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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for ATF7
Z-value: 0.36
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Transcription factors associated with ATF7
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| ATF7 | hg19_v2_chr12_-_54020107_54020199, hg19_v2_chr12_-_53994805_53994817 | 0.14 | 3.4e-02 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of ATF7
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.6 | GO:0070126 | mitochondrial translational elongation(GO:0070125) mitochondrial translational termination(GO:0070126) |
| 0.6 | 13.5 | GO:0051231 | spindle elongation(GO:0051231) |
| 0.3 | 12.8 | GO:1902895 | positive regulation of pri-miRNA transcription from RNA polymerase II promoter(GO:1902895) |
| 0.2 | 10.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 2.6 | 10.5 | GO:0009386 | translational attenuation(GO:0009386) |
| 1.0 | 7.9 | GO:0000055 | ribosomal large subunit export from nucleus(GO:0000055) negative regulation of RNA polymerase II regulatory region sequence-specific DNA binding(GO:1903026) |
| 0.2 | 7.8 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.5 | 7.6 | GO:0050774 | negative regulation of dendrite morphogenesis(GO:0050774) |
| 0.1 | 7.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.3 | 7.4 | GO:0009263 | deoxyribonucleotide biosynthetic process(GO:0009263) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 15.6 | GO:0005759 | mitochondrial matrix(GO:0005759) |
| 2.9 | 14.5 | GO:0071148 | TEAD-1-YAP complex(GO:0071148) |
| 0.1 | 11.6 | GO:0005811 | lipid particle(GO:0005811) |
| 0.3 | 11.4 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 1.2 | 10.5 | GO:0033588 | Elongator holoenzyme complex(GO:0033588) |
| 0.3 | 9.2 | GO:0030687 | preribosome, large subunit precursor(GO:0030687) |
| 0.3 | 8.2 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.7 | 8.1 | GO:1990023 | mitotic spindle midzone(GO:1990023) |
| 2.0 | 7.9 | GO:0005971 | ribonucleoside-diphosphate reductase complex(GO:0005971) |
| 0.1 | 7.6 | GO:0055038 | recycling endosome membrane(GO:0055038) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 18.0 | GO:0001134 | transcription factor activity, transcription factor recruiting(GO:0001134) |
| 0.3 | 12.7 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.4 | 10.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 2.6 | 7.9 | GO:0000035 | acyl binding(GO:0000035) phosphopantetheine binding(GO:0031177) |
| 2.0 | 7.9 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.4 | 7.8 | GO:0003857 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) |
| 0.3 | 7.6 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.1 | 7.5 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.3 | 7.1 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.5 | 7.0 | GO:0016813 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines(GO:0016813) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 21.3 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.2 | 12.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 11.5 | PID E2F PATHWAY | E2F transcription factor network |
| 0.2 | 9.0 | PID INSULIN GLUCOSE PATHWAY | Insulin-mediated glucose transport |
| 0.2 | 8.4 | SIG REGULATION OF THE ACTIN CYTOSKELETON BY RHO GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.2 | 7.2 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.2 | 6.1 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.2 | 5.8 | PID HDAC CLASSIII PATHWAY | Signaling events mediated by HDAC Class III |
| 0.2 | 5.3 | PID ERBB NETWORK PATHWAY | ErbB receptor signaling network |
| 0.2 | 3.8 | PID IL5 PATHWAY | IL5-mediated signaling events |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 14.5 | REACTOME YAP1 AND WWTR1 TAZ STIMULATED GENE EXPRESSION | Genes involved in YAP1- and WWTR1 (TAZ)-stimulated gene expression |
| 0.3 | 9.6 | REACTOME G0 AND EARLY G1 | Genes involved in G0 and Early G1 |
| 0.3 | 8.2 | REACTOME PHOSPHORYLATION OF THE APC C | Genes involved in Phosphorylation of the APC/C |
| 0.4 | 7.8 | REACTOME MITOCHONDRIAL FATTY ACID BETA OXIDATION | Genes involved in Mitochondrial Fatty Acid Beta-Oxidation |
| 0.1 | 7.5 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 0.2 | 7.4 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.1 | 7.1 | REACTOME ION TRANSPORT BY P TYPE ATPASES | Genes involved in Ion transport by P-type ATPases |
| 0.2 | 6.7 | REACTOME FORMATION OF INCISION COMPLEX IN GG NER | Genes involved in Formation of incision complex in GG-NER |
| 0.1 | 6.3 | REACTOME DEPOSITION OF NEW CENPA CONTAINING NUCLEOSOMES AT THE CENTROMERE | Genes involved in Deposition of New CENPA-containing Nucleosomes at the Centromere |
| 0.2 | 5.9 | REACTOME CYTOSOLIC SULFONATION OF SMALL MOLECULES | Genes involved in Cytosolic sulfonation of small molecules |