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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BARHL1
Z-value: 1.13
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Transcription factors associated with BARHL1
| Promoter | Log-likelihood | Transcript | Gene | Gene Info |
|---|---|---|---|---|
| chr5_-_68665084 Show fit | 35.84 |
ENST00000509462.1
|
TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa |
|
| chr19_-_14945933 Show fit | 32.99 |
ENST00000322301.3
|
olfactory receptor, family 7, subfamily A, member 5 |
|
| chr12_+_104682496 Show fit | 31.36 |
ENST00000378070.4
|
thioredoxin reductase 1 |
|
| chr18_+_657578 Show fit | 30.04 |
ENST00000323274.10
|
thymidylate synthetase |
|
| chr3_-_107777208 Show fit | 29.76 |
ENST00000398258.3
|
CD47 molecule |
|
| chr1_-_145826450 Show fit | 29.33 |
ENST00000462900.2
|
G protein-coupled receptor 89A |
|
| chr14_+_56127989 Show fit | 29.07 |
ENST00000555573.1
|
kinectin 1 (kinesin receptor) |
|
| chr13_+_48611665 Show fit | 28.62 |
ENST00000258662.2
|
nudix (nucleoside diphosphate linked moiety X)-type motif 15 |
|
| chr15_+_65843130 Show fit | 27.86 |
ENST00000569894.1
|
protein tyrosine phosphatase-like A domain containing 1 |
|
| chr12_+_104337515 Show fit | 27.27 |
ENST00000550595.1
|
heat shock protein 90kDa beta (Grp94), member 1 |
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL1
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.1 | 247.7 | GO:0031145 | anaphase-promoting complex-dependent catabolic process(GO:0031145) |
| 3.1 | 230.6 | GO:0070125 | mitochondrial translational elongation(GO:0070125) |
| 2.0 | 129.0 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.4 | 91.7 | GO:0000398 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile(GO:0000377) mRNA splicing, via spliceosome(GO:0000398) |
| 1.8 | 78.8 | GO:0006409 | tRNA export from nucleus(GO:0006409) tRNA transport(GO:0051031) tRNA-containing ribonucleoprotein complex export from nucleus(GO:0071431) |
| 4.4 | 74.2 | GO:0006265 | DNA topological change(GO:0006265) |
| 4.6 | 73.1 | GO:0000338 | protein deneddylation(GO:0000338) |
| 1.5 | 56.6 | GO:0090503 | RNA phosphodiester bond hydrolysis, exonucleolytic(GO:0090503) |
| 2.2 | 56.2 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 13.9 | 55.5 | GO:0019860 | dTTP biosynthetic process(GO:0006235) pyrimidine deoxyribonucleoside triphosphate biosynthetic process(GO:0009212) transformation of host cell by virus(GO:0019087) uracil metabolic process(GO:0019860) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 232.9 | GO:0005730 | nucleolus(GO:0005730) |
| 4.6 | 125.2 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
| 1.6 | 100.0 | GO:0045271 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 2.3 | 88.9 | GO:0000315 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.3 | 84.5 | GO:0005743 | mitochondrial inner membrane(GO:0005743) |
| 5.1 | 81.3 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 1.7 | 79.6 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.6 | 76.5 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.1 | 72.5 | GO:0005739 | mitochondrion(GO:0005739) |
| 0.6 | 66.0 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 182.1 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 2.0 | 105.8 | GO:0050136 | NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 7.1 | 99.2 | GO:1990825 | sequence-specific mRNA binding(GO:1990825) |
| 3.3 | 98.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 2.2 | 88.7 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 0.3 | 84.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 1.9 | 71.4 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 1.2 | 66.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 1.5 | 60.7 | GO:0061631 | ubiquitin conjugating enzyme activity(GO:0061631) |
| 1.7 | 53.3 | GO:0008308 | voltage-gated anion channel activity(GO:0008308) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 169.3 | PID E2F PATHWAY | E2F transcription factor network |
| 0.6 | 98.2 | PID P53 DOWNSTREAM PATHWAY | Direct p53 effectors |
| 1.3 | 78.5 | PID PLK1 PATHWAY | PLK1 signaling events |
| 1.0 | 72.1 | PID DELTA NP63 PATHWAY | Validated transcriptional targets of deltaNp63 isoforms |
| 1.4 | 57.5 | PID NFKAPPAB CANONICAL PATHWAY | Canonical NF-kappaB pathway |
| 1.0 | 56.5 | PID AURORA B PATHWAY | Aurora B signaling |
| 0.6 | 56.5 | PID TRKR PATHWAY | Neurotrophic factor-mediated Trk receptor signaling |
| 0.8 | 52.0 | PID P38 ALPHA BETA DOWNSTREAM PATHWAY | Signaling mediated by p38-alpha and p38-beta |
| 0.7 | 50.9 | PID RAC1 PATHWAY | RAC1 signaling pathway |
| 0.6 | 50.6 | PID MYC ACTIV PATHWAY | Validated targets of C-MYC transcriptional activation |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.7 | 282.2 | REACTOME APC C CDH1 MEDIATED DEGRADATION OF CDC20 AND OTHER APC C CDH1 TARGETED PROTEINS IN LATE MITOSIS EARLY G1 | Genes involved in APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 |
| 1.9 | 163.2 | REACTOME RESPIRATORY ELECTRON TRANSPORT | Genes involved in Respiratory electron transport |
| 2.3 | 129.5 | REACTOME RNA POL II TRANSCRIPTION PRE INITIATION AND PROMOTER OPENING | Genes involved in RNA Polymerase II Transcription Pre-Initiation And Promoter Opening |
| 1.5 | 114.0 | REACTOME GOLGI ASSOCIATED VESICLE BIOGENESIS | Genes involved in Golgi Associated Vesicle Biogenesis |
| 2.3 | 86.6 | REACTOME TRANSPORT OF RIBONUCLEOPROTEINS INTO THE HOST NUCLEUS | Genes involved in Transport of Ribonucleoproteins into the Host Nucleus |
| 1.9 | 80.6 | REACTOME DOWNREGULATION OF SMAD2 3 SMAD4 TRANSCRIPTIONAL ACTIVITY | Genes involved in Downregulation of SMAD2/3:SMAD4 transcriptional activity |
| 0.6 | 77.1 | REACTOME SRP DEPENDENT COTRANSLATIONAL PROTEIN TARGETING TO MEMBRANE | Genes involved in SRP-dependent cotranslational protein targeting to membrane |
| 2.1 | 76.1 | REACTOME CYTOSOLIC TRNA AMINOACYLATION | Genes involved in Cytosolic tRNA aminoacylation |
| 1.0 | 71.7 | REACTOME MITOTIC PROMETAPHASE | Genes involved in Mitotic Prometaphase |
| 3.7 | 71.1 | REACTOME G2 M DNA DAMAGE CHECKPOINT | Genes involved in G2/M DNA damage checkpoint |