ISMARA results: ATF6

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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for ATF6

Z-value: 0.49

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Transcription factors associated with ATF6

Gene Symbol	Gene ID	Gene Info
ATF6 Ensembl NCBI GeneCards UniProt NextProt	ENSG00000118217.5	activating transcription factor 6

Activity-expression correlation:

Gene	Promoter	Pearson corr. coef.	P-value	Plot
ATF6	hg19_v2_chr1_+_161736072_161736093	0.37	2.3e-08	Click!

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

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Promoter	Log-likelihood	Transcript	Gene	Gene Info
chr12_+_72148614 Show fit	26.21	ENST00000261263.3	RAB21 Ensembl NCBI GeneCards UniProt NextProt Show fit	RAB21, member RAS oncogene family
chr19_+_16186903 Show fit	23.32	ENST00000588507.1	TPM4 Ensembl NCBI GeneCards UniProt NextProt Show fit	tropomyosin 4
chrX_-_102941596 Show fit	20.17	ENST00000441076.2 ENST00000422355.1 ENST00000442614.1 ENST00000422154.2 ENST00000451301.1	MORF4L2 Ensembl NCBI GeneCards UniProt NextProt Show fit	mortality factor 4 like 2
chr19_-_48894104 Show fit	19.37	ENST00000597017.1	KDELR1 Ensembl NCBI GeneCards UniProt NextProt Show fit	KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1
chr2_-_10588630 Show fit	19.11	ENST00000234111.4	ODC1 Ensembl NCBI GeneCards UniProt NextProt Show fit	ornithine decarboxylase 1
chr21_-_38445470 Show fit	19.03	ENST00000399098.1	PIGP Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class P
chr1_+_110527308 Show fit	18.48	ENST00000369799.5	AHCYL1 Ensembl NCBI GeneCards UniProt NextProt Show fit	adenosylhomocysteinase-like 1
chr21_-_38445011 Show fit	17.89	ENST00000464265.1 ENST00000399102.1	PIGP Ensembl NCBI GeneCards UniProt NextProt Show fit	phosphatidylinositol glycan anchor biosynthesis, class P
chrX_+_48433326 Show fit	17.55	ENST00000376755.1	RBM3 Ensembl NCBI GeneCards UniProt NextProt Show fit	RNA binding motif (RNP1, RRM) protein 3
chr10_-_120840309 Show fit	17.41	ENST00000369144.3	EIF3A Ensembl NCBI GeneCards UniProt NextProt Show fit	eukaryotic translation initiation factor 3, subunit A

Showing 1 to 10 of 200 entries

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

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Log-likelihood per target	Total log-likelihood	Term	Description
3.1	61.6	GO:0016254	preassembly of GPI anchor in ER membrane(GO:0016254)
0.5	40.2	GO:0030049	muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
3.4	37.3	GO:0031584	activation of phospholipase D activity(GO:0031584)
3.1	34.5	GO:0006621	protein retention in ER lumen(GO:0006621)
0.6	32.0	GO:0006891	intra-Golgi vesicle-mediated transport(GO:0006891)
9.9	29.8	GO:0036353	histone H2A-K119 monoubiquitination(GO:0036353)
0.6	29.8	GO:0070911	global genome nucleotide-excision repair(GO:0070911)
2.1	27.0	GO:0019511	peptidyl-proline hydroxylation(GO:0019511)
2.6	26.2	GO:2000643	positive regulation of early endosome to late endosome transport(GO:2000643)
3.7	25.9	GO:0070934	CRD-mediated mRNA stabilization(GO:0070934)

Showing 1 to 10 of 157 entries

Gene overrepresentation in cellular_component category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	61.6	GO:0000506	glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex(GO:0000506)
3.7	51.3	GO:0030663	COPI-coated vesicle membrane(GO:0030663)
2.1	40.2	GO:0005862	muscle thin filament tropomyosin(GO:0005862)
1.0	36.2	GO:0030173	integral component of Golgi membrane(GO:0030173)
1.7	34.4	GO:0031588	nucleotide-activated protein kinase complex(GO:0031588)
0.2	33.3	GO:0032587	ruffle membrane(GO:0032587)
1.1	29.8	GO:0035098	ESC/E(Z) complex(GO:0035098)
0.5	28.0	GO:0005834	heterotrimeric G-protein complex(GO:0005834)
1.9	27.1	GO:0097227	sperm annulus(GO:0097227)
3.3	26.2	GO:0098559	cytoplasmic side of early endosome membrane(GO:0098559)

Showing 1 to 10 of 92 entries

Gene overrepresentation in molecular_function category:

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Log-likelihood per target	Total log-likelihood	Term	Description
6.2	61.6	GO:0017176	phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.1	58.5	GO:0045296	cadherin binding(GO:0045296)
1.7	45.3	GO:0005086	ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.6	45.1	GO:0019003	GDP binding(GO:0019003)
0.9	35.6	GO:0051059	NF-kappaB binding(GO:0051059)
0.4	35.3	GO:0008307	structural constituent of muscle(GO:0008307)
1.7	34.4	GO:0008603	cAMP-dependent protein kinase regulator activity(GO:0008603)
0.7	31.2	GO:0005164	tumor necrosis factor receptor binding(GO:0005164)
7.7	30.7	GO:0005046	KDEL sequence binding(GO:0005046)
5.4	27.0	GO:0004656	procollagen-proline 4-dioxygenase activity(GO:0004656) procollagen-proline dioxygenase activity(GO:0019798)

Showing 1 to 10 of 127 entries

Gene overrepresentation in C2:CP category:

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Log-likelihood per target	Total log-likelihood	Term	Description
0.5	65.3	PID MYC ACTIV PATHWAY	Validated targets of C-MYC transcriptional activation
1.9	48.2	PID ARF 3PATHWAY	Arf1 pathway
0.2	29.7	PID ERBB1 DOWNSTREAM PATHWAY	ErbB1 downstream signaling
0.1	19.8	NABA ECM REGULATORS	Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix
0.2	18.3	PID LKB1 PATHWAY	LKB1 signaling events
0.2	16.9	PID INTEGRIN A4B1 PATHWAY	Alpha4 beta1 integrin signaling events
0.3	16.1	PID IL2 PI3K PATHWAY	IL2 signaling events mediated by PI3K
0.3	14.7	PID CDC42 PATHWAY	CDC42 signaling events
0.3	13.1	PID THROMBIN PAR1 PATHWAY	PAR1-mediated thrombin signaling events
0.2	12.1	ST FAS SIGNALING PATHWAY	Fas Signaling Pathway

Showing 1 to 10 of 36 entries

Gene overrepresentation in C2:CP:REACTOME category:

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Log-likelihood per target	Total log-likelihood	Term	Description
2.7	61.6	REACTOME SYNTHESIS OF GLYCOSYLPHOSPHATIDYLINOSITOL GPI	Genes involved in Synthesis of glycosylphosphatidylinositol (GPI)
5.3	53.1	REACTOME COPI MEDIATED TRANSPORT	Genes involved in COPI Mediated Transport
0.6	38.3	REACTOME SMOOTH MUSCLE CONTRACTION	Genes involved in Smooth Muscle Contraction
0.2	35.5	REACTOME RESPONSE TO ELEVATED PLATELET CYTOSOLIC CA2	Genes involved in Response to elevated platelet cytosolic Ca2+
0.8	29.2	REACTOME DOWNREGULATION OF TGF BETA RECEPTOR SIGNALING	Genes involved in Downregulation of TGF-beta receptor signaling
0.2	24.9	REACTOME P75 NTR RECEPTOR MEDIATED SIGNALLING	Genes involved in p75 NTR receptor-mediated signalling
0.3	23.5	REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S	Genes involved in Activation of Chaperone Genes by XBP1(S)
1.2	21.7	REACTOME BASE FREE SUGAR PHOSPHATE REMOVAL VIA THE SINGLE NUCLEOTIDE REPLACEMENT PATHWAY	Genes involved in Base-free sugar-phosphate removal via the single-nucleotide replacement pathway
0.6	21.4	REACTOME DEADENYLATION OF MRNA	Genes involved in Deadenylation of mRNA
0.1	20.2	REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION	Genes involved in Antigen processing: Ubiquitination & Proteasome degradation

Showing 1 to 10 of 53 entries

Results for ATF6

Z-value: 0.49

Motif logo

Transcription factors associated with ATF6

Activity-expression correlation:

Activity profile of ATF6 motif

Sorted Z-values of ATF6 motif

Top targets:

Network of associatons between targets according to the STRING database.

First level regulatory network of ATF6

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Gene overrepresentation in cellular_component category:

Gene overrepresentation in molecular_function category:

Gene overrepresentation in C2:CP category:

Gene overrepresentation in C2:CP:REACTOME category: