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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AUAAAGU
Z-value: 1.31
Motif logo
miRNA associated with seed AUAAAGU
Network of associatons between targets according to the STRING database.
First level regulatory network of AUAAAGU
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 18.7 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.2 | 16.9 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) |
| 1.2 | 16.8 | GO:2000675 | negative regulation of type B pancreatic cell apoptotic process(GO:2000675) |
| 0.3 | 14.3 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 0.2 | 13.2 | GO:0032465 | regulation of cytokinesis(GO:0032465) |
| 4.2 | 12.5 | GO:0016344 | meiotic chromosome movement towards spindle pole(GO:0016344) |
| 0.4 | 12.5 | GO:0043555 | regulation of translation in response to stress(GO:0043555) |
| 1.1 | 12.1 | GO:2001032 | regulation of double-strand break repair via nonhomologous end joining(GO:2001032) |
| 0.1 | 11.8 | GO:0043488 | regulation of mRNA stability(GO:0043488) |
| 0.2 | 11.5 | GO:0007029 | endoplasmic reticulum organization(GO:0007029) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 15.7 | GO:0005643 | nuclear pore(GO:0005643) |
| 1.1 | 15.5 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.7 | 12.5 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.4 | 11.5 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 11.5 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 11.5 | GO:0048471 | perinuclear region of cytoplasm(GO:0048471) |
| 0.3 | 11.1 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.7 | 10.8 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.2 | 10.8 | GO:0031519 | PcG protein complex(GO:0031519) |
| 0.5 | 10.7 | GO:0032156 | septin cytoskeleton(GO:0032156) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 20.7 | GO:0042393 | histone binding(GO:0042393) |
| 0.2 | 17.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 2.8 | 16.8 | GO:0010859 | calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859) |
| 1.7 | 15.5 | GO:1990226 | histone methyltransferase binding(GO:1990226) |
| 0.0 | 15.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.4 | 13.9 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.3 | 13.4 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 0.3 | 13.3 | GO:0035255 | ionotropic glutamate receptor binding(GO:0035255) |
| 0.3 | 12.2 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.1 | 11.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 23.1 | SIG CHEMOTAXIS | Genes related to chemotaxis |
| 0.3 | 19.8 | ST ERK1 ERK2 MAPK PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.2 | 17.4 | PID TGFBR PATHWAY | TGF-beta receptor signaling |
| 0.2 | 12.9 | PID HES HEY PATHWAY | Notch-mediated HES/HEY network |
| 0.1 | 12.2 | PID REG GR PATHWAY | Glucocorticoid receptor regulatory network |
| 0.1 | 9.7 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 0.1 | 8.4 | PID PDGFRB PATHWAY | PDGFR-beta signaling pathway |
| 0.1 | 7.0 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 6.0 | ST IL 13 PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.1 | 5.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 20.0 | REACTOME RNA POL I TRANSCRIPTION | Genes involved in RNA Polymerase I Transcription |
| 0.1 | 16.4 | REACTOME ANTIGEN PROCESSING UBIQUITINATION PROTEASOME DEGRADATION | Genes involved in Antigen processing: Ubiquitination & Proteasome degradation |
| 0.4 | 15.7 | REACTOME CREB PHOSPHORYLATION THROUGH THE ACTIVATION OF RAS | Genes involved in CREB phosphorylation through the activation of Ras |
| 0.3 | 12.9 | REACTOME NEP NS2 INTERACTS WITH THE CELLULAR EXPORT MACHINERY | Genes involved in NEP/NS2 Interacts with the Cellular Export Machinery |
| 0.4 | 12.1 | REACTOME NEPHRIN INTERACTIONS | Genes involved in Nephrin interactions |
| 0.1 | 8.6 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.4 | 8.2 | REACTOME ACTIVATION OF RAC | Genes involved in Activation of Rac |
| 0.2 | 7.8 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.3 | 7.4 | REACTOME BIOSYNTHESIS OF THE N GLYCAN PRECURSOR DOLICHOL LIPID LINKED OLIGOSACCHARIDE LLO AND TRANSFER TO A NASCENT PROTEIN | Genes involved in Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| 0.0 | 7.4 | REACTOME INFLUENZA VIRAL RNA TRANSCRIPTION AND REPLICATION | Genes involved in Influenza Viral RNA Transcription and Replication |