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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ATF4

Z-value: 0.76

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Transcription factors associated with ATF4

Gene Symbol Gene ID Gene Info
ATF4
ENSG00000128272.10 activating transcription factor 4

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
ATF4hg19_v2_chr22_+_39916558_399165790.653.4e-27Click!

Activity profile of ATF4 motif

Sorted Z-values of ATF4 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr12_+_57624085 32.97 ENST00000553474.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_+_57624119 29.04 ENST00000555773.1
ENST00000554975.1
ENST00000449049.3
ENST00000393827.4
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr9_-_95055956 29.00 ENST00000375629.3
ENST00000447699.2
ENST00000375643.3
ENST00000395554.3
IARS
isoleucyl-tRNA synthetase
chr7_+_30634297 26.89 ENST00000389266.3
GARS
glycyl-tRNA synthetase
chr5_+_33440802 26.63 ENST00000502553.1
ENST00000514259.1
ENST00000265112.3
TARS
threonyl-tRNA synthetase
chr5_+_33441053 26.15 ENST00000541634.1
ENST00000455217.2
ENST00000414361.2
TARS
threonyl-tRNA synthetase
chr14_-_100841670 26.08 ENST00000557297.1
ENST00000555813.1
ENST00000557135.1
ENST00000556698.1
ENST00000554509.1
ENST00000555410.1
WARS
tryptophanyl-tRNA synthetase
chr12_+_57623869 25.57 ENST00000414700.3
ENST00000557703.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr12_-_46662772 24.66 ENST00000549049.1
ENST00000439706.1
ENST00000398637.5
SLC38A1
solute carrier family 38, member 1
chr12_+_57623477 22.98 ENST00000557487.1
ENST00000555634.1
ENST00000556689.1
SHMT2
serine hydroxymethyltransferase 2 (mitochondrial)
chr14_-_100841930 20.51 ENST00000555031.1
ENST00000553395.1
ENST00000553545.1
ENST00000344102.5
ENST00000556338.1
ENST00000392882.2
ENST00000553934.1
WARS
tryptophanyl-tRNA synthetase
chr19_-_47287990 19.01 ENST00000593713.1
ENST00000598022.1
ENST00000434726.2
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_79895097 18.53 ENST00000402252.2
ENST00000583564.1
ENST00000585244.1
ENST00000337943.5
ENST00000579698.1
PYCR1
pyrroline-5-carboxylate reductase 1
chr19_-_47288162 17.88 ENST00000594991.1
SLC1A5
solute carrier family 1 (neutral amino acid transporter), member 5
chr17_-_79895154 16.86 ENST00000405481.4
ENST00000585215.1
ENST00000577624.1
ENST00000403172.4
PYCR1
pyrroline-5-carboxylate reductase 1
chrX_+_24072833 16.73 ENST00000253039.4
EIF2S3
eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
chr7_+_99006550 16.15 ENST00000222969.5
BUD31
BUD31 homolog (S. cerevisiae)
chr5_+_44809027 15.98 ENST00000507110.1
MRPS30
mitochondrial ribosomal protein S30
chr9_+_100745615 15.57 ENST00000339399.4
ANP32B
acidic (leucine-rich) nuclear phosphoprotein 32 family, member B
chr12_-_92539614 14.09 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr7_+_99006232 13.56 ENST00000403633.2
BUD31
BUD31 homolog (S. cerevisiae)
chr14_+_24563262 13.33 ENST00000559250.1
ENST00000216780.4
ENST00000560736.1
ENST00000396973.4
ENST00000559837.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr10_+_14880157 12.73 ENST00000378372.3
HSPA14
heat shock 70kDa protein 14
chr19_+_33865218 12.66 ENST00000585933.2
CEBPG
CCAAT/enhancer binding protein (C/EBP), gamma
chr7_-_56101826 12.49 ENST00000421626.1
PSPH
phosphoserine phosphatase
chrX_+_77359671 11.95 ENST00000373316.4
PGK1
phosphoglycerate kinase 1
chr9_+_80912059 11.91 ENST00000347159.2
ENST00000376588.3
PSAT1
phosphoserine aminotransferase 1
chrX_+_77359726 11.64 ENST00000442431.1
PGK1
phosphoglycerate kinase 1
chr14_+_24563510 11.23 ENST00000545054.2
ENST00000561286.1
ENST00000558096.1
PCK2
phosphoenolpyruvate carboxykinase 2 (mitochondrial)
chr16_-_70323422 10.85 ENST00000261772.8
AARS
alanyl-tRNA synthetase
chr11_-_3078838 10.72 ENST00000397111.5
CARS
cysteinyl-tRNA synthetase
chr1_-_220220000 10.70 ENST00000366923.3
EPRS
glutamyl-prolyl-tRNA synthetase
chr11_-_3078616 10.19 ENST00000401769.3
ENST00000278224.9
ENST00000397114.3
ENST00000380525.4
CARS
cysteinyl-tRNA synthetase
chr15_+_89182178 9.86 ENST00000559876.1
ISG20
interferon stimulated exonuclease gene 20kDa
chr10_+_102106829 9.15 ENST00000370355.2
SCD
stearoyl-CoA desaturase (delta-9-desaturase)
chr12_+_57849048 9.14 ENST00000266646.2
INHBE
inhibin, beta E
chr11_+_62649158 8.99 ENST00000539891.1
ENST00000536981.1
SLC3A2
solute carrier family 3 (amino acid transporter heavy chain), member 2
chr7_-_93633658 8.96 ENST00000433727.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr7_-_93633684 8.93 ENST00000222547.3
ENST00000425626.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr15_+_89181974 8.50 ENST00000306072.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr17_+_39846114 8.42 ENST00000586699.1
EIF1
eukaryotic translation initiation factor 1
chr17_-_77813186 8.09 ENST00000448310.1
ENST00000269397.4
CBX4
chromobox homolog 4
chr11_-_8680383 7.62 ENST00000299550.6
TRIM66
tripartite motif containing 66
chr21_-_44495919 7.59 ENST00000398158.1
CBS
cystathionine-beta-synthase
chr16_+_56970567 6.76 ENST00000563911.1
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr2_+_46769798 6.42 ENST00000238738.4
RHOQ
ras homolog family member Q
chr1_-_220219775 6.27 ENST00000609181.1
EPRS
glutamyl-prolyl-tRNA synthetase
chr1_+_154244987 5.94 ENST00000328703.7
ENST00000457918.2
ENST00000483970.2
ENST00000435087.1
ENST00000532105.1
HAX1
HCLS1 associated protein X-1
chr12_+_50135588 5.87 ENST00000423828.1
ENST00000550445.1
TMBIM6
transmembrane BAX inhibitor motif containing 6
chr4_+_77870856 5.72 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11
septin 11
chr7_-_99006443 5.40 ENST00000350498.3
PDAP1
PDGFA associated protein 1
chr21_-_44495964 5.27 ENST00000398168.1
ENST00000398165.3
CBS
cystathionine-beta-synthase
chr16_-_18908196 4.45 ENST00000565324.1
ENST00000561947.1
SMG1
SMG1 phosphatidylinositol 3-kinase-related kinase
chr2_-_216300784 3.67 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
FN1
fibronectin 1
chr15_+_89182156 3.49 ENST00000379224.5
ISG20
interferon stimulated exonuclease gene 20kDa
chr12_-_25102252 3.45 ENST00000261192.7
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr17_+_73089382 3.41 ENST00000538213.2
ENST00000584118.1
SLC16A5
solute carrier family 16 (monocarboxylate transporter), member 5
chrX_-_133792480 3.25 ENST00000359237.4
PLAC1
placenta-specific 1
chr17_-_46703826 3.23 ENST00000550387.1
ENST00000311177.5
HOXB9
homeobox B9
chr12_-_117318788 3.16 ENST00000550505.1
HRK
harakiri, BCL2 interacting protein (contains only BH3 domain)
chr10_-_101190202 3.09 ENST00000543866.1
ENST00000370508.5
GOT1
glutamic-oxaloacetic transaminase 1, soluble
chr15_+_41245160 2.94 ENST00000444189.2
ENST00000446533.3
CHAC1
ChaC, cation transport regulator homolog 1 (E. coli)
chr4_-_70725856 2.59 ENST00000226444.3
SULT1E1
sulfotransferase family 1E, estrogen-preferring, member 1
chr11_+_118955583 2.58 ENST00000278715.3
ENST00000536813.1
ENST00000537841.1
ENST00000542729.1
ENST00000546302.1
ENST00000442944.2
ENST00000544387.1
ENST00000543090.1
HMBS
hydroxymethylbilane synthase
chr19_-_49258606 1.94 ENST00000310160.3
FUT1
fucosyltransferase 1 (galactoside 2-alpha-L-fucosyltransferase, H blood group)
chr12_-_25101920 1.92 ENST00000539780.1
ENST00000546285.1
ENST00000342945.5
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chrX_+_9431324 1.88 ENST00000407597.2
ENST00000424279.1
ENST00000536365.1
ENST00000441088.1
ENST00000380961.1
ENST00000415293.1
TBL1X
transducin (beta)-like 1X-linked
chr10_+_63661053 1.64 ENST00000279873.7
ARID5B
AT rich interactive domain 5B (MRF1-like)
chr3_-_33686743 1.44 ENST00000333778.6
ENST00000539981.1
CLASP2
cytoplasmic linker associated protein 2
chr14_-_92413353 1.34 ENST00000556154.1
FBLN5
fibulin 5
chr5_-_145562147 1.23 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS
leucyl-tRNA synthetase
chr1_-_44497024 0.97 ENST00000372306.3
ENST00000372310.3
ENST00000475075.2
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr12_-_10324716 0.73 ENST00000545927.1
ENST00000432556.2
ENST00000309539.3
ENST00000544577.1
OLR1
oxidized low density lipoprotein (lectin-like) receptor 1
chrX_-_80457385 0.61 ENST00000451455.1
ENST00000436386.1
ENST00000358130.2
HMGN5
high mobility group nucleosome binding domain 5
chr16_+_56965960 0.34 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr3_+_11314099 0.33 ENST00000446450.2
ENST00000354956.5
ENST00000354449.3
ENST00000419112.1
ATG7
autophagy related 7
chr1_-_44497118 0.28 ENST00000537678.1
ENST00000466926.1
SLC6A9
solute carrier family 6 (neurotransmitter transporter, glycine), member 9
chr3_-_48130707 0.27 ENST00000360240.6
ENST00000383737.4
MAP4
microtubule-associated protein 4
chr5_+_174151536 0.26 ENST00000239243.6
ENST00000507785.1
MSX2
msh homeobox 2
chr22_+_42229100 0.14 ENST00000361204.4
SREBF2
sterol regulatory element binding transcription factor 2
chr1_+_212782012 0.10 ENST00000341491.4
ENST00000366985.1
ATF3
activating transcription factor 3

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF4

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
17.6 52.8 GO:0006435 threonyl-tRNA aminoacylation(GO:0006435)
15.8 110.6 GO:0019264 glycine biosynthetic process from serine(GO:0019264)
9.7 29.0 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
9.3 46.6 GO:0006436 tryptophanyl-tRNA aminoacylation(GO:0006436)
9.2 36.9 GO:0036229 glutamine secretion(GO:0010585) L-glutamine import(GO:0036229) L-glutamine import into cell(GO:1903803)
7.3 21.8 GO:0000738 DNA catabolic process, exonucleolytic(GO:0000738)
7.0 20.9 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
6.7 26.9 GO:0015965 diadenosine polyphosphate biosynthetic process(GO:0015960) diadenosine tetraphosphate metabolic process(GO:0015965) diadenosine tetraphosphate biosynthetic process(GO:0015966)
5.9 35.4 GO:0055129 proline biosynthetic process(GO:0006561) L-proline biosynthetic process(GO:0055129)
4.3 12.9 GO:0006535 cysteine biosynthetic process from serine(GO:0006535)
4.2 12.7 GO:0051083 'de novo' cotranslational protein folding(GO:0051083)
3.7 29.7 GO:2000825 positive regulation of androgen receptor activity(GO:2000825)
3.6 10.9 GO:0006419 alanyl-tRNA aminoacylation(GO:0006419)
3.1 24.6 GO:0006116 NADH oxidation(GO:0006116)
2.7 24.4 GO:0006564 L-serine biosynthetic process(GO:0006564)
2.6 17.9 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
1.8 9.0 GO:0060356 leucine import(GO:0060356)
1.6 12.7 GO:0043353 enucleate erythrocyte differentiation(GO:0043353)
1.2 3.7 GO:0052047 interaction with other organism via secreted substance involved in symbiotic interaction(GO:0052047)
1.1 14.1 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
1.0 3.1 GO:0006106 fumarate metabolic process(GO:0006106) aspartate catabolic process(GO:0006533)
1.0 5.9 GO:1904721 negative regulation of mRNA cleavage(GO:0031438) negative regulation of immunoglobulin secretion(GO:0051025) negative regulation of ribonuclease activity(GO:0060701) negative regulation of endoribonuclease activity(GO:0060702) negative regulation of mRNA endonucleolytic cleavage involved in unfolded protein response(GO:1904721)
0.9 25.9 GO:0015804 neutral amino acid transport(GO:0015804)
0.9 5.4 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.9 2.6 GO:0006711 estrogen catabolic process(GO:0006711)
0.8 23.6 GO:0031639 plasminogen activation(GO:0031639)
0.8 8.4 GO:0009048 dosage compensation by inactivation of X chromosome(GO:0009048)
0.5 15.6 GO:0046827 positive regulation of protein export from nucleus(GO:0046827)
0.5 7.1 GO:1903071 positive regulation of ER-associated ubiquitin-dependent protein catabolic process(GO:1903071)
0.4 18.2 GO:0006418 tRNA aminoacylation for protein translation(GO:0006418)
0.3 5.9 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.3 6.4 GO:0090005 negative regulation of establishment of protein localization to plasma membrane(GO:0090005)
0.2 9.2 GO:0046949 fatty-acyl-CoA biosynthetic process(GO:0046949)
0.2 16.0 GO:0070126 mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126)
0.2 2.6 GO:0006782 protoporphyrinogen IX biosynthetic process(GO:0006782)
0.2 3.2 GO:0032464 positive regulation of protein homooligomerization(GO:0032464)
0.2 2.9 GO:0006751 glutathione catabolic process(GO:0006751)
0.2 3.3 GO:0060712 spongiotrophoblast layer development(GO:0060712)
0.2 1.4 GO:1903690 negative regulation of wound healing, spreading of epidermal cells(GO:1903690)
0.2 0.3 GO:1901859 negative regulation of mitochondrial DNA replication(GO:0090298) negative regulation of mitochondrial DNA metabolic process(GO:1901859)
0.2 1.9 GO:0042354 fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355)
0.1 9.1 GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation(GO:0010862)
0.1 0.3 GO:0051795 positive regulation of catagen(GO:0051795) frontal suture morphogenesis(GO:0060364) BMP signaling pathway involved in heart development(GO:0061312)
0.1 8.1 GO:0016925 protein sumoylation(GO:0016925)
0.0 4.2 GO:0032204 regulation of telomere maintenance(GO:0032204)
0.0 1.6 GO:0016577 histone demethylation(GO:0016577)
0.0 0.1 GO:1903121 regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance(GO:0061394) regulation of TRAIL-activated apoptotic signaling pathway(GO:1903121) positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:0090370 negative regulation of cholesterol efflux(GO:0090370)
0.0 3.2 GO:0048706 embryonic skeletal system development(GO:0048706)
0.0 0.6 GO:0071157 negative regulation of cell cycle arrest(GO:0071157)
0.0 1.9 GO:0016575 histone deacetylation(GO:0016575)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
13.8 110.6 GO:0070552 BRISC complex(GO:0070552)
5.6 16.7 GO:0005850 eukaryotic translation initiation factor 2 complex(GO:0005850)
2.4 17.0 GO:0097452 GAIT complex(GO:0097452)
1.6 30.2 GO:0017101 aminoacyl-tRNA synthetase multienzyme complex(GO:0017101)
1.2 7.1 GO:1990037 Lewy body core(GO:1990037)
0.6 8.1 GO:0035102 PRC1 complex(GO:0035102)
0.3 21.8 GO:0015030 Cajal body(GO:0015030)
0.3 3.7 GO:0005577 fibrinogen complex(GO:0005577)
0.3 17.9 GO:0031201 SNARE complex(GO:0031201)
0.1 1.4 GO:0045180 basal cortex(GO:0045180)
0.1 7.6 GO:0016235 aggresome(GO:0016235)
0.1 70.4 GO:0005759 mitochondrial matrix(GO:0005759)
0.1 29.7 GO:0005681 spliceosomal complex(GO:0005681)
0.1 23.3 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.1 6.4 GO:0030660 Golgi-associated vesicle membrane(GO:0030660)
0.1 28.7 GO:0005840 ribosome(GO:0005840)
0.1 5.9 GO:0016529 sarcoplasmic reticulum(GO:0016529)
0.1 46.1 GO:0015629 actin cytoskeleton(GO:0015629)
0.1 0.1 GO:1990622 CHOP-ATF3 complex(GO:1990622)
0.0 17.9 GO:0045121 membrane raft(GO:0045121)
0.0 5.7 GO:1904813 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 1.9 GO:0032580 Golgi cisterna membrane(GO:0032580)
0.0 0.1 GO:0032937 SREBP-SCAP-Insig complex(GO:0032937)
0.0 1.9 GO:0005876 spindle microtubule(GO:0005876)
0.0 3.1 GO:0043679 axon terminus(GO:0043679)
0.0 71.7 GO:0070062 extracellular exosome(GO:0070062)
0.0 2.9 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.3 GO:0098793 presynapse(GO:0098793)
0.0 15.0 GO:0005789 endoplasmic reticulum membrane(GO:0005789)
0.0 10.7 GO:0043005 neuron projection(GO:0043005)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
17.6 52.8 GO:0004829 threonine-tRNA ligase activity(GO:0004829)
15.8 110.6 GO:0008732 glycine hydroxymethyltransferase activity(GO:0004372) threonine aldolase activity(GO:0004793) L-allo-threonine aldolase activity(GO:0008732)
9.7 29.0 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
9.3 46.6 GO:0004830 tryptophan-tRNA ligase activity(GO:0004830)
8.8 35.4 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
8.2 24.6 GO:0004611 phosphoenolpyruvate carboxykinase activity(GO:0004611) phosphoenolpyruvate carboxykinase (GTP) activity(GO:0004613)
7.9 23.6 GO:0004618 phosphoglycerate kinase activity(GO:0004618)
7.3 21.8 GO:0008859 exoribonuclease II activity(GO:0008859)
7.0 20.9 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
5.3 36.9 GO:0015186 L-glutamine transmembrane transporter activity(GO:0015186)
4.3 12.9 GO:0070025 cystathionine beta-synthase activity(GO:0004122) oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor(GO:0016662) nitrite reductase (NO-forming) activity(GO:0050421) carbon monoxide binding(GO:0070025) nitrite reductase activity(GO:0098809)
3.6 10.9 GO:0004813 alanine-tRNA ligase activity(GO:0004813)
3.1 9.2 GO:0004768 stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215)
2.5 12.5 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
2.1 6.4 GO:0032427 GBD domain binding(GO:0032427)
1.7 26.9 GO:0004551 nucleotide diphosphatase activity(GO:0004551)
1.3 25.9 GO:0005283 sodium:amino acid symporter activity(GO:0005283)
1.0 3.1 GO:0070546 phosphatidylserine decarboxylase activity(GO:0004609) L-phenylalanine aminotransferase activity(GO:0070546) L-phenylalanine:2-oxoglutarate aminotransferase activity(GO:0080130)
1.0 5.9 GO:0060698 endoribonuclease inhibitor activity(GO:0060698)
0.9 17.3 GO:0008483 transaminase activity(GO:0008483)
0.9 9.0 GO:0005432 calcium:sodium antiporter activity(GO:0005432)
0.9 17.0 GO:0035613 RNA stem-loop binding(GO:0035613)
0.4 1.2 GO:0004819 glutamine-tRNA ligase activity(GO:0004819) valine-tRNA ligase activity(GO:0004832)
0.4 8.1 GO:0019789 SUMO transferase activity(GO:0019789) SUMO binding(GO:0032183)
0.4 5.9 GO:0019966 interleukin-1 binding(GO:0019966)
0.4 2.6 GO:0047894 flavonol 3-sulfotransferase activity(GO:0047894) steroid sulfotransferase activity(GO:0050294)
0.4 12.7 GO:0008301 DNA binding, bending(GO:0008301)
0.3 25.1 GO:0003743 translation initiation factor activity(GO:0003743)
0.3 19.7 GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374)
0.2 15.6 GO:0070063 RNA polymerase binding(GO:0070063)
0.2 2.9 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.2 17.9 GO:0019905 syntaxin binding(GO:0019905)
0.1 9.1 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 1.9 GO:0008417 fucosyltransferase activity(GO:0008417)
0.1 4.2 GO:0042162 telomeric DNA binding(GO:0042162)
0.1 3.2 GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding(GO:0000977)
0.1 16.0 GO:0003735 structural constituent of ribosome(GO:0003735)
0.1 3.7 GO:0016504 peptidase activator activity(GO:0016504)
0.1 3.4 GO:0008028 monocarboxylic acid transmembrane transporter activity(GO:0008028)
0.1 1.4 GO:0002162 dystroglycan binding(GO:0002162)
0.1 0.3 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.1 1.6 GO:0032452 histone demethylase activity(GO:0032452)
0.0 0.7 GO:0005041 low-density lipoprotein receptor activity(GO:0005041)
0.0 2.6 GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765)
0.0 3.9 GO:0044325 ion channel binding(GO:0044325)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 0.6 GO:0031492 nucleosomal DNA binding(GO:0031492)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 29.0 ST INTERLEUKIN 4 PATHWAY Interleukin 4 (IL-4) Pathway
0.5 23.6 PID HIF2PATHWAY HIF-2-alpha transcription factor network
0.2 6.4 PID INSULIN GLUCOSE PATHWAY Insulin-mediated glucose transport
0.2 24.6 PID REG GR PATHWAY Glucocorticoid receptor regulatory network
0.1 9.0 PID NFAT TFPATHWAY Calcineurin-regulated NFAT-dependent transcription in lymphocytes
0.1 3.7 PID INTEGRIN5 PATHWAY Beta5 beta6 beta7 and beta8 integrin cell surface interactions
0.1 3.2 PID ATF2 PATHWAY ATF-2 transcription factor network
0.1 8.1 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 5.4 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 1.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
5.7 205.2 REACTOME CYTOSOLIC TRNA AMINOACYLATION Genes involved in Cytosolic tRNA aminoacylation
2.2 62.9 REACTOME AMINO ACID SYNTHESIS AND INTERCONVERSION TRANSAMINATION Genes involved in Amino acid synthesis and interconversion (transamination)
1.7 70.5 REACTOME AMINO ACID TRANSPORT ACROSS THE PLASMA MEMBRANE Genes involved in Amino acid transport across the plasma membrane
0.8 48.1 REACTOME GLUCONEOGENESIS Genes involved in Gluconeogenesis
0.7 9.1 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.4 12.9 REACTOME SULFUR AMINO ACID METABOLISM Genes involved in Sulfur amino acid metabolism
0.2 21.8 REACTOME INTERFERON ALPHA BETA SIGNALING Genes involved in Interferon alpha/beta signaling
0.2 16.7 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.2 5.4 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.1 3.7 REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS Genes involved in p130Cas linkage to MAPK signaling for integrins
0.1 2.6 REACTOME METABOLISM OF PORPHYRINS Genes involved in Metabolism of porphyrins
0.1 2.6 REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES Genes involved in Cytosolic sulfonation of small molecules
0.1 1.3 REACTOME NA CL DEPENDENT NEUROTRANSMITTER TRANSPORTERS Genes involved in Na+/Cl- dependent neurotransmitter transporters
0.1 1.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 6.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 4.5 REACTOME NONSENSE MEDIATED DECAY ENHANCED BY THE EXON JUNCTION COMPLEX Genes involved in Nonsense Mediated Decay Enhanced by the Exon Junction Complex