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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BACH1_NFE2_NFE2L2
Z-value: 1.14
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Transcription factors associated with BACH1_NFE2_NFE2L2
| Gene Symbol | Gene ID | Gene Info |
|---|---|---|
| ENSG00000156273.11 | BTB domain and CNC homolog 1 | |
| ENSG00000123405.9 | nuclear factor, erythroid 2 | |
| ENSG00000116044.11 | nuclear factor, erythroid 2 like 2 |
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| NFE2L2 | hg19_v2_chr2_-_178257401_178257432, hg19_v2_chr2_-_178129853_178129860, hg19_v2_chr2_-_178128528_178128574, hg19_v2_chr2_-_178128250_178128300 | 0.27 | 4.9e-05 | Click! |
| BACH1 | hg19_v2_chr21_+_30671189_30671207, hg19_v2_chr21_+_30671690_30671762 | -0.20 | 2.8e-03 | Click! |
| NFE2 | hg19_v2_chr12_-_54689532_54689551, hg19_v2_chr12_-_54694807_54694905, hg19_v2_chr12_-_54694758_54694805 | 0.02 | 7.5e-01 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH1_NFE2_NFE2L2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 6.7 | 699.1 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 2.3 | 176.8 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 16.8 | 151.1 | GO:0030091 | protein repair(GO:0030091) |
| 4.5 | 80.9 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 1.4 | 59.9 | GO:0043486 | histone exchange(GO:0043486) |
| 8.7 | 52.3 | GO:0060316 | positive regulation of ryanodine-sensitive calcium-release channel activity(GO:0060316) |
| 12.4 | 49.6 | GO:1903660 | negative regulation of complement-dependent cytotoxicity(GO:1903660) |
| 5.5 | 49.5 | GO:0001887 | selenium compound metabolic process(GO:0001887) |
| 0.8 | 49.4 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 6.1 | 48.7 | GO:0006528 | asparagine metabolic process(GO:0006528) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 30.4 | 364.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 273.0 | GO:0005829 | cytosol(GO:0005829) |
| 1.6 | 137.7 | GO:1904724 | tertiary granule lumen(GO:1904724) |
| 1.8 | 100.2 | GO:0000502 | proteasome complex(GO:0000502) |
| 8.7 | 87.5 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.2 | 87.1 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 7.3 | 79.9 | GO:0031595 | nuclear proteasome complex(GO:0031595) |
| 0.4 | 74.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 3.4 | 72.2 | GO:0000812 | Swr1 complex(GO:0000812) |
| 5.9 | 64.4 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 13.0 | 390.3 | GO:0070003 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 25.1 | 176.0 | GO:0047134 | protein-disulfide reductase activity(GO:0047134) |
| 12.5 | 112.4 | GO:0016721 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.5 | 89.1 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 7.4 | 80.9 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 7.3 | 79.9 | GO:0036402 | proteasome-activating ATPase activity(GO:0036402) |
| 1.5 | 79.7 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 23.0 | 68.9 | GO:0004362 | glutathione-disulfide reductase activity(GO:0004362) |
| 8.4 | 67.5 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 17.4 | 52.3 | GO:0050610 | oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor(GO:0016672) glutathione dehydrogenase (ascorbate) activity(GO:0045174) methylarsonate reductase activity(GO:0050610) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.6 | 145.8 | PID P38 MKK3 6PATHWAY | p38 MAPK signaling pathway |
| 1.8 | 119.1 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.9 | 104.0 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 1.1 | 97.0 | PID TAP63 PATHWAY | Validated transcriptional targets of TAp63 isoforms |
| 0.9 | 59.3 | ST B CELL ANTIGEN RECEPTOR | B Cell Antigen Receptor |
| 0.6 | 55.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.5 | 49.1 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
| 0.6 | 40.6 | PID HNF3A PATHWAY | FOXA1 transcription factor network |
| 0.6 | 39.0 | PID MTOR 4PATHWAY | mTOR signaling pathway |
| 0.7 | 36.9 | PID HDAC CLASSII PATHWAY | Signaling events mediated by HDAC Class II |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 9.0 | 699.1 | REACTOME REGULATION OF ORNITHINE DECARBOXYLASE ODC | Genes involved in Regulation of ornithine decarboxylase (ODC) |
| 10.6 | 200.7 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 4.0 | 140.4 | REACTOME GLUTATHIONE CONJUGATION | Genes involved in Glutathione conjugation |
| 3.6 | 116.1 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 4.1 | 111.5 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 3.3 | 88.7 | REACTOME METABOLISM OF PORPHYRINS | Genes involved in Metabolism of porphyrins |
| 1.6 | 81.7 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 0.4 | 49.9 | REACTOME PPARA ACTIVATES GENE EXPRESSION | Genes involved in PPARA Activates Gene Expression |
| 1.5 | 46.8 | REACTOME CHOLESTEROL BIOSYNTHESIS | Genes involved in Cholesterol biosynthesis |
| 3.1 | 37.5 | REACTOME IKK COMPLEX RECRUITMENT MEDIATED BY RIP1 | Genes involved in IKK complex recruitment mediated by RIP1 |