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GNF SymAtlas + NCI-60 cancer cell lines, comparison of cancers vs non-cancers, human (Su, 2004; Ross, 2000)
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Results for BATF3
Z-value: 0.15
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Transcription factors associated with BATF3
Activity-expression correlation:
| Gene | Promoter | Pearson corr. coef. | P-value | Plot |
|---|---|---|---|---|
| BATF3 | hg19_v2_chr1_-_212873267_212873332 | -0.20 | 2.6e-03 | Click! |
Network of associatons between targets according to the STRING database.
First level regulatory network of BATF3
Gene Ontology Analysis
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 12.3 | GO:0035970 | peptidyl-threonine dephosphorylation(GO:0035970) |
| 0.8 | 11.0 | GO:2000271 | positive regulation of fibroblast apoptotic process(GO:2000271) |
| 0.0 | 6.9 | GO:0021987 | cerebral cortex development(GO:0021987) |
| 0.9 | 6.0 | GO:0048280 | vesicle fusion with Golgi apparatus(GO:0048280) |
| 0.0 | 4.9 | GO:0006334 | nucleosome assembly(GO:0006334) |
| 0.0 | 4.9 | GO:0006614 | SRP-dependent cotranslational protein targeting to membrane(GO:0006614) |
| 0.2 | 4.2 | GO:0007567 | parturition(GO:0007567) |
| 1.4 | 4.1 | GO:1902523 | positive regulation of protein K63-linked ubiquitination(GO:1902523) |
| 0.0 | 3.7 | GO:1902593 | single-organism nuclear import(GO:1902593) |
| 0.8 | 3.3 | GO:1902626 | assembly of large subunit precursor of preribosome(GO:1902626) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 10.7 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.1 | 6.0 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.6 | 5.8 | GO:0072546 | ER membrane protein complex(GO:0072546) |
| 0.1 | 4.9 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.3 | 4.4 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 3.7 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.0 | 3.3 | GO:0022625 | cytosolic large ribosomal subunit(GO:0022625) |
| 0.4 | 3.1 | GO:0035976 | AP1 complex(GO:0035976) |
| 0.0 | 3.0 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 2.8 | GO:0043198 | dendritic shaft(GO:0043198) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.1 | 12.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 9.9 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 9.2 | GO:0003712 | transcription cofactor activity(GO:0003712) |
| 0.0 | 8.2 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.1 | 6.0 | GO:0019905 | syntaxin binding(GO:0019905) |
| 0.0 | 5.8 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.1 | 4.9 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 1.4 | 4.1 | GO:0098770 | FBXO family protein binding(GO:0098770) |
| 0.3 | 3.7 | GO:0001206 | transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0001206) |
| 0.1 | 3.1 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 12.3 | SIG CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 4.9 | PID RB 1PATHWAY | Regulation of retinoblastoma protein |
| 0.1 | 4.1 | SA CASPASE CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 3.1 | PID FRA PATHWAY | Validated transcriptional targets of AP1 family members Fra1 and Fra2 |
| 0.0 | 2.6 | PID PLK1 PATHWAY | PLK1 signaling events |
| 0.0 | 1.6 | PID AP1 PATHWAY | AP-1 transcription factor network |
| 0.0 | 1.2 | PID ARF6 TRAFFICKING PATHWAY | Arf6 trafficking events |
| 0.0 | 1.1 | PID FAS PATHWAY | FAS (CD95) signaling pathway |
| 0.0 | 0.4 | PID TCR CALCIUM PATHWAY | Calcium signaling in the CD4+ TCR pathway |
Gene overrepresentation in C2:CP:REACTOME category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.9 | REACTOME FORMATION OF THE TERNARY COMPLEX AND SUBSEQUENTLY THE 43S COMPLEX | Genes involved in Formation of the ternary complex, and subsequently, the 43S complex |
| 0.0 | 4.8 | REACTOME FACTORS INVOLVED IN MEGAKARYOCYTE DEVELOPMENT AND PLATELET PRODUCTION | Genes involved in Factors involved in megakaryocyte development and platelet production |
| 0.1 | 4.1 | REACTOME NOD1 2 SIGNALING PATHWAY | Genes involved in NOD1/2 Signaling Pathway |
| 0.0 | 3.3 | REACTOME PEPTIDE CHAIN ELONGATION | Genes involved in Peptide chain elongation |
| 0.1 | 2.8 | REACTOME SYNTHESIS OF PIPS AT THE PLASMA MEMBRANE | Genes involved in Synthesis of PIPs at the plasma membrane |
| 0.1 | 2.7 | REACTOME NEGATIVE REGULATORS OF RIG I MDA5 SIGNALING | Genes involved in Negative regulators of RIG-I/MDA5 signaling |
| 0.0 | 1.6 | REACTOME CLASS B 2 SECRETIN FAMILY RECEPTORS | Genes involved in Class B/2 (Secretin family receptors) |
| 0.0 | 1.5 | REACTOME MRNA 3 END PROCESSING | Genes involved in mRNA 3'-end processing |
| 0.0 | 0.4 | REACTOME RNA POL III TRANSCRIPTION INITIATION FROM TYPE 3 PROMOTER | Genes involved in RNA Polymerase III Transcription Initiation From Type 3 Promoter |