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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BARHL2
Z-value: 0.01
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Transcription factors associated with BARHL2
Network of associatons between targets according to the STRING database.
First level regulatory network of BARHL2
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 93.0 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 6.2 | 74.9 | GO:1900747 | negative regulation of vascular endothelial growth factor signaling pathway(GO:1900747) |
| 1.2 | 25.7 | GO:0051764 | actin crosslink formation(GO:0051764) |
| 0.8 | 18.3 | GO:0003334 | keratinocyte development(GO:0003334) |
| 5.8 | 17.5 | GO:0070563 | negative regulation of vitamin D receptor signaling pathway(GO:0070563) |
| 3.6 | 14.4 | GO:0001970 | positive regulation of activation of membrane attack complex(GO:0001970) |
| 4.8 | 14.3 | GO:1990523 | bone regeneration(GO:1990523) |
| 1.7 | 13.5 | GO:0032914 | positive regulation of transforming growth factor beta1 production(GO:0032914) |
| 0.2 | 12.8 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.1 | 11.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 11.9 | 166.4 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.2 | 26.8 | GO:0032432 | actin filament bundle(GO:0032432) |
| 0.3 | 25.1 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.3 | 19.2 | GO:0002102 | podosome(GO:0002102) |
| 0.1 | 14.9 | GO:0072562 | blood microparticle(GO:0072562) |
| 1.1 | 13.5 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 11.8 | GO:0034358 | plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777) |
| 0.3 | 11.6 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 10.7 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.7 | 9.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 107.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 1.0 | 100.2 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 22.5 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.1 | 19.2 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.1 | 15.6 | GO:0008201 | heparin binding(GO:0008201) |
| 0.7 | 15.0 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 10.3 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.4 | 9.9 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 9.2 | GO:0051087 | chaperone binding(GO:0051087) |
| 2.1 | 8.4 | GO:0035373 | chondroitin sulfate proteoglycan binding(GO:0035373) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 94.1 | NABA PROTEOGLYCANS | Genes encoding proteoglycans |
| 1.9 | 91.5 | NABA COLLAGENS | Genes encoding collagen proteins |
| 0.1 | 31.8 | NABA ECM GLYCOPROTEINS | Genes encoding structural ECM glycoproteins |
| 0.2 | 14.3 | PID UPA UPAR PATHWAY | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| 0.1 | 13.3 | PID KIT PATHWAY | Signaling events mediated by Stem cell factor receptor (c-Kit) |
| 0.5 | 10.7 | PID ERB GENOMIC PATHWAY | Validated nuclear estrogen receptor beta network |
| 0.0 | 10.4 | NABA ECM REGULATORS | Genes encoding enzymes and their regulators involved in the remodeling of the extracellular matrix |
| 0.1 | 10.1 | PID HNF3B PATHWAY | FOXA2 and FOXA3 transcription factor networks |
| 0.1 | 7.5 | PID CD8 TCR DOWNSTREAM PATHWAY | Downstream signaling in naïve CD8+ T cells |
| 0.3 | 7.3 | PID INTEGRIN4 PATHWAY | Alpha6 beta4 integrin-ligand interactions |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 91.7 | REACTOME NCAM1 INTERACTIONS | Genes involved in NCAM1 interactions |
| 2.7 | 73.2 | REACTOME CS DS DEGRADATION | Genes involved in CS/DS degradation |
| 0.6 | 16.0 | REACTOME P130CAS LINKAGE TO MAPK SIGNALING FOR INTEGRINS | Genes involved in p130Cas linkage to MAPK signaling for integrins |
| 1.1 | 15.0 | REACTOME KERATAN SULFATE DEGRADATION | Genes involved in Keratan sulfate degradation |
| 0.6 | 12.6 | REACTOME INITIAL TRIGGERING OF COMPLEMENT | Genes involved in Initial triggering of complement |
| 0.1 | 12.3 | REACTOME CELL JUNCTION ORGANIZATION | Genes involved in Cell junction organization |
| 0.2 | 11.0 | REACTOME SMOOTH MUSCLE CONTRACTION | Genes involved in Smooth Muscle Contraction |
| 0.5 | 10.1 | REACTOME CHYLOMICRON MEDIATED LIPID TRANSPORT | Genes involved in Chylomicron-mediated lipid transport |
| 0.2 | 7.0 | REACTOME THROMBIN SIGNALLING THROUGH PROTEINASE ACTIVATED RECEPTORS PARS | Genes involved in Thrombin signalling through proteinase activated receptors (PARs) |
| 0.4 | 6.6 | REACTOME ZINC TRANSPORTERS | Genes involved in Zinc transporters |