2
ENST00000251772.4
PLXNA1
plexin A1
chr4_+_3076388 0.09 ENST00000355072.5
HTT
huntingtin
chr2_-_172967621 0.04 ENST00000234198.4
ENST00000466293.2
DLX2
distal-less homeobox 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AAUCUCA

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 2.3 GO:2000426 plasmacytoid dendritic cell activation(GO:0002270) T cell mediated immune response to tumor cell(GO:0002424) regulation of T cell mediated immune response to tumor cell(GO:0002840) regulation of restriction endodeoxyribonuclease activity(GO:0032072) negative regulation of apoptotic cell clearance(GO:2000426)
0.2 2.1 GO:0018206 peptidyl-methionine modification(GO:0018206)
0.2 1.0 GO:0007352 zygotic specification of dorsal/ventral axis(GO:0007352)
0.1 0.9 GO:0006065 UDP-glucuronate biosynthetic process(GO:0006065)
0.1 0.6 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
0.1 0.4 GO:0071288 cellular response to mercury ion(GO:0071288)
0.1 2.1 GO:0043555 regulation of translation in response to stress(GO:0043555)
0.1 0.7 GO:0007379 segment specification(GO:0007379) positive regulation of Wnt signaling pathway, planar cell polarity pathway(GO:2000096)
0.1 0.9 GO:0034384 high-density lipoprotein particle clearance(GO:0034384)
0.1 0.9 GO:0021794 thalamus development(GO:0021794)
0.0 0.2 GO:0072302 posterior mesonephric tubule development(GO:0072166) negative regulation of metanephric glomerulus development(GO:0072299) negative regulation of metanephric glomerular mesangial cell proliferation(GO:0072302)
0.0 1.2 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 1.4 GO:0071174 mitotic spindle checkpoint(GO:0071174)
0.0 0.1 GO:0031587 positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0031587)
0.0 0.4 GO:0031507 heterochromatin assembly(GO:0031507)
0.0 0.2 GO:0060666 dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.0 GO:0061074 regulation of neural retina development(GO:0061074) regulation of retina development in camera-type eye(GO:1902866)
0.0 0.7 GO:0007040 lysosome organization(GO:0007040) lytic vacuole organization(GO:0080171)
0.0 1.1 GO:0006521 regulation of cellular amino acid metabolic process(GO:0006521)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.6 GO:0005956 protein kinase CK2 complex(GO:0005956)
0.1 0.6 GO:0005677 chromatin silencing complex(GO:0005677)
0.1 1.1 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540) cytosolic proteasome complex(GO:0031597)
0.0 2.3 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.9 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.0 0.2 GO:0002116 semaphorin receptor complex(GO:0002116)
0.0 0.7 GO:0008023 transcription elongation factor complex(GO:0008023)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.3 GO:0010858 calcium-dependent protein kinase regulator activity(GO:0010858)
0.2 0.6 GO:0038025 reelin receptor activity(GO:0038025)
0.1 0.9 GO:0015165 pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165)
0.1 0.4 GO:0015168 glycerol transmembrane transporter activity(GO:0015168)
0.0 1.6 GO:0043027 cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027)
0.0 2.1 GO:0004177 aminopeptidase activity(GO:0004177)
0.0 0.2 GO:0044729 hemi-methylated DNA-binding(GO:0044729)
0.0 1.2 GO:0036002 pre-mRNA binding(GO:0036002)
0.0 1.9 GO:0003730 mRNA 3'-UTR binding(GO:0003730)
0.0 0.3 GO:0001164 RNA polymerase I regulatory region DNA binding(GO:0001013) RNA polymerase I regulatory region sequence-specific DNA binding(GO:0001163) RNA polymerase I CORE element sequence-specific DNA binding(GO:0001164)
0.0 0.6 GO:0051879 Hsp90 protein binding(GO:0051879)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 2.1 SA B CELL RECEPTOR COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 1.3 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.0 1.0 ST WNT BETA CATENIN PATHWAY Wnt/beta-catenin Pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 REACTOME APOPTOSIS INDUCED DNA FRAGMENTATION Genes involved in Apoptosis induced DNA fragmentation
0.1 2.1 REACTOME ERK MAPK TARGETS Genes involved in ERK/MAPK targets
0.0 0.6 REACTOME PLATELET SENSITIZATION BY LDL Genes involved in Platelet sensitization by LDL
0.0 0.9 REACTOME GLUCURONIDATION Genes involved in Glucuronidation
0.0 0.4 REACTOME PASSIVE TRANSPORT BY AQUAPORINS Genes involved in Passive Transport by Aquaporins
0.0 1.1 REACTOME CROSS PRESENTATION OF SOLUBLE EXOGENOUS ANTIGENS ENDOSOMES Genes involved in Cross-presentation of soluble exogenous antigens (endosomes)
0.0 0.6 REACTOME SIGNAL TRANSDUCTION BY L1 Genes involved in Signal transduction by L1
0.0 0.2 REACTOME SEMA3A PLEXIN REPULSION SIGNALING BY INHIBITING INTEGRIN ADHESION Genes involved in SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion