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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AGUGGUU
Z-value: 0.07
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miRNA associated with seed AGUGGUU
| Name | miRBASE accession |
|---|---|
|
hsa-miR-140-5p
|
MIMAT0000431 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr1_-_68299130 Show fit | 8.40 |
ENST00000370982.3
|
guanine nucleotide binding protein (G protein), gamma 12 |
|
| chr3_-_149688896 Show fit | 6.97 |
ENST00000239940.7
|
profilin 2 |
|
| chr1_+_182992545 Show fit | 6.81 |
ENST00000258341.4
|
laminin, gamma 1 (formerly LAMB2) |
|
| chr15_-_48937982 Show fit | 6.77 |
ENST00000316623.5
|
fibrillin 1 |
|
| chr1_+_11994715 Show fit | 6.09 |
ENST00000449038.1
ENST00000376369.3 ENST00000429000.2 ENST00000196061.4 |
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 1 |
|
| chr2_-_183903133 Show fit | 5.79 |
ENST00000361354.4
|
NCK-associated protein 1 |
|
| chr4_+_55095264 Show fit | 5.73 |
ENST00000257290.5
|
platelet-derived growth factor receptor, alpha polypeptide |
|
| chr9_+_112810878 Show fit | 5.35 |
ENST00000434623.2
ENST00000374525.1 |
A kinase (PRKA) anchor protein 2 |
|
| chr7_-_30029367 Show fit | 4.70 |
ENST00000242059.5
|
secernin 1 |
|
| chr9_+_112542572 Show fit | 4.65 |
ENST00000374530.3
|
PALM2-AKAP2 readthrough |
Network of associatons between targets according to the STRING database.
First level regulatory network of AGUGGUU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 8.4 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.6 | 7.0 | GO:1900028 | negative regulation of ruffle assembly(GO:1900028) |
| 1.4 | 6.8 | GO:0035582 | sequestering of BMP in extracellular matrix(GO:0035582) |
| 0.4 | 6.8 | GO:0070831 | basement membrane assembly(GO:0070831) |
| 0.7 | 6.5 | GO:2000601 | positive regulation of Arp2/3 complex-mediated actin nucleation(GO:2000601) |
| 2.0 | 6.1 | GO:0046947 | hydroxylysine metabolic process(GO:0046946) hydroxylysine biosynthetic process(GO:0046947) |
| 1.9 | 5.7 | GO:0072275 | metanephric glomerulus morphogenesis(GO:0072275) metanephric glomerulus vasculature morphogenesis(GO:0072276) metanephric glomerular capillary formation(GO:0072277) |
| 0.0 | 5.2 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 5.0 | GO:0002576 | platelet degranulation(GO:0002576) |
| 0.0 | 4.2 | GO:0030516 | regulation of axon extension(GO:0030516) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 9.1 | GO:0043205 | microfibril(GO:0001527) fibril(GO:0043205) |
| 0.2 | 8.4 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.1 | 7.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 7.0 | GO:0043195 | terminal bouton(GO:0043195) |
| 1.7 | 6.8 | GO:0043259 | laminin-1 complex(GO:0005606) laminin-10 complex(GO:0043259) laminin-11 complex(GO:0043260) |
| 0.5 | 6.5 | GO:0031209 | SCAR complex(GO:0031209) |
| 0.2 | 6.1 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.2 | 5.0 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.0 | 4.4 | GO:0031965 | nuclear membrane(GO:0031965) |
| 0.0 | 4.2 | GO:0005874 | microtubule(GO:0005874) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 9.1 | GO:0030023 | extracellular matrix constituent conferring elasticity(GO:0030023) |
| 0.7 | 8.4 | GO:0042301 | phosphate ion binding(GO:0042301) |
| 0.2 | 7.0 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 6.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 6.6 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 2.0 | 6.1 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) procollagen glucosyltransferase activity(GO:0033823) |
| 1.9 | 5.7 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.2 | 4.7 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 4.5 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 1.4 | 4.2 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 14.1 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 8.4 | PID ECADHERIN NASCENT AJ PATHWAY | E-cadherin signaling in the nascent adherens junction |
| 0.1 | 7.8 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.3 | 6.8 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
| 0.2 | 5.7 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.2 | 5.7 | PID PDGFRA PATHWAY | PDGFR-alpha signaling pathway |
| 0.0 | 4.3 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.9 | PID CDC42 PATHWAY | CDC42 signaling events |
| 0.1 | 2.7 | PID P38 ALPHA BETA PATHWAY | Regulation of p38-alpha and p38-beta |
| 0.1 | 2.2 | PID NETRIN PATHWAY | Netrin-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 13.7 | REACTOME INTEGRIN CELL SURFACE INTERACTIONS | Genes involved in Integrin cell surface interactions |
| 0.4 | 8.4 | REACTOME G BETA GAMMA SIGNALLING THROUGH PLC BETA | Genes involved in G beta:gamma signalling through PLC beta |
| 0.1 | 7.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 6.1 | REACTOME COLLAGEN FORMATION | Genes involved in Collagen formation |
| 0.0 | 5.3 | REACTOME DOWNSTREAM SIGNAL TRANSDUCTION | Genes involved in Downstream signal transduction |
| 0.1 | 5.1 | REACTOME RECYCLING PATHWAY OF L1 | Genes involved in Recycling pathway of L1 |
| 0.0 | 3.6 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 3.4 | REACTOME SIGNALING BY NOTCH2 | Genes involved in Signaling by NOTCH2 |
| 0.0 | 2.9 | REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 | Genes involved in Response to elevated platelet cytosolic Ca2+ |
| 0.1 | 2.7 | REACTOME P38MAPK EVENTS | Genes involved in p38MAPK events |