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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for AUGUGCC
Z-value: 0.56
Motif logo
miRNA associated with seed AUGUGCC
| Name | miRBASE accession |
|---|---|
|
hsa-miR-455-5p
|
MIMAT0003150 |
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr2_-_38978492 Show fit | 6.59 |
ENST00000409276.1
ENST00000446327.2 ENST00000313117.6 |
serine/arginine-rich splicing factor 7 |
|
| chr1_-_70671216 Show fit | 5.08 |
ENST00000370952.3
|
leucine rich repeat containing 40 |
|
| chr9_-_74980113 Show fit | 4.54 |
ENST00000376962.5
ENST00000376960.4 ENST00000237937.3 |
zinc finger, AN1-type domain 5 |
|
| chr17_-_62658186 Show fit | 4.24 |
ENST00000262435.9
|
SMAD specific E3 ubiquitin protein ligase 2 |
|
| chrX_+_41192595 Show fit | 4.07 |
ENST00000399959.2
|
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked |
|
| chr2_+_85198216 Show fit | 4.05 |
ENST00000456682.1
ENST00000409785.4 |
potassium channel modulatory factor 1 |
|
| chr12_+_12870055 Show fit | 3.97 |
ENST00000228872.4
|
cyclin-dependent kinase inhibitor 1B (p27, Kip1) |
|
| chr6_+_89790490 Show fit | 3.96 |
ENST00000336032.3
|
proline-rich nuclear receptor coactivator 1 |
|
| chr4_+_39699664 Show fit | 3.91 |
ENST00000261427.5
ENST00000510934.1 ENST00000295963.6 |
ubiquitin-conjugating enzyme E2K |
|
| chr4_-_185395672 Show fit | 3.90 |
ENST00000393593.3
|
interferon regulatory factor 2 |
Network of associatons between targets according to the STRING database.
First level regulatory network of AUGUGCC
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 6.6 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.1 | 5.8 | GO:0070534 | protein K63-linked ubiquitination(GO:0070534) |
| 1.1 | 4.2 | GO:1901165 | positive regulation of trophoblast cell migration(GO:1901165) |
| 1.0 | 4.1 | GO:0042256 | mature ribosome assembly(GO:0042256) |
| 0.6 | 4.0 | GO:1902746 | regulation of lens fiber cell differentiation(GO:1902746) |
| 0.5 | 4.0 | GO:0031087 | deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087) |
| 0.5 | 3.9 | GO:0010993 | regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.0 | 3.9 | GO:0060337 | type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.1 | 3.5 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.2 | 3.3 | GO:0071550 | death-inducing signaling complex assembly(GO:0071550) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 6.5 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 4.2 | GO:0000151 | ubiquitin ligase complex(GO:0000151) |
| 0.2 | 4.1 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.3 | 4.0 | GO:0031464 | Cul4A-RING E3 ubiquitin ligase complex(GO:0031464) |
| 0.0 | 4.0 | GO:0101002 | ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813) |
| 0.2 | 3.9 | GO:0032433 | filopodium tip(GO:0032433) |
| 0.3 | 3.5 | GO:0070938 | contractile ring(GO:0070938) |
| 0.0 | 3.4 | GO:0018995 | host(GO:0018995) host cell(GO:0043657) |
| 0.1 | 3.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.3 | 3.2 | GO:0001739 | sex chromatin(GO:0001739) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 14.5 | GO:0008270 | zinc ion binding(GO:0008270) |
| 0.0 | 9.2 | GO:0061630 | ubiquitin protein ligase activity(GO:0061630) |
| 0.1 | 4.2 | GO:0005160 | transforming growth factor beta receptor binding(GO:0005160) |
| 0.4 | 4.1 | GO:0033592 | RNA strand annealing activity(GO:0033592) |
| 0.2 | 4.0 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.3 | 3.9 | GO:0034450 | ubiquitin-ubiquitin ligase activity(GO:0034450) |
| 0.1 | 3.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.0 | 3.5 | GO:0004843 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) |
| 0.1 | 3.3 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.4 | 3.2 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.5 | PID FOXO PATHWAY | FoxO family signaling |
| 0.1 | 4.2 | PID BMP PATHWAY | BMP receptor signaling |
| 0.2 | 4.0 | SA REG CASCADE OF CYCLIN EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.3 | PID TCR RAS PATHWAY | Ras signaling in the CD4+ TCR pathway |
| 0.1 | 2.7 | PID TOLL ENDOGENOUS PATHWAY | Endogenous TLR signaling |
| 0.1 | 2.6 | PID IL1 PATHWAY | IL1-mediated signaling events |
| 0.0 | 2.1 | PID TELOMERASE PATHWAY | Regulation of Telomerase |
| 0.0 | 1.9 | PID BETA CATENIN NUC PATHWAY | Regulation of nuclear beta catenin signaling and target gene transcription |
| 0.1 | 1.7 | PID S1P META PATHWAY | Sphingosine 1-phosphate (S1P) pathway |
| 0.0 | 1.1 | PID REELIN PATHWAY | Reelin signaling pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.6 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.1 | 5.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.2 | 4.0 | REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL | Genes involved in AKT phosphorylates targets in the cytosol |
| 0.2 | 3.9 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.1 | 3.9 | REACTOME TRAF6 MEDIATED IRF7 ACTIVATION | Genes involved in TRAF6 mediated IRF7 activation |
| 0.1 | 3.5 | REACTOME CHONDROITIN SULFATE BIOSYNTHESIS | Genes involved in Chondroitin sulfate biosynthesis |
| 0.2 | 3.3 | REACTOME RAF MAP KINASE CASCADE | Genes involved in RAF/MAP kinase cascade |
| 0.3 | 3.1 | REACTOME IRAK1 RECRUITS IKK COMPLEX | Genes involved in IRAK1 recruits IKK complex |
| 0.1 | 2.8 | REACTOME PRE NOTCH PROCESSING IN GOLGI | Genes involved in Pre-NOTCH Processing in Golgi |
| 0.1 | 2.6 | REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION | Genes involved in Pre-NOTCH Transcription and Translation |