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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)

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Results for BATF3

Z-value: 0.15

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Transcription factors associated with BATF3

Gene Symbol Gene ID Gene Info
BATF3
ENSG00000123685.4 basic leucine zipper ATF-like transcription factor 3

Activity-expression correlation:

GenePromoterPearson corr. coef.P-valuePlot
BATF3hg19_v2_chr1_-_212873267_212873332-0.202.6e-03Click!

Activity profile of BATF3 motif

Sorted Z-values of BATF3 motif

Top targets:  

Promoter Log-likelihood Transcript Gene Gene Info
chr5_-_172198190 12.35 ENST00000239223.3
DUSP1
dual specificity phosphatase 1
chr12_-_92539614 11.00 ENST00000256015.3
BTG1
B-cell translocation gene 1, anti-proliferative
chr6_+_32939964 4.89 ENST00000607833.1
BRD2
bromodomain containing 2
chr14_-_50053081 4.85 ENST00000396020.3
ENST00000245458.6
RPS29
ribosomal protein S29
chr22_+_38597889 4.21 ENST00000338483.2
ENST00000538320.1
ENST00000538999.1
ENST00000441709.1
MAFF
v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F
chr11_+_102217936 4.15 ENST00000532832.1
ENST00000530675.1
ENST00000533742.1
ENST00000227758.2
ENST00000532672.1
ENST00000531259.1
ENST00000527465.1
BIRC2
baculoviral IAP repeat containing 2
chr15_-_34394119 3.62 ENST00000256545.4
EMC7
ER membrane protein complex subunit 7
chr19_-_47616992 3.58 ENST00000253048.5
ZC3H4
zinc finger CCCH-type containing 4
chr10_+_123923205 3.43 ENST00000369004.3
ENST00000260733.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr10_+_123922941 3.35 ENST00000360561.3
TACC2
transforming, acidic coiled-coil containing protein 2
chr3_-_101405539 3.32 ENST00000469605.1
ENST00000495401.1
ENST00000394077.3
RPL24
ribosomal protein L24
chr10_+_123923105 3.16 ENST00000368999.1
TACC2
transforming, acidic coiled-coil containing protein 2
chr19_-_18392422 3.09 ENST00000252818.3
JUND
jun D proto-oncogene
chr16_+_3068393 2.99 ENST00000573001.1
TNFRSF12A
tumor necrosis factor receptor superfamily, member 12A
chr7_-_93633684 2.99 ENST00000222547.3
ENST00000425626.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr7_-_93633658 2.98 ENST00000433727.1
BET1
Bet1 golgi vesicular membrane trafficking protein
chr22_+_31518938 2.84 ENST00000412985.1
ENST00000331075.5
ENST00000412277.2
ENST00000420017.1
ENST00000400294.2
ENST00000405300.1
ENST00000404390.3
INPP5J
inositol polyphosphate-5-phosphatase J
chr5_-_175964366 2.84 ENST00000274811.4
RNF44
ring finger protein 44
chr2_-_220264703 2.78 ENST00000519905.1
ENST00000523282.1
ENST00000434339.1
ENST00000457935.1
DNPEP
aspartyl aminopeptidase
chr3_+_38206975 2.74 ENST00000446845.1
ENST00000311806.3
OXSR1
oxidative stress responsive 1
chr3_-_52312636 2.20 ENST00000296490.3
WDR82
WD repeat domain 82
chr15_-_34394008 2.20 ENST00000527822.1
ENST00000528949.1
EMC7
ER membrane protein complex subunit 7
chr6_+_31939608 2.18 ENST00000375331.2
ENST00000375333.2
STK19
serine/threonine kinase 19
chr6_-_91006627 2.12 ENST00000537989.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_+_156030937 2.10 ENST00000361084.5
RAB25
RAB25, member RAS oncogene family
chr2_-_74757066 1.90 ENST00000377526.3
AUP1
ancient ubiquitous protein 1
chr7_+_100464760 1.64 ENST00000200457.4
TRIP6
thyroid hormone receptor interactor 6
chr8_-_67090825 1.64 ENST00000276571.3
CRH
corticotropin releasing hormone
chr2_-_65357225 1.60 ENST00000398529.3
ENST00000409751.1
ENST00000356214.7
ENST00000409892.1
ENST00000409784.3
RAB1A
RAB1A, member RAS oncogene family
chr6_-_91006461 1.59 ENST00000257749.4
ENST00000343122.3
ENST00000406998.2
ENST00000453877.1
BACH2
BTB and CNC homology 1, basic leucine zipper transcription factor 2
chr1_+_70671363 1.53 ENST00000370951.1
ENST00000370950.3
ENST00000405432.1
ENST00000454435.2
SRSF11
serine/arginine-rich splicing factor 11
chr8_+_37594130 1.33 ENST00000518526.1
ENST00000523887.1
ENST00000276461.5
ERLIN2
ER lipid raft associated 2
chr15_-_42840961 1.30 ENST00000563454.1
ENST00000397130.3
ENST00000570160.1
ENST00000323443.2
LRRC57
leucine rich repeat containing 57
chr2_-_43823093 1.16 ENST00000405006.4
THADA
thyroid adenoma associated
chr17_-_49124230 1.15 ENST00000510283.1
ENST00000510855.1
SPAG9
sperm associated antigen 9
chr4_-_39367949 1.14 ENST00000503784.1
ENST00000349703.2
ENST00000381897.1
RFC1
replication factor C (activator 1) 1, 145kDa
chr2_-_43823119 1.12 ENST00000403856.1
ENST00000404790.1
ENST00000405975.2
ENST00000415080.2
THADA
thyroid adenoma associated
chr6_-_106773491 0.96 ENST00000360666.4
ATG5
autophagy related 5
chr6_-_106773610 0.91 ENST00000369076.3
ENST00000369070.1
ATG5
autophagy related 5
chr4_-_104119528 0.90 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE
centromere protein E, 312kDa
chr1_+_153750622 0.89 ENST00000532853.1
SLC27A3
solute carrier family 27 (fatty acid transporter), member 3
chr6_-_106773291 0.86 ENST00000343245.3
ATG5
autophagy related 5
chr3_-_119182523 0.81 ENST00000319172.5
TMEM39A
transmembrane protein 39A
chr20_+_42219559 0.79 ENST00000373030.3
ENST00000373039.4
IFT52
intraflagellar transport 52 homolog (Chlamydomonas)
chr5_+_112849373 0.75 ENST00000161863.4
ENST00000515883.1
YTHDC2
YTH domain containing 2
chr6_+_37400974 0.73 ENST00000455891.1
ENST00000373451.4
CMTR1
cap methyltransferase 1
chr11_-_28129656 0.58 ENST00000263181.6
KIF18A
kinesin family member 18A
chr1_-_70671216 0.57 ENST00000370952.3
LRRC40
leucine rich repeat containing 40
chr18_+_76829441 0.54 ENST00000458297.2
ATP9B
ATPase, class II, type 9B
chr1_+_228353495 0.43 ENST00000366711.3
IBA57
IBA57, iron-sulfur cluster assembly homolog (S. cerevisiae)
chr15_-_66790146 0.42 ENST00000316634.5
SNAPC5
small nuclear RNA activating complex, polypeptide 5, 19kDa
chr10_+_35484793 0.38 ENST00000488741.1
ENST00000474931.1
ENST00000468236.1
ENST00000344351.5
ENST00000490511.1
CREM
cAMP responsive element modulator
chr2_+_74757050 0.21 ENST00000352222.3
ENST00000437202.1
HTRA2
HtrA serine peptidase 2
chr11_+_12696102 0.19 ENST00000527636.1
ENST00000527376.1
TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr15_+_42841008 0.13 ENST00000260372.3
ENST00000568876.1
ENST00000568846.2
ENST00000562398.1
HAUS2
HAUS augmin-like complex, subunit 2
chr4_+_170581213 0.12 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr9_-_100684845 0.06 ENST00000375119.3
C9orf156
chromosome 9 open reading frame 156
chr9_-_99381660 0.05 ENST00000375240.3
ENST00000463569.1
CDC14B
cell division cycle 14B

Network of associatons between targets according to the STRING database.

First level regulatory network of BATF3

PNG image of the network

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Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.4 4.1 GO:1902523 positive regulation of protein K63-linked ubiquitination(GO:1902523)
0.9 2.7 GO:2000687 negative regulation of rubidium ion transport(GO:2000681) negative regulation of rubidium ion transmembrane transporter activity(GO:2000687)
0.9 2.7 GO:0044034 negative stranded viral RNA replication(GO:0039689) multi-organism biosynthetic process(GO:0044034)
0.9 6.0 GO:0048280 vesicle fusion with Golgi apparatus(GO:0048280)
0.8 11.0 GO:2000271 positive regulation of fibroblast apoptotic process(GO:2000271)
0.8 3.3 GO:1902626 assembly of large subunit precursor of preribosome(GO:1902626)
0.8 12.3 GO:0035970 peptidyl-threonine dephosphorylation(GO:0035970)
0.6 2.3 GO:1901895 negative regulation of calcium-transporting ATPase activity(GO:1901895)
0.5 1.6 GO:0051462 cortisol secretion(GO:0043400) positive regulation of corticotropin secretion(GO:0051461) regulation of cortisol secretion(GO:0051462) negative regulation of glucagon secretion(GO:0070093) positive regulation of corticosterone secretion(GO:2000854)
0.4 3.0 GO:0006931 substrate-dependent cell migration, cell attachment to substrate(GO:0006931)
0.3 1.6 GO:0008588 release of cytoplasmic sequestered NF-kappaB(GO:0008588)
0.3 1.3 GO:0090206 negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206)
0.2 0.8 GO:0035720 intraciliary anterograde transport(GO:0035720)
0.2 4.2 GO:0007567 parturition(GO:0007567)
0.2 1.2 GO:0090074 negative regulation of protein homodimerization activity(GO:0090074)
0.2 2.2 GO:0080182 histone H3-K4 trimethylation(GO:0080182)
0.1 0.9 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079)
0.1 0.7 GO:0080009 mRNA methylation(GO:0080009)
0.1 2.8 GO:0031115 negative regulation of microtubule polymerization(GO:0031115)
0.1 2.1 GO:0031268 pseudopodium organization(GO:0031268)
0.1 3.1 GO:0002076 osteoblast development(GO:0002076)
0.1 1.6 GO:0090110 cargo loading into COPII-coated vesicle(GO:0090110)
0.1 0.8 GO:0044829 positive regulation by host of viral genome replication(GO:0044829)
0.1 0.2 GO:1904924 negative regulation of mitophagy in response to mitochondrial depolarization(GO:1904924)
0.1 1.9 GO:0030970 retrograde protein transport, ER to cytosol(GO:0030970)
0.1 0.4 GO:0006384 transcription initiation from RNA polymerase III promoter(GO:0006384)
0.0 1.1 GO:0070987 error-free translesion synthesis(GO:0070987)
0.0 6.9 GO:0021987 cerebral cortex development(GO:0021987)
0.0 0.6 GO:0072520 seminiferous tubule development(GO:0072520)
0.0 4.9 GO:0006334 nucleosome assembly(GO:0006334)
0.0 4.9 GO:0006614 SRP-dependent cotranslational protein targeting to membrane(GO:0006614)
0.0 0.1 GO:0048388 endosomal lumen acidification(GO:0048388)
0.0 0.4 GO:0016226 iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163)
0.0 1.5 GO:0006369 termination of RNA polymerase II transcription(GO:0006369)
0.0 0.3 GO:0045332 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.0 3.7 GO:1902593 single-organism nuclear import(GO:1902593)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.6 5.8 GO:0072546 ER membrane protein complex(GO:0072546)
0.5 2.7 GO:0034274 Atg12-Atg5-Atg16 complex(GO:0034274)
0.4 3.1 GO:0035976 AP1 complex(GO:0035976)
0.4 1.9 GO:0000836 Hrd1p ubiquitin ligase complex(GO:0000836)
0.3 1.6 GO:0045323 interleukin-1 receptor complex(GO:0045323)
0.3 2.3 GO:0098554 cytoplasmic side of endoplasmic reticulum membrane(GO:0098554)
0.3 4.4 GO:0035631 CD40 receptor complex(GO:0035631)
0.3 1.6 GO:0043196 varicosity(GO:0043196)
0.2 2.2 GO:0072357 PTW/PP1 phosphatase complex(GO:0072357)
0.2 1.1 GO:0005663 DNA replication factor C complex(GO:0005663)
0.1 1.5 GO:1990023 mitotic spindle midzone(GO:1990023)
0.1 6.0 GO:0005801 cis-Golgi network(GO:0005801)
0.1 0.8 GO:0044292 dendrite terminus(GO:0044292)
0.1 2.1 GO:0031143 pseudopodium(GO:0031143)
0.1 4.9 GO:0022627 cytosolic small ribosomal subunit(GO:0022627)
0.1 3.7 GO:0031463 Cul3-RING ubiquitin ligase complex(GO:0031463)
0.0 2.8 GO:0043198 dendritic shaft(GO:0043198)
0.0 3.3 GO:0022625 cytosolic large ribosomal subunit(GO:0022625)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 10.7 GO:0005815 microtubule organizing center(GO:0005815)
0.0 3.0 GO:0001726 ruffle(GO:0001726)
0.0 2.8 GO:0072562 blood microparticle(GO:0072562)
0.0 1.6 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)
0.0 0.1 GO:0071148 TEAD-1-YAP complex(GO:0071148)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
4.1 12.3 GO:0008330 protein tyrosine/threonine phosphatase activity(GO:0008330)
1.4 4.1 GO:0098770 FBXO family protein binding(GO:0098770)
0.5 2.7 GO:0019776 Atg8 ligase activity(GO:0019776)
0.3 3.7 GO:0001206 transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206)
0.3 2.8 GO:0004445 inositol-polyphosphate 5-phosphatase activity(GO:0004445) phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity(GO:0034485)
0.2 0.9 GO:0043515 kinetochore binding(GO:0043515)
0.2 1.1 GO:0003689 DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170)
0.2 1.9 GO:0097027 ubiquitin-protein transferase activator activity(GO:0097027)
0.1 0.7 GO:0008174 mRNA methyltransferase activity(GO:0008174)
0.1 2.2 GO:0042800 histone methyltransferase activity (H3-K4 specific)(GO:0042800)
0.1 4.9 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.1 2.8 GO:0070006 metalloaminopeptidase activity(GO:0070006)
0.1 3.1 GO:0016922 ligand-dependent nuclear receptor binding(GO:0016922)
0.1 1.2 GO:0005078 MAP-kinase scaffold activity(GO:0005078)
0.1 1.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.1 0.9 GO:0031957 very long-chain fatty acid-CoA ligase activity(GO:0031957)
0.1 6.0 GO:0019905 syntaxin binding(GO:0019905)
0.1 0.8 GO:1990247 N6-methyladenosine-containing RNA binding(GO:1990247)
0.0 9.9 GO:0035257 nuclear hormone receptor binding(GO:0035257)
0.0 1.6 GO:0005184 neuropeptide hormone activity(GO:0005184)
0.0 8.2 GO:0003735 structural constituent of ribosome(GO:0003735)
0.0 2.7 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 0.4 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 1.3 GO:0015485 cholesterol binding(GO:0015485)
0.0 0.6 GO:0051010 microtubule plus-end binding(GO:0051010)
0.0 0.1 GO:0072320 volume-sensitive chloride channel activity(GO:0072320)
0.0 5.8 GO:0030246 carbohydrate binding(GO:0030246)
0.0 0.4 GO:0031489 myosin V binding(GO:0031489)
0.0 9.2 GO:0003712 transcription cofactor activity(GO:0003712)
0.0 0.3 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 2.8 GO:0061630 ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 12.3 SIG CD40PATHWAYMAP Genes related to CD40 signaling
0.1 4.1 SA CASPASE CASCADE Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade.
0.0 4.9 PID RB 1PATHWAY Regulation of retinoblastoma protein
0.0 3.1 PID FRA PATHWAY Validated transcriptional targets of AP1 family members Fra1 and Fra2
0.0 2.6 PID PLK1 PATHWAY PLK1 signaling events
0.0 1.1 PID FAS PATHWAY FAS (CD95) signaling pathway
0.0 1.6 PID AP1 PATHWAY AP-1 transcription factor network
0.0 1.2 PID ARF6 TRAFFICKING PATHWAY Arf6 trafficking events
0.0 0.4 PID TCR CALCIUM PATHWAY Calcium signaling in the CD4+ TCR pathway

Gene overrepresentation in C2:CP:REACTOME category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 4.1 REACTOME NOD1 2 SIGNALING PATHWAY Genes involved in NOD1/2 Signaling Pathway
0.1 2.8 REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE Genes involved in Synthesis of PIPs at the plasma membrane
0.1 4.9 REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX Genes involved in Formation of the ternary complex, and subsequently, the 43S complex
0.1 2.7 REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING Genes involved in Negative regulators of RIG-I/MDA5 signaling
0.0 1.5 REACTOME MRNA 3 END PROCESSING Genes involved in mRNA 3'-end processing
0.0 3.3 REACTOME PEPTIDE CHAIN ELONGATION Genes involved in Peptide chain elongation
0.0 4.8 REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION Genes involved in Factors involved in megakaryocyte development and platelet production
0.0 1.6 REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS Genes involved in Class B/2 (Secretin family receptors)
0.0 0.4 REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter