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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ACAGUAC
Z-value: 0.04
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miRNA associated with seed ACAGUAC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-101-3p.1
|
MIMAT0000099 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ACAGUAC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.1 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 1.8 | 5.4 | GO:0032804 | negative regulation of low-density lipoprotein particle receptor catabolic process(GO:0032804) |
| 0.6 | 4.0 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.0 | 3.6 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.1 | 3.5 | GO:0050849 | negative regulation of calcium-mediated signaling(GO:0050849) |
| 0.0 | 3.4 | GO:0032435 | negative regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032435) |
| 1.1 | 3.3 | GO:0045659 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) regulation of neutrophil differentiation(GO:0045658) negative regulation of neutrophil differentiation(GO:0045659) |
| 1.1 | 3.3 | GO:0090526 | regulation of gluconeogenesis involved in cellular glucose homeostasis(GO:0090526) |
| 0.8 | 3.3 | GO:1902544 | oxidative DNA demethylation(GO:0035511) regulation of DNA N-glycosylase activity(GO:1902544) |
| 0.5 | 3.2 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.2 | GO:0010494 | cytoplasmic stress granule(GO:0010494) |
| 0.0 | 6.2 | GO:0030529 | intracellular ribonucleoprotein complex(GO:0030529) |
| 0.1 | 5.5 | GO:0005811 | lipid particle(GO:0005811) |
| 1.1 | 5.4 | GO:0044354 | pinosome(GO:0044352) macropinosome(GO:0044354) |
| 0.0 | 5.4 | GO:0071013 | catalytic step 2 spliceosome(GO:0071013) |
| 0.0 | 5.3 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 5.0 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 3.8 | GO:0035770 | ribonucleoprotein granule(GO:0035770) |
| 0.0 | 3.8 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
| 0.4 | 3.4 | GO:0035976 | AP1 complex(GO:0035976) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.3 | GO:0019003 | GDP binding(GO:0019003) |
| 0.9 | 5.4 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.1 | 5.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 1.7 | 5.1 | GO:0001069 | regulatory region RNA binding(GO:0001069) |
| 0.0 | 3.9 | GO:0004386 | helicase activity(GO:0004386) |
| 0.0 | 3.8 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.2 | 3.5 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.1 | 3.4 | GO:0032452 | histone demethylase activity(GO:0032452) |
| 1.1 | 3.3 | GO:0016262 | protein N-acetylglucosaminyltransferase activity(GO:0016262) |
| 1.1 | 3.3 | GO:0043739 | G/U mismatch-specific uracil-DNA glycosylase activity(GO:0043739) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 4.6 | PID NECTIN PATHWAY | Nectin adhesion pathway |
| 0.1 | 4.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 4.1 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.0 | 3.7 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.0 | 3.5 | PID TCR PATHWAY | TCR signaling in naïve CD4+ T cells |
| 0.0 | 3.5 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 2.4 | ST P38 MAPK PATHWAY | p38 MAPK Pathway |
| 0.0 | 2.2 | PID INSULIN PATHWAY | Insulin Pathway |
| 0.0 | 2.2 | PID P53 REGULATION PATHWAY | p53 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.8 | REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION | Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription |
| 0.2 | 5.0 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 0.0 | 3.8 | REACTOME MRNA SPLICING | Genes involved in mRNA Splicing |
| 0.2 | 3.3 | REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY | Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway |
| 0.1 | 3.0 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 3.0 | REACTOME MEIOTIC SYNAPSIS | Genes involved in Meiotic Synapsis |
| 0.1 | 2.9 | REACTOME SPHINGOLIPID DE NOVO BIOSYNTHESIS | Genes involved in Sphingolipid de novo biosynthesis |
| 0.1 | 2.7 | REACTOME INSULIN SYNTHESIS AND PROCESSING | Genes involved in Insulin Synthesis and Processing |
| 0.0 | 2.5 | REACTOME DNA REPAIR | Genes involved in DNA Repair |
| 0.1 | 1.8 | REACTOME ANTIGEN PRESENTATION FOLDING ASSEMBLY AND PEPTIDE LOADING OF CLASS I MHC | Genes involved in Antigen Presentation: Folding, assembly and peptide loading of class I MHC |