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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ACUGGCC
Z-value: 0.77
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miRNA associated with seed ACUGGCC
Network of associatons between targets according to the STRING database.
First level regulatory network of ACUGGCC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 4.2 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
| 1.2 | 3.6 | GO:0098746 | fast, calcium ion-dependent exocytosis of neurotransmitter(GO:0098746) |
| 1.2 | 3.5 | GO:0048170 | response to stem cell factor(GO:0036215) cellular response to stem cell factor stimulus(GO:0036216) Kit signaling pathway(GO:0038109) erythropoietin-mediated signaling pathway(GO:0038162) positive regulation of long-term neuronal synaptic plasticity(GO:0048170) |
| 0.1 | 3.3 | GO:0010763 | positive regulation of fibroblast migration(GO:0010763) |
| 0.3 | 2.6 | GO:0060414 | aorta smooth muscle tissue morphogenesis(GO:0060414) |
| 0.5 | 2.1 | GO:0072658 | positive regulation of cell communication by electrical coupling(GO:0010650) maintenance of protein location in membrane(GO:0072658) maintenance of protein location in plasma membrane(GO:0072660) positive regulation of membrane depolarization during cardiac muscle cell action potential(GO:1900827) |
| 0.0 | 2.1 | GO:0030433 | ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) |
| 0.6 | 1.9 | GO:1904204 | regulation of skeletal muscle hypertrophy(GO:1904204) |
| 0.6 | 1.9 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.2 | 1.8 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 6.9 | GO:0035102 | PRC1 complex(GO:0035102) |
| 0.7 | 3.6 | GO:0060200 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 3.5 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.0 | 3.2 | GO:0032154 | cleavage furrow(GO:0032154) cell surface furrow(GO:0097610) |
| 0.0 | 2.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.1 | 2.1 | GO:0043194 | axon initial segment(GO:0043194) |
| 0.5 | 1.9 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 1.9 | GO:0042567 | insulin-like growth factor ternary complex(GO:0042567) |
| 0.2 | 1.8 | GO:0031467 | Cul7-RING ubiquitin ligase complex(GO:0031467) |
| 0.0 | 1.8 | GO:0009925 | basal plasma membrane(GO:0009925) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.2 | GO:0004716 | receptor signaling protein tyrosine kinase activity(GO:0004716) |
| 0.7 | 3.6 | GO:0030348 | syntaxin-3 binding(GO:0030348) |
| 0.5 | 3.3 | GO:0030368 | interleukin-17 receptor activity(GO:0030368) |
| 0.1 | 3.3 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.9 | 2.6 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.5 | 2.6 | GO:0004687 | myosin light chain kinase activity(GO:0004687) |
| 0.2 | 2.5 | GO:0001087 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087) |
| 0.1 | 2.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 2.1 | GO:0030507 | spectrin binding(GO:0030507) |
| 0.0 | 2.1 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 5.0 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.6 | PID FGF PATHWAY | FGF signaling pathway |
| 0.0 | 2.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 1.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.0 | 1.4 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.0 | 1.2 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 1.1 | SIG IL4RECEPTOR IN B LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.8 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.0 | 0.8 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 4.3 | REACTOME DOPAMINE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Dopamine Neurotransmitter Release Cycle |
| 0.1 | 3.5 | REACTOME REGULATION OF KIT SIGNALING | Genes involved in Regulation of KIT signaling |
| 0.0 | 2.6 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.1 | 2.5 | REACTOME MYOGENESIS | Genes involved in Myogenesis |
| 0.1 | 2.1 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 2.1 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.1 | 1.9 | REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS | Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| 0.1 | 1.8 | REACTOME RAS ACTIVATION UOPN CA2 INFUX THROUGH NMDA RECEPTOR | Genes involved in Ras activation uopn Ca2+ infux through NMDA receptor |
| 0.1 | 1.8 | REACTOME PROLACTIN RECEPTOR SIGNALING | Genes involved in Prolactin receptor signaling |
| 0.0 | 1.8 | REACTOME METABOLISM OF VITAMINS AND COFACTORS | Genes involved in Metabolism of vitamins and cofactors |