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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AIRE
Z-value: 0.78
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Transcription factors associated with AIRE
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| AIRE | hg19_v2_chr21_+_45705752_45705767 | 0.38 | 5.4e-09 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr4_-_88450612 Show fit | 26.51 |
ENST00000418378.1
ENST00000282470.6 |
SPARC-like 1 (hevin) |
|
| chr6_-_31514333 Show fit | 16.02 |
ENST00000376151.4
|
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 |
|
| chr4_-_57524061 Show fit | 15.33 |
ENST00000508121.1
|
HOP homeobox |
|
| chr6_-_31514516 Show fit | 13.45 |
ENST00000303892.5
ENST00000483251.1 |
ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2 |
|
| chr19_+_18208603 Show fit | 11.73 |
ENST00000262811.6
|
microtubule associated serine/threonine kinase 3 |
|
| chr19_-_36643329 Show fit | 11.36 |
ENST00000589154.1
|
cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) |
|
| chrM_+_12331 Show fit | 10.91 |
ENST00000361567.2
|
mitochondrially encoded NADH dehydrogenase 5 |
|
| chr10_-_69597810 Show fit | 10.66 |
ENST00000483798.2
|
DnaJ (Hsp40) homolog, subfamily C, member 12 |
|
| chr20_+_44036900 Show fit | 9.85 |
ENST00000443296.1
|
dysbindin (dystrobrevin binding protein 1) domain containing 2 |
|
| chr20_+_44036620 Show fit | 9.71 |
ENST00000372710.3
|
dysbindin (dystrobrevin binding protein 1) domain containing 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AIRE
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 29.5 | GO:0090383 | phagosome acidification(GO:0090383) |
| 0.1 | 24.8 | GO:0043687 | post-translational protein modification(GO:0043687) |
| 4.7 | 18.9 | GO:0010900 | negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
| 0.9 | 18.4 | GO:0035493 | SNARE complex assembly(GO:0035493) |
| 0.1 | 17.1 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.7 | 15.3 | GO:0001829 | trophectodermal cell differentiation(GO:0001829) |
| 0.0 | 12.5 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.3 | 12.1 | GO:0010107 | potassium ion import(GO:0010107) |
| 4.0 | 11.9 | GO:1904395 | retinal rod cell differentiation(GO:0060221) positive regulation of skeletal muscle acetylcholine-gated channel clustering(GO:1904395) negative regulation of neuromuscular junction development(GO:1904397) |
| 0.1 | 11.4 | GO:1902600 | hydrogen ion transmembrane transport(GO:1902600) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.9 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.1 | 30.2 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 1.2 | 29.5 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.2 | 19.0 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
| 0.8 | 18.9 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 11.9 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.6 | 10.3 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.2 | 6.7 | GO:0071437 | invadopodium(GO:0071437) |
| 0.1 | 6.1 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 6.0 | GO:0031234 | extrinsic component of cytoplasmic side of plasma membrane(GO:0031234) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 29.5 | GO:0016820 | hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances(GO:0016820) |
| 0.4 | 26.5 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 24.1 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 2.4 | 18.9 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
| 0.4 | 18.4 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.7 | 12.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 3.0 | 11.9 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
| 3.9 | 11.8 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.0 | 11.7 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.4 | 11.4 | GO:0016676 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 28.4 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.3 | 12.1 | PID INTEGRIN A9B1 PATHWAY | Alpha9 beta1 integrin signaling events |
| 0.3 | 11.9 | PID SYNDECAN 3 PATHWAY | Syndecan-3-mediated signaling events |
| 0.0 | 7.3 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 6.6 | PID LYSOPHOSPHOLIPID PATHWAY | LPA receptor mediated events |
| 0.2 | 4.5 | PID TCR JNK PATHWAY | JNK signaling in the CD4+ TCR pathway |
| 0.0 | 4.2 | PID IL12 2PATHWAY | IL12-mediated signaling events |
| 0.0 | 3.1 | PID RHOA REG PATHWAY | Regulation of RhoA activity |
| 0.1 | 3.0 | PID CDC42 REG PATHWAY | Regulation of CDC42 activity |
| 0.3 | 2.8 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 29.5 | REACTOME INSULIN RECEPTOR RECYCLING | Genes involved in Insulin receptor recycling |
| 0.7 | 18.4 | REACTOME PROTEOLYTIC CLEAVAGE OF SNARE COMPLEX PROTEINS | Genes involved in Proteolytic cleavage of SNARE complex proteins |
| 0.3 | 12.1 | REACTOME INHIBITION OF VOLTAGE GATED CA2 CHANNELS VIA GBETA GAMMA SUBUNITS | Genes involved in Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits |
| 0.0 | 8.4 | REACTOME G ALPHA Q SIGNALLING EVENTS | Genes involved in G alpha (q) signalling events |
| 0.2 | 6.7 | REACTOME ABC FAMILY PROTEINS MEDIATED TRANSPORT | Genes involved in ABC-family proteins mediated transport |
| 0.2 | 5.5 | REACTOME INTERACTION BETWEEN L1 AND ANKYRINS | Genes involved in Interaction between L1 and Ankyrins |
| 0.0 | 5.2 | REACTOME METABOLISM OF AMINO ACIDS AND DERIVATIVES | Genes involved in Metabolism of amino acids and derivatives |
| 0.1 | 4.5 | REACTOME GENERATION OF SECOND MESSENGER MOLECULES | Genes involved in Generation of second messenger molecules |
| 0.8 | 4.2 | REACTOME BINDING AND ENTRY OF HIV VIRION | Genes involved in Binding and entry of HIV virion |
| 0.1 | 3.8 | REACTOME OLFACTORY SIGNALING PATHWAY | Genes involved in Olfactory Signaling Pathway |