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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AGUGCUU
Z-value: 0.08
Motif logo
miRNA associated with seed AGUGCUU
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGCUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 7.8 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 0.0 | 7.1 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 1.3 | 6.5 | GO:0071874 | cellular response to norepinephrine stimulus(GO:0071874) |
| 0.1 | 5.8 | GO:1900449 | regulation of glutamate receptor signaling pathway(GO:1900449) |
| 0.5 | 5.3 | GO:0001766 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
| 0.4 | 5.2 | GO:0060137 | maternal process involved in parturition(GO:0060137) |
| 1.5 | 4.5 | GO:0007412 | axon target recognition(GO:0007412) regulation of synaptic vesicle fusion to presynaptic membrane(GO:0031630) |
| 0.7 | 4.2 | GO:0010724 | regulation of definitive erythrocyte differentiation(GO:0010724) |
| 0.7 | 4.2 | GO:2000324 | positive regulation of glucocorticoid receptor signaling pathway(GO:2000324) |
| 0.2 | 4.1 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.2 | GO:0045211 | postsynaptic membrane(GO:0045211) |
| 0.5 | 7.4 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.7 | 7.2 | GO:0097449 | astrocyte projection(GO:0097449) |
| 0.2 | 5.3 | GO:0043218 | compact myelin(GO:0043218) |
| 0.9 | 4.5 | GO:0048787 | presynaptic active zone membrane(GO:0048787) |
| 0.1 | 4.3 | GO:0030670 | phagocytic vesicle membrane(GO:0030670) |
| 0.4 | 3.8 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.0 | 3.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 3.5 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 3.1 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 11.5 | GO:0010858 | calcium-dependent protein kinase regulator activity(GO:0010858) |
| 0.1 | 7.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.6 | 6.5 | GO:0051425 | PTB domain binding(GO:0051425) |
| 0.4 | 5.3 | GO:0019911 | structural constituent of myelin sheath(GO:0019911) |
| 0.2 | 4.5 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 4.1 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.4 | 3.9 | GO:0097157 | pre-mRNA intronic binding(GO:0097157) |
| 0.0 | 3.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.4 | 3.8 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.0 | 3.8 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 7.6 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.1 | 4.9 | PID IL12 STAT4 PATHWAY | IL12 signaling mediated by STAT4 |
| 0.1 | 4.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.1 | 4.0 | PID GLYPICAN 1PATHWAY | Glypican 1 network |
| 0.1 | 3.5 | SA PTEN PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.1 | 2.2 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.0 | 1.9 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 1.8 | PID PS1 PATHWAY | Presenilin action in Notch and Wnt signaling |
| 0.1 | 1.7 | PID P38 GAMMA DELTA PATHWAY | Signaling mediated by p38-gamma and p38-delta |
| 0.1 | 1.7 | PID WNT SIGNALING PATHWAY | Wnt signaling network |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 7.2 | REACTOME GLUTAMATE NEUROTRANSMITTER RELEASE CYCLE | Genes involved in Glutamate Neurotransmitter Release Cycle |
| 0.3 | 6.5 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.1 | 3.8 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 3.5 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.1 | 3.4 | REACTOME KINESINS | Genes involved in Kinesins |
| 0.1 | 3.3 | REACTOME NRAGE SIGNALS DEATH THROUGH JNK | Genes involved in NRAGE signals death through JNK |
| 0.1 | 2.5 | REACTOME SIGNAL REGULATORY PROTEIN SIRP FAMILY INTERACTIONS | Genes involved in Signal regulatory protein (SIRP) family interactions |
| 0.1 | 2.5 | REACTOME VOLTAGE GATED POTASSIUM CHANNELS | Genes involved in Voltage gated Potassium channels |
| 0.0 | 2.4 | REACTOME ACTIVATION OF NF KAPPAB IN B CELLS | Genes involved in Activation of NF-kappaB in B Cells |
| 0.0 | 2.2 | REACTOME TRAFFICKING OF AMPA RECEPTORS | Genes involved in Trafficking of AMPA receptors |