ISMARA results: ATF5

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ATF5

Z-value: 0.62

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Transcription factors associated with ATF5

Gene Symbol	Gene ID	Gene Info
ATF5 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000169136.4	activating transcription factor 5

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF5	hg19_v2_chr19_+_50432400_50432479	0.22	1.3e-03	Click!

Activity profile of ATF5 motif

Sorted Z-values of ATF5 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_-_52967600 Show fit	12.74	ENST00000549343.1 ENST00000305620.2	KRT74 Ensembl NCBI GeneCards UniProt NextProt Show fit	keratin 74
chr12_+_104680659 Show fit	11.05	ENST00000526691.1 ENST00000531691.1 ENST00000388854.3 ENST00000354940.6 ENST00000526390.1 ENST00000531689.1	TXNRD1 Ensembl NCBI GeneCards UniProt NextProt Show fit	thioredoxin reductase 1
chr12_-_54652060 Show fit	10.20	ENST00000552562.1	CBX5 Ensembl NCBI GeneCards UniProt NextProt Show fit	chromobox homolog 5
chr7_+_128399002 Show fit	9.07	ENST00000493278.1	CALU Ensembl NCBI GeneCards UniProt NextProt Show fit	calumenin
chr17_-_73149921 Show fit	8.97	ENST00000481647.1 ENST00000470924.1	HN1 Ensembl NCBI GeneCards UniProt NextProt Show fit	hematological and neurological expressed 1
chr5_+_34757309 Show fit	8.87	ENST00000397449.1	RAI14 Ensembl NCBI GeneCards UniProt NextProt Show fit	retinoic acid induced 14
chr22_-_36236265 Show fit	8.16	ENST00000414461.2 ENST00000416721.2 ENST00000449924.2 ENST00000262829.7 ENST00000397305.3	RBFOX2 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_+_2622085 Show fit	7.10	ENST00000382099.2	VLDLR Ensembl NCBI GeneCards UniProt NextProt Show fit	very low density lipoprotein receptor
chr14_-_36988882 Show fit	7.02	ENST00000498187.2	NKX2-1 Ensembl NCBI GeneCards UniProt NextProt Show fit	NK2 homeobox 1
chr7_-_41740181 Show fit	6.82	ENST00000442711.1	INHBA Ensembl NCBI GeneCards UniProt NextProt Show fit	inhibin, beta A

Showing 1 to 10 of 148 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.4	20.1	GO:0010724	regulation of definitive erythrocyte differentiation(GO:0010724)
1.4	14.1	GO:1901409	positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
2.8	13.8	GO:0038026	reelin-mediated signaling pathway(GO:0038026)
0.5	13.5	GO:0030208	dermatan sulfate biosynthetic process(GO:0030208)
1.2	11.1	GO:0001887	selenium compound metabolic process(GO:0001887)
0.2	11.1	GO:0045104	intermediate filament cytoskeleton organization(GO:0045104)
0.3	10.7	GO:0036120	cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.0	10.5	GO:0043488	regulation of mRNA stability(GO:0043488)
0.0	10.3	GO:0007596	blood coagulation(GO:0007596)
3.0	9.0	GO:0006097	glyoxylate cycle(GO:0006097)

Showing 1 to 10 of 81 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	18.9	GO:0001650	fibrillar center(GO:0001650)
0.4	14.1	GO:0016592	mediator complex(GO:0016592)
0.4	13.8	GO:0034385	very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.1	13.5	GO:0005796	Golgi lumen(GO:0005796)
0.3	12.3	GO:0045095	keratin filament(GO:0045095)
0.2	11.0	GO:0005637	nuclear inner membrane(GO:0005637)
0.1	11.0	GO:0005884	actin filament(GO:0005884)
0.7	10.2	GO:0031618	nuclear pericentric heterochromatin(GO:0031618)
0.1	9.7	GO:0031093	platelet alpha granule lumen(GO:0031093)
0.8	9.1	GO:0033018	sarcoplasmic reticulum lumen(GO:0033018)

Showing 1 to 10 of 43 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.1	25.3	GO:0044822	mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.3	14.1	GO:0016538	cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
3.4	13.8	GO:0038025	glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)
0.4	13.5	GO:0005540	hyaluronic acid binding(GO:0005540)
2.1	12.7	GO:1990254	keratin filament binding(GO:1990254)
3.7	11.1	GO:0098625	methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
0.2	10.7	GO:0005154	epidermal growth factor receptor binding(GO:0005154)
0.1	10.2	GO:0035064	methylated histone binding(GO:0035064)
3.0	9.0	GO:0004450	isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.0	8.9	GO:0005509	calcium ion binding(GO:0005509)

Showing 1 to 10 of 65 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	15.5	PID GLYPICAN 1PATHWAY	Glypican 1 network
0.3	13.8	PID LIS1 PATHWAY	Lissencephaly gene (LIS1) in neuronal migration and development
0.4	13.5	PID TOLL ENDOGENOUS PATHWAY	Endogenous TLR signaling
0.2	11.5	PID AURORA B PATHWAY	Aurora B signaling
0.0	7.1	PID P53 DOWNSTREAM PATHWAY	Direct p53 effectors
0.1	7.0	PID HNF3B PATHWAY	FOXA2 and FOXA3 transcription factor networks
0.2	6.8	PID ALK1 PATHWAY	ALK1 signaling events
0.1	6.7	PID NOTCH PATHWAY	Notch signaling pathway
0.1	6.6	PID PLK1 PATHWAY	PLK1 signaling events
0.1	5.9	NABA COLLAGENS	Genes encoding collagen proteins

Showing 1 to 10 of 23 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.3	14.1	REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION	Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.5	13.5	REACTOME CS DS DEGRADATION	Genes involved in CS/DS degradation
0.1	12.2	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.1	11.2	REACTOME MEIOSIS	Genes involved in Meiosis
0.3	11.1	REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES	Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.6	10.7	REACTOME PECAM1 INTERACTIONS	Genes involved in PECAM1 interactions
0.3	9.0	REACTOME PEROXISOMAL LIPID METABOLISM	Genes involved in Peroxisomal lipid metabolism
0.3	7.7	REACTOME RETROGRADE NEUROTROPHIN SIGNALLING	Genes involved in Retrograde neurotrophin signalling
0.0	7.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0	7.1	REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION	Genes involved in Factors involved in megakaryocyte development and platelet production

Showing 1 to 10 of 32 entries

Results for ATF5

Z-value: 0.62

Motif logo

Transcription factors associated with ATF5

Activity-expression correlation:

Activity profile of ATF5 motif

Sorted Z-values of ATF5 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF5

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: