ISMARA results: ACAUUCA

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ACAUUCA

Z-value: 0.16

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miRNA associated with seed ACAUUCA

Name	miRBASE accession
hsa-miR-181a-5p miRBase	MIMAT0000256
hsa-miR-181b-5p miRBase	MIMAT0000257
hsa-miR-181c-5p miRBase	MIMAT0000258
hsa-miR-181d-5p miRBase	MIMAT0002821
hsa-miR-4262 miRBase	MIMAT0016894

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr20_+_10199468 Show fit	12.52	ENST00000254976.2 ENST00000304886.2	SNAP25 Ensembl NCBI GeneCards UniProt NextProt Show fit	synaptosomal-associated protein, 25kDa
chr4_+_158141843 Show fit	12.45	ENST00000509417.1 ENST00000296526.7	GRIA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	glutamate receptor, ionotropic, AMPA 2
chr14_+_90863327 Show fit	10.52	ENST00000356978.4	CALM1 Ensembl NCBI GeneCards UniProt NextProt Show fit	calmodulin 1 (phosphorylase kinase, delta)
chr8_+_26435359 Show fit	9.89	ENST00000311151.5	DPYSL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	dihydropyrimidinase-like 2
chr5_-_108745689 Show fit	9.10	ENST00000361189.2	PJA2 Ensembl NCBI GeneCards UniProt NextProt Show fit	praja ring finger 2, E3 ubiquitin protein ligase
chr5_+_71403061 Show fit	8.17	ENST00000512974.1 ENST00000296755.7	MAP1B Ensembl NCBI GeneCards UniProt NextProt Show fit	microtubule-associated protein 1B
chr6_-_99797522 Show fit	7.61	ENST00000389677.5	FAXC Ensembl NCBI GeneCards UniProt NextProt Show fit	failed axon connections homolog (Drosophila)
chr20_+_11871371 Show fit	6.99	ENST00000254977.3	BTBD3 Ensembl NCBI GeneCards UniProt NextProt Show fit	BTB (POZ) domain containing 3
chr1_+_50574585 Show fit	6.98	ENST00000371824.1 ENST00000371823.4	ELAVL4 Ensembl NCBI GeneCards UniProt NextProt Show fit	ELAV like neuron-specific RNA binding protein 4
chr15_-_51914996 Show fit	6.88	ENST00000251076.5	DMXL2 Ensembl NCBI GeneCards UniProt NextProt Show fit	Dmx-like 2

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.2	38.6	GO:0007156	homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.1	13.1	GO:0048675	axon extension(GO:0048675)
0.3	12.7	GO:0035329	hippo signaling(GO:0035329)
2.5	12.5	GO:0099590	neurotransmitter receptor internalization(GO:0099590)
0.3	11.8	GO:0035235	ionotropic glutamate receptor signaling pathway(GO:0035235)
0.2	10.9	GO:0010501	RNA secondary structure unwinding(GO:0010501)
1.0	8.2	GO:0032482	Rab protein signal transduction(GO:0032482)
0.5	8.2	GO:0061162	establishment of monopolar cell polarity(GO:0061162) establishment or maintenance of monopolar cell polarity(GO:0061339)
0.8	7.9	GO:0031547	brain-derived neurotrophic factor receptor signaling pathway(GO:0031547)
1.3	7.8	GO:0090170	regulation of Golgi inheritance(GO:0090170)

Showing 1 to 10 of 239 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	14.8	GO:0005815	microtubule organizing center(GO:0005815)
3.1	12.5	GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex(GO:0070032)
2.5	12.4	GO:0098843	postsynaptic endocytic zone(GO:0098843)
0.0	12.4	GO:0016607	nuclear speck(GO:0016607)
0.0	11.4	GO:0014069	postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572)
0.1	10.1	GO:0001750	photoreceptor outer segment(GO:0001750)
0.0	10.0	GO:0005874	microtubule(GO:0005874)
0.1	9.4	GO:0000922	spindle pole(GO:0000922)
0.5	9.2	GO:0000164	protein phosphatase type 1 complex(GO:0000164)
0.6	8.0	GO:0031209	SCAR complex(GO:0031209)

Showing 1 to 10 of 128 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.0	24.9	GO:0005509	calcium ion binding(GO:0005509)
0.1	15.5	GO:0008017	microtubule binding(GO:0008017)
0.4	12.5	GO:0017075	syntaxin-1 binding(GO:0017075)
1.0	12.4	GO:0004971	AMPA glutamate receptor activity(GO:0004971)
0.1	11.2	GO:0044325	ion channel binding(GO:0044325)
3.3	9.9	GO:0004157	dihydropyrimidinase activity(GO:0004157)
0.1	9.1	GO:0004004	ATP-dependent RNA helicase activity(GO:0004004) RNA-dependent ATPase activity(GO:0008186)
0.4	8.6	GO:0034237	protein kinase A regulatory subunit binding(GO:0034237)
0.2	8.1	GO:0017091	AU-rich element binding(GO:0017091)
0.3	7.8	GO:0004708	MAP kinase kinase activity(GO:0004708)

Showing 1 to 10 of 168 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	18.5	PID NCADHERIN PATHWAY	N-cadherin signaling events
0.5	10.3	PID TCR RAS PATHWAY	Ras signaling in the CD4+ TCR pathway
0.3	10.2	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.2	9.7	PID INSULIN GLUCOSE PATHWAY	Insulin-mediated glucose transport
0.1	6.6	SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES	Genes related to regulation of the actin cytoskeleton
0.3	6.0	PID P38 GAMMA DELTA PATHWAY	Signaling mediated by p38-gamma and p38-delta
0.1	5.3	PID NFKAPPAB CANONICAL PATHWAY	Canonical NF-kappaB pathway
0.1	5.0	PID ERBB1 INTERNALIZATION PATHWAY	Internalization of ErbB1
0.1	4.3	PID HDAC CLASSIII PATHWAY	Signaling events mediated by HDAC Class III
0.1	4.1	PID HEDGEHOG GLI PATHWAY	Hedgehog signaling events mediated by Gli proteins

Showing 1 to 10 of 42 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	16.9	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
1.1	15.0	REACTOME RAF MAP KINASE CASCADE	Genes involved in RAF/MAP kinase cascade
0.7	12.5	REACTOME NOREPINEPHRINE NEUROTRANSMITTER RELEASE CYCLE	Genes involved in Norepinephrine Neurotransmitter Release Cycle
1.0	12.4	REACTOME UNBLOCKING OF NMDA RECEPTOR GLUTAMATE BINDING AND ACTIVATION	Genes involved in Unblocking of NMDA receptor, glutamate binding and activation
0.1	12.3	REACTOME SIGNALING BY RHO GTPASES	Genes involved in Signaling by Rho GTPases
0.5	10.5	REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR	Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1	10.5	REACTOME TRANSPORT OF INORGANIC CATIONS ANIONS AND AMINO ACIDS OLIGOPEPTIDES	Genes involved in Transport of inorganic cations/anions and amino acids/oligopeptides
0.5	9.6	REACTOME SYNTHESIS OF PIPS AT THE GOLGI MEMBRANE	Genes involved in Synthesis of PIPs at the Golgi membrane
0.2	7.7	REACTOME GABA A RECEPTOR ACTIVATION	Genes involved in GABA A receptor activation
0.1	7.7	REACTOME MITOTIC PROMETAPHASE	Genes involved in Mitotic Prometaphase

Showing 1 to 10 of 62 entries

Results for ACAUUCA

Z-value: 0.16

Motif logo

miRNA associated with seed ACAUUCA

Activity profile of ACAUUCA motif

Sorted Z-values of ACAUUCA motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ACAUUCA

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: