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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ALX1_ARX
Z-value: 0.44
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Transcription factors associated with ALX1_ARX
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ALX1 | hg19_v2_chr12_+_85673868_85673885 | 0.05 | 4.3e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ALX1_ARX
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.9 | GO:0051491 | positive regulation of filopodium assembly(GO:0051491) |
| 1.3 | 5.3 | GO:0090402 | oncogene-induced cell senescence(GO:0090402) |
| 0.2 | 5.3 | GO:0007095 | mitotic G2 DNA damage checkpoint(GO:0007095) |
| 0.2 | 4.5 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 1.3 | 3.9 | GO:0002188 | translation reinitiation(GO:0002188) |
| 0.8 | 3.8 | GO:0097338 | response to clozapine(GO:0097338) |
| 0.3 | 3.6 | GO:0001915 | negative regulation of T cell mediated cytotoxicity(GO:0001915) |
| 0.6 | 3.5 | GO:0032790 | ribosome disassembly(GO:0032790) |
| 0.1 | 3.0 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.1 | 2.7 | GO:0007084 | mitotic nuclear envelope reassembly(GO:0007084) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 6.9 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.5 | 5.3 | GO:0035985 | senescence-associated heterochromatin focus(GO:0035985) |
| 0.1 | 3.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.2 | 3.8 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.4 | 3.6 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 2.7 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.2 | 2.6 | GO:0044327 | dendritic spine head(GO:0044327) |
| 0.1 | 2.5 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 2.5 | GO:0090575 | RNA polymerase II transcription factor complex(GO:0090575) |
| 0.1 | 2.2 | GO:0034663 | endoplasmic reticulum chaperone complex(GO:0034663) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.5 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.1 | 5.1 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.4 | 5.0 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
| 0.6 | 4.5 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.1 | 4.0 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.1 | 3.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.2 | 3.8 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.4 | 3.6 | GO:0033192 | calmodulin-dependent protein phosphatase activity(GO:0033192) |
| 0.3 | 3.5 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.1 | 3.0 | GO:0015248 | sterol transporter activity(GO:0015248) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.3 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 0.1 | 5.3 | PID IL4 2PATHWAY | IL4-mediated signaling events |
| 0.1 | 4.7 | PID ERBB2 ERBB3 PATHWAY | ErbB2/ErbB3 signaling events |
| 0.1 | 4.5 | PID EPHB FWD PATHWAY | EPHB forward signaling |
| 0.1 | 3.8 | PID IL3 PATHWAY | IL3-mediated signaling events |
| 0.0 | 3.2 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.0 | 2.9 | PID FOXO PATHWAY | FoxO family signaling |
| 0.0 | 2.7 | PID E2F PATHWAY | E2F transcription factor network |
| 0.0 | 2.2 | PID ERBB1 DOWNSTREAM PATHWAY | ErbB1 downstream signaling |
| 0.0 | 1.7 | PID IL6 7 PATHWAY | IL6-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 5.3 | REACTOME APOBEC3G MEDIATED RESISTANCE TO HIV1 INFECTION | Genes involved in APOBEC3G mediated resistance to HIV-1 infection |
| 0.1 | 4.4 | REACTOME G1 PHASE | Genes involved in G1 Phase |
| 0.0 | 3.9 | REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES | Genes involved in Antiviral mechanism by IFN-stimulated genes |
| 0.1 | 3.8 | REACTOME HORMONE SENSITIVE LIPASE HSL MEDIATED TRIACYLGLYCEROL HYDROLYSIS | Genes involved in Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis |
| 0.1 | 3.1 | REACTOME SIGNALING BY ROBO RECEPTOR | Genes involved in Signaling by Robo receptor |
| 0.1 | 3.0 | REACTOME DARPP 32 EVENTS | Genes involved in DARPP-32 events |
| 0.0 | 2.7 | REACTOME MHC CLASS II ANTIGEN PRESENTATION | Genes involved in MHC class II antigen presentation |
| 0.2 | 2.2 | REACTOME ACTIVATION OF CHAPERONE GENES BY ATF6 ALPHA | Genes involved in Activation of Chaperone Genes by ATF6-alpha |
| 0.1 | 1.9 | REACTOME SYNTHESIS OF PIPS AT THE EARLY ENDOSOME MEMBRANE | Genes involved in Synthesis of PIPs at the early endosome membrane |
| 0.1 | 1.7 | REACTOME IONOTROPIC ACTIVITY OF KAINATE RECEPTORS | Genes involved in Ionotropic activity of Kainate Receptors |