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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AUGACAC

Z-value: 0.06

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miRNA associated with seed AUGACAC

NamemiRBASE accession
hsa-miR-425-5p
MIMAT0003393

Activity profile of AUGACAC motif

Sorted Z-values of AUGACAC motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr15_-_48937982 0.21 ENST00000316623.5
FBN1
fibrillin 1
chr6_-_86352642 0.12 ENST00000355238.6
SYNCRIP
synaptotagmin binding, cytoplasmic RNA interacting protein
chr10_+_89622870 0.11 ENST00000371953.3
PTEN
phosphatase and tensin homolog
chr6_+_118869452 0.11 ENST00000357525.5
PLN
phospholamban
chr2_+_208394616 0.10 ENST00000432329.2
ENST00000353267.3
ENST00000445803.1
CREB1
cAMP responsive element binding protein 1
chr3_+_187930719 0.09 ENST00000312675.4
LPP
LIM domain containing preferred translocation partner in lipoma
chrX_-_119694538 0.08 ENST00000371322.5
CUL4B
cullin 4B
chr5_-_72744336 0.08 ENST00000499003.3
FOXD1
forkhead box D1
chr12_-_102874416 0.07 ENST00000392904.1
ENST00000337514.6
IGF1
insulin-like growth factor 1 (somatomedin C)
chr18_-_54305658 0.06 ENST00000586262.1
ENST00000217515.6
TXNL1
thioredoxin-like 1
chr3_-_150481164 0.06 ENST00000312960.3
SIAH2
siah E3 ubiquitin protein ligase 2
chr2_+_114647504 0.06 ENST00000263238.2
ACTR3
ARP3 actin-related protein 3 homolog (yeast)
chr13_-_107187462 0.05 ENST00000245323.4
EFNB2
ephrin-B2
chr3_-_125094093 0.05 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148
zinc finger protein 148
chr9_-_16870704 0.05 ENST00000380672.4
ENST00000380667.2
ENST00000380666.2
ENST00000486514.1
BNC2
basonuclin 2
chr17_-_65362678 0.04 ENST00000357146.4
ENST00000356126.3
PSMD12
proteasome (prosome, macropain) 26S subunit, non-ATPase, 12
chrX_-_39956656 0.04 ENST00000397354.3
ENST00000378444.4
BCOR
BCL6 corepressor
chr14_-_91976488 0.04 ENST00000554684.1
ENST00000337238.4
ENST00000428424.2
ENST00000554511.1
SMEK1
SMEK homolog 1, suppressor of mek1 (Dictyostelium)
chr6_-_136610911 0.04 ENST00000530767.1
ENST00000527759.1
ENST00000527536.1
ENST00000529826.1
ENST00000531224.1
ENST00000353331.4
BCLAF1
BCL2-associated transcription factor 1
chr11_-_77532050 0.04 ENST00000308488.6
RSF1
remodeling and spacing factor 1
chr1_+_111991474 0.03 ENST00000369722.3
ATP5F1
ATP synthase, H+ transporting, mitochondrial Fo complex, subunit B1
chr13_+_22245522 0.03 ENST00000382353.5
FGF9
fibroblast growth factor 9
chr3_-_24536253 0.03 ENST00000428492.1
ENST00000396671.2
ENST00000431815.1
ENST00000418247.1
ENST00000416420.1
ENST00000356447.4
THRB
thyroid hormone receptor, beta
chr18_-_45456930 0.03 ENST00000262160.6
ENST00000587269.1
SMAD2
SMAD family member 2
chr2_-_40679186 0.03 ENST00000406785.2
SLC8A1
solute carrier family 8 (sodium/calcium exchanger), member 1
chr5_+_141348598 0.03 ENST00000394520.2
ENST00000347642.3
RNF14
ring finger protein 14
chr22_+_21771656 0.03 ENST00000407464.2
HIC2
hypermethylated in cancer 2
chr12_-_65146636 0.03 ENST00000418919.2
GNS
glucosamine (N-acetyl)-6-sulfatase
chr9_-_102861267 0.02 ENST00000262455.6
ERP44
endoplasmic reticulum protein 44
chr10_-_98346801 0.02 ENST00000371142.4
TM9SF3
transmembrane 9 superfamily member 3
chr5_+_179159813 0.02 ENST00000292599.3
MAML1
mastermind-like 1 (Drosophila)
chr2_+_176987088 0.02 ENST00000249499.6
HOXD9
homeobox D9
chr19_-_44143939 0.02 ENST00000222374.2
CADM4
cell adhesion molecule 4
chrX_+_28605516 0.02 ENST00000378993.1
IL1RAPL1
interleukin 1 receptor accessory protein-like 1
chr2_+_113033164 0.02 ENST00000409871.1
ENST00000343936.4
ZC3H6
zinc finger CCCH-type containing 6
chr21_+_39628655 0.02 ENST00000398925.1
ENST00000398928.1
ENST00000328656.4
ENST00000443341.1
KCNJ15
potassium inwardly-rectifying channel, subfamily J, member 15
chrX_+_9983602 0.01 ENST00000380861.4
WWC3
WWC family member 3
chr15_-_35261996 0.01 ENST00000156471.5
AQR
aquarius intron-binding spliceosomal factor
chr5_-_132299313 0.01 ENST00000265343.5
AFF4
AF4/FMR2 family, member 4
chr1_+_237205476 0.01 ENST00000366574.2
RYR2
ryanodine receptor 2 (cardiac)
chr15_-_27018175 0.01 ENST00000311550.5
GABRB3
gamma-aminobutyric acid (GABA) A receptor, beta 3
chr3_-_57678772 0.01 ENST00000311128.5
DENND6A
DENN/MADD domain containing 6A
chr4_+_144434584 0.01 ENST00000283131.3
SMARCA5
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5
chr5_+_135468516 0.01 ENST00000507118.1
ENST00000511116.1
ENST00000545279.1
ENST00000545620.1
SMAD5
SMAD family member 5
chr6_+_44355257 0.00 ENST00000371477.3
CDC5L
cell division cycle 5-like
chr15_+_72766651 0.00 ENST00000379887.4
ARIH1
ariadne RBR E3 ubiquitin protein ligase 1
chr3_-_186080012 0.00 ENST00000544847.1
ENST00000265022.3
DGKG
diacylglycerol kinase, gamma 90kDa

Network of associatons between targets according to the STRING database.

First level regulatory network of AUGACAC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.2 GO:0035582 sequestering of BMP in extracellular matrix(GO:0035582)
0.0 0.1 GO:0086092 regulation of the force of heart contraction by cardiac conduction(GO:0086092) regulation of calcium ion binding(GO:1901876) negative regulation of calcium ion binding(GO:1901877) regulation of calcium ion import into sarcoplasmic reticulum(GO:1902080) negative regulation of calcium ion import into sarcoplasmic reticulum(GO:1902081)
0.0 0.1 GO:1903984 positive regulation of TRAIL-activated apoptotic signaling pathway(GO:1903984)
0.0 0.1 GO:0016344 meiotic chromosome movement towards spindle pole(GO:0016344)
0.0 0.1 GO:0070934 CRD-mediated mRNA stabilization(GO:0070934)
0.0 0.1 GO:1904550 chemotaxis to arachidonic acid(GO:0034670) response to arachidonic acid(GO:1904550)
0.0 0.1 GO:0072076 nephrogenic mesenchyme development(GO:0072076)
0.0 0.0 GO:0070171 negative regulation of tooth mineralization(GO:0070171)
0.0 0.1 GO:1904075 trophectodermal cell proliferation(GO:0001834) regulation of trophectodermal cell proliferation(GO:1904073) positive regulation of trophectodermal cell proliferation(GO:1904075)
0.0 0.0 GO:0008050 female courtship behavior(GO:0008050)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0097452 GAIT complex(GO:0097452)
0.0 0.0 GO:0031213 RSF complex(GO:0031213)
0.0 0.1 GO:1990589 ATF4-CREB1 transcription factor complex(GO:1990589)
0.0 0.1 GO:0031465 Cul4B-RING E3 ubiquitin ligase complex(GO:0031465)
0.0 0.1 GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex(GO:0035867)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0016314 phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314)
0.0 0.1 GO:0042030 ATPase inhibitor activity(GO:0042030)
0.0 0.2 GO:0030023 extracellular matrix constituent conferring elasticity(GO:0030023)
0.0 0.1 GO:1990763 arrestin family protein binding(GO:1990763)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 REACTOME NEGATIVE REGULATION OF THE PI3K AKT NETWORK Genes involved in Negative regulation of the PI3K/AKT network