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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ARID5A
Z-value: 0.23
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Transcription factors associated with ARID5A
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ARID5A | hg19_v2_chr2_+_97203082_97203159, hg19_v2_chr2_+_97202480_97202499 | 0.08 | 2.6e-01 | Click! |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr13_-_88323218 Show fit | 21.58 |
ENST00000436290.2
ENST00000453832.2 ENST00000606590.1 |
MIR4500 host gene (non-protein coding) |
|
| chr3_-_112127981 Show fit | 20.54 |
ENST00000486726.2
|
RP11-231E6.1 |
|
| chr2_-_217724767 Show fit | 13.75 |
ENST00000236979.2
|
transition protein 1 (during histone to protamine replacement) |
|
| chr3_+_101546827 Show fit | 8.71 |
ENST00000461724.1
ENST00000483180.1 ENST00000394054.2 |
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta |
|
| chr12_+_8995832 Show fit | 8.54 |
ENST00000541459.1
|
alpha-2-macroglobulin-like 1 |
|
| chr6_+_150920999 Show fit | 8.29 |
ENST00000367328.1
ENST00000367326.1 |
pleckstrin homology domain containing, family G (with RhoGef domain) member 1 |
|
| chr16_+_55542910 Show fit | 8.17 |
ENST00000262134.5
|
lysophosphatidylcholine acyltransferase 2 |
|
| chr16_-_11375179 Show fit | 7.59 |
ENST00000312511.3
|
protamine 1 |
|
| chr4_+_106631966 Show fit | 6.74 |
ENST00000360505.5
ENST00000510865.1 ENST00000509336.1 |
glutathione S-transferase, C-terminal domain containing |
|
| chr2_+_152214098 Show fit | 5.44 |
ENST00000243347.3
|
tumor necrosis factor, alpha-induced protein 6 |
Network of associatons between targets according to the STRING database.
First level regulatory network of ARID5A
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.6 | 13.7 | GO:0007290 | spermatid nucleus elongation(GO:0007290) |
| 2.0 | 8.2 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.1 | 7.6 | GO:0031295 | T cell costimulation(GO:0031295) |
| 0.5 | 7.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.6 | 7.4 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 0.0 | 7.2 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 6.7 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
| 0.2 | 6.1 | GO:0030261 | chromosome condensation(GO:0030261) |
| 0.1 | 5.8 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 1.8 | 5.4 | GO:0045645 | regulation of eosinophil differentiation(GO:0045643) positive regulation of eosinophil differentiation(GO:0045645) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 27.9 | GO:0005615 | extracellular space(GO:0005615) |
| 1.1 | 15.0 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 8.7 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.4 | 8.2 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 8.2 | GO:0005811 | lipid particle(GO:0005811) |
| 0.1 | 8.1 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 0.0 | 7.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.5 | 7.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.0 | 5.4 | GO:0072562 | blood microparticle(GO:0072562) |
| 0.1 | 4.8 | GO:0035577 | azurophil granule membrane(GO:0035577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 12.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 8.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 2.7 | 8.2 | GO:0047192 | 1-alkylglycerophosphocholine O-acetyltransferase activity(GO:0047192) |
| 0.1 | 8.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.5 | 7.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 7.4 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.0 | 5.8 | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.1 | 5.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 5.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 1.8 | 5.4 | GO:0005137 | interleukin-5 receptor binding(GO:0005137) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 23.3 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.2 | 11.5 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 0.0 | 6.1 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.0 | 6.0 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.2 | 4.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
| 0.1 | 4.7 | PID PI3KCI PATHWAY | Class I PI3K signaling events |
| 0.1 | 3.1 | PID ARF6 DOWNSTREAM PATHWAY | Arf6 downstream pathway |
| 0.1 | 2.8 | PID BETA CATENIN DEG PATHWAY | Degradation of beta catenin |
| 0.1 | 2.8 | PID INTEGRIN CS PATHWAY | Integrin family cell surface interactions |
| 0.1 | 1.9 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 8.3 | REACTOME TRANSLOCATION OF ZAP 70 TO IMMUNOLOGICAL SYNAPSE | Genes involved in Translocation of ZAP-70 to Immunological synapse |
| 0.3 | 8.2 | REACTOME ACYL CHAIN REMODELLING OF PC | Genes involved in Acyl chain remodelling of PC |
| 0.0 | 8.1 | REACTOME PEPTIDE LIGAND BINDING RECEPTORS | Genes involved in Peptide ligand-binding receptors |
| 0.3 | 7.4 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.1 | 6.4 | REACTOME IL RECEPTOR SHC SIGNALING | Genes involved in Interleukin receptor SHC signaling |
| 0.1 | 5.0 | REACTOME DEGRADATION OF THE EXTRACELLULAR MATRIX | Genes involved in Degradation of the extracellular matrix |
| 0.1 | 4.9 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 0.1 | 4.4 | REACTOME IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON LYMPHOID CELL | Genes involved in Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| 0.0 | 3.4 | REACTOME LOSS OF NLP FROM MITOTIC CENTROSOMES | Genes involved in Loss of Nlp from mitotic centrosomes |
| 0.2 | 3.3 | REACTOME REVERSIBLE HYDRATION OF CARBON DIOXIDE | Genes involved in Reversible Hydration of Carbon Dioxide |