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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BACH2
Z-value: 1.17
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Transcription factors associated with BACH2
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BACH2 | hg19_v2_chr6_-_91006627_91006641, hg19_v2_chr6_-_91006461_91006517 | -0.25 | 1.4e-04 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BACH2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 76.2 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 1.3 | 45.0 | GO:0061621 | NADH regeneration(GO:0006735) canonical glycolysis(GO:0061621) glucose catabolic process to pyruvate(GO:0061718) |
| 0.2 | 33.8 | GO:0022617 | extracellular matrix disassembly(GO:0022617) |
| 0.2 | 29.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 1.6 | 29.4 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
| 0.1 | 26.3 | GO:0007411 | axon guidance(GO:0007411) |
| 0.1 | 25.2 | GO:0000226 | microtubule cytoskeleton organization(GO:0000226) |
| 0.3 | 24.1 | GO:0030834 | regulation of actin filament depolymerization(GO:0030834) |
| 2.5 | 22.9 | GO:0030091 | protein repair(GO:0030091) |
| 4.4 | 22.2 | GO:0035105 | sterol regulatory element binding protein import into nucleus(GO:0035105) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 71.1 | GO:0005829 | cytosol(GO:0005829) |
| 7.3 | 43.9 | GO:0000015 | phosphopyruvate hydratase complex(GO:0000015) |
| 0.2 | 33.5 | GO:0048770 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 32.9 | GO:0005819 | spindle(GO:0005819) |
| 0.6 | 29.4 | GO:0031430 | M band(GO:0031430) |
| 1.2 | 26.5 | GO:0005838 | proteasome regulatory particle(GO:0005838) |
| 2.5 | 22.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.1 | 20.1 | GO:0005874 | microtubule(GO:0005874) |
| 2.0 | 19.8 | GO:0008541 | proteasome regulatory particle, lid subcomplex(GO:0008541) |
| 0.0 | 18.2 | GO:0016604 | nuclear body(GO:0016604) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.3 | 52.4 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 7.3 | 43.9 | GO:0004634 | phosphopyruvate hydratase activity(GO:0004634) |
| 0.1 | 42.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.8 | 37.2 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 30.1 | GO:0005198 | structural molecule activity(GO:0005198) |
| 1.0 | 29.9 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.7 | 29.4 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
| 1.8 | 24.8 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.0 | 24.0 | GO:0003723 | RNA binding(GO:0003723) |
| 7.6 | 22.9 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 37.2 | PID ILK PATHWAY | Integrin-linked kinase signaling |
| 0.4 | 34.9 | PID VEGFR1 2 PATHWAY | Signaling events mediated by VEGFR1 and VEGFR2 |
| 0.3 | 29.4 | PID HIF1 TFPATHWAY | HIF-1-alpha transcription factor network |
| 0.3 | 24.4 | PID FAK PATHWAY | Signaling events mediated by focal adhesion kinase |
| 0.3 | 16.6 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
| 0.1 | 13.5 | PID CASPASE PATHWAY | Caspase cascade in apoptosis |
| 0.4 | 11.6 | PID ECADHERIN KERATINOCYTE PATHWAY | E-cadherin signaling in keratinocytes |
| 0.2 | 9.7 | PID RAS PATHWAY | Regulation of Ras family activation |
| 0.2 | 9.4 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.4 | 8.8 | PID ARF 3PATHWAY | Arf1 pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 80.5 | REACTOME AUTODEGRADATION OF THE E3 UBIQUITIN LIGASE COP1 | Genes involved in Autodegradation of the E3 ubiquitin ligase COP1 |
| 1.5 | 74.3 | REACTOME GLYCOLYSIS | Genes involved in Glycolysis |
| 1.7 | 44.7 | REACTOME POST CHAPERONIN TUBULIN FOLDING PATHWAY | Genes involved in Post-chaperonin tubulin folding pathway |
| 0.3 | 23.4 | REACTOME ACTIVATION OF CHAPERONE GENES BY XBP1S | Genes involved in Activation of Chaperone Genes by XBP1(S) |
| 0.8 | 15.2 | REACTOME THE NLRP3 INFLAMMASOME | Genes involved in The NLRP3 inflammasome |
| 0.4 | 14.2 | REACTOME SYNTHESIS AND INTERCONVERSION OF NUCLEOTIDE DI AND TRIPHOSPHATES | Genes involved in Synthesis and interconversion of nucleotide di- and triphosphates |
| 0.7 | 14.1 | REACTOME ENDOSOMAL SORTING COMPLEX REQUIRED FOR TRANSPORT ESCRT | Genes involved in Endosomal Sorting Complex Required For Transport (ESCRT) |
| 0.3 | 12.4 | REACTOME TRANSPORT OF VITAMINS NUCLEOSIDES AND RELATED MOLECULES | Genes involved in Transport of vitamins, nucleosides, and related molecules |
| 0.4 | 11.6 | REACTOME ADHERENS JUNCTIONS INTERACTIONS | Genes involved in Adherens junctions interactions |
| 0.8 | 11.1 | REACTOME VITAMIN B5 PANTOTHENATE METABOLISM | Genes involved in Vitamin B5 (pantothenate) metabolism |