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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ARID3A
Z-value: 0.37
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Transcription factors associated with ARID3A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID3A | hg19_v2_chr19_+_926000_926046 | 0.16 | 1.8e-02 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_+_90198535 Show fit | 15.09 |
ENST00000390276.2
|
immunoglobulin kappa variable 1D-12 |
|
| chr7_-_38305279 Show fit | 14.99 |
ENST00000443402.2
|
T cell receptor gamma constant 1 |
|
| chr11_+_67351213 Show fit | 13.51 |
ENST00000398603.1
|
glutathione S-transferase pi 1 |
|
| chr3_-_121379739 Show fit | 13.51 |
ENST00000428394.2
ENST00000314583.3 |
hematopoietic cell-specific Lyn substrate 1 |
|
| chr1_+_145438469 Show fit | 13.39 |
ENST00000369317.4
|
thioredoxin interacting protein |
|
| chr11_+_67351019 Show fit | 11.22 |
ENST00000398606.3
|
glutathione S-transferase pi 1 |
|
| chr2_-_89340242 Show fit | 10.65 |
ENST00000480492.1
|
immunoglobulin kappa variable 1-12 |
|
| chr2_+_90248739 Show fit | 10.30 |
ENST00000468879.1
|
immunoglobulin kappa variable 1D-43 |
|
| chr2_-_89399845 Show fit | 8.97 |
ENST00000479981.1
|
immunoglobulin kappa variable 1-16 |
|
| chr12_-_53601055 Show fit | 8.76 |
ENST00000552972.1
ENST00000422257.3 ENST00000267082.5 |
integrin, beta 7 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID3A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 49.1 | GO:0030449 | regulation of complement activation(GO:0030449) |
| 6.2 | 24.7 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process(GO:0051771) |
| 0.2 | 23.8 | GO:0002377 | immunoglobulin production(GO:0002377) |
| 0.7 | 22.3 | GO:0035590 | purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 4.4 | 17.5 | GO:0003366 | cell-matrix adhesion involved in ameboidal cell migration(GO:0003366) |
| 0.8 | 13.5 | GO:0045651 | positive regulation of granulocyte differentiation(GO:0030854) positive regulation of macrophage differentiation(GO:0045651) |
| 0.6 | 12.8 | GO:0002347 | response to tumor cell(GO:0002347) |
| 3.4 | 10.2 | GO:0044278 | cell wall disruption in other organism(GO:0044278) |
| 0.2 | 8.8 | GO:0044364 | killing of cells of other organism(GO:0031640) disruption of cells of other organism(GO:0044364) |
| 1.1 | 7.5 | GO:0034316 | negative regulation of Arp2/3 complex-mediated actin nucleation(GO:0034316) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 8.2 | 24.7 | GO:0097057 | TRAF2-GSTP1 complex(GO:0097057) |
| 0.0 | 22.7 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 22.3 | GO:0044453 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.1 | 20.2 | GO:0072562 | blood microparticle(GO:0072562) |
| 4.4 | 17.5 | GO:0034669 | integrin alpha4-beta7 complex(GO:0034669) |
| 0.2 | 14.3 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 9.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.1 | 8.8 | GO:0031985 | Golgi cisterna(GO:0031985) |
| 0.6 | 7.5 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 7.5 | GO:1904813 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 74.6 | GO:0003823 | antigen binding(GO:0003823) |
| 4.9 | 24.7 | GO:0070026 | nitric oxide binding(GO:0070026) |
| 2.0 | 22.3 | GO:0004931 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.1 | 13.5 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.4 | 11.6 | GO:0042288 | MHC class I protein binding(GO:0042288) |
| 0.9 | 10.2 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.1 | 8.8 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.9 | 7.5 | GO:0071933 | Arp2/3 complex binding(GO:0071933) |
| 0.5 | 7.5 | GO:0031996 | thioesterase binding(GO:0031996) |
| 0.0 | 6.0 | GO:0000287 | magnesium ion binding(GO:0000287) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 18.8 | PID FCER1 PATHWAY | Fc-epsilon receptor I signaling in mast cells |
| 0.6 | 17.5 | PID INTEGRIN5 PATHWAY | Beta5 beta6 beta7 and beta8 integrin cell surface interactions |
| 0.1 | 16.3 | NABA ECM AFFILIATED | Genes encoding proteins affiliated structurally or functionally to extracellular matrix proteins |
| 0.2 | 9.4 | PID CD8 TCR PATHWAY | TCR signaling in naïve CD8+ T cells |
| 0.2 | 7.5 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.2 | 6.4 | PID AR NONGENOMIC PATHWAY | Nongenotropic Androgen signaling |
| 0.0 | 5.2 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.1 | 3.8 | ST MYOCYTE AD PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.7 | PID NEPHRIN NEPH1 PATHWAY | Nephrin/Neph1 signaling in the kidney podocyte |
| 0.0 | 1.7 | PID ALPHA SYNUCLEIN PATHWAY | Alpha-synuclein signaling |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.7 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.6 | 20.3 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.7 | 13.4 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 7.1 | REACTOME ACYL CHAIN REMODELLING OF PI | Genes involved in Acyl chain remodelling of PI |
| 0.1 | 5.7 | REACTOME ANTIGEN ACTIVATES B CELL RECEPTOR LEADING TO GENERATION OF SECOND MESSENGERS | Genes involved in Antigen Activates B Cell Receptor Leading to Generation of Second Messengers |
| 0.2 | 3.9 | REACTOME TERMINATION OF O GLYCAN BIOSYNTHESIS | Genes involved in Termination of O-glycan biosynthesis |
| 0.1 | 3.6 | REACTOME METABOLISM OF STEROID HORMONES AND VITAMINS A AND D | Genes involved in Metabolism of steroid hormones and vitamins A and D |
| 0.1 | 3.4 | REACTOME INTERFERON ALPHA BETA SIGNALING | Genes involved in Interferon alpha/beta signaling |
| 0.1 | 3.3 | REACTOME REGULATION OF COMPLEMENT CASCADE | Genes involved in Regulation of Complement cascade |
| 0.1 | 2.9 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |