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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AGCUUAU
Z-value: 0.74
Motif logo
miRNA associated with seed AGCUUAU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGCUUAU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.3 | 13.0 | GO:0060940 | epithelial to mesenchymal transition involved in cardiac fibroblast development(GO:0060940) |
| 2.2 | 8.9 | GO:1903984 | positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984) |
| 0.5 | 7.7 | GO:0043374 | CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.0 | 7.1 | GO:0045637 | regulation of myeloid cell differentiation(GO:0045637) |
| 1.0 | 6.7 | GO:1904627 | response to phorbol 13-acetate 12-myristate(GO:1904627) cellular response to phorbol 13-acetate 12-myristate(GO:1904628) |
| 0.1 | 6.1 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.4 | 5.9 | GO:0071786 | endoplasmic reticulum tubular network organization(GO:0071786) |
| 0.0 | 5.3 | GO:0050868 | negative regulation of T cell activation(GO:0050868) |
| 1.3 | 5.1 | GO:2000686 | regulation of rubidium ion transmembrane transporter activity(GO:2000686) |
| 0.3 | 5.1 | GO:0071420 | cellular response to histamine(GO:0071420) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 16.3 | GO:0005794 | Golgi apparatus(GO:0005794) |
| 0.1 | 9.8 | GO:0031225 | anchored component of membrane(GO:0031225) |
| 0.5 | 8.9 | GO:0031089 | platelet dense granule lumen(GO:0031089) |
| 0.2 | 8.5 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.5 | 7.5 | GO:0005662 | DNA replication factor A complex(GO:0005662) |
| 0.2 | 6.1 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 5.4 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 5.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 5.1 | GO:1902711 | GABA-A receptor complex(GO:1902711) |
| 0.0 | 5.1 | GO:0005923 | bicellular tight junction(GO:0005923) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 21.5 | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001227) |
| 0.5 | 12.9 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 12.7 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.5 | 8.8 | GO:0035925 | mRNA 3'-UTR AU-rich region binding(GO:0035925) |
| 0.0 | 7.9 | GO:0001077 | transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) |
| 0.0 | 7.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.4 | 6.9 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 6.3 | GO:0019208 | phosphatase regulator activity(GO:0019208) |
| 0.3 | 6.1 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.7 | 5.1 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 9.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 7.9 | PID ER NONGENOMIC PATHWAY | Plasma membrane estrogen receptor signaling |
| 0.1 | 7.8 | PID SHP2 PATHWAY | SHP2 signaling |
| 0.1 | 6.6 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.1 | 6.3 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.1 | 4.8 | PID RXR VDR PATHWAY | RXR and RAR heterodimerization with other nuclear receptor |
| 0.2 | 4.4 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.1 | 3.9 | PID ALK1 PATHWAY | ALK1 signaling events |
| 0.0 | 2.7 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.1 | 2.5 | PID RAS PATHWAY | Regulation of Ras family activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.7 | REACTOME EGFR DOWNREGULATION | Genes involved in EGFR downregulation |
| 0.1 | 6.6 | REACTOME APOPTOTIC CLEAVAGE OF CELLULAR PROTEINS | Genes involved in Apoptotic cleavage of cellular proteins |
| 0.2 | 5.1 | REACTOME GABA A RECEPTOR ACTIVATION | Genes involved in GABA A receptor activation |
| 0.1 | 4.4 | REACTOME TRAF6 MEDIATED NFKB ACTIVATION | Genes involved in TRAF6 mediated NF-kB activation |
| 0.4 | 4.3 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.0 | 3.9 | REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION | Genes involved in Transcriptional Regulation of White Adipocyte Differentiation |
| 0.0 | 3.7 | REACTOME NUCLEAR RECEPTOR TRANSCRIPTION PATHWAY | Genes involved in Nuclear Receptor transcription pathway |
| 0.1 | 3.4 | REACTOME PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | Genes involved in Phosphorylation of CD3 and TCR zeta chains |
| 0.0 | 3.3 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 2.9 | REACTOME SIGNALING BY CONSTITUTIVELY ACTIVE EGFR | Genes involved in Signaling by constitutively active EGFR |