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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for AUGUGCC

Z-value: 0.56

Motif logo

miRNA associated with seed AUGUGCC

NamemiRBASE accession
MIMAT0003150

Activity profile of AUGUGCC motif

Sorted Z-values of AUGUGCC motif

Promoter Log-likelihood Transcript Gene Gene Info
chr2_-_38978492 6.59 ENST00000409276.1
ENST00000446327.2
ENST00000313117.6
serine/arginine-rich splicing factor 7
chr1_-_70671216 5.08 ENST00000370952.3
leucine rich repeat containing 40
chr9_-_74980113 4.54 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
zinc finger, AN1-type domain 5
chr17_-_62658186 4.24 ENST00000262435.9
SMAD specific E3 ubiquitin protein ligase 2
chrX_+_41192595 4.07 ENST00000399959.2
DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked
chr2_+_85198216 4.05 ENST00000456682.1
ENST00000409785.4
potassium channel modulatory factor 1
chr12_+_12870055 3.97 ENST00000228872.4
cyclin-dependent kinase inhibitor 1B (p27, Kip1)
chr6_+_89790490 3.96 ENST00000336032.3
proline-rich nuclear receptor coactivator 1
chr4_+_39699664 3.91 ENST00000261427.5
ENST00000510934.1
ENST00000295963.6
ubiquitin-conjugating enzyme E2K
chr4_-_185395672 3.90 ENST00000393593.3
interferon regulatory factor 2
chr15_+_63796779 3.47 ENST00000561442.1
ENST00000560070.1
ENST00000540797.1
ENST00000380324.3
ENST00000268049.7
ENST00000536001.1
ENST00000539772.1
ubiquitin specific peptidase 3
chr3_-_12705600 3.28 ENST00000542177.1
ENST00000442415.2
ENST00000251849.4
v-raf-1 murine leukemia viral oncogene homolog 1
chr17_+_30264014 3.20 ENST00000322652.5
ENST00000580398.1
SUZ12 polycomb repressive complex 2 subunit
chr20_-_48770174 3.14 ENST00000341698.2
TMEM189-UBE2V1 readthrough
chr12_+_62654119 3.08 ENST00000353364.3
ENST00000549523.1
ENST00000280377.5
ubiquitin specific peptidase 15
chr12_+_124069070 2.80 ENST00000262225.3
ENST00000438031.2
transmembrane emp24 domain trafficking protein 2
chr5_+_82767284 2.72 ENST00000265077.3
versican
chr20_-_48729670 2.65 ENST00000371657.5
ubiquitin-conjugating enzyme E2 variant 1
chr22_+_40573921 2.57 ENST00000454349.2
ENST00000335727.9
trinucleotide repeat containing 6B
chr10_+_112679301 2.49 ENST00000265277.5
ENST00000369452.4
soc-2 suppressor of clear homolog (C. elegans)
chr5_-_175964366 2.44 ENST00000274811.4
ring finger protein 44
chr13_-_50367057 2.24 ENST00000261667.3
karyopherin alpha 3 (importin alpha 4)
chr17_+_57642886 2.23 ENST00000251241.4
ENST00000451169.2
ENST00000425628.3
ENST00000584385.1
ENST00000580030.1
DEAH (Asp-Glu-Ala-His) box polypeptide 40
chr14_-_21737610 2.10 ENST00000320084.7
ENST00000449098.1
ENST00000336053.6
heterogeneous nuclear ribonucleoprotein C (C1/C2)
chr22_+_39077947 2.01 ENST00000216034.4
translocase of outer mitochondrial membrane 22 homolog (yeast)
chr3_-_176914238 1.94 ENST00000430069.1
ENST00000428970.1
transducin (beta)-like 1 X-linked receptor 1
chr19_-_33166045 1.92 ENST00000586693.3
ENST00000587352.1
ENST00000586463.1
ENST00000306065.4
ankyrin repeat domain 27 (VPS9 domain)
chr1_+_101702417 1.69 ENST00000305352.6
sphingosine-1-phosphate receptor 1
chr1_+_193091080 1.65 ENST00000367435.3
cell division cycle 73
chr20_-_48770244 1.48 ENST00000371650.5
ENST00000371652.4
ENST00000557021.1
transmembrane protein 189
chr14_-_90085458 1.42 ENST00000345097.4
ENST00000555855.1
ENST00000555353.1
forkhead box N3
chr1_+_27022485 1.31 ENST00000324856.7
AT rich interactive domain 1A (SWI-like)
chr18_-_74207146 1.23 ENST00000443185.2
zinc finger protein 516
chr8_-_8751068 1.21 ENST00000276282.6
malignant fibrous histiocytoma amplified sequence 1
chr5_-_76788317 1.17 ENST00000296679.4
WD repeat domain 41
chr10_-_15210666 1.16 ENST00000378165.4
N-myristoyltransferase 2
chr2_+_106361333 1.09 ENST00000233154.4
ENST00000451463.2
NCK adaptor protein 2
chr20_-_60640866 1.04 ENST00000252996.4
TAF4 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 135kDa
chr17_+_48796905 0.93 ENST00000505658.1
ENST00000393227.2
ENST00000240304.1
ENST00000311571.3
ENST00000505619.1
ENST00000544170.1
ENST00000510984.1
LUC7-like 3 (S. cerevisiae)
chr11_+_9406169 0.85 ENST00000379719.3
ENST00000527431.1
importin 7
chrX_+_46433193 0.80 ENST00000276055.3
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 7
chrX_+_40944871 0.75 ENST00000378308.2
ENST00000324545.8
ubiquitin specific peptidase 9, X-linked
chr12_+_94542459 0.71 ENST00000258526.4
plexin C1
chr10_+_20105157 0.70 ENST00000377242.3
ENST00000377252.4
plexin domain containing 2
chr20_+_19867150 0.67 ENST00000255006.6
Ras and Rab interactor 2
chr12_-_57824739 0.62 ENST00000347140.3
ENST00000402412.1
R3H domain containing 2
chr1_+_212458834 0.62 ENST00000261461.2
protein phosphatase 2, regulatory subunit B', alpha
chr7_+_39989611 0.62 ENST00000181839.4
cyclin-dependent kinase 13
chr5_+_141488070 0.62 ENST00000253814.4
Nedd4 family interacting protein 1
chr4_+_41937131 0.61 ENST00000504986.1
ENST00000508448.1
ENST00000513702.1
ENST00000325094.5
transmembrane protein 33
chr1_-_115053781 0.60 ENST00000358465.2
ENST00000369543.2
tripartite motif containing 33
chr21_-_16437255 0.59 ENST00000400199.1
ENST00000400202.1
nuclear receptor interacting protein 1
chr1_-_10856694 0.57 ENST00000377022.3
ENST00000344008.5
castor zinc finger 1
chr2_-_202316260 0.42 ENST00000332624.3
trafficking protein, kinesin binding 2
chr12_+_104458235 0.36 ENST00000229330.4
host cell factor C2
chr11_-_128392085 0.33 ENST00000526145.2
ENST00000531611.1
ENST00000319397.6
ENST00000345075.4
ENST00000535549.1
v-ets avian erythroblastosis virus E26 oncogene homolog 1
chr17_-_5389477 0.32 ENST00000572834.1
ENST00000570848.1
ENST00000571971.1
ENST00000158771.4
derlin 2
chr20_+_34894247 0.30 ENST00000373913.3
discs, large (Drosophila) homolog-associated protein 4
chr7_-_155604967 0.25 ENST00000297261.2
sonic hedgehog
chr15_-_56535464 0.21 ENST00000559447.2
ENST00000422057.1
ENST00000317318.6
ENST00000423270.1
regulatory factor X, 7
chr17_-_46682321 0.17 ENST00000225648.3
ENST00000484302.2
homeobox B6
chr15_+_59279851 0.17 ENST00000348370.4
ENST00000434298.1
ENST00000559160.1
ring finger protein 111
chr13_-_52027134 0.15 ENST00000311234.4
ENST00000425000.1
ENST00000463928.1
ENST00000442263.3
ENST00000398119.2
integrator complex subunit 6
chr8_+_61429416 0.14 ENST00000262646.7
ENST00000531289.1
RAB2A, member RAS oncogene family
chr10_-_94003003 0.06 ENST00000412050.4
cytoplasmic polyadenylation element binding protein 3
chr5_+_102455853 0.06 ENST00000515845.1
ENST00000321521.9
ENST00000507921.1
diphosphoinositol pentakisphosphate kinase 2

Network of associatons between targets according to the STRING database.

First level regulatory network of AUGUGCC

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 4.2 GO:1901165 positive regulation of trophoblast cell migration(GO:1901165)
1.0 4.1 GO:0042256 mature ribosome assembly(GO:0042256)
0.8 3.1 GO:0035616 histone H2B conserved C-terminal lysine deubiquitination(GO:0035616)
0.7 2.8 GO:0048200 COPI-coated vesicle budding(GO:0035964) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.6 4.0 GO:1902746 regulation of lens fiber cell differentiation(GO:1902746)
0.6 1.7 GO:0003241 growth involved in heart morphogenesis(GO:0003241)
0.5 4.0 GO:0031087 deadenylation-independent decapping of nuclear-transcribed mRNA(GO:0031087)
0.5 3.9 GO:0010993 regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994)
0.5 1.9 GO:0031339 negative regulation of vesicle fusion(GO:0031339)
0.4 1.2 GO:0018008 N-terminal peptidyl-glycine N-myristoylation(GO:0018008) peptidyl-glycine modification(GO:0018201)
0.3 1.9 GO:0060613 fat pad development(GO:0060613)
0.3 1.3 GO:0003408 optic cup formation involved in camera-type eye development(GO:0003408)
0.2 3.3 GO:0071550 death-inducing signaling complex assembly(GO:0071550)
0.2 0.6 GO:0090219 negative regulation of lipid kinase activity(GO:0090219)
0.2 6.6 GO:0048025 negative regulation of mRNA splicing, via spliceosome(GO:0048025)
0.2 0.6 GO:0048294 negative regulation of isotype switching to IgE isotypes(GO:0048294)
0.2 0.6 GO:1903371 regulation of endoplasmic reticulum tubular network organization(GO:1903371)
0.2 2.6 GO:0035278 miRNA mediated inhibition of translation(GO:0035278) negative regulation of translation, ncRNA-mediated(GO:0040033) regulation of translation, ncRNA-mediated(GO:0045974)
0.2 2.0 GO:0045040 protein import into mitochondrial outer membrane(GO:0045040)
0.2 1.1 GO:0036493 positive regulation of translation in response to endoplasmic reticulum stress(GO:0036493)
0.1 3.5 GO:0016578 histone deubiquitination(GO:0016578)
0.1 0.4 GO:0098937 dendritic transport(GO:0098935) anterograde dendritic transport(GO:0098937)
0.1 3.2 GO:0070734 histone H3-K27 methylation(GO:0070734)
0.1 0.3 GO:0060769 positive regulation of epithelial cell proliferation involved in prostate gland development(GO:0060769)
0.1 5.8 GO:0070534 protein K63-linked ubiquitination(GO:0070534)
0.1 1.6 GO:0032968 endodermal cell fate commitment(GO:0001711) positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) histone H2B ubiquitination(GO:0033523)
0.1 2.7 GO:0030208 dermatan sulfate biosynthetic process(GO:0030208)
0.1 2.1 GO:0070935 3'-UTR-mediated mRNA stabilization(GO:0070935)
0.1 2.9 GO:0048745 smooth muscle tissue development(GO:0048745)
0.1 2.2 GO:0019054 modulation by virus of host process(GO:0019054)
0.1 1.4 GO:0097094 craniofacial suture morphogenesis(GO:0097094)
0.1 0.8 GO:0030206 chondroitin sulfate biosynthetic process(GO:0030206)
0.0 0.3 GO:1904153 negative regulation of protein exit from endoplasmic reticulum(GO:0070862) negative regulation of retrograde protein transport, ER to cytosol(GO:1904153)
0.0 0.3 GO:0030578 PML body organization(GO:0030578)
0.0 2.5 GO:0046579 positive regulation of Ras protein signal transduction(GO:0046579)
0.0 0.6 GO:0001542 ovulation from ovarian follicle(GO:0001542)
0.0 0.6 GO:0070816 phosphorylation of RNA polymerase II C-terminal domain(GO:0070816)
0.0 3.9 GO:0060337 type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357)
0.0 1.2 GO:0050873 brown fat cell differentiation(GO:0050873)
0.0 0.9 GO:0006376 mRNA splice site selection(GO:0006376)
0.0 0.2 GO:0030579 ubiquitin-dependent SMAD protein catabolic process(GO:0030579)
0.0 0.1 GO:0045900 negative regulation of translational elongation(GO:0045900)
0.0 0.7 GO:0071526 semaphorin-plexin signaling pathway(GO:0071526)
0.0 1.0 GO:0051123 RNA polymerase II transcriptional preinitiation complex assembly(GO:0051123)
0.0 0.6 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0035370 UBC13-UEV1A complex(GO:0035370)
0.4 1.9 GO:0097422 tubular endosome(GO:0097422)
0.3 3.5 GO:0070938 contractile ring(GO:0070938)
0.3 4.0 GO:0031464 Cul4A-RING E3 ubiquitin ligase complex(GO:0031464)
0.3 3.2 GO:0001739 sex chromatin(GO:0001739)
0.3 2.0 GO:0005742 mitochondrial outer membrane translocase complex(GO:0005742)
0.2 0.6 GO:0002945 cyclin K-CDK13 complex(GO:0002945)
0.2 2.8 GO:0030663 COPI-coated vesicle membrane(GO:0030663)
0.2 3.9 GO:0032433 filopodium tip(GO:0032433)
0.2 1.2 GO:1990316 ATG1/ULK1 kinase complex(GO:1990316)
0.2 1.6 GO:0016593 Cdc73/Paf1 complex(GO:0016593)
0.2 4.1 GO:0005852 eukaryotic translation initiation factor 3 complex(GO:0005852)
0.1 2.5 GO:0000164 protein phosphatase type 1 complex(GO:0000164)
0.1 3.3 GO:0031143 pseudopodium(GO:0031143)
0.1 2.1 GO:0005697 telomerase holoenzyme complex(GO:0005697)
0.1 1.3 GO:0071564 npBAF complex(GO:0071564)
0.1 1.0 GO:0033276 transcription factor TFTC complex(GO:0033276)
0.0 6.5 GO:0000932 cytoplasmic mRNA processing body(GO:0000932)
0.0 0.3 GO:0005785 signal recognition particle receptor complex(GO:0005785)
0.0 0.9 GO:0071004 U2-type prespliceosome(GO:0071004)
0.0 3.4 GO:0018995 host(GO:0018995) host cell(GO:0043657)
0.0 2.7 GO:0005796 Golgi lumen(GO:0005796)
0.0 1.5 GO:0005643 nuclear pore(GO:0005643)
0.0 4.0 GO:0101002 ficolin-1-rich granule(GO:0101002) ficolin-1-rich granule lumen(GO:1904813)
0.0 0.6 GO:0000159 protein phosphatase type 2A complex(GO:0000159)
0.0 1.0 GO:0005876 spindle microtubule(GO:0005876)
0.0 0.1 GO:0032039 integrator complex(GO:0032039)
0.0 0.1 GO:1990124 messenger ribonucleoprotein complex(GO:1990124)
0.0 4.2 GO:0000151 ubiquitin ligase complex(GO:0000151)
0.0 0.4 GO:0032839 dendrite cytoplasm(GO:0032839)
0.0 2.2 GO:0005681 spliceosomal complex(GO:0005681)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 3.1 GO:0061649 ubiquitinated histone binding(GO:0061649)
0.4 1.2 GO:0004379 glycylpeptide N-tetradecanoyltransferase activity(GO:0004379) myristoyltransferase activity(GO:0019107)
0.4 4.1 GO:0033592 RNA strand annealing activity(GO:0033592)
0.4 3.2 GO:0046976 histone methyltransferase activity (H3-K27 specific)(GO:0046976)
0.3 3.9 GO:0034450 ubiquitin-ubiquitin ligase activity(GO:0034450)
0.2 4.0 GO:0004861 cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861)
0.2 0.8 GO:0034481 chondroitin sulfotransferase activity(GO:0034481)
0.2 2.0 GO:0015266 protein channel activity(GO:0015266)
0.2 2.1 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.1 1.7 GO:0038036 sphingosine-1-phosphate receptor activity(GO:0038036) sphingolipid binding(GO:0046625)
0.1 3.3 GO:0031434 mitogen-activated protein kinase kinase binding(GO:0031434)
0.1 2.7 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 2.5 GO:0008157 protein phosphatase 1 binding(GO:0008157)
0.1 1.0 GO:0017162 transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly(GO:0001075) aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.4 GO:0070410 co-SMAD binding(GO:0070410)
0.1 3.8 GO:0017112 Rab guanyl-nucleotide exchange factor activity(GO:0017112)
0.1 4.2 GO:0005160 transforming growth factor beta receptor binding(GO:0005160)
0.1 2.2 GO:0008139 nuclear localization sequence binding(GO:0008139)
0.1 0.2 GO:0032184 SUMO polymer binding(GO:0032184)
0.1 1.6 GO:0000993 RNA polymerase II core binding(GO:0000993)
0.0 1.3 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.0 3.5 GO:0004843 thiol-dependent ubiquitin-specific protease activity(GO:0004843)
0.0 0.3 GO:0043237 laminin-1 binding(GO:0043237)
0.0 0.7 GO:0017154 semaphorin receptor activity(GO:0017154)
0.0 1.1 GO:0008093 cytoskeletal adaptor activity(GO:0008093)
0.0 9.2 GO:0061630 ubiquitin protein ligase activity(GO:0061630)
0.0 0.6 GO:0017056 structural constituent of nuclear pore(GO:0017056)
0.0 2.2 GO:0004004 ATP-dependent RNA helicase activity(GO:0004004)
0.0 0.5 GO:0035259 glucocorticoid receptor binding(GO:0035259)
0.0 0.6 GO:0008353 RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353)
0.0 0.4 GO:0050811 GABA receptor binding(GO:0050811)
0.0 1.9 GO:0008013 beta-catenin binding(GO:0008013)
0.0 14.5 GO:0008270 zinc ion binding(GO:0008270)
0.0 0.6 GO:0050699 WW domain binding(GO:0050699)
0.0 1.2 GO:0033613 activating transcription factor binding(GO:0033613)
0.0 0.3 GO:0035035 histone acetyltransferase binding(GO:0035035)
0.0 0.1 GO:0033857 diphosphoinositol-pentakisphosphate kinase activity(GO:0033857)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 4.0 SA REG CASCADE OF CYCLIN EXPR Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases.
0.1 3.3 PID TCR RAS PATHWAY Ras signaling in the CD4+ TCR pathway
0.1 2.7 PID TOLL ENDOGENOUS PATHWAY Endogenous TLR signaling
0.1 4.2 PID BMP PATHWAY BMP receptor signaling
0.1 1.7 PID S1P META PATHWAY Sphingosine 1-phosphate (S1P) pathway
0.1 4.5 PID FOXO PATHWAY FoxO family signaling
0.1 2.6 PID IL1 PATHWAY IL1-mediated signaling events
0.0 1.1 PID REELIN PATHWAY Reelin signaling pathway
0.0 0.6 PID MYC PATHWAY C-MYC pathway
0.0 2.1 PID TELOMERASE PATHWAY Regulation of Telomerase
0.0 1.9 PID BETA CATENIN NUC PATHWAY Regulation of nuclear beta catenin signaling and target gene transcription
0.0 0.6 PID RETINOIC ACID PATHWAY Retinoic acid receptors-mediated signaling
0.0 0.3 PID HEDGEHOG 2PATHWAY Signaling events mediated by the Hedgehog family
0.0 1.0 PID MET PATHWAY Signaling events mediated by Hepatocyte Growth Factor Receptor (c-Met)

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.1 REACTOME IRAK1 RECRUITS IKK COMPLEX Genes involved in IRAK1 recruits IKK complex
0.2 3.3 REACTOME RAF MAP KINASE CASCADE Genes involved in RAF/MAP kinase cascade
0.2 4.0 REACTOME AKT PHOSPHORYLATES TARGETS IN THE CYTOSOL Genes involved in AKT phosphorylates targets in the cytosol
0.2 1.2 REACTOME MEMBRANE BINDING AND TARGETTING OF GAG PROTEINS Genes involved in Membrane binding and targetting of GAG proteins
0.2 3.9 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.1 6.6 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.1 2.6 REACTOME PRE NOTCH TRANSCRIPTION AND TRANSLATION Genes involved in Pre-NOTCH Transcription and Translation
0.1 2.8 REACTOME PRE NOTCH PROCESSING IN GOLGI Genes involved in Pre-NOTCH Processing in Golgi
0.1 3.5 REACTOME CHONDROITIN SULFATE BIOSYNTHESIS Genes involved in Chondroitin sulfate biosynthesis
0.1 5.6 REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity
0.1 3.9 REACTOME TRAF6 MEDIATED IRF7 ACTIVATION Genes involved in TRAF6 mediated IRF7 activation
0.1 1.9 REACTOME CIRCADIAN REPRESSION OF EXPRESSION BY REV ERBA Genes involved in Circadian Repression of Expression by REV-ERBA
0.0 1.1 REACTOME ACTIVATION OF RAC Genes involved in Activation of Rac
0.0 2.0 REACTOME MITOCHONDRIAL PROTEIN IMPORT Genes involved in Mitochondrial Protein Import
0.0 0.7 REACTOME OTHER SEMAPHORIN INTERACTIONS Genes involved in Other semaphorin interactions
0.0 1.0 REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
0.0 2.2 REACTOME ANTIVIRAL MECHANISM BY IFN STIMULATED GENES Genes involved in Antiviral mechanism by IFN-stimulated genes
0.0 0.6 REACTOME CTNNB1 PHOSPHORYLATION CASCADE Genes involved in Beta-catenin phosphorylation cascade
0.0 2.1 REACTOME MRNA SPLICING Genes involved in mRNA Splicing