GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)


Results for ATF5

Z-value: 0.62

Motif logo

Transcription factors associated with ATF5

Gene Symbol Gene ID Gene Info
ENSG00000169136.4 activating transcription factor 5

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot

Activity profile of ATF5 motif

Sorted Z-values of ATF5 motif

Promoter Log-likelihood Transcript Gene Gene Info
chr12_-_52967600 12.74 ENST00000549343.1
keratin 74
chr12_+_104680659 11.05 ENST00000526691.1
thioredoxin reductase 1
chr12_-_54652060 10.20 ENST00000552562.1
chromobox homolog 5
chr7_+_128399002 9.07 ENST00000493278.1
chr17_-_73149921 8.97 ENST00000481647.1
hematological and neurological expressed 1
chr5_+_34757309 8.87 ENST00000397449.1
retinoic acid induced 14
chr22_-_36236265 8.16 ENST00000414461.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr9_+_2622085 7.10 ENST00000382099.2
very low density lipoprotein receptor
chr14_-_36988882 7.02 ENST00000498187.2
NK2 homeobox 1
chr7_-_41740181 6.82 ENST00000442711.1
inhibin, beta A
chr9_+_2621798 6.67 ENST00000382100.3
very low density lipoprotein receptor
chr1_-_17304771 6.64 ENST00000375534.3
microfibrillar-associated protein 2
chr5_+_154393260 6.44 ENST00000435029.4
kinesin family member 4B
chr22_-_36236623 6.35 ENST00000405409.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr22_-_36357671 5.63 ENST00000408983.2
RNA binding protein, fox-1 homolog (C. elegans) 2
chr18_-_812517 5.41 ENST00000584307.1
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr18_-_812231 5.33 ENST00000314574.4
v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
chr1_-_67896009 5.31 ENST00000370990.5
SERPINE1 mRNA binding protein 1
chr6_-_100016678 5.27 ENST00000523799.1
cyclin C
chr1_-_67896069 5.16 ENST00000370995.2
SERPINE1 mRNA binding protein 1
chr6_+_43738444 4.81 ENST00000324450.6
vascular endothelial growth factor A
chr16_-_65155979 4.70 ENST00000562325.1
cadherin 11, type 2, OB-cadherin (osteoblast)
chr5_+_82767284 4.62 ENST00000265077.3
chr5_+_82767583 4.55 ENST00000512590.2
chr6_-_100016492 4.53 ENST00000369217.4
cyclin C
chr2_-_209118974 4.52 ENST00000415913.1
isocitrate dehydrogenase 1 (NADP+), soluble
chr2_-_209119831 4.47 ENST00000345146.2
isocitrate dehydrogenase 1 (NADP+), soluble
chr5_+_82767487 4.32 ENST00000343200.5
chr2_+_189839046 4.29 ENST00000304636.3
collagen, type III, alpha 1
chr6_-_100016527 4.26 ENST00000523985.1
cyclin C
chr3_-_99569821 4.11 ENST00000487087.1
filamin A interacting protein 1-like
chr17_+_33914460 4.03 ENST00000537622.2
adaptor-related protein complex 2, beta 1 subunit
chr2_-_225434538 3.97 ENST00000409096.1
cullin 3
chr2_-_188419200 3.88 ENST00000233156.3
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr8_-_13134045 3.81 ENST00000512044.2
deleted in liver cancer 1
chr17_+_33914276 3.66 ENST00000592545.1
adaptor-related protein complex 2, beta 1 subunit
chr8_+_95732095 3.52 ENST00000414645.2
dpy-19-like 4 (C. elegans)
chrX_+_123095155 3.41 ENST00000371160.1
stromal antigen 2
chr12_-_120884175 3.28 ENST00000546954.1
TP53 regulated inhibitor of apoptosis 1
chrX_+_123095546 3.23 ENST00000371157.3
stromal antigen 2
chr16_+_30075463 3.09 ENST00000562168.1
aldolase A, fructose-bisphosphate
chr16_-_65155833 3.02 ENST00000566827.1
cadherin 11, type 2, OB-cadherin (osteoblast)
chr5_+_138629417 2.93 ENST00000510056.1
matrin 3
chr5_+_137203541 2.88 ENST00000421631.2
chr16_-_30537839 2.72 ENST00000380412.5
zinc finger protein 768
chr5_+_137203557 2.63 ENST00000515645.1
chr14_+_96968802 2.62 ENST00000556619.1
poly(A) polymerase alpha
chr5_+_138629337 2.53 ENST00000394805.3
matrin 3
chr6_+_114178512 2.44 ENST00000368635.4
myristoylated alanine-rich protein kinase C substrate
chr12_-_56843161 2.41 ENST00000554616.1
timeless circadian clock
chr3_-_182698381 2.41 ENST00000292782.4
DCN1, defective in cullin neddylation 1, domain containing 1
chr3_+_37035263 2.35 ENST00000458205.2
mutL homolog 1
chr3_-_69129501 2.29 ENST00000540295.1
ubiquitin-like modifier activating enzyme 3
chr3_+_37035289 2.26 ENST00000455445.2
mutL homolog 1
chr17_-_47022140 2.17 ENST00000290330.3
SNF8, ESCRT-II complex subunit
chr3_+_38206975 2.05 ENST00000446845.1
oxidative stress responsive 1
chr2_-_188419078 2.03 ENST00000437725.1
tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_+_138629389 2.02 ENST00000504045.1
matrin 3
chrX_+_47050236 2.00 ENST00000377351.4
ubiquitin-like modifier activating enzyme 1
chr2_+_217498105 1.96 ENST00000233809.4
insulin-like growth factor binding protein 2, 36kDa
chr2_-_113999260 1.92 ENST00000468980.2
paired box 8
chr9_-_38069208 1.90 ENST00000377707.3
Src homology 2 domain containing adaptor protein B
chr5_+_137203465 1.85 ENST00000239926.4
chr3_-_47950745 1.80 ENST00000429422.1
microtubule-associated protein 4
chr8_-_131028869 1.78 ENST00000518283.1
family with sequence similarity 49, member B
chr1_+_16083154 1.72 ENST00000375771.1
filamin binding LIM protein 1
chr8_+_79428539 1.71 ENST00000352966.5
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
chr14_+_96968707 1.67 ENST00000216277.8
poly(A) polymerase alpha
chr1_-_103574024 1.66 ENST00000512756.1
collagen, type XI, alpha 1
chr19_-_39330818 1.64 ENST00000594769.1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial
chr15_-_75871589 1.62 ENST00000306726.2
protein tyrosine phosphatase, non-receptor type 9
chr3_+_193853927 1.55 ENST00000232424.3
hes family bHLH transcription factor 1
chr6_+_30297306 1.52 ENST00000420746.1
tripartite motif containing 39
TRIM39-RPP21 readthrough
chr2_-_113542063 1.49 ENST00000263339.3
interleukin 1, alpha
chr2_-_190927447 1.38 ENST00000260950.4
chr17_+_18761417 1.37 ENST00000419284.2
phosphoribosyl pyrophosphate synthetase-associated protein 2
chrX_+_153409678 1.33 ENST00000369951.4
opsin 1 (cone pigments), long-wave-sensitive
chr22_-_26875631 1.26 ENST00000402105.3
Hermansky-Pudlak syndrome 4
chr3_+_101504200 1.23 ENST00000422132.1
neurexophilin and PC-esterase domain family, member 3
chr17_+_41150793 1.22 ENST00000586277.1
ribosomal protein L27
chr12_-_115121962 1.20 ENST00000349155.2
T-box 3
chr7_-_27142290 1.19 ENST00000222718.5
homeobox A2
chr6_+_87865262 1.18 ENST00000369577.3
zinc finger protein 292
chr12_-_25101920 1.18 ENST00000539780.1
branched chain amino-acid transaminase 1, cytosolic
chr4_+_77172847 1.17 ENST00000515604.1
uncharacterized protein LOC100631383
FAM47E-STBD1 readthrough
family with sequence similarity 47, member E
chr5_+_92919043 1.14 ENST00000327111.3
nuclear receptor subfamily 2, group F, member 1
chr4_-_74124502 1.14 ENST00000358602.4
ankyrin repeat domain 17
chr12_+_56915713 1.10 ENST00000262031.5
RNA binding motif, single stranded interacting protein 2
chr1_+_158323755 1.04 ENST00000368157.1
CD1e molecule
chr19_-_45926739 1.04 ENST00000589381.1
excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)
chr2_-_128784846 1.03 ENST00000259235.3
Sin3A-associated protein, 130kDa
chr8_-_95449155 0.98 ENST00000481490.2
fibrinogen silencer binding protein
chr20_+_54987168 0.98 ENST00000360314.3
Cas scaffolding protein family member 4
chr20_+_43211149 0.96 ENST00000372886.1
protein kinase (cAMP-dependent, catalytic) inhibitor gamma
chr12_+_56915776 0.96 ENST00000550726.1
RNA binding motif, single stranded interacting protein 2
chr17_+_41150290 0.94 ENST00000589037.1
ribosomal protein L27
chr12_+_56415100 0.94 ENST00000547791.1
IKAROS family zinc finger 4 (Eos)
chr10_+_102505468 0.92 ENST00000361791.3
paired box 2
chr1_-_11863171 0.92 ENST00000376592.1
methylenetetrahydrofolate reductase (NAD(P)H)
chr17_+_41150479 0.91 ENST00000589913.1
ribosomal protein L27
chr15_+_63481668 0.89 ENST00000321437.4
RAB8B, member RAS oncogene family
chr4_-_122085469 0.87 ENST00000057513.3
TNFAIP3 interacting protein 3
chr20_+_54987305 0.85 ENST00000371336.3
Cas scaffolding protein family member 4
chr5_-_132200477 0.81 ENST00000296875.2
growth differentiation factor 9
chr7_-_37956409 0.81 ENST00000436072.2
secreted frizzled-related protein 4
chr1_-_11863571 0.75 ENST00000376583.3
methylenetetrahydrofolate reductase (NAD(P)H)
chr5_+_175223715 0.73 ENST00000515502.1
complexin 2
chr2_+_27274506 0.73 ENST00000451003.1
ATP/GTP binding protein-like 5
chr16_-_72206034 0.72 ENST00000537465.1
polyamine modulated factor 1 binding protein 1
chr3_+_23958632 0.71 ENST00000412097.1
ribosomal protein L15
chr14_-_65569244 0.66 ENST00000557277.1
MYC associated factor X
chr2_-_100759037 0.63 ENST00000317233.4
AF4/FMR2 family, member 3
chr8_+_22462532 0.62 ENST00000389279.3
cell cycle and apoptosis regulator 2
chr5_+_50678921 0.59 ENST00000230658.7
ISL LIM homeobox 1
chr15_-_90222642 0.58 ENST00000430628.2
perilipin 1
chr15_-_90222610 0.58 ENST00000300055.5
perilipin 1
chr14_-_21566731 0.57 ENST00000360947.3
zinc finger protein 219
chr12_-_57030115 0.55 ENST00000379441.3
bromodomain adjacent to zinc finger domain, 2A
chr22_-_30662828 0.49 ENST00000403463.1
oncostatin M
chr8_+_22462145 0.48 ENST00000308511.4
cell cycle and apoptosis regulator 2
chr12_+_120884222 0.47 ENST00000551765.1
glutamyl-tRNA(Gln) amidotransferase, subunit C
chr6_+_29079668 0.37 ENST00000377169.1
olfactory receptor, family 2, subfamily J, member 3
chr3_-_183145765 0.34 ENST00000473233.1
MCF.2 cell line derived transforming sequence-like 2
chr17_+_7533439 0.31 ENST00000441599.2
sex hormone-binding globulin
chr22_-_26875345 0.31 ENST00000398141.1
Hermansky-Pudlak syndrome 4
chr19_+_4229495 0.30 ENST00000221847.5
Epstein-Barr virus induced 3
chr3_+_19988885 0.29 ENST00000422242.1
RAB5A, member RAS oncogene family
chr13_-_36944307 0.27 ENST00000355182.4
spastic paraplegia 20 (Troyer syndrome)
chr7_+_150688166 0.23 ENST00000461406.1
nitric oxide synthase 3 (endothelial cell)
chr19_-_45873642 0.22 ENST00000485403.2
excision repair cross-complementing rodent repair deficiency, complementation group 2
chr12_-_80084594 0.22 ENST00000548426.1
PRKC, apoptosis, WT1, regulator
chr3_-_183145873 0.21 ENST00000447025.2
MCF.2 cell line derived transforming sequence-like 2
chr18_-_53089723 0.21 ENST00000561992.1
transcription factor 4
chr1_+_209859510 0.19 ENST00000367028.2
hydroxysteroid (11-beta) dehydrogenase 1
chr2_+_234601512 0.17 ENST00000305139.6
UDP glucuronosyltransferase 1 family, polypeptide A6
chr7_-_102232891 0.16 ENST00000514917.2
chr1_+_202091980 0.16 ENST00000367282.5
G protein-coupled receptor 37 like 1
chr1_+_3607228 0.14 ENST00000378285.1
tumor protein p73
chr1_-_27930102 0.14 ENST00000247087.5
AT hook, DNA binding motif, containing 1
chr3_+_190105909 0.13 ENST00000456423.1
claudin 16
chr5_+_132009675 0.07 ENST00000231449.2
interleukin 4
chr4_-_175750364 0.06 ENST00000340217.5
glycine receptor, alpha 3
chr2_+_191334212 0.06 ENST00000444317.1
major facilitator superfamily domain containing 6
chr4_-_68620053 0.05 ENST00000420975.2
gonadotropin-releasing hormone receptor
chr2_-_214016314 0.05 ENST00000434687.1
IKAROS family zinc finger 2 (Helios)
chr11_+_124735282 0.04 ENST00000397801.1
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr16_-_57513657 0.02 ENST00000566936.1
docking protein 4
chr14_-_65569057 0.01 ENST00000555419.1
MYC associated factor X

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF5

PNG image of the network

In order to view interactive SVG image please either update your browser to latest version or install SVG plugin.

View svg image
View png image

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
3.4 20.1 GO:0010724 regulation of definitive erythrocyte differentiation(GO:0010724)
3.0 9.0 GO:0006097 glyoxylate cycle(GO:0006097)
2.8 13.8 GO:0038026 reelin-mediated signaling pathway(GO:0038026)
2.3 6.8 GO:0060278 regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
1.6 4.8 GO:1903572 regulation of protein kinase D signaling(GO:1903570) positive regulation of protein kinase D signaling(GO:1903572)
1.5 7.7 GO:0099590 neurotransmitter receptor internalization(GO:0099590)
1.5 4.6 GO:0051257 meiotic metaphase I plate congression(GO:0043060) meiotic spindle midzone assembly(GO:0051257) meiotic metaphase plate congression(GO:0051311)
1.4 14.1 GO:1901409 positive regulation of phosphorylation of RNA polymerase II C-terminal domain(GO:1901409)
1.4 7.0 GO:0021759 globus pallidus development(GO:0021759)
1.2 11.1 GO:0001887 selenium compound metabolic process(GO:0001887)
1.2 3.5 GO:0018406 protein C-linked glycosylation(GO:0018103) peptidyl-tryptophan modification(GO:0018211) protein C-linked glycosylation via tryptophan(GO:0018317) protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan(GO:0018406)
1.0 4.0 GO:0001831 trophectodermal cellular morphogenesis(GO:0001831)
0.8 2.3 GO:0007113 endomitotic cell cycle(GO:0007113)
0.7 7.4 GO:0021957 corticospinal tract morphogenesis(GO:0021957)
0.7 5.9 GO:0007598 blood coagulation, extrinsic pathway(GO:0007598)
0.7 6.6 GO:0048050 post-embryonic eye morphogenesis(GO:0048050)
0.7 2.2 GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043328)
0.7 2.8 GO:0072004 pronephric field specification(GO:0039003) pattern specification involved in pronephros development(GO:0039017) kidney rudiment formation(GO:0072003) kidney field specification(GO:0072004) regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072304) negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:0072305) mesenchymal stem cell maintenance involved in metanephric nephron morphogenesis(GO:0072309) mesenchymal cell apoptotic process involved in metanephros development(GO:1900200) apoptotic process involved in metanephric collecting duct development(GO:1900204) apoptotic process involved in metanephric nephron tubule development(GO:1900205) regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900211) negative regulation of mesenchymal cell apoptotic process involved in metanephros development(GO:1900212) regulation of apoptotic process involved in metanephric collecting duct development(GO:1900214) negative regulation of apoptotic process involved in metanephric collecting duct development(GO:1900215) regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900217) negative regulation of apoptotic process involved in metanephric nephron tubule development(GO:1900218) mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis(GO:1901147) regulation of metanephric DCT cell differentiation(GO:2000592) positive regulation of metanephric DCT cell differentiation(GO:2000594)
0.7 2.0 GO:2000681 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.6 6.6 GO:0032876 negative regulation of DNA endoreduplication(GO:0032876)
0.5 13.5 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.5 4.3 GO:0060414 aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 1.6 GO:0048075 positive regulation of eye pigmentation(GO:0048075)
0.5 1.5 GO:2000977 midbrain-hindbrain boundary morphogenesis(GO:0021555) trochlear nerve development(GO:0021558) regulation of timing of neuron differentiation(GO:0060164) regulation of forebrain neuron differentiation(GO:2000977)
0.5 1.9 GO:1900194 negative regulation of oocyte maturation(GO:1900194)
0.4 6.4 GO:0051256 mitotic spindle midzone assembly(GO:0051256)
0.4 2.4 GO:0072719 cellular response to cisplatin(GO:0072719)
0.4 1.2 GO:0060926 cardiac pacemaker cell differentiation(GO:0060920) cardiac pacemaker cell development(GO:0060926)
0.4 1.2 GO:0021569 rhombomere 3 development(GO:0021569) central nervous system segmentation(GO:0035283) brain segmentation(GO:0035284)
0.4 3.3 GO:2001138 regulation of phospholipid transport(GO:2001138) positive regulation of phospholipid transport(GO:2001140)
0.3 10.7 GO:0036120 cellular response to platelet-derived growth factor stimulus(GO:0036120)
0.3 1.4 GO:0014816 skeletal muscle satellite cell differentiation(GO:0014816) negative regulation of skeletal muscle cell proliferation(GO:0014859) regulation of skeletal muscle tissue growth(GO:0048631) negative regulation of skeletal muscle satellite cell proliferation(GO:1902723)
0.3 1.7 GO:0070829 response to vitamin B2(GO:0033274) heterochromatin maintenance(GO:0070829)
0.3 1.8 GO:0051012 microtubule sliding(GO:0051012)
0.3 1.8 GO:0035709 memory T cell activation(GO:0035709) regulation of memory T cell activation(GO:2000567) positive regulation of memory T cell activation(GO:2000568)
0.3 0.9 GO:0051461 positive regulation of corticotropin secretion(GO:0051461)
0.3 0.6 GO:0048936 peripheral nervous system neuron axonogenesis(GO:0048936)
0.3 1.1 GO:1900245 positive regulation of MDA-5 signaling pathway(GO:1900245)
0.3 3.8 GO:1900119 positive regulation of execution phase of apoptosis(GO:1900119)
0.3 0.8 GO:2000870 regulation of progesterone secretion(GO:2000870)
0.3 0.8 GO:2000118 regulation of sodium-dependent phosphate transport(GO:2000118)
0.2 1.5 GO:2000391 positive regulation of neutrophil extravasation(GO:2000391)
0.2 11.1 GO:0045104 intermediate filament cytoskeleton organization(GO:0045104)
0.2 1.7 GO:0050910 detection of mechanical stimulus involved in sensory perception of sound(GO:0050910)
0.2 1.2 GO:0009098 branched-chain amino acid biosynthetic process(GO:0009082) leucine biosynthetic process(GO:0009098) valine biosynthetic process(GO:0009099)
0.2 2.7 GO:2000480 negative regulation of cAMP-dependent protein kinase activity(GO:2000480)
0.2 1.0 GO:0000720 pyrimidine dimer repair by nucleotide-excision repair(GO:0000720) positive regulation of t-circle formation(GO:1904431)
0.2 3.1 GO:0030388 fructose 1,6-bisphosphate metabolic process(GO:0030388)
0.2 2.4 GO:0045116 protein neddylation(GO:0045116)
0.1 0.5 GO:0038165 oncostatin-M-mediated signaling pathway(GO:0038165)
0.1 2.4 GO:0051764 actin crosslink formation(GO:0051764)
0.1 0.2 GO:0014806 smooth muscle hyperplasia(GO:0014806)
0.1 0.7 GO:0035608 protein deglutamylation(GO:0035608)
0.1 1.5 GO:2000059 negative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process(GO:2000059)
0.1 1.0 GO:0048003 antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) antigen processing and presentation, exogenous lipid antigen via MHC class Ib(GO:0048007)
0.1 1.1 GO:1901978 mitochondrial fragmentation involved in apoptotic process(GO:0043653) positive regulation of cell cycle checkpoint(GO:1901978)
0.1 1.1 GO:0018298 protein-chromophore linkage(GO:0018298)
0.1 0.2 GO:0032289 central nervous system myelin formation(GO:0032289)
0.1 2.0 GO:0010226 response to lithium ion(GO:0010226)
0.1 0.3 GO:0048698 negative regulation of collateral sprouting in absence of injury(GO:0048698)
0.1 0.2 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 2.8 GO:0006378 mRNA polyadenylation(GO:0006378)
0.0 10.5 GO:0043488 regulation of mRNA stability(GO:0043488)
0.0 0.5 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.4 GO:0033623 regulation of integrin activation(GO:0033623)
0.0 0.3 GO:0045078 positive regulation of interferon-gamma biosynthetic process(GO:0045078)
0.0 0.6 GO:0031915 positive regulation of synaptic plasticity(GO:0031915)
0.0 0.5 GO:0006450 regulation of translational fidelity(GO:0006450)
0.0 0.2 GO:0021940 positive regulation of cerebellar granule cell precursor proliferation(GO:0021940)
0.0 0.6 GO:0035116 embryonic hindlimb morphogenesis(GO:0035116)
0.0 10.3 GO:0007596 blood coagulation(GO:0007596)
0.0 0.1 GO:2000317 T-helper 1 cell lineage commitment(GO:0002296) cellular response to mercury ion(GO:0071288) negative regulation of complement-dependent cytotoxicity(GO:1903660) negative regulation of T-helper 17 type immune response(GO:2000317) negative regulation of T-helper 17 cell differentiation(GO:2000320) positive regulation of eosinophil migration(GO:2000418)
0.0 0.9 GO:0002756 MyD88-independent toll-like receptor signaling pathway(GO:0002756)
0.0 7.1 GO:0006936 muscle contraction(GO:0006936)
0.0 1.6 GO:0035335 peptidyl-tyrosine dephosphorylation(GO:0035335)
0.0 0.1 GO:0097210 response to gonadotropin-releasing hormone(GO:0097210) cellular response to gonadotropin-releasing hormone(GO:0097211)
0.0 0.0 GO:0016199 axon midline choice point recognition(GO:0016199)
0.0 0.2 GO:0052696 flavonoid glucuronidation(GO:0052696) xenobiotic glucuronidation(GO:0052697)
0.0 1.7 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 4.1 GO:0043687 post-translational protein modification(GO:0043687)
0.0 0.2 GO:0006704 glucocorticoid biosynthetic process(GO:0006704)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
2.3 6.8 GO:0043511 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
1.5 4.6 GO:0005715 late recombination nodule(GO:0005715)
0.8 9.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.7 10.2 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.5 5.9 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.4 4.0 GO:0005827 polar microtubule(GO:0005827)
0.4 13.8 GO:0034385 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)
0.4 7.7 GO:0036020 endolysosome membrane(GO:0036020)
0.4 1.6 GO:0031085 BLOC-3 complex(GO:0031085)
0.4 14.1 GO:0016592 mediator complex(GO:0016592)
0.4 1.1 GO:0044609 DBIRD complex(GO:0044609)
0.3 1.4 GO:0002189 ribose phosphate diphosphokinase complex(GO:0002189)
0.3 6.6 GO:0001527 microfibril(GO:0001527) fibril(GO:0043205)
0.3 12.3 GO:0045095 keratin filament(GO:0045095)
0.2 2.4 GO:0043073 germ cell nucleus(GO:0043073)
0.2 9.0 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.2 11.0 GO:0005637 nuclear inner membrane(GO:0005637)
0.1 1.0 GO:0070522 nucleotide-excision repair factor 1 complex(GO:0000110) ERCC4-ERCC1 complex(GO:0070522)
0.1 0.9 GO:0051286 cell tip(GO:0051286)
0.1 0.5 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 6.4 GO:0045171 intercellular bridge(GO:0045171)
0.1 18.9 GO:0001650 fibrillar center(GO:0001650)
0.1 13.5 GO:0005796 Golgi lumen(GO:0005796)
0.1 2.7 GO:0005665 DNA-directed RNA polymerase II, core complex(GO:0005665)
0.1 2.2 GO:0036452 ESCRT complex(GO:0036452)
0.1 9.7 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.1 0.6 GO:0070554 synaptobrevin 2-SNAP-25-syntaxin-3-complexin complex(GO:0070554)
0.1 2.0 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.1 11.0 GO:0005884 actin filament(GO:0005884)
0.0 1.1 GO:0097381 photoreceptor disc membrane(GO:0097381)
0.0 0.9 GO:0034451 centriolar satellite(GO:0034451)
0.0 3.8 GO:0030864 cortical actin cytoskeleton(GO:0030864)
0.0 1.0 GO:0070822 Sin3-type complex(GO:0070822)
0.0 7.4 GO:0042383 sarcolemma(GO:0042383)
0.0 0.2 GO:0071817 MMXD complex(GO:0071817)
0.0 2.5 GO:0072686 mitotic spindle(GO:0072686)
0.0 3.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 6.6 GO:0000775 chromosome, centromeric region(GO:0000775)
0.0 3.3 GO:0031225 anchored component of membrane(GO:0031225)
0.0 0.1 GO:0016935 glycine-gated chloride channel complex(GO:0016935)
0.0 1.4 GO:0005811 lipid particle(GO:0005811)
0.0 1.7 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 1.0 GO:0043202 lysosomal lumen(GO:0043202)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
3.7 11.1 GO:0098625 methylselenol reductase activity(GO:0098625) methylseleninic acid reductase activity(GO:0098626)
3.4 13.8 GO:0038025 glycoprotein transporter activity(GO:0034437) reelin receptor activity(GO:0038025)
3.0 9.0 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
2.3 6.8 GO:0070699 type II activin receptor binding(GO:0070699)
2.1 12.7 GO:1990254 keratin filament binding(GO:1990254)
1.0 4.0 GO:0031208 POZ domain binding(GO:0031208)
0.8 4.8 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.6 4.6 GO:0032137 guanine/thymine mispair binding(GO:0032137)
0.5 4.3 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.4 13.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.4 6.1 GO:0001161 intronic transcription regulatory region sequence-specific DNA binding(GO:0001161) intronic transcription regulatory region DNA binding(GO:0044213)
0.3 7.7 GO:0098748 clathrin adaptor activity(GO:0035615) endocytic adaptor activity(GO:0098748)
0.3 14.1 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.3 1.7 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.3 2.0 GO:0004839 ubiquitin activating enzyme activity(GO:0004839)
0.3 2.3 GO:0008641 small protein activating enzyme activity(GO:0008641)
0.3 4.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.3 1.8 GO:0023025 MHC class Ib protein complex binding(GO:0023025) MHC class Ib protein binding, via antigen binding groove(GO:0023030)
0.3 1.1 GO:0044323 retinoic acid-responsive element binding(GO:0044323)
0.3 3.1 GO:0004332 fructose-bisphosphate aldolase activity(GO:0004332)
0.3 1.9 GO:0004996 thyroid-stimulating hormone receptor activity(GO:0004996)
0.2 1.4 GO:0004749 ribose phosphate diphosphokinase activity(GO:0004749)
0.2 6.4 GO:0008574 ATP-dependent microtubule motor activity, plus-end-directed(GO:0008574)
0.2 1.2 GO:0004084 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.2 10.7 GO:0005154 epidermal growth factor receptor binding(GO:0005154)
0.2 3.5 GO:0000030 mannosyltransferase activity(GO:0000030)
0.2 2.0 GO:0031995 insulin-like growth factor II binding(GO:0031995)
0.2 7.4 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 1.0 GO:1990599 3' overhang single-stranded DNA endodeoxyribonuclease activity(GO:1990599)
0.1 10.2 GO:0035064 methylated histone binding(GO:0035064)
0.1 2.7 GO:0004862 cAMP-dependent protein kinase inhibitor activity(GO:0004862)
0.1 2.4 GO:0097602 cullin family protein binding(GO:0097602)
0.1 1.6 GO:0004726 non-membrane spanning protein tyrosine phosphatase activity(GO:0004726)
0.1 1.0 GO:0030884 lipid antigen binding(GO:0030882) endogenous lipid antigen binding(GO:0030883) exogenous lipid antigen binding(GO:0030884)
0.1 1.1 GO:0008020 G-protein coupled photoreceptor activity(GO:0008020)
0.1 0.9 GO:0030911 TPR domain binding(GO:0030911)
0.1 25.3 GO:0044822 mRNA binding(GO:0003729) poly(A) RNA binding(GO:0044822)
0.1 1.7 GO:0031005 filamin binding(GO:0031005)
0.1 1.5 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 3.3 GO:0005548 phospholipid transporter activity(GO:0005548)
0.1 0.2 GO:0003845 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845)
0.1 0.2 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.1 5.9 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.9 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.0 1.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 2.4 GO:0005080 protein kinase C binding(GO:0005080)
0.0 1.1 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 0.3 GO:0005497 androgen binding(GO:0005497)
0.0 0.5 GO:0016884 carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884)
0.0 0.2 GO:0043139 5'-3' DNA helicase activity(GO:0043139)
0.0 0.7 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 1.1 GO:0001784 phosphotyrosine binding(GO:0001784)
0.0 2.0 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.9 GO:0031593 polyubiquitin binding(GO:0031593)
0.0 1.7 GO:0005201 extracellular matrix structural constituent(GO:0005201)
0.0 0.6 GO:0017075 syntaxin-1 binding(GO:0017075)
0.0 0.2 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, TFIIB-class binding(GO:0001087)
0.0 0.9 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.0 2.2 GO:0047485 protein N-terminus binding(GO:0047485)
0.0 2.4 GO:0001078 transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001078)
0.0 0.1 GO:0016934 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.0 0.2 GO:0043522 leucine zipper domain binding(GO:0043522)
0.0 0.1 GO:0097371 MDM2/MDM4 family protein binding(GO:0097371)
0.0 8.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.4 GO:0000983 transcription factor activity, RNA polymerase II core promoter sequence-specific(GO:0000983)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 13.5 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.3 13.8 PID LIS1 PATHWAY Lissencephaly gene (LIS1) in neuronal migration and development
0.3 15.5 PID GLYPICAN 1PATHWAY Glypican 1 network
0.2 11.5 PID AURORA B PATHWAY Aurora B signaling
0.2 6.8 PID ALK1 PATHWAY ALK1 signaling events
0.1 5.9 NABA COLLAGENS Genes encoding collagen proteins
0.1 5.9 PID SYNDECAN 4 PATHWAY Syndecan-4-mediated signaling events
0.1 6.6 PID PLK1 PATHWAY PLK1 signaling events
0.1 2.3 PID ERB GENOMIC PATHWAY Validated nuclear estrogen receptor beta network
0.1 2.4 PID CIRCADIAN PATHWAY Circadian rhythm pathway
0.1 7.0 PID HNF3B PATHWAY FOXA2 and FOXA3 transcription factor networks
0.1 6.7 PID NOTCH PATHWAY Notch signaling pathway
0.1 1.9 PID PDGFRA PATHWAY PDGFR-alpha signaling pathway
0.0 3.0 PID DELTA NP63 PATHWAY Validated transcriptional targets of deltaNp63 isoforms
0.0 3.1 PID HIF1 TFPATHWAY HIF-1-alpha transcription factor network
0.0 7.1 PID P53 DOWNSTREAM PATHWAY Direct p53 effectors
0.0 1.3 ST DIFFERENTIATION PATHWAY IN PC12 CELLS Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway.
0.0 1.9 PID RHOA REG PATHWAY Regulation of RhoA activity
0.0 0.4 PID MYC PATHWAY C-MYC pathway
0.0 0.5 PID IL3 PATHWAY IL3-mediated signaling events
0.0 1.2 PID MYC ACTIV PATHWAY Validated targets of C-MYC transcriptional activation
0.0 0.3 PID AR NONGENOMIC PATHWAY Nongenotropic Androgen signaling
0.0 0.2 PID VEGFR1 PATHWAY VEGFR1 specific signals

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 10.7 REACTOME PECAM1 INTERACTIONS Genes involved in PECAM1 interactions
0.5 13.5 REACTOME CS DS DEGRADATION Genes involved in CS/DS degradation
0.5 6.8 REACTOME GLYCOPROTEIN HORMONES Genes involved in Glycoprotein hormones
0.3 7.7 REACTOME RETROGRADE NEUROTROPHIN SIGNALLING Genes involved in Retrograde neurotrophin signalling
0.3 11.1 REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates
0.3 14.1 REACTOME SMAD2 SMAD3 SMAD4 HETEROTRIMER REGULATES TRANSCRIPTION Genes involved in SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
0.3 9.0 REACTOME PEROXISOMAL LIPID METABOLISM Genes involved in Peroxisomal lipid metabolism
0.3 4.8 REACTOME VEGF LIGAND RECEPTOR INTERACTIONS Genes involved in VEGF ligand-receptor interactions
0.2 6.4 REACTOME RECYCLING PATHWAY OF L1 Genes involved in Recycling pathway of L1
0.2 4.3 REACTOME PROCESSING OF INTRONLESS PRE MRNAS Genes involved in Processing of Intronless Pre-mRNAs
0.2 2.4 REACTOME REGULATION OF INSULIN SECRETION BY ACETYLCHOLINE Genes involved in Regulation of Insulin Secretion by Acetylcholine
0.2 5.5 REACTOME ADHERENS JUNCTIONS INTERACTIONS Genes involved in Adherens junctions interactions
0.1 5.9 REACTOME FORMATION OF FIBRIN CLOT CLOTTING CASCADE Genes involved in Formation of Fibrin Clot (Clotting Cascade)
0.1 2.2 REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT)
0.1 1.1 REACTOME OPSINS Genes involved in Opsins
0.1 12.2 REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2 Genes involved in Response to elevated platelet cytosolic Ca2+
0.1 5.9 REACTOME COLLAGEN FORMATION Genes involved in Collagen formation
0.1 11.2 REACTOME MEIOSIS Genes involved in Meiosis
0.1 2.0 REACTOME REGULATION OF INSULIN LIKE GROWTH FACTOR IGF ACTIVITY BY INSULIN LIKE GROWTH FACTOR BINDING PROTEINS IGFBPS Genes involved in Regulation of Insulin-like Growth Factor (IGF) Activity by Insulin-like Growth Factor Binding Proteins (IGFBPs)
0.1 1.7 REACTOME CELL EXTRACELLULAR MATRIX INTERACTIONS Genes involved in Cell-extracellular matrix interactions
0.1 1.3 REACTOME FORMATION OF INCISION COMPLEX IN GG NER Genes involved in Formation of incision complex in GG-NER
0.0 7.1 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.2 REACTOME BRANCHED CHAIN AMINO ACID CATABOLISM Genes involved in Branched-chain amino acid catabolism
0.0 1.5 REACTOME REGULATION OF BETA CELL DEVELOPMENT Genes involved in Regulation of beta-cell development
0.0 0.6 REACTOME SYNTHESIS SECRETION AND INACTIVATION OF GIP Genes involved in Synthesis, Secretion, and Inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)
0.0 1.5 REACTOME IL1 SIGNALING Genes involved in Interleukin-1 signaling
0.0 7.2 REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION Genes involved in Antigen processing: Ubiquitination & Proteasome degradation
0.0 0.4 REACTOME CYCLIN E ASSOCIATED EVENTS DURING G1 S TRANSITION Genes involved in Cyclin E associated events during G1/S transition
0.0 0.2 REACTOME TETRAHYDROBIOPTERIN BH4 SYNTHESIS RECYCLING SALVAGE AND REGULATION Genes involved in Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation
0.0 1.2 REACTOME TRANSCRIPTIONAL REGULATION OF WHITE ADIPOCYTE DIFFERENTIATION Genes involved in Transcriptional Regulation of White Adipocyte Differentiation
0.0 2.4 REACTOME SIGNALING BY RHO GTPASES Genes involved in Signaling by Rho GTPases
0.0 1.7 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation