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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AGCUGCC
Z-value: 0.75
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miRNA associated with seed AGCUGCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-22-3p
|
MIMAT0000077 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUGCC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 20.9 | GO:1903898 | negative regulation of PERK-mediated unfolded protein response(GO:1903898) |
| 3.6 | 10.7 | GO:0032290 | peripheral nervous system myelin formation(GO:0032290) |
| 1.6 | 6.6 | GO:0043983 | histone H4-K12 acetylation(GO:0043983) |
| 1.1 | 6.4 | GO:2000323 | negative regulation of glucocorticoid receptor signaling pathway(GO:2000323) |
| 0.2 | 6.0 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.1 | 6.0 | GO:0016573 | histone acetylation(GO:0016573) |
| 1.4 | 5.8 | GO:1901162 | primary amino compound biosynthetic process(GO:1901162) |
| 0.5 | 5.4 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 5.0 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.1 | 4.8 | GO:0009083 | branched-chain amino acid metabolic process(GO:0009081) branched-chain amino acid catabolic process(GO:0009083) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 20.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.6 | 10.7 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.3 | 8.7 | GO:0071011 | precatalytic spliceosome(GO:0071011) |
| 0.1 | 7.5 | GO:0000123 | histone acetyltransferase complex(GO:0000123) |
| 0.1 | 5.9 | GO:0034705 | voltage-gated potassium channel complex(GO:0008076) potassium channel complex(GO:0034705) |
| 0.4 | 5.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.5 | 5.2 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.1 | 5.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.4 | 4.8 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 4.7 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 21.0 | GO:0019888 | protein phosphatase regulator activity(GO:0019888) |
| 0.2 | 12.3 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.9 | 10.7 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.4 | 8.9 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 7.3 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) |
| 0.1 | 7.1 | GO:0070888 | E-box binding(GO:0070888) |
| 0.2 | 7.0 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.5 | 6.7 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
| 0.0 | 6.7 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 6.6 | GO:0003688 | DNA replication origin binding(GO:0003688) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 8.8 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 0.1 | 7.8 | PID AR TF PATHWAY | Regulation of Androgen receptor activity |
| 0.2 | 7.5 | PID EPHA2 FWD PATHWAY | EPHA2 forward signaling |
| 0.3 | 6.4 | PID CIRCADIAN PATHWAY | Circadian rhythm pathway |
| 0.1 | 4.8 | PID FGF PATHWAY | FGF signaling pathway |
| 0.1 | 4.2 | PID HDAC CLASSI PATHWAY | Signaling events mediated by HDAC Class I |
| 0.1 | 4.1 | SA B CELL RECEPTOR COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.1 | 3.8 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 3.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.2 | 3.4 | PID RANBP2 PATHWAY | Sumoylation by RanBP2 regulates transcriptional repression |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.8 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.1 | 6.5 | REACTOME BMAL1 CLOCK NPAS2 ACTIVATES CIRCADIAN EXPRESSION | Genes involved in BMAL1:CLOCK/NPAS2 Activates Circadian Expression |
| 0.1 | 6.5 | REACTOME NOTCH1 INTRACELLULAR DOMAIN REGULATES TRANSCRIPTION | Genes involved in NOTCH1 Intracellular Domain Regulates Transcription |
| 0.2 | 5.8 | REACTOME METABOLISM OF POLYAMINES | Genes involved in Metabolism of polyamines |
| 0.4 | 5.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.3 | 4.8 | REACTOME IL 6 SIGNALING | Genes involved in Interleukin-6 signaling |
| 0.1 | 4.8 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 4.6 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.0 | 4.5 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.1 | 3.7 | REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE | Genes involved in Amino acid transport across the plasma membrane |