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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ACUGGCC

Z-value: 0.77

Motif logo

logo of

miRNA associated with seed ACUGGCC

NamemiRBASE accession
hsa-miR-193a-3p
MIMAT0000459
hsa-miR-193b-3p
MIMAT0002819

Activity profile of ACUGGCC motif

Sorted Z-values of ACUGGCC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr22_-_39548627 6.88 ENST00000216133.5
CBX7
chromobox homolog 7
chr12_+_79258547 3.61 ENST00000457153.2
SYT1
synaptotagmin I
chr4_+_55524085 3.46 ENST00000412167.2
ENST00000288135.5
KIT
v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
chrX_+_110339439 3.32 ENST00000372010.1
ENST00000519681.1
ENST00000372007.5
PAK3
p21 protein (Cdc42/Rac)-activated kinase 3
chr3_-_57199397 3.30 ENST00000296318.7
IL17RD
interleukin 17 receptor D
chr3_-_123603137 2.64 ENST00000360304.3
ENST00000359169.1
ENST00000346322.5
ENST00000360772.3
MYLK
myosin light chain kinase
chr1_+_183605200 2.63 ENST00000304685.4
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr18_-_53255766 2.48 ENST00000566286.1
ENST00000564999.1
ENST00000566279.1
ENST00000354452.3
ENST00000356073.4
TCF4
transcription factor 4
chr11_-_62494821 2.19 ENST00000301785.5
HNRNPUL2
heterogeneous nuclear ribonucleoprotein U-like 2
chr7_+_108210012 2.14 ENST00000249356.3
DNAJB9
DnaJ (Hsp40) homolog, subfamily B, member 9
chr10_-_62149433 2.13 ENST00000280772.2
ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr2_-_217560248 1.90 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chr1_-_92351769 1.88 ENST00000212355.4
TGFBR3
transforming growth factor, beta receptor III
chr14_+_90863327 1.78 ENST00000356978.4
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr20_-_4982132 1.77 ENST00000338244.1
ENST00000424750.2
SLC23A2
solute carrier family 23 (ascorbic acid transporter), member 2
chr5_-_133512683 1.76 ENST00000353411.6
SKP1
S-phase kinase-associated protein 1
chr10_+_70480963 1.73 ENST00000265872.6
ENST00000535016.1
ENST00000538031.1
ENST00000543719.1
ENST00000539539.1
ENST00000543225.1
ENST00000536012.1
ENST00000494903.2
CCAR1
cell division cycle and apoptosis regulator 1
chrX_-_40594755 1.70 ENST00000324817.1
MED14
mediator complex subunit 14
chr12_-_111021110 1.56 ENST00000354300.3
PPTC7
PTC7 protein phosphatase homolog (S. cerevisiae)
chr5_+_177540444 1.52 ENST00000274605.5
N4BP3
NEDD4 binding protein 3
chr14_-_80677970 1.50 ENST00000438257.4
DIO2
deiodinase, iodothyronine, type II
chr11_+_128563652 1.48 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr4_-_87281224 1.39 ENST00000395169.3
ENST00000395161.2
MAPK10
mitogen-activated protein kinase 10
chr2_+_12857015 1.34 ENST00000155926.4
TRIB2
tribbles pseudokinase 2
chr13_+_98794810 1.34 ENST00000595437.1
FARP1
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived)
chr1_+_77333117 1.31 ENST00000477717.1
ST6GALNAC5
ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5
chr2_+_176957619 1.29 ENST00000392539.3
HOXD13
homeobox D13
chr12_-_50297638 1.23 ENST00000320634.3
FAIM2
Fas apoptotic inhibitory molecule 2
chr15_+_64443905 1.21 ENST00000325881.4
SNX22
sorting nexin 22
chr22_+_40390930 1.18 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr5_+_172483347 1.18 ENST00000522692.1
ENST00000296953.2
ENST00000540014.1
ENST00000520420.1
CREBRF
CREB3 regulatory factor
chr18_+_46065393 1.17 ENST00000256413.3
CTIF
CBP80/20-dependent translation initiation factor
chr11_-_115375107 1.17 ENST00000545380.1
ENST00000452722.3
ENST00000537058.1
ENST00000536727.1
ENST00000542447.2
ENST00000331581.6
CADM1
cell adhesion molecule 1
chr2_+_242641442 1.16 ENST00000313552.6
ENST00000406941.1
ING5
inhibitor of growth family, member 5
chr8_-_93115445 1.14 ENST00000523629.1
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr14_-_50698276 1.08 ENST00000216373.5
SOS2
son of sevenless homolog 2 (Drosophila)
chr6_+_39760783 1.03 ENST00000398904.2
ENST00000538976.1
DAAM2
dishevelled associated activator of morphogenesis 2
chr11_-_46940074 0.96 ENST00000378623.1
ENST00000534404.1
LRP4
low density lipoprotein receptor-related protein 4
chr2_-_206950781 0.95 ENST00000403263.1
INO80D
INO80 complex subunit D
chr17_-_4167142 0.91 ENST00000570535.1
ENST00000574367.1
ENST00000341657.4
ENST00000433651.1
ANKFY1
ankyrin repeat and FYVE domain containing 1
chr7_-_143059845 0.89 ENST00000443739.2
FAM131B
family with sequence similarity 131, member B
chr2_+_48541776 0.88 ENST00000413569.1
ENST00000340553.3
FOXN2
forkhead box N2
chr12_-_42538657 0.88 ENST00000398675.3
GXYLT1
glucoside xylosyltransferase 1
chr3_-_128902729 0.83 ENST00000451728.2
ENST00000446936.2
ENST00000502976.1
ENST00000500450.2
ENST00000441626.2
CNBP
CCHC-type zinc finger, nucleic acid binding protein
chr10_-_102279586 0.82 ENST00000370345.3
ENST00000451524.1
ENST00000370329.5
SEC31B
SEC31 homolog B (S. cerevisiae)
chr17_+_68165657 0.82 ENST00000243457.3
KCNJ2
potassium inwardly-rectifying channel, subfamily J, member 2
chr2_-_213403565 0.75 ENST00000342788.4
ENST00000436443.1
ERBB4
v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 4
chr6_-_29527702 0.74 ENST00000377050.4
UBD
ubiquitin D
chrX_-_47479246 0.66 ENST00000295987.7
ENST00000340666.4
SYN1
synapsin I
chr16_-_4166186 0.62 ENST00000294016.3
ADCY9
adenylate cyclase 9
chr19_+_39616410 0.62 ENST00000602004.1
ENST00000599470.1
ENST00000321944.4
ENST00000593480.1
ENST00000358301.3
ENST00000593690.1
ENST00000599386.1
PAK4
p21 protein (Cdc42/Rac)-activated kinase 4
chr12_-_96794143 0.61 ENST00000543119.2
CDK17
cyclin-dependent kinase 17
chrX_+_151806637 0.59 ENST00000370306.2
GABRQ
gamma-aminobutyric acid (GABA) A receptor, theta
chr12_+_11802753 0.59 ENST00000396373.4
ETV6
ets variant 6
chr12_-_104234966 0.57 ENST00000392876.3
NT5DC3
5'-nucleotidase domain containing 3
chr7_-_14029515 0.56 ENST00000430479.1
ENST00000405218.2
ENST00000343495.5
ETV1
ets variant 1
chr2_+_113931513 0.55 ENST00000245796.6
ENST00000441564.3
PSD4
pleckstrin and Sec7 domain containing 4
chr17_-_33416231 0.53 ENST00000584655.1
ENST00000447669.2
ENST00000315249.7
RFFL
ring finger and FYVE-like domain containing E3 ubiquitin protein ligase
chr7_+_155250824 0.52 ENST00000297375.4
EN2
engrailed homeobox 2
chr14_+_23775971 0.52 ENST00000250405.5
BCL2L2
BCL2-like 2
chr3_+_71803201 0.50 ENST00000304411.2
GPR27
G protein-coupled receptor 27
chr1_+_151584544 0.46 ENST00000458013.2
ENST00000368843.3
SNX27
sorting nexin family member 27
chr17_+_8213590 0.44 ENST00000361926.3
ARHGEF15
Rho guanine nucleotide exchange factor (GEF) 15
chr16_+_56225248 0.43 ENST00000262493.6
GNAO1
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O
chr2_-_69870835 0.43 ENST00000409085.4
ENST00000406297.3
AAK1
AP2 associated kinase 1
chr10_-_38146510 0.42 ENST00000395867.3
ZNF248
zinc finger protein 248
chr14_-_27066636 0.40 ENST00000267422.7
ENST00000344429.5
ENST00000574031.1
ENST00000465357.2
ENST00000547619.1
NOVA1
neuro-oncological ventral antigen 1
chr17_+_44668035 0.40 ENST00000398238.4
ENST00000225282.8
NSF
N-ethylmaleimide-sensitive factor
chr9_-_135819987 0.38 ENST00000298552.3
ENST00000403810.1
TSC1
tuberous sclerosis 1
chr20_+_57226284 0.36 ENST00000458280.1
ENST00000355957.5
ENST00000361770.5
ENST00000312283.8
ENST00000412911.1
ENST00000359617.4
ENST00000371141.4
STX16
syntaxin 16
chr11_-_124670550 0.36 ENST00000239614.4
MSANTD2
Myb/SANT-like DNA-binding domain containing 2
chr9_-_37465396 0.33 ENST00000307750.4
ZBTB5
zinc finger and BTB domain containing 5
chr11_+_120207787 0.33 ENST00000397843.2
ENST00000356641.3
ARHGEF12
Rho guanine nucleotide exchange factor (GEF) 12
chr1_-_169863016 0.32 ENST00000367772.4
ENST00000367771.6
SCYL3
SCY1-like 3 (S. cerevisiae)
chr11_-_128392085 0.31 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
ETS1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr13_+_111365602 0.31 ENST00000333219.7
ING1
inhibitor of growth family, member 1
chr2_+_29204161 0.31 ENST00000379558.4
ENST00000403861.2
FAM179A
family with sequence similarity 179, member A
chr18_+_55711575 0.30 ENST00000356462.6
ENST00000400345.3
ENST00000589054.1
ENST00000256832.7
NEDD4L
neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase
chr1_+_109792641 0.30 ENST00000271332.3
CELSR2
cadherin, EGF LAG seven-pass G-type receptor 2
chr11_+_118307179 0.26 ENST00000534358.1
ENST00000531904.2
ENST00000389506.5
ENST00000354520.4
KMT2A
lysine (K)-specific methyltransferase 2A
chr21_-_35831880 0.25 ENST00000399289.3
ENST00000432085.1
KCNE1
potassium voltage-gated channel, Isk-related family, member 1
chr9_-_3525968 0.23 ENST00000382004.3
ENST00000302303.1
ENST00000449190.1
RFX3
regulatory factor X, 3 (influences HLA class II expression)
chr12_+_94542459 0.22 ENST00000258526.4
PLXNC1
plexin C1
chr19_-_14629224 0.22 ENST00000254322.2
DNAJB1
DnaJ (Hsp40) homolog, subfamily B, member 1
chr5_+_133861790 0.18 ENST00000395003.1
PHF15
jade family PHD finger 2
chr10_-_99052382 0.17 ENST00000453547.2
ENST00000316676.8
ENST00000358308.3
ENST00000466484.1
ENST00000358531.4
ARHGAP19-SLIT1
ARHGAP19
ARHGAP19-SLIT1 readthrough (NMD candidate)
Rho GTPase activating protein 19
chr14_+_57046500 0.15 ENST00000261556.6
TMEM260
transmembrane protein 260
chr17_-_66287257 0.14 ENST00000327268.4
SLC16A6
solute carrier family 16, member 6
chr1_+_203764742 0.14 ENST00000432282.1
ENST00000453771.1
ENST00000367214.1
ENST00000367212.3
ENST00000332127.4
ZC3H11A
zinc finger CCCH-type containing 11A
chr10_+_97515409 0.13 ENST00000371207.3
ENST00000543964.1
ENTPD1
ectonucleoside triphosphate diphosphohydrolase 1
chr22_+_24666763 0.13 ENST00000437398.1
ENST00000421374.1
ENST00000314328.9
ENST00000541492.1
SPECC1L
sperm antigen with calponin homology and coiled-coil domains 1-like
chr20_+_42086525 0.09 ENST00000244020.3
SRSF6
serine/arginine-rich splicing factor 6
chr17_+_48796905 0.09 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr15_+_84322827 0.07 ENST00000286744.5
ENST00000567476.1
ADAMTSL3
ADAMTS-like 3
chr17_+_61627814 0.07 ENST00000310827.4
ENST00000431926.1
ENST00000415273.2
DCAF7
DDB1 and CUL4 associated factor 7
chr15_-_61521495 0.07 ENST00000335670.6
RORA
RAR-related orphan receptor A
chr8_-_91095099 0.05 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr17_-_38020392 0.05 ENST00000346872.3
ENST00000439167.2
ENST00000377945.3
ENST00000394189.2
ENST00000377944.3
ENST00000377958.2
ENST00000535189.1
ENST00000377952.2
IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr5_+_38846101 0.04 ENST00000274276.3
OSMR
oncostatin M receptor
chr20_-_14318248 0.04 ENST00000378053.3
ENST00000341420.4
FLRT3
fibronectin leucine rich transmembrane protein 3
chr4_-_23891693 0.04 ENST00000264867.2
PPARGC1A
peroxisome proliferator-activated receptor gamma, coactivator 1 alpha
chr1_+_145507587 0.03 ENST00000330165.8
ENST00000369307.3
RBM8A
RNA binding motif protein 8A
chr1_-_150552006 0.02 ENST00000307940.3
ENST00000369026.2
MCL1
myeloid cell leukemia sequence 1 (BCL2-related)

Network of associatons between targets according to the STRING database.

First level regulatory network of ACUGGCC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0098746 fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746)
1.2 3.5 GO:0048170 response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.6 1.9 GO:1904204 regulation of skeletal muscle hypertrophy(GO:1904204)
0.6 1.9 GO:0007181 transforming growth factor beta receptor complex assembly(GO:0007181)
0.5 2.1 GO:0072658 positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827)
0.4 1.2 GO:1900169 regulation of glucocorticoid mediated signaling pathway(GO:1900169)
0.3 2.6 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.3 1.0 GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395)
0.3 1.2 GO:0042271 susceptibility to natural killer cell mediated cytotoxicity(GO:0042271)
0.3 1.3 GO:0045074 interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074)
0.3 0.8 GO:2000364 regulation of STAT protein import into nucleus(GO:2000364) positive regulation of STAT protein import into nucleus(GO:2000366)
0.2 1.3 GO:0048619 embryonic hindgut morphogenesis(GO:0048619)
0.2 0.8 GO:0090076 relaxation of skeletal muscle(GO:0090076)
0.2 1.8 GO:0035461 vitamin transmembrane transport(GO:0035461)
0.2 1.8 GO:0010265 SCF complex assembly(GO:0010265)
0.2 1.4 GO:0007258 JUN phosphorylation(GO:0007258)
0.2 0.9 GO:0048549 positive regulation of pinocytosis(GO:0048549)
0.1 0.7 GO:0070842 aggresome assembly(GO:0070842)
0.1 3.3 GO:0010763 positive regulation of fibroblast migration(GO:0010763)
0.1 1.5 GO:0006451 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.1 0.5 GO:2001271 negative regulation of cysteine-type endopeptidase activity involved in execution phase of apoptosis(GO:2001271)
0.1 0.5 GO:1900738 positive regulation of phospholipase C-activating G-protein coupled receptor signaling pathway(GO:1900738)
0.1 0.6 GO:0007296 vitellogenesis(GO:0007296)
0.1 1.3 GO:0021702 cerebellar Purkinje cell layer formation(GO:0021694) cerebellar Purkinje cell differentiation(GO:0021702)
0.1 0.4 GO:0051029 rRNA transport(GO:0051029)
0.1 0.2 GO:0002071 glandular epithelial cell maturation(GO:0002071) type B pancreatic cell maturation(GO:0072560)
0.1 0.5 GO:0060011 Sertoli cell proliferation(GO:0060011)
0.1 1.5 GO:0035855 megakaryocyte development(GO:0035855)
0.1 0.3 GO:1901674 histone H3-K27 acetylation(GO:0043974) regulation of histone H3-K27 acetylation(GO:1901674)
0.1 0.3 GO:2001288 positive regulation of caveolin-mediated endocytosis(GO:2001288)
0.1 1.3 GO:0009312 oligosaccharide biosynthetic process(GO:0009312)
0.0 0.5 GO:1990403 embryonic brain development(GO:1990403)
0.0 0.3 GO:0021999 neural plate anterior/posterior regionalization(GO:0021999)
0.0 0.3 GO:0030578 PML body organization(GO:0030578)
0.0 0.4 GO:0061299 retina vasculature morphogenesis in camera-type eye(GO:0061299)
0.0 0.5 GO:0001767 establishment of lymphocyte polarity(GO:0001767)
0.0 0.6 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.6 GO:0071880 adenylate cyclase-activating adrenergic receptor signaling pathway(GO:0071880)
0.0 0.3 GO:1902260 negative regulation of delayed rectifier potassium channel activity(GO:1902260)
0.0 0.6 GO:0007638 mechanosensory behavior(GO:0007638)
0.0 2.1 GO:0030433 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433)
0.0 1.1 GO:0045599 negative regulation of fat cell differentiation(GO:0045599)
0.0 0.4 GO:0090161 Golgi ribbon formation(GO:0090161)
0.0 0.0 GO:1903378 positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway(GO:1903378)
0.0 0.7 GO:2000300 regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.4 GO:2000369 regulation of clathrin-mediated endocytosis(GO:2000369)
0.0 4.2 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.9 GO:0016266 O-glycan processing(GO:0016266)
0.0 0.2 GO:0070389 chaperone cofactor-dependent protein refolding(GO:0070389)
0.0 1.0 GO:0043966 histone H3 acetylation(GO:0043966)
0.0 0.4 GO:0001921 positive regulation of receptor recycling(GO:0001921)
0.0 0.9 GO:0035914 skeletal muscle cell differentiation(GO:0035914)
0.0 1.0 GO:0007368 determination of left/right symmetry(GO:0007368)
0.0 1.2 GO:0006446 regulation of translational initiation(GO:0006446)
0.0 0.1 GO:0060501 positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501)
0.0 1.7 GO:0035023 regulation of Rho protein signal transduction(GO:0035023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0060200 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.5 6.9 GO:0035102 PRC1 complex(GO:0035102)
0.5 1.9 GO:0034673 inhibin-betaglycan-ActRII complex(GO:0034673)
0.3 1.7 GO:0070847 core mediator complex(GO:0070847)
0.2 1.9 GO:0042567 insulin-like growth factor ternary complex(GO:0042567)
0.2 1.8 GO:0031467 Cul7-RING ubiquitin ligase complex(GO:0031467)
0.2 0.9 GO:0044354 pinosome(GO:0044352) macropinosome(GO:0044354)
0.1 2.1 GO:0043194 axon initial segment(GO:0043194)
0.1 1.0 GO:0070775 H3 histone acetyltransferase complex(GO:0070775) MOZ/MORF histone acetyltransferase complex(GO:0070776)
0.1 0.4 GO:0033596 TSC1-TSC2 complex(GO:0033596)
0.1 3.5 GO:0042629 mast cell granule(GO:0042629)
0.1 1.0 GO:0016600 flotillin complex(GO:0016600)
0.0 1.8 GO:0009925 basal plasma membrane(GO:0009925)
0.0 0.3 GO:0071203 WASH complex(GO:0071203)
0.0 0.5 GO:0097136 Bcl-2 family protein complex(GO:0097136)
0.0 3.2 GO:0032154 cleavage furrow(GO:0032154) cell surface furrow(GO:0097610)
0.0 0.6 GO:0008074 guanylate cyclase complex, soluble(GO:0008074)
0.0 0.7 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.8 GO:0005790 smooth endoplasmic reticulum(GO:0005790)
0.0 0.6 GO:1902711 GABA-A receptor complex(GO:1902711)
0.0 1.8 GO:0005913 cell-cell adherens junction(GO:0005913)
0.0 0.7 GO:0016235 aggresome(GO:0016235)
0.0 0.8 GO:0030120 vesicle coat(GO:0030120)
0.0 2.5 GO:0032993 protein-DNA complex(GO:0032993)
0.0 1.8 GO:0000922 spindle pole(GO:0000922)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.9 2.6 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.7 3.6 GO:0030348 syntaxin-3 binding(GO:0030348)
0.6 1.8 GO:0008523 sodium-dependent multivitamin transmembrane transporter activity(GO:0008523)
0.5 2.6 GO:0004687 myosin light chain kinase activity(GO:0004687)
0.5 3.3 GO:0030368 interleukin-17 receptor activity(GO:0030368)
0.4 1.3 GO:0001665 alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity(GO:0001665)
0.2 1.5 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.2 4.2 GO:0004716 receptor signaling protein tyrosine kinase activity(GO:0004716)
0.2 1.4 GO:0016909 JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909)
0.2 2.5 GO:0001087 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.2 1.9 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 0.9 GO:0035252 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.1 3.3 GO:0004708 MAP kinase kinase activity(GO:0004708)
0.1 2.1 GO:0051787 misfolded protein binding(GO:0051787)
0.1 1.7 GO:0042809 vitamin D receptor binding(GO:0042809)
0.1 1.9 GO:0048185 activin binding(GO:0048185)
0.1 1.8 GO:0097602 cullin family protein binding(GO:0097602)
0.1 0.3 GO:0045322 unmethylated CpG binding(GO:0045322)
0.1 1.3 GO:0055106 ubiquitin-protein transferase regulator activity(GO:0055106)
0.1 1.3 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.1 1.1 GO:0086008 voltage-gated potassium channel activity involved in cardiac muscle cell action potential repolarization(GO:0086008)
0.0 1.0 GO:0034185 apolipoprotein binding(GO:0034185)
0.0 2.1 GO:0030507 spectrin binding(GO:0030507)
0.0 0.7 GO:0070628 proteasome binding(GO:0070628)
0.0 0.4 GO:0051429 corticotropin-releasing hormone receptor binding(GO:0051429) corticotropin-releasing hormone receptor 1 binding(GO:0051430)
0.0 0.3 GO:0019871 sodium channel inhibitor activity(GO:0019871)
0.0 1.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.0 0.4 GO:0035612 AP-2 adaptor complex binding(GO:0035612)
0.0 0.5 GO:0051400 BH domain binding(GO:0051400)
0.0 0.6 GO:0004383 guanylate cyclase activity(GO:0004383)
0.0 1.9 GO:0005089 Rho guanyl-nucleotide exchange factor activity(GO:0005089)
0.0 0.6 GO:0098641 cadherin binding involved in cell-cell adhesion(GO:0098641)
0.0 0.6 GO:0005326 neurotransmitter transporter activity(GO:0005326)
0.0 0.6 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 1.5 GO:0035064 methylated histone binding(GO:0035064)
0.0 0.4 GO:0032794 GTPase activating protein binding(GO:0032794)
0.0 0.0 GO:0004924 oncostatin-M receptor activity(GO:0004924)
0.0 0.4 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.4 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.5 GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding(GO:0000980)
0.0 0.1 GO:0008142 oxysterol binding(GO:0008142)
0.0 2.1 GO:0035091 phosphatidylinositol binding(GO:0035091)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 6.6 SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES Genes related to regulation of the actin cytoskeleton
0.1 5.0 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 1.8 PID BETA CATENIN DEG PATHWAY Degradation of beta catenin
0.0 2.6 PID FGF PATHWAY FGF signaling pathway
0.0 0.4 PID S1P S1P4 PATHWAY S1P4 pathway
0.0 1.1 SIG IL4RECEPTOR IN B LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 2.1 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 1.4 PID KIT PATHWAY Signaling events mediated by Stem cell factor receptor (c-Kit)
0.0 0.6 PID LPA4 PATHWAY LPA4-mediated signaling events
0.0 1.2 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 0.8 PID ERBB NETWORK PATHWAY ErbB receptor signaling network
0.0 0.4 SIG PIP3 SIGNALING IN CARDIAC MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.8 PID TGFBR PATHWAY TGF-beta receptor signaling

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.3 REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE Genes involved in Dopamine Neurotransmitter Release Cycle
0.1 3.5 REACTOME REGULATION OF KIT SIGNALING Genes involved in Regulation of KIT signaling
0.1 1.8 REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor
0.1 1.7 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.1 1.9 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.4 REACTOME ACTIVATION OF THE AP1 FAMILY OF TRANSCRIPTION FACTORS Genes involved in Activation of the AP-1 family of transcription factors
0.1 1.8 REACTOME PROLACTIN RECEPTOR SIGNALING Genes involved in Prolactin receptor signaling
0.1 2.1 REACTOME INTERACTION BETWEEN L1 AND ANKYRINS Genes involved in Interaction between L1 and Ankyrins
0.1 1.5 REACTOME AMINE DERIVED HORMONES Genes involved in Amine-derived hormones
0.1 0.6 REACTOME ADENYLATE CYCLASE ACTIVATING PATHWAY Genes involved in Adenylate cyclase activating pathway
0.1 2.5 REACTOME MYOGENESIS Genes involved in Myogenesis
0.0 2.6 REACTOME SMOOTH MUSCLE CONTRACTION Genes involved in Smooth Muscle Contraction
0.0 1.2 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.0 2.1 REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S Genes involved in Activation of Chaperone Genes by XBP1(S)
0.0 1.8 REACTOME METABOLISM OF VITAMINS AND COFACTORS Genes involved in Metabolism of vitamins and cofactors
0.0 0.9 REACTOME A TETRASACCHARIDE LINKER SEQUENCE IS REQUIRED FOR GAG SYNTHESIS Genes involved in A tetrasaccharide linker sequence is required for GAG synthesis
0.0 0.4 REACTOME INHIBITION OF INSULIN SECRETION BY ADRENALINE NORADRENALINE Genes involved in Inhibition of Insulin Secretion by Adrenaline/Noradrenaline
0.0 0.8 REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
0.0 0.4 REACTOME REGULATION OF RHEB GTPASE ACTIVITY BY AMPK Genes involved in Regulation of Rheb GTPase activity by AMPK
0.0 0.8 REACTOME NUCLEAR SIGNALING BY ERBB4 Genes involved in Nuclear signaling by ERBB4
0.0 0.4 REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS Genes involved in Proteolytic cleavage of SNARE complex proteins
0.0 0.4 REACTOME TRAFFICKING OF GLUR2 CONTAINING AMPA RECEPTORS Genes involved in Trafficking of GluR2-containing AMPA receptors