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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ACCCUGU
Z-value: 0.61
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miRNA associated with seed ACCCUGU
Network of associatons between targets according to the STRING database.
First level regulatory network of ACCCUGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 5.5 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 0.5 | 3.7 | GO:0043634 | polyadenylation-dependent ncRNA catabolic process(GO:0043634) |
| 0.0 | 3.4 | GO:0006310 | DNA recombination(GO:0006310) |
| 0.1 | 3.2 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.1 | 2.9 | GO:0071420 | cellular response to histamine(GO:0071420) |
| 0.3 | 2.7 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 2.6 | GO:0097178 | ruffle assembly(GO:0097178) |
| 0.0 | 2.6 | GO:0045637 | regulation of myeloid cell differentiation(GO:0045637) |
| 0.0 | 2.5 | GO:0090102 | cochlea development(GO:0090102) |
| 0.8 | 2.4 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.2 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.0 | 3.0 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.1 | 2.9 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 2.9 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 2.6 | GO:0030864 | cortical actin cytoskeleton(GO:0030864) |
| 0.0 | 2.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.7 | 2.2 | GO:0034686 | integrin alphav-beta8 complex(GO:0034686) |
| 0.0 | 1.9 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.9 | GO:0005923 | bicellular tight junction(GO:0005923) |
| 0.1 | 1.8 | GO:0014731 | spectrin-associated cytoskeleton(GO:0014731) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.2 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.5 | 3.7 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 3.5 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.3 | 3.0 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.2 | 2.7 | GO:0001042 | RNA polymerase I core binding(GO:0001042) |
| 0.1 | 2.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 2.6 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.8 | 2.5 | GO:0032184 | SUMO polymer binding(GO:0032184) |
| 0.3 | 2.4 | GO:0008142 | oxysterol binding(GO:0008142) |
| 0.2 | 2.4 | GO:0019211 | phosphatase activator activity(GO:0019211) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 3.1 | ST DIFFERENTIATION PATHWAY IN PC12 CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
| 0.0 | 2.7 | WNT SIGNALING | Genes related to Wnt-mediated signal transduction |
| 0.0 | 2.6 | ST TUMOR NECROSIS FACTOR PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 2.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.0 | 1.8 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 1.6 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 1.4 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.0 | 1.1 | ST WNT CA2 CYCLIC GMP PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 1.1 | PID LKB1 PATHWAY | LKB1 signaling events |
| 0.0 | 0.9 | PID VEGF VEGFR PATHWAY | VEGF and VEGFR signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 2.9 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 2.3 | REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA | Genes involved in Circadian Repression of Expression by REV-ERBA |
| 0.0 | 2.2 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.0 | 2.1 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.0 | 1.9 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.1 | 1.8 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.1 | 1.7 | REACTOME MRNA DECAY BY 5 TO 3 EXORIBONUCLEASE | Genes involved in mRNA Decay by 5' to 3' Exoribonuclease |
| 0.1 | 1.6 | REACTOME PROLONGED ERK ACTIVATION EVENTS | Genes involved in Prolonged ERK activation events |
| 0.1 | 1.6 | REACTOME SYNTHESIS OF PA | Genes involved in Synthesis of PA |